Rattus norvegicus

0 known processes

Spock1

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1

Spock1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
synaptic transmission GO:0007268 235 0.303
cellular response to oxygen containing compound GO:1901701 386 0.210
regulation of phosphate metabolic process GO:0019220 349 0.205
cell cell signaling GO:0007267 335 0.174
vesicle mediated transport GO:0016192 181 0.172
protein complex assembly GO:0006461 263 0.158
head development GO:0060322 247 0.150
neuron differentiation GO:0030182 368 0.138
Human
macromolecular complex subunit organization GO:0043933 339 0.134
regulation of cellular component organization GO:0051128 368 0.131
Human
protein complex biogenesis GO:0070271 263 0.128
positive regulation of transport GO:0051050 245 0.128
response to inorganic substance GO:0010035 377 0.123
hormone transport GO:0009914 121 0.119
neuron projection development GO:0031175 273 0.112
Human
monovalent inorganic cation transport GO:0015672 172 0.109
macromolecular complex assembly GO:0065003 273 0.099
intracellular signal transduction GO:0035556 314 0.098
protein complex subunit organization GO:0071822 302 0.097
inorganic ion transmembrane transport GO:0098660 229 0.092
transmembrane transport GO:0055085 412 0.090
brain development GO:0007420 247 0.090
tissue development GO:0009888 252 0.087
positive regulation of signaling GO:0023056 270 0.081
ion transmembrane transport GO:0034220 365 0.080
positive regulation of signal transduction GO:0009967 175 0.078
neuron development GO:0048666 286 0.076
Human
regulation of cellular localization GO:0060341 263 0.075
cellular component biogenesis GO:0044085 368 0.074
cation transmembrane transport GO:0098655 263 0.074
cellular component assembly GO:0022607 360 0.072
cellular homeostasis GO:0019725 252 0.071
response to metal ion GO:0010038 253 0.070
response to glucocorticoid GO:0051384 223 0.068
cellular ketone metabolic process GO:0042180 51 0.065
regulation of hormone levels GO:0010817 187 0.065
organophosphate metabolic process GO:0019637 370 0.062
regulation of secretion GO:0051046 224 0.060
chemical homeostasis GO:0048878 292 0.060
response to estradiol GO:0032355 164 0.058
single organism behavior GO:0044708 130 0.057
regulation of signal transduction GO:0009966 318 0.057
regulation of multicellular organismal development GO:2000026 376 0.056
Human
response to bacterium GO:0009617 200 0.055
regulation of neuron projection development GO:0010975 161 0.055
Human
secretion GO:0046903 307 0.054
cellular response to endogenous stimulus GO:0071495 377 0.054
exocytosis GO:0006887 60 0.053
protein heterooligomerization GO:0051291 89 0.052
carboxylic acid metabolic process GO:0019752 289 0.051
regulation of peptide secretion GO:0002791 82 0.051
protein oligomerization GO:0051259 191 0.050
central nervous system development GO:0007417 311 0.050
clustering of voltage gated potassium channels GO:0045163 1 0.050
programmed cell death GO:0012501 392 0.050
negative regulation of cellular biosynthetic process GO:0031327 161 0.050
ribose phosphate metabolic process GO:0019693 235 0.049
protein localization GO:0008104 191 0.048
cell morphogenesis GO:0000902 142 0.048
regulation of protein metabolic process GO:0051246 289 0.046
Human
oxoacid metabolic process GO:0043436 290 0.046
positive regulation of cellular biosynthetic process GO:0031328 295 0.045
cellular divalent inorganic cation homeostasis GO:0072503 162 0.045
purine ribonucleotide metabolic process GO:0009150 227 0.045
regulation of ion transmembrane transport GO:0034765 121 0.044
regulation of phosphorus metabolic process GO:0051174 349 0.044
cellular calcium ion homeostasis GO:0006874 160 0.043
carbohydrate derivative metabolic process GO:1901135 346 0.043
regulation of vesicle mediated transport GO:0060627 81 0.042
aging GO:0007568 241 0.042
peptide secretion GO:0002790 86 0.042
purine containing compound metabolic process GO:0072521 253 0.042
cellular component morphogenesis GO:0032989 155 0.041
regulation of ion transport GO:0043269 245 0.041
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.041
positive regulation of biosynthetic process GO:0009891 319 0.040
signal release GO:0023061 145 0.040
negative regulation of vesicle fusion GO:0031339 2 0.040
positive regulation of developmental process GO:0051094 283 0.040
insulin secretion GO:0030073 69 0.040
lipid modification GO:0030258 52 0.039
neuronal ion channel clustering GO:0045161 3 0.039
positive regulation of multicellular organismal process GO:0051240 387 0.039
cell projection morphogenesis GO:0048858 123 0.039
nucleoside phosphate metabolic process GO:0006753 283 0.039
establishment of organelle localization GO:0051656 37 0.038
cell projection organization GO:0030030 302 0.038
Human
detection of calcium ion GO:0005513 1 0.038
cellular metal ion homeostasis GO:0006875 172 0.038
negative regulation of phosphorus metabolic process GO:0010563 80 0.038
cation transport GO:0006812 382 0.038
nucleotide metabolic process GO:0009117 279 0.037
camp metabolic process GO:0046058 63 0.037
response to radiation GO:0009314 137 0.037
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.037
single organism reproductive process GO:0044702 297 0.037
neurological system process GO:0050877 219 0.037
ion homeostasis GO:0050801 212 0.037
regulation of protein modification process GO:0031399 194 0.037
regulation of cellular ketone metabolic process GO:0010565 27 0.037
positive regulation of neurogenesis GO:0050769 165 0.037
nucleobase containing small molecule metabolic process GO:0055086 316 0.037
cellular chemical homeostasis GO:0055082 247 0.036
phosphatidylinositol dephosphorylation GO:0046856 4 0.035
organelle organization GO:0006996 266 0.035
behavior GO:0007610 205 0.035
single organism organelle organization GO:1902589 180 0.035
synaptic vesicle exocytosis GO:0016079 15 0.034
anatomical structure morphogenesis GO:0009653 298 0.034
regulation of molecular function GO:0065009 398 0.034
Human
macromolecule localization GO:0033036 252 0.033
secretion by cell GO:0032940 248 0.032
g protein coupled receptor signaling pathway GO:0007186 242 0.032
inorganic cation transmembrane transport GO:0098662 202 0.031
negative regulation of cellular metabolic process GO:0031324 281 0.031
Human
regulation of cell development GO:0060284 263 0.031
Human
metal ion homeostasis GO:0055065 186 0.030
cation homeostasis GO:0055080 195 0.030
endocytosis GO:0006897 84 0.030
regulation of rna metabolic process GO:0051252 391 0.030
amine metabolic process GO:0009308 38 0.029
cellular response to stress GO:0033554 269 0.029
cellular response to nitrogen compound GO:1901699 210 0.029
regulation of growth GO:0040008 105 0.029
neuron projection morphogenesis GO:0048812 122 0.028
intracellular transport GO:0046907 185 0.028
regulation of nucleic acid templated transcription GO:1903506 380 0.028
multicellular organismal reproductive process GO:0048609 233 0.028
regulation of synaptic transmission GO:0050804 141 0.028
regulation of metal ion transport GO:0010959 118 0.028
cellular cation homeostasis GO:0030003 180 0.028
organic acid metabolic process GO:0006082 292 0.028
multicellular organism reproduction GO:0032504 233 0.028
calcium ion homeostasis GO:0055074 162 0.028
positive regulation of cell differentiation GO:0045597 217 0.028
rna biosynthetic process GO:0032774 380 0.028
reproduction GO:0000003 245 0.027
response to monosaccharide GO:0034284 159 0.027
cellular lipid metabolic process GO:0044255 208 0.027
defecation GO:0030421 1 0.027
carbohydrate derivative catabolic process GO:1901136 147 0.027
regulation of transcription dna templated GO:0006355 374 0.027
negative regulation of phosphate metabolic process GO:0045936 80 0.027
positive regulation of cell development GO:0010720 176 0.027
regulation of membrane potential GO:0042391 110 0.027
synaptic vesicle transport GO:0048489 23 0.026
positive regulation of cell communication GO:0010647 271 0.026
response to hexose GO:0009746 144 0.026
apoptotic process GO:0006915 381 0.026
response to ketone GO:1901654 182 0.025
homeostatic process GO:0042592 331 0.025
cellular catabolic process GO:0044248 295 0.025
organic substance catabolic process GO:1901575 316 0.025
catabolic process GO:0009056 351 0.025
regulation of peptide hormone secretion GO:0090276 80 0.025
startle response GO:0001964 2 0.024
response to oxidative stress GO:0006979 186 0.024
membrane organization GO:0061024 94 0.024
regulation of programmed cell death GO:0043067 341 0.024
rna metabolic process GO:0016070 406 0.024
regulation of secretion by cell GO:1903530 208 0.024
response to nutrient levels GO:0031667 370 0.024
response to peptide GO:1901652 292 0.024
divalent inorganic cation homeostasis GO:0072507 165 0.024
action potential GO:0001508 54 0.023
lipid metabolic process GO:0006629 283 0.023
transcription dna templated GO:0006351 377 0.023
establishment of protein localization GO:0045184 141 0.023
positive regulation of rna biosynthetic process GO:1902680 197 0.023
regulation of cell proliferation GO:0042127 359 0.022
regulation of phosphatidylinositol dephosphorylation GO:0060304 1 0.022
cellular response to organonitrogen compound GO:0071417 197 0.022
response to glucose GO:0009749 136 0.022
regulation of cellular amine metabolic process GO:0033238 8 0.022
negative regulation of calcium ion dependent exocytosis GO:0045955 5 0.022
metal ion transport GO:0030001 289 0.022
peptide hormone secretion GO:0030072 84 0.022
response to growth factor GO:0070848 189 0.021
peptide transport GO:0015833 97 0.021
cell cycle process GO:0022402 57 0.021
single organism intracellular transport GO:1902582 166 0.021
negative regulation of rna biosynthetic process GO:1902679 118 0.021
protein homooligomerization GO:0051260 91 0.021
cell part morphogenesis GO:0032990 123 0.020
negative regulation of biosynthetic process GO:0009890 168 0.020
response to ammonium ion GO:0060359 71 0.020
positive regulation of rna metabolic process GO:0051254 203 0.020
response to estrogen GO:0043627 232 0.020
response to external biotic stimulus GO:0043207 221 0.020
positive regulation of transcription dna templated GO:0045893 197 0.020
glycosyl compound metabolic process GO:1901657 182 0.020
negative regulation of macromolecule metabolic process GO:0010605 260 0.020
Human
regulation of camp metabolic process GO:0030814 43 0.020
synapse assembly GO:0007416 29 0.020
transcription from rna polymerase ii promoter GO:0006366 252 0.020
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.019
potassium ion transport GO:0006813 97 0.019
positive regulation of secretion GO:0051047 140 0.019
hormone secretion GO:0046879 115 0.019
response to carbohydrate GO:0009743 183 0.019
taxis GO:0042330 67 0.019
cellular response to growth factor stimulus GO:0071363 162 0.019
response to peptide hormone GO:0043434 278 0.019
regulation of hormone secretion GO:0046883 106 0.019
regulation of peptide transport GO:0090087 87 0.019
protein transport GO:0015031 132 0.019
cellular amine metabolic process GO:0044106 38 0.019
reproductive process GO:0022414 372 0.019
single organism cellular localization GO:1902580 102 0.018
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.018
cellular ion homeostasis GO:0006873 184 0.018
regulation of transporter activity GO:0032409 50 0.018
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.018
regulation of cell cycle GO:0051726 73 0.018
protein phosphorylation GO:0006468 345 0.018
axon guidance GO:0007411 24 0.018
regulation of insulin secretion GO:0050796 65 0.018
hormone metabolic process GO:0042445 69 0.018
neuron projection guidance GO:0097485 24 0.018
response to oxygen levels GO:0070482 265 0.018
positive regulation of protein metabolic process GO:0051247 178 0.018
regulation of neuron differentiation GO:0045664 208 0.018
Human
axon development GO:0061564 96 0.018
potassium ion transmembrane transport GO:0071805 71 0.018
atp metabolic process GO:0046034 72 0.018
amide transport GO:0042886 105 0.018
regulation of transmembrane transport GO:0034762 122 0.018
ribonucleotide metabolic process GO:0009259 231 0.018
dephosphorylation GO:0016311 98 0.018
single organism membrane organization GO:0044802 74 0.017
regulation of cellular amino acid metabolic process GO:0006521 2 0.017
ribose phosphate biosynthetic process GO:0046390 87 0.017
sensory organ development GO:0007423 74 0.017
cellular potassium ion transport GO:0071804 72 0.017
organonitrogen compound catabolic process GO:1901565 179 0.017
positive regulation of phosphate metabolic process GO:0045937 262 0.017
organelle localization GO:0051640 55 0.017
negative regulation of cell communication GO:0010648 158 0.017
regulation of intracellular signal transduction GO:1902531 218 0.017
cyclic nucleotide metabolic process GO:0009187 80 0.017
negative regulation of programmed cell death GO:0043069 183 0.017
axonogenesis GO:0007409 71 0.017
regulation of cell differentiation GO:0045595 320 0.017
Human
positive regulation of molecular function GO:0044093 230 0.017
regulation of cell maturation GO:1903429 3 0.017
neuron projection extension GO:1990138 26 0.017
multicellular organism growth GO:0035264 1 0.017
regulation of phosphorylation GO:0042325 248 0.017
organophosphate catabolic process GO:0046434 148 0.017
cellular amino acid metabolic process GO:0006520 107 0.016
positive regulation of secretion by cell GO:1903532 128 0.016
purine nucleoside metabolic process GO:0042278 169 0.016
sexual reproduction GO:0019953 148 0.016
negative regulation of transcription dna templated GO:0045892 116 0.016
cytoplasmic transport GO:0016482 115 0.016
positive regulation of response to stimulus GO:0048584 285 0.016
growth GO:0040007 165 0.016
positive regulation of cellular component organization GO:0051130 200 0.016
response to corticosteroid GO:0031960 235 0.016
positive regulation of catalytic activity GO:0043085 184 0.016
actin filament based process GO:0030029 86 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.016
intracellular protein transport GO:0006886 79 0.016
single organism catabolic process GO:0044712 283 0.015
cardiac conduction GO:0061337 2 0.015
cytosolic calcium ion homeostasis GO:0051480 140 0.015
grooming behavior GO:0007625 4 0.015
negative regulation of metabolic process GO:0009892 331 0.015
Human
tube development GO:0035295 89 0.015
response to hydrogen peroxide GO:0042542 89 0.015
regulation of blood pressure GO:0008217 83 0.015
divalent metal ion transport GO:0070838 132 0.015
regulation of system process GO:0044057 208 0.015
development of primary sexual characteristics GO:0045137 107 0.015
regulation of intracellular transport GO:0032386 65 0.015
regulation of apoptotic process GO:0042981 335 0.015
positive regulation of cell proliferation GO:0008284 249 0.015
nucleic acid templated transcription GO:0097659 379 0.015
cellular macromolecule localization GO:0070727 122 0.015
peptidyl amino acid modification GO:0018193 126 0.015
neuromuscular process GO:0050905 2 0.015
positive regulation of phosphorus metabolic process GO:0010562 262 0.015
microtubule cytoskeleton organization GO:0000226 25 0.015
organic cyclic compound catabolic process GO:1901361 175 0.015
lipid biosynthetic process GO:0008610 128 0.014
cell cycle GO:0007049 101 0.014
positive regulation of neuron differentiation GO:0045666 126 0.014
negative regulation of gene expression GO:0010629 199 0.014
Human
cytoskeleton organization GO:0007010 111 0.014
nucleoside monophosphate metabolic process GO:0009123 93 0.014
developmental growth GO:0048589 100 0.014
locomotor rhythm GO:0045475 1 0.014
regulation of protein kinase activity GO:0045859 105 0.014
gonad development GO:0008406 104 0.014
nucleoside phosphate biosynthetic process GO:1901293 102 0.014
regulation of protein phosphorylation GO:0001932 183 0.014
positive regulation of synaptic transmission GO:0050806 62 0.014
positive regulation of nucleic acid templated transcription GO:1903508 197 0.014
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.014
regulation of cell growth GO:0001558 85 0.014
proteolysis GO:0006508 175 0.014
Human
regulation of neurotransmitter levels GO:0001505 42 0.014
endoplasmic reticulum organization GO:0007029 1 0.014
purine nucleotide metabolic process GO:0006163 229 0.014
negative regulation of transport GO:0051051 136 0.014
negative regulation of multicellular organismal process GO:0051241 203 0.014
Human
positive regulation of neuron projection development GO:0010976 99 0.014
regulation of kinase activity GO:0043549 117 0.014
glycerolipid metabolic process GO:0046486 67 0.013
regulation of nervous system development GO:0051960 264 0.013
Human
blood circulation GO:0008015 183 0.013
synaptic vesicle localization GO:0097479 24 0.013
circadian rhythm GO:0007623 88 0.013
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.013
nitrogen compound transport GO:0071705 229 0.013
positive regulation of cell death GO:0010942 184 0.013
nucleobase containing compound catabolic process GO:0034655 152 0.013
purine ribonucleotide biosynthetic process GO:0009152 81 0.013
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.013
cellular response to inorganic substance GO:0071241 65 0.013
mechanoreceptor differentiation GO:0042490 2 0.013
response to reactive oxygen species GO:0000302 120 0.013
regulation of nucleotide metabolic process GO:0006140 117 0.013
regulation of mrna splicing via spliceosome GO:0048024 3 0.013
receptor internalization GO:0031623 14 0.013
pancreatic a cell differentiation GO:0003310 1 0.013
cell growth GO:0016049 104 0.013
developmental process involved in reproduction GO:0003006 159 0.013
purine nucleoside triphosphate metabolic process GO:0009144 141 0.013
cellular response to hexose stimulus GO:0071331 65 0.013
cell morphogenesis involved in differentiation GO:0000904 119 0.013
regulation of protein localization GO:0032880 81 0.013
positive regulation of growth GO:0045927 55 0.013
negative regulation of cellular component organization GO:0051129 83 0.012
Human
synaptic transmission glutamatergic GO:0035249 33 0.012
heterocycle catabolic process GO:0046700 167 0.012
regulation of calcium ion transport GO:0051924 77 0.012
vesicle localization GO:0051648 33 0.012
regulation of purine nucleotide metabolic process GO:1900542 115 0.012
reproductive structure development GO:0048608 128 0.012
positive regulation of cellular amine metabolic process GO:0033240 3 0.012
regulation of body fluid levels GO:0050878 90 0.012
nucleotide biosynthetic process GO:0009165 98 0.012
response to other organism GO:0051707 220 0.012
anterior posterior pattern specification GO:0009952 1 0.012
signal transduction by phosphorylation GO:0023014 144 0.012
protein maturation GO:0051604 68 0.012
Human
purine nucleotide biosynthetic process GO:0006164 83 0.012
cellular response to organic cyclic compound GO:0071407 202 0.012
nucleoside phosphate catabolic process GO:1901292 140 0.012
organonitrogen compound biosynthetic process GO:1901566 167 0.012
single organism biosynthetic process GO:0044711 342 0.012
detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 4 0.012
positive regulation of cell projection organization GO:0031346 111 0.012
positive regulation of hydrolase activity GO:0051345 86 0.012
response to molecule of bacterial origin GO:0002237 194 0.012
coronary vasculature morphogenesis GO:0060977 3 0.012
regulation of protein transport GO:0051223 68 0.012
axis specification GO:0009798 4 0.012
glutamate receptor signaling pathway GO:0007215 43 0.012
response to alkaloid GO:0043279 132 0.012
gamete generation GO:0007276 124 0.012
positive regulation of phosphorylation GO:0042327 177 0.012
response to electrical stimulus GO:0051602 56 0.012
regulation of nucleotide catabolic process GO:0030811 65 0.012
response to extracellular stimulus GO:0009991 380 0.012
negative regulation of rna metabolic process GO:0051253 123 0.011
sex differentiation GO:0007548 113 0.011
organic hydroxy compound metabolic process GO:1901615 115 0.011
regulation of brown fat cell proliferation GO:0070347 1 0.011
nucleoside metabolic process GO:0009116 179 0.011
ribonucleoside metabolic process GO:0009119 174 0.011
motor neuron axon guidance GO:0008045 1 0.011
regulation of catalytic activity GO:0050790 304 0.011
Human
receptor mediated endocytosis GO:0006898 42 0.011
forebrain development GO:0030900 98 0.011
positive regulation of nucleotide metabolic process GO:0045981 91 0.011
positive regulation of intracellular signal transduction GO:1902533 138 0.011
detection of chemical stimulus GO:0009593 10 0.011
regulation of transferase activity GO:0051338 123 0.011
response to lipopolysaccharide GO:0032496 191 0.011
sequestering of metal ion GO:0051238 9 0.011
dna metabolic process GO:0006259 96 0.011
carbohydrate homeostasis GO:0033500 75 0.011
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.011
regulation of cyclic nucleotide metabolic process GO:0030799 51 0.011
cyclic nucleotide biosynthetic process GO:0009190 63 0.011
phospholipid metabolic process GO:0006644 61 0.011
activation of phospholipase d activity GO:0031584 2 0.011
cardiovascular system development GO:0072358 134 0.011
positive regulation of lipid biosynthetic process GO:0046889 25 0.011
glycerophospholipid metabolic process GO:0006650 47 0.011
response to calcium ion GO:0051592 59 0.011
carbohydrate derivative biosynthetic process GO:1901137 124 0.011
endoplasmic reticulum membrane organization GO:0090158 1 0.011
negative regulation of nucleic acid templated transcription GO:1903507 117 0.011
striated muscle tissue development GO:0014706 58 0.011
calcium ion transport GO:0006816 131 0.011
ribonucleotide biosynthetic process GO:0009260 85 0.011
eye morphogenesis GO:0048592 4 0.011
gland development GO:0048732 155 0.011
response to cytokine GO:0034097 215 0.011
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 51 0.011
regulation of neurogenesis GO:0050767 247 0.011
Human
cellular response to histamine GO:0071420 3 0.011
response to hypoxia GO:0001666 231 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.011
dicarboxylic acid metabolic process GO:0043648 42 0.010
ras protein signal transduction GO:0007265 29 0.010
regulation of exocytosis GO:0017157 37 0.010
glucose homeostasis GO:0042593 75 0.010
regulation of ion transmembrane transporter activity GO:0032412 48 0.010
regulation of canonical wnt signaling pathway GO:0060828 4 0.010
positive regulation of camp metabolic process GO:0030816 31 0.010
cell migration GO:0016477 197 0.010
glycosyl compound catabolic process GO:1901658 126 0.010
synaptic growth at neuromuscular junction GO:0051124 1 0.010
positive regulation of cytoplasmic transport GO:1903651 32 0.010
regeneration GO:0031099 163 0.010
tissue morphogenesis GO:0048729 22 0.010
response to decreased oxygen levels GO:0036293 237 0.010
nucleotide catabolic process GO:0009166 139 0.010

Spock1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.017
nervous system disease DOID:863 0 0.017
sensory system disease DOID:0050155 0 0.013
eye and adnexa disease DOID:1492 0 0.013
retinal disease DOID:5679 0 0.012
retinal degeneration DOID:8466 0 0.012
eye disease DOID:5614 0 0.012
central nervous system disease DOID:331 0 0.011