Rattus norvegicus

203 known processes

Epha4

Eph receptor A4

(Aliases: RGD1560587)

Epha4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cell motility GO:0048870 202 0.084
neuron projection development GO:0031175 273 0.079
central nervous system development GO:0007417 311 0.069
brain development GO:0007420 247 0.057
regulation of rna metabolic process GO:0051252 391 0.051
circulatory system development GO:0072359 134 0.049
neuron development GO:0048666 286 0.048
neuron differentiation GO:0030182 368 0.045
rna metabolic process GO:0016070 406 0.042
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.042
regulation of transcription dna templated GO:0006355 374 0.041
cell projection organization GO:0030030 302 0.041
cell migration GO:0016477 197 0.040
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.039
regulation of cellular component organization GO:0051128 368 0.039
head development GO:0060322 247 0.039
response to extracellular stimulus GO:0009991 380 0.038
regulation of molecular function GO:0065009 398 0.037
regulation of multicellular organismal development GO:2000026 376 0.037
divalent metal ion transport GO:0070838 132 0.037
positive regulation of multicellular organismal process GO:0051240 387 0.037
cellular response to endogenous stimulus GO:0071495 377 0.037
positive regulation of gene expression GO:0010628 244 0.036
locomotion GO:0040011 237 0.036
regulation of cellular amino acid metabolic process GO:0006521 2 0.036
neuron death GO:0070997 127 0.036
cation transport GO:0006812 382 0.036
positive regulation of cell proliferation GO:0008284 249 0.035
cellular chemical homeostasis GO:0055082 247 0.035
anatomical structure morphogenesis GO:0009653 298 0.033
cell morphogenesis GO:0000902 142 0.033
cellular component morphogenesis GO:0032989 155 0.033
homeostatic process GO:0042592 331 0.033
regulation of phosphorus metabolic process GO:0051174 349 0.032
gland development GO:0048732 155 0.032
localization of cell GO:0051674 202 0.032
regulation of protein metabolic process GO:0051246 289 0.032
intracellular signal transduction GO:0035556 314 0.032
carbohydrate derivative metabolic process GO:1901135 346 0.031
heart morphogenesis GO:0003007 3 0.031
regulation of cellular protein metabolic process GO:0032268 267 0.031
negative regulation of cell death GO:0060548 229 0.031
positive regulation of cell development GO:0010720 176 0.031
regulation of programmed cell death GO:0043067 341 0.031
negative regulation of macromolecule metabolic process GO:0010605 260 0.031
negative regulation of cellular metabolic process GO:0031324 281 0.030
negative regulation of metabolic process GO:0009892 331 0.030
nucleoside phosphate metabolic process GO:0006753 283 0.030
protein complex subunit organization GO:0071822 302 0.029
protein oligomerization GO:0051259 191 0.029
programmed cell death GO:0012501 392 0.029
response to wounding GO:0009611 254 0.029
negative regulation of nervous system development GO:0051961 79 0.029
positive regulation of developmental process GO:0051094 283 0.029
cellular ketone metabolic process GO:0042180 51 0.029
regulation of cellular amine metabolic process GO:0033238 8 0.029
cellular component movement GO:0006928 248 0.028
positive regulation of cellular component organization GO:0051130 200 0.028
cellular amine metabolic process GO:0044106 38 0.028
cardiovascular system development GO:0072358 134 0.028
organic acid metabolic process GO:0006082 292 0.028
metal ion transport GO:0030001 289 0.028
response to growth factor GO:0070848 189 0.028
amine metabolic process GO:0009308 38 0.027
regulation of phosphorylation GO:0042325 248 0.027
macromolecular complex subunit organization GO:0043933 339 0.027
response to nutrient levels GO:0031667 370 0.027
regulation of cell differentiation GO:0045595 320 0.027
multi organism reproductive process GO:0044703 262 0.027
ribose phosphate metabolic process GO:0019693 235 0.026
regulation of cellular ketone metabolic process GO:0010565 27 0.026
protein targeting GO:0006605 61 0.026
salivary gland morphogenesis GO:0007435 1 0.026
rna biosynthetic process GO:0032774 380 0.026
reproductive process GO:0022414 372 0.026
tissue development GO:0009888 252 0.026
regulation of neuron differentiation GO:0045664 208 0.026
positive regulation of phosphorus metabolic process GO:0010562 262 0.026
regulation of anatomical structure size GO:0090066 135 0.025
divalent inorganic cation homeostasis GO:0072507 165 0.025
protein complex assembly GO:0006461 263 0.025
regulation of anatomical structure morphogenesis GO:0022603 141 0.025
regulation of signal transduction GO:0009966 318 0.025
positive regulation of cell differentiation GO:0045597 217 0.025
carboxylic acid metabolic process GO:0019752 289 0.025
nucleobase containing small molecule metabolic process GO:0055086 316 0.024
metal ion homeostasis GO:0055065 186 0.024
nucleoside triphosphate catabolic process GO:0009143 123 0.024
regulation of canonical wnt signaling pathway GO:0060828 4 0.024
positive regulation of nervous system development GO:0051962 178 0.024
regulation of nervous system development GO:0051960 264 0.024
apoptotic process GO:0006915 381 0.024
oxoacid metabolic process GO:0043436 290 0.024
regulation of cellular component movement GO:0051270 150 0.024
response to inorganic substance GO:0010035 377 0.024
biological adhesion GO:0022610 110 0.023
positive regulation of molecular function GO:0044093 230 0.023
cellular metal ion homeostasis GO:0006875 172 0.023
nucleoside triphosphate metabolic process GO:0009141 144 0.023
cellular response to oxygen containing compound GO:1901701 386 0.023
neuron projection morphogenesis GO:0048812 122 0.023
cellular cation homeostasis GO:0030003 180 0.023
establishment of protein localization GO:0045184 141 0.023
response to nutrient GO:0007584 248 0.023
regulation of cell proliferation GO:0042127 359 0.023
oxidation reduction process GO:0055114 304 0.023
macromolecule localization GO:0033036 252 0.023
regulation of nucleic acid templated transcription GO:1903506 380 0.023
positive regulation of biosynthetic process GO:0009891 319 0.022
response to estradiol GO:0032355 164 0.022
negative regulation of apoptotic process GO:0043066 181 0.022
chemical homeostasis GO:0048878 292 0.022
intracellular protein transport GO:0006886 79 0.022
organophosphate metabolic process GO:0019637 370 0.022
cellular homeostasis GO:0019725 252 0.021
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.021
purine nucleoside metabolic process GO:0042278 169 0.021
purine ribonucleotide catabolic process GO:0009154 136 0.021
calcium ion transport GO:0006816 131 0.021
negative regulation of multicellular organismal process GO:0051241 203 0.021
regulation of phosphate metabolic process GO:0019220 349 0.021
negative regulation of response to stimulus GO:0048585 155 0.021
cellular component assembly GO:0022607 360 0.021
neuron apoptotic process GO:0051402 88 0.021
anterior posterior pattern specification GO:0009952 1 0.020
ion homeostasis GO:0050801 212 0.020
protein localization GO:0008104 191 0.020
regulation of locomotion GO:0040012 148 0.020
regulation of stem cell differentiation GO:2000736 2 0.020
gastrulation GO:0007369 2 0.020
negative regulation of neuron death GO:1901215 69 0.020
circulatory system process GO:0003013 183 0.020
positive regulation of phosphorylation GO:0042327 177 0.020
response to estrogen GO:0043627 232 0.020
regulation of cell development GO:0060284 263 0.020
cellular response to organic cyclic compound GO:0071407 202 0.020
regulation of protein modification process GO:0031399 194 0.020
negative regulation of gene expression GO:0010629 199 0.020
protein transport GO:0015031 132 0.020
reproductive system development GO:0061458 128 0.020
transcription dna templated GO:0006351 377 0.020
purine nucleoside triphosphate metabolic process GO:0009144 141 0.020
positive regulation of rna metabolic process GO:0051254 203 0.019
single organism intracellular transport GO:1902582 166 0.019
cellular protein localization GO:0034613 122 0.019
nucleic acid templated transcription GO:0097659 379 0.019
positive regulation of response to stimulus GO:0048584 285 0.019
blood circulation GO:0008015 183 0.019
growth GO:0040007 165 0.019
dendrite development GO:0016358 72 0.019
intracellular transport GO:0046907 185 0.019
positive regulation of cellular amine metabolic process GO:0033240 3 0.019
response to oxygen levels GO:0070482 265 0.019
motor neuron axon guidance GO:0008045 1 0.019
regulation of protein phosphorylation GO:0001932 183 0.019
positive regulation of neurogenesis GO:0050769 165 0.019
cellular response to stress GO:0033554 269 0.019
nucleoside metabolic process GO:0009116 179 0.018
embryonic skeletal system development GO:0048706 3 0.018
regulation of membrane potential GO:0042391 110 0.018
regulation of neuron death GO:1901214 115 0.018
reproduction GO:0000003 245 0.018
macromolecular complex assembly GO:0065003 273 0.018
glycosyl compound catabolic process GO:1901658 126 0.018
telencephalon development GO:0021537 62 0.018
regulation of apoptotic process GO:0042981 335 0.018
heart development GO:0007507 72 0.018
transmembrane transport GO:0055085 412 0.018
single organism reproductive process GO:0044702 297 0.018
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.018
calcium ion homeostasis GO:0055074 162 0.017
cytoplasmic transport GO:0016482 115 0.017
purine ribonucleotide metabolic process GO:0009150 227 0.017
female pregnancy GO:0007565 122 0.017
positive regulation of phosphate metabolic process GO:0045937 262 0.017
regulation of catalytic activity GO:0050790 304 0.017
ribonucleoside metabolic process GO:0009119 174 0.017
regulation of hydrolase activity GO:0051336 143 0.017
response to cytokine GO:0034097 215 0.017
salivary gland development GO:0007431 3 0.017
regulation of neurogenesis GO:0050767 247 0.017
regulation of proteasomal protein catabolic process GO:0061136 4 0.017
multicellular organism reproduction GO:0032504 233 0.017
purine ribonucleoside metabolic process GO:0046128 168 0.017
cellular response to growth factor stimulus GO:0071363 162 0.017
nucleotide metabolic process GO:0009117 279 0.017
regulation of cell projection organization GO:0031344 175 0.017
negative regulation of programmed cell death GO:0043069 183 0.017
cardiac chamber development GO:0003205 1 0.017
cytosolic calcium ion homeostasis GO:0051480 140 0.017
positive regulation of neuron differentiation GO:0045666 126 0.017
multicellular organismal reproductive process GO:0048609 233 0.017
regulation of rna biosynthetic process GO:2001141 381 0.017
multi multicellular organism process GO:0044706 138 0.017
neuronal action potential GO:0019228 35 0.016
protein complex biogenesis GO:0070271 263 0.016
transmission of nerve impulse GO:0019226 42 0.016
negative regulation of neuron differentiation GO:0045665 62 0.016
cellular divalent inorganic cation homeostasis GO:0072503 162 0.016
regulation of intracellular signal transduction GO:1902531 218 0.016
gliogenesis GO:0042063 93 0.016
endoplasmic reticulum to cytosol transport GO:1903513 4 0.016
negative regulation of signaling GO:0023057 157 0.016
positive regulation of nucleotide metabolic process GO:0045981 91 0.016
divalent inorganic cation transport GO:0072511 134 0.016
cellular macromolecule localization GO:0070727 122 0.015
cellular amino acid metabolic process GO:0006520 107 0.015
regulation of neuron projection development GO:0010975 161 0.015
response to purine containing compound GO:0014074 126 0.015
small gtpase mediated signal transduction GO:0007264 36 0.015
regeneration GO:0031099 163 0.015
ras protein signal transduction GO:0007265 29 0.015
single organism carbohydrate metabolic process GO:0044723 118 0.015
positive regulation of catalytic activity GO:0043085 184 0.015
wound healing GO:0042060 122 0.015
negative regulation of cell communication GO:0010648 158 0.015
regulation of homeostatic process GO:0032844 101 0.015
response to carbohydrate GO:0009743 183 0.015
positive regulation of neuron projection development GO:0010976 99 0.015
positive regulation of protein metabolic process GO:0051247 178 0.015
positive regulation of cellular protein metabolic process GO:0032270 167 0.015
regulation of catabolic process GO:0009894 113 0.015
hepaticobiliary system development GO:0061008 90 0.015
cellular component biogenesis GO:0044085 368 0.014
cellular response to lipid GO:0071396 201 0.014
cerebral cortex tangential migration GO:0021800 1 0.014
cation homeostasis GO:0055080 195 0.014
reproductive structure development GO:0048608 128 0.014
response to vitamin d GO:0033280 34 0.014
response to vitamin GO:0033273 131 0.014
positive regulation of intracellular signal transduction GO:1902533 138 0.014
purine nucleotide metabolic process GO:0006163 229 0.014
cellular calcium ion homeostasis GO:0006874 160 0.014
nuclear transport GO:0051169 49 0.014
heterocycle catabolic process GO:0046700 167 0.014
multicellular organismal signaling GO:0035637 44 0.014
cell adhesion GO:0007155 110 0.014
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.014
anatomical structure formation involved in morphogenesis GO:0048646 83 0.014
actin filament based process GO:0030029 86 0.014
cell part morphogenesis GO:0032990 123 0.014
taxis GO:0042330 67 0.014
action potential GO:0001508 54 0.014
negative regulation of canonical wnt signaling pathway GO:0090090 4 0.014
ensheathment of neurons GO:0007272 40 0.014
enzyme linked receptor protein signaling pathway GO:0007167 116 0.014
response to hypoxia GO:0001666 231 0.014
negative regulation of cell differentiation GO:0045596 99 0.014
catabolic process GO:0009056 351 0.014
protein phosphorylation GO:0006468 345 0.014
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.013
positive regulation of transport GO:0051050 245 0.013
carbohydrate derivative catabolic process GO:1901136 147 0.013
cell type specific apoptotic process GO:0097285 134 0.013
single organism cellular localization GO:1902580 102 0.013
positive regulation of cellular biosynthetic process GO:0031328 295 0.013
purine nucleoside catabolic process GO:0006152 124 0.013
regulation of mesenchymal cell proliferation GO:0010464 4 0.013
regulation of growth GO:0040008 105 0.013
positive regulation of nucleic acid templated transcription GO:1903508 197 0.013
negative regulation of developmental process GO:0051093 125 0.013
regulation of cell growth GO:0001558 85 0.013
developmental growth GO:0048589 100 0.013
aging GO:0007568 241 0.013
developmental process involved in reproduction GO:0003006 159 0.013
regulation of neuron apoptotic process GO:0043523 83 0.013
negative regulation of cell development GO:0010721 82 0.013
positive regulation of locomotion GO:0040017 102 0.013
cellular ion homeostasis GO:0006873 184 0.013
muscle system process GO:0003012 115 0.013
organic cyclic compound catabolic process GO:1901361 175 0.013
single organism cell adhesion GO:0098602 46 0.013
regulation of system process GO:0044057 208 0.013
regulation of cell morphogenesis GO:0022604 77 0.013
purine containing compound metabolic process GO:0072521 253 0.013
embryonic pattern specification GO:0009880 1 0.013
forebrain development GO:0030900 98 0.013
nucleobase containing compound catabolic process GO:0034655 152 0.013
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 4 0.013
response to other organism GO:0051707 220 0.012
neuromuscular process GO:0050905 2 0.012
proteolysis GO:0006508 175 0.012
cellular response to hormone stimulus GO:0032870 247 0.012
organ regeneration GO:0031100 101 0.012
positive regulation of protein modification process GO:0031401 142 0.012
positive regulation of protein phosphorylation GO:0001934 135 0.012
response to decreased oxygen levels GO:0036293 237 0.012
establishment of planar polarity GO:0001736 1 0.012
negative regulation of cell proliferation GO:0008285 119 0.012
ribonucleotide catabolic process GO:0009261 136 0.012
cellular catabolic process GO:0044248 295 0.012
response to molecule of bacterial origin GO:0002237 194 0.012
glycosyl compound metabolic process GO:1901657 182 0.012
development of primary sexual characteristics GO:0045137 107 0.012
cell growth GO:0016049 104 0.012
positive regulation of transcription dna templated GO:0045893 197 0.012
regulation of mrna splicing via spliceosome GO:0048024 3 0.012
cell projection morphogenesis GO:0048858 123 0.012
nucleoside phosphate catabolic process GO:1901292 140 0.012
mesoderm development GO:0007498 2 0.012
regulation of cell migration GO:0030334 128 0.012
regulation of cell motility GO:2000145 131 0.012
peptidyl amino acid modification GO:0018193 126 0.012
rho protein signal transduction GO:0007266 11 0.011
single organism biosynthetic process GO:0044711 342 0.011
axonogenesis GO:0007409 71 0.011
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.011
cardiac ventricle development GO:0003231 1 0.011
establishment of tissue polarity GO:0007164 2 0.011
appendage morphogenesis GO:0035107 4 0.011
positive regulation of rna biosynthetic process GO:1902680 197 0.011
hair follicle development GO:0001942 2 0.011
carbohydrate metabolic process GO:0005975 130 0.011
neural crest cell development GO:0014032 2 0.011
purine nucleotide catabolic process GO:0006195 136 0.011
regulation of nucleotide metabolic process GO:0006140 117 0.011
gonad development GO:0008406 104 0.011
regulation of protein transport GO:0051223 68 0.011
neurological system process GO:0050877 219 0.011
regulation of establishment of protein localization GO:0070201 69 0.011
regulation of immune system process GO:0002682 123 0.011
membrane organization GO:0061024 94 0.011
male gamete generation GO:0048232 99 0.011
cellular response to alcohol GO:0097306 87 0.011
response to glucose GO:0009749 136 0.011
mesenchymal cell proliferation GO:0010463 4 0.011
negative regulation of cellular component organization GO:0051129 83 0.011
regulation of axonogenesis GO:0050770 37 0.011
purine containing compound catabolic process GO:0072523 138 0.011
regulation of sodium ion transmembrane transporter activity GO:2000649 4 0.011
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.011
regulation of notch signaling pathway GO:0008593 3 0.010
liver development GO:0001889 90 0.010
cell activation GO:0001775 97 0.010
cytokinetic process GO:0032506 1 0.010
camera type eye development GO:0043010 48 0.010
striated muscle tissue development GO:0014706 58 0.010
response to monosaccharide GO:0034284 159 0.010
alternative mrna splicing via spliceosome GO:0000380 4 0.010
cell cell signaling involved in cell fate commitment GO:0045168 2 0.010
purine ribonucleoside catabolic process GO:0046130 124 0.010
neuron fate commitment GO:0048663 4 0.010
regulation of cellular localization GO:0060341 263 0.010
positive regulation of response to external stimulus GO:0032103 51 0.010
regulation of secretion by cell GO:1903530 208 0.010
insulin like growth factor receptor signaling pathway GO:0048009 3 0.010
regulation of kinase activity GO:0043549 117 0.010
regulation of metal ion transport GO:0010959 118 0.010
l glutamate import GO:0051938 2 0.010
substrate dependent cell migration GO:0006929 1 0.010
nucleotide catabolic process GO:0009166 139 0.010
kidney development GO:0001822 67 0.010
establishment of protein localization to organelle GO:0072594 44 0.010
organelle organization GO:0006996 266 0.010
inorganic ion transmembrane transport GO:0098660 229 0.010
response to metal ion GO:0010038 253 0.010
maintenance of location GO:0051235 17 0.010
muscle tissue development GO:0060537 58 0.010
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.010

Epha4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.020
nervous system disease DOID:863 0 0.020
cardiovascular system disease DOID:1287 0 0.019
central nervous system disease DOID:331 0 0.017
musculoskeletal system disease DOID:17 0 0.017
myopathy DOID:423 0 0.016
muscular disease DOID:0080000 0 0.016
muscle tissue disease DOID:66 0 0.016
brain disease DOID:936 0 0.012