Rattus norvegicus

64 known processes

Gclc

glutamate-cysteine ligase, catalytic subunit

(Aliases: MGC93096,Glclc)

Gclc biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular modified amino acid metabolic process GO:0006575 61 0.843
cellular amino acid metabolic process GO:0006520 107 0.738
cellular amino acid biosynthetic process GO:0008652 32 0.588
carboxylic acid metabolic process GO:0019752 289 0.576
sulfur compound metabolic process GO:0006790 70 0.528
organic acid metabolic process GO:0006082 292 0.397
glutathione metabolic process GO:0006749 15 0.296
small molecule biosynthetic process GO:0044283 124 0.294
carboxylic acid biosynthetic process GO:0046394 83 0.279
cellular amide metabolic process GO:0043603 44 0.278
alpha amino acid metabolic process GO:1901605 71 0.261
organonitrogen compound biosynthetic process GO:1901566 167 0.247
single organism biosynthetic process GO:0044711 342 0.246
response to inorganic substance GO:0010035 377 0.214
amide biosynthetic process GO:0043604 10 0.196
response to extracellular stimulus GO:0009991 380 0.191
oxoacid metabolic process GO:0043436 290 0.191
cellular modified amino acid biosynthetic process GO:0042398 18 0.188
response to wounding GO:0009611 254 0.184
negative regulation of apoptotic process GO:0043066 181 0.178
peptide metabolic process GO:0006518 32 0.176
cellular response to oxygen containing compound GO:1901701 386 0.165
single organism reproductive process GO:0044702 297 0.152
response to nutrient GO:0007584 248 0.138
response to oxidative stress GO:0006979 186 0.128
response to metal ion GO:0010038 253 0.126
regulation of apoptotic process GO:0042981 335 0.113
organic acid biosynthetic process GO:0016053 83 0.106
negative regulation of cell death GO:0060548 229 0.089
intracellular signal transduction GO:0035556 314 0.084
mesoderm development GO:0007498 2 0.079
response to nutrient levels GO:0031667 370 0.076
apoptotic process GO:0006915 381 0.074
cofactor metabolic process GO:0051186 95 0.074
macromolecular complex assembly GO:0065003 273 0.073
response to carbohydrate GO:0009743 183 0.072
tube development GO:0035295 89 0.071
regulation of organelle organization GO:0033043 80 0.070
coenzyme metabolic process GO:0006732 86 0.067
oxidation reduction process GO:0055114 304 0.063
organelle organization GO:0006996 266 0.063
cellular response to stress GO:0033554 269 0.063
organic hydroxy compound metabolic process GO:1901615 115 0.063
cellular response to organic cyclic compound GO:0071407 202 0.062
cellular lipid metabolic process GO:0044255 208 0.060
response to oxygen levels GO:0070482 265 0.060
protein complex subunit organization GO:0071822 302 0.057
regulation of signal transduction GO:0009966 318 0.056
lipid metabolic process GO:0006629 283 0.054
neuron apoptotic process GO:0051402 88 0.054
central nervous system development GO:0007417 311 0.053
negative regulation of neuron apoptotic process GO:0043524 45 0.052
cellular component assembly GO:0022607 360 0.050
regulation of cellular amine metabolic process GO:0033238 8 0.050
reactive oxygen species metabolic process GO:0072593 37 0.049
response to vitamin GO:0033273 131 0.049
macromolecule localization GO:0033036 252 0.049
regulation of programmed cell death GO:0043067 341 0.049
circulatory system process GO:0003013 183 0.048
positive regulation of developmental process GO:0051094 283 0.048
cellular amine metabolic process GO:0044106 38 0.046
response to acid chemical GO:0001101 222 0.044
protein oligomerization GO:0051259 191 0.044
positive regulation of cell death GO:0010942 184 0.043
amine metabolic process GO:0009308 38 0.043
protein complex biogenesis GO:0070271 263 0.043
organophosphate metabolic process GO:0019637 370 0.042
response to ethanol GO:0045471 162 0.040
cellular ketone metabolic process GO:0042180 51 0.039
macromolecular complex subunit organization GO:0043933 339 0.038
negative regulation of programmed cell death GO:0043069 183 0.038
reproductive process GO:0022414 372 0.038
regulation of phosphorus metabolic process GO:0051174 349 0.038
neuron death GO:0070997 127 0.038
response to axon injury GO:0048678 59 0.036
response to decreased oxygen levels GO:0036293 237 0.036
blood circulation GO:0008015 183 0.036
regulation of neuron death GO:1901214 115 0.035
homeostatic process GO:0042592 331 0.035
response to hydrogen peroxide GO:0042542 89 0.035
negative regulation of molecular function GO:0044092 133 0.035
regulation of transcription dna templated GO:0006355 374 0.034
secretion GO:0046903 307 0.033
response to lipopolysaccharide GO:0032496 191 0.033
response to peptide hormone GO:0043434 278 0.033
regulation of cellular component organization GO:0051128 368 0.033
anatomical structure morphogenesis GO:0009653 298 0.033
gastrulation GO:0007369 2 0.033
cellular component biogenesis GO:0044085 368 0.033
brain development GO:0007420 247 0.033
protein phosphorylation GO:0006468 345 0.032
response to estrogen GO:0043627 232 0.032
mesoderm formation GO:0001707 1 0.032
positive regulation of molecular function GO:0044093 230 0.032
protein complex assembly GO:0006461 263 0.031
benzene containing compound metabolic process GO:0042537 22 0.031
protein homooligomerization GO:0051260 91 0.030
programmed cell death GO:0012501 392 0.030
regulation of cell differentiation GO:0045595 320 0.030
cellular response to oxidative stress GO:0034599 76 0.030
regulation of cell projection organization GO:0031344 175 0.030
growth GO:0040007 165 0.030
reproductive system development GO:0061458 128 0.030
mesoderm morphogenesis GO:0048332 1 0.030
single organism catabolic process GO:0044712 283 0.029
nucleobase containing small molecule metabolic process GO:0055086 316 0.029
cellular response to reactive oxygen species GO:0034614 55 0.029
transcription dna templated GO:0006351 377 0.029
regulation of cell development GO:0060284 263 0.028
aging GO:0007568 241 0.028
dephosphorylation GO:0016311 98 0.027
response to reactive oxygen species GO:0000302 120 0.027
cell growth GO:0016049 104 0.027
response to radiation GO:0009314 137 0.027
positive regulation of phosphate metabolic process GO:0045937 262 0.027
regulation of neuron projection development GO:0010975 161 0.026
head development GO:0060322 247 0.026
nucleoside phosphate metabolic process GO:0006753 283 0.026
neurological system process GO:0050877 219 0.026
reactive oxygen species biosynthetic process GO:1903409 8 0.026
regulation of catalytic activity GO:0050790 304 0.026
response to glucocorticoid GO:0051384 223 0.026
cellular response to nitrogen compound GO:1901699 210 0.026
regulation of cellular amino acid metabolic process GO:0006521 2 0.026
nitrogen compound transport GO:0071705 229 0.025
single organism cellular localization GO:1902580 102 0.025
organic acid transport GO:0015849 116 0.025
regulation of transferase activity GO:0051338 123 0.025
negative regulation of cell communication GO:0010648 158 0.025
organic anion transport GO:0015711 132 0.025
inflammatory response GO:0006954 150 0.025
rna biosynthetic process GO:0032774 380 0.025
negative regulation of signaling GO:0023057 157 0.025
response to nitrosative stress GO:0051409 2 0.024
cellular response to lipid GO:0071396 201 0.024
p38mapk cascade GO:0038066 1 0.024
response to peptide GO:1901652 292 0.024
response to monosaccharide GO:0034284 159 0.024
multicellular organism reproduction GO:0032504 233 0.024
negative regulation of cell differentiation GO:0045596 99 0.023
response to retinoic acid GO:0032526 63 0.023
multicellular organismal reproductive process GO:0048609 233 0.023
formation of primary germ layer GO:0001704 1 0.023
protein localization GO:0008104 191 0.023
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.023
reactive nitrogen species metabolic process GO:2001057 1 0.023
regulation of cellular ketone metabolic process GO:0010565 27 0.023
regulation of synaptic transmission GO:0050804 141 0.023
cellular response to hormone stimulus GO:0032870 247 0.023
regulation of intracellular signal transduction GO:1902531 218 0.023
carbohydrate derivative biosynthetic process GO:1901137 124 0.023
regulation of phosphate metabolic process GO:0019220 349 0.023
regulation of molecular function GO:0065009 398 0.023
positive regulation of cellular biosynthetic process GO:0031328 295 0.022
glycerolipid metabolic process GO:0046486 67 0.022
regulation of hormone levels GO:0010817 187 0.022
positive regulation of multicellular organismal process GO:0051240 387 0.022
regulation of cell proliferation GO:0042127 359 0.022
positive regulation of cellular component organization GO:0051130 200 0.022
regulation of secretion GO:0051046 224 0.022
digestive system development GO:0055123 41 0.022
cellular response to corticosteroid stimulus GO:0071384 69 0.022
response to hexose GO:0009746 144 0.022
developmental process involved in reproduction GO:0003006 159 0.022
response to corticosteroid GO:0031960 235 0.022
regulation of rna biosynthetic process GO:2001141 381 0.021
vascular process in circulatory system GO:0003018 96 0.021
neuron differentiation GO:0030182 368 0.021
response to ketone GO:1901654 182 0.021
positive regulation of programmed cell death GO:0043068 157 0.021
regulation of anatomical structure morphogenesis GO:0022603 141 0.021
cellular response to metal ion GO:0071248 55 0.021
response to glucose GO:0009749 136 0.021
positive regulation of cellular amine metabolic process GO:0033240 3 0.021
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.021
transmembrane transport GO:0055085 412 0.021
nucleic acid templated transcription GO:0097659 379 0.020
positive regulation of cell communication GO:0010647 271 0.020
g protein coupled receptor signaling pathway GO:0007186 242 0.020
defense response GO:0006952 194 0.020
retinal metabolic process GO:0042574 3 0.020
catabolic process GO:0009056 351 0.020
response to transition metal nanoparticle GO:1990267 122 0.020
single organism organelle organization GO:1902589 180 0.020
alpha amino acid biosynthetic process GO:1901607 23 0.020
response to cadmium ion GO:0046686 35 0.020
positive regulation of catalytic activity GO:0043085 184 0.020
wound healing GO:0042060 122 0.020
tube formation GO:0035148 3 0.020
response to amino acid GO:0043200 75 0.020
anatomical structure formation involved in morphogenesis GO:0048646 83 0.019
regulation of reactive oxygen species metabolic process GO:2000377 26 0.019
positive regulation of signal transduction GO:0009967 175 0.019
negative regulation of cellular component organization GO:0051129 83 0.019
regulation of anion transport GO:0044070 43 0.019
regeneration GO:0031099 163 0.019
positive regulation of apoptotic process GO:0043065 154 0.019
negative regulation of neuron death GO:1901215 69 0.019
cellular homeostasis GO:0019725 252 0.019
regulation of system process GO:0044057 208 0.019
response to toxic substance GO:0009636 133 0.019
regulation of protein metabolic process GO:0051246 289 0.019
negative regulation of catalytic activity GO:0043086 103 0.019
synaptic transmission GO:0007268 235 0.019
lipid localization GO:0010876 62 0.019
carbohydrate derivative metabolic process GO:1901135 346 0.018
positive regulation of transcription from rna polymerase ii promoter in response to stress GO:0036003 3 0.018
regulation of multicellular organismal development GO:2000026 376 0.018
regulation of phosphorylation GO:0042325 248 0.018
transcription from rna polymerase ii promoter GO:0006366 252 0.018
lipid biosynthetic process GO:0008610 128 0.018
negative regulation of multicellular organismal process GO:0051241 203 0.018
regulation of rna metabolic process GO:0051252 391 0.017
response to interleukin 1 GO:0070555 55 0.017
cell type specific apoptotic process GO:0097285 134 0.017
positive regulation of signaling GO:0023056 270 0.017
regulation of secretion by cell GO:1903530 208 0.017
peptidyl tyrosine modification GO:0018212 72 0.017
organophosphate biosynthetic process GO:0090407 143 0.017
positive regulation of biosynthetic process GO:0009891 319 0.017
cellular response to alcohol GO:0097306 87 0.017
cellular response to organonitrogen compound GO:0071417 197 0.017
protein tetramerization GO:0051262 38 0.017
reproductive structure development GO:0048608 128 0.017
cellular cation homeostasis GO:0030003 180 0.017
regulation of nervous system development GO:0051960 264 0.017
rna metabolic process GO:0016070 406 0.017
cellular response to peptide GO:1901653 133 0.017
response to growth factor GO:0070848 189 0.017
negative regulation of cell proliferation GO:0008285 119 0.016
hepaticobiliary system development GO:0061008 90 0.016
anterior posterior pattern specification GO:0009952 1 0.016
rhythmic process GO:0048511 156 0.016
regulation of kinase activity GO:0043549 117 0.016
anion transport GO:0006820 178 0.016
cellular response to endogenous stimulus GO:0071495 377 0.016
neuron projection development GO:0031175 273 0.016
purine containing compound metabolic process GO:0072521 253 0.016
circulatory system development GO:0072359 134 0.016
response to hypoxia GO:0001666 231 0.016
response to external biotic stimulus GO:0043207 221 0.016
neuron development GO:0048666 286 0.016
carboxylic acid transport GO:0046942 115 0.016
cellular response to abiotic stimulus GO:0071214 85 0.016
regulation of response to stress GO:0080134 126 0.015
monocarboxylic acid transport GO:0015718 52 0.015
hormone metabolic process GO:0042445 69 0.015
regulation of hormone secretion GO:0046883 106 0.015
regulation of p38mapk cascade GO:1900744 1 0.015
multi organism reproductive process GO:0044703 262 0.015
placenta development GO:0001890 22 0.015
positive regulation of gene expression GO:0010628 244 0.015
cellular response to glucocorticoid stimulus GO:0071385 68 0.015
intracellular transport GO:0046907 185 0.015
positive regulation of intracellular signal transduction GO:1902533 138 0.015
alcohol metabolic process GO:0006066 77 0.015
positive regulation of cell differentiation GO:0045597 217 0.015
establishment of protein localization GO:0045184 141 0.015
amide transport GO:0042886 105 0.015
positive regulation of ligase activity GO:0051351 1 0.015
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.015
pyridine containing compound metabolic process GO:0072524 32 0.015
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.015
peptidyl tyrosine phosphorylation GO:0018108 72 0.015
response to estradiol GO:0032355 164 0.014
regulation of neuron differentiation GO:0045664 208 0.014
regulation of arp2 3 complex mediated actin nucleation GO:0034315 2 0.014
response to bacterium GO:0009617 200 0.014
epithelium development GO:0060429 96 0.014
prostaglandin secretion GO:0032310 6 0.014
negative regulation of macromolecule metabolic process GO:0010605 260 0.014
embryonic pattern specification GO:0009880 1 0.014
positive regulation of cell proliferation GO:0008284 249 0.014
membrane organization GO:0061024 94 0.014
isoprenoid metabolic process GO:0006720 45 0.014
cell projection organization GO:0030030 302 0.014
spermatogenesis GO:0007283 99 0.013
cation homeostasis GO:0055080 195 0.013
organelle inheritance GO:0048308 2 0.013
response to molecule of bacterial origin GO:0002237 194 0.013
negative regulation of neurogenesis GO:0050768 78 0.013
negative regulation of metabolic process GO:0009892 331 0.013
regulation of peptide transport GO:0090087 87 0.013
regulation of fatty acid transport GO:2000191 10 0.013
cellular response to oxygen levels GO:0071453 60 0.013
regulation of ion transport GO:0043269 245 0.013
protein autophosphorylation GO:0046777 66 0.013
cation transport GO:0006812 382 0.013
behavior GO:0007610 205 0.013
multi multicellular organism process GO:0044706 138 0.013
regulation of embryonic development GO:0045995 2 0.013
actin filament based process GO:0030029 86 0.013
chemical homeostasis GO:0048878 292 0.013
signal release GO:0023061 145 0.013
dna metabolic process GO:0006259 96 0.013
cellular macromolecule localization GO:0070727 122 0.013
carbohydrate homeostasis GO:0033500 75 0.013
negative regulation of phosphorus metabolic process GO:0010563 80 0.013
gland development GO:0048732 155 0.012
regulation of blood circulation GO:1903522 110 0.012
response to nicotine GO:0035094 51 0.012
muscle cell proliferation GO:0033002 84 0.012
regulation of membrane potential GO:0042391 110 0.012
positive regulation of protein modification process GO:0031401 142 0.012
positive regulation of hydrolase activity GO:0051345 86 0.012
response to calcium ion GO:0051592 59 0.012
regulation of insulin secretion GO:0050796 65 0.012
negative regulation of cellular metabolic process GO:0031324 281 0.012
stress activated protein kinase signaling cascade GO:0031098 37 0.012
dna replication GO:0006260 37 0.012
cytoskeleton dependent cytokinesis GO:0061640 2 0.012
carbohydrate metabolic process GO:0005975 130 0.012
regulation of protein modification process GO:0031399 194 0.012
oxidoreduction coenzyme metabolic process GO:0006733 31 0.012
tissue development GO:0009888 252 0.012
cytokine production GO:0001816 61 0.012
response to manganese ion GO:0010042 13 0.012
positive regulation of lipid biosynthetic process GO:0046889 25 0.012
regulation of protein kinase activity GO:0045859 105 0.012
ion homeostasis GO:0050801 212 0.012
purine nucleoside metabolic process GO:0042278 169 0.012
nucleotide metabolic process GO:0009117 279 0.012
cellular response to inorganic substance GO:0071241 65 0.011
immune response GO:0006955 104 0.011
peptide transport GO:0015833 97 0.011
regulation of nucleic acid templated transcription GO:1903506 380 0.011
positive regulation of defense response GO:0031349 37 0.011
digestive tract development GO:0048565 39 0.011
ras protein signal transduction GO:0007265 29 0.011
positive regulation of transcription dna templated GO:0045893 197 0.011
regulation of protein localization GO:0032880 81 0.011
negative regulation of protein metabolic process GO:0051248 114 0.011
nicotinamide nucleotide metabolic process GO:0046496 28 0.011
response to alkaloid GO:0043279 132 0.011
regulation of peptide secretion GO:0002791 82 0.011
cellular catabolic process GO:0044248 295 0.011
nucleocytoplasmic transport GO:0006913 48 0.011
liver development GO:0001889 90 0.011
hydrogen peroxide metabolic process GO:0042743 13 0.011
inner ear receptor cell differentiation GO:0060113 2 0.011
single organism behavior GO:0044708 130 0.011
cellular ion homeostasis GO:0006873 184 0.011
morphogenesis of embryonic epithelium GO:0016331 3 0.011
small gtpase mediated signal transduction GO:0007264 36 0.011
regulation of lipid metabolic process GO:0019216 68 0.011
cytoskeleton organization GO:0007010 111 0.011
heart morphogenesis GO:0003007 3 0.011
negative regulation of transport GO:0051051 136 0.011
gamete generation GO:0007276 124 0.011
alpha amino acid catabolic process GO:1901606 20 0.011
regulation of tube size GO:0035150 89 0.011
response to osmotic stress GO:0006970 42 0.011
regulation of cell motility GO:2000145 131 0.011
glucose homeostasis GO:0042593 75 0.011
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.011
cellular metal ion homeostasis GO:0006875 172 0.011
positive regulation of cellular protein metabolic process GO:0032270 167 0.011
regulation of muscle system process GO:0090257 79 0.011
serine family amino acid metabolic process GO:0009069 12 0.010
acid secretion GO:0046717 48 0.010
positive regulation of reactive oxygen species metabolic process GO:2000379 16 0.010
generation of precursor metabolites and energy GO:0006091 62 0.010
steroid biosynthetic process GO:0006694 48 0.010
reproduction GO:0000003 245 0.010
regulation of response to external stimulus GO:0032101 106 0.010
cellular response to steroid hormone stimulus GO:0071383 93 0.010
multicellular organismal homeostasis GO:0048871 49 0.010
positive regulation of endothelial cell migration GO:0010595 4 0.010
negative regulation of muscle cell apoptotic process GO:0010656 21 0.010
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.010
regulation of smoothened signaling pathway GO:0008589 2 0.010
regulation of cellular response to stress GO:0080135 49 0.010
cellular response to lipopolysaccharide GO:0071222 55 0.010
positive regulation of immune system process GO:0002684 90 0.010
chromosome segregation GO:0007059 2 0.010

Gclc disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.022
disease of cellular proliferation DOID:14566 0 0.022
organ system cancer DOID:0050686 0 0.022
disease of metabolism DOID:0014667 0 0.015
disease of anatomical entity DOID:7 0 0.014
nervous system disease DOID:863 0 0.014
inherited metabolic disorder DOID:655 0 0.011