Rattus norvegicus

18 known processes

Trim25

tripartite motif-containing 25

(Aliases: Efp,MGC72607,Znf147)

Trim25 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
rna biosynthetic process GO:0032774 380 0.155
Human
regulation of nucleic acid templated transcription GO:1903506 380 0.153
Human
nucleic acid templated transcription GO:0097659 379 0.125
Human
transcription from rna polymerase ii promoter GO:0006366 252 0.121
protein phosphorylation GO:0006468 345 0.112
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.111
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.111
regulation of transcription dna templated GO:0006355 374 0.092
Human
regulation of phosphate metabolic process GO:0019220 349 0.090
single organism reproductive process GO:0044702 297 0.090
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.085
regulation of rna metabolic process GO:0051252 391 0.084
Human
transcription dna templated GO:0006351 377 0.082
Human
positive regulation of rna biosynthetic process GO:1902680 197 0.079
regulation of rna biosynthetic process GO:2001141 381 0.079
Human
rna metabolic process GO:0016070 406 0.076
Human
positive regulation of gene expression GO:0010628 244 0.072
regulation of molecular function GO:0065009 398 0.072
Human
positive regulation of cellular biosynthetic process GO:0031328 295 0.070
regulation of protein modification process GO:0031399 194 0.068
organic acid metabolic process GO:0006082 292 0.067
carboxylic acid metabolic process GO:0019752 289 0.066
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.065
reproductive process GO:0022414 372 0.059
regulation of phosphorus metabolic process GO:0051174 349 0.059
positive regulation of biosynthetic process GO:0009891 319 0.058
oxoacid metabolic process GO:0043436 290 0.055
regulation of protein phosphorylation GO:0001932 183 0.055
immune system process GO:0002376 204 0.053
Human Mouse
response to peptide hormone GO:0043434 278 0.051
positive regulation of phosphate metabolic process GO:0045937 262 0.051
reproductive system development GO:0061458 128 0.051
negative regulation of metabolic process GO:0009892 331 0.051
regulation of protein metabolic process GO:0051246 289 0.050
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.049
cellular response to nitrogen compound GO:1901699 210 0.049
cellular response to endogenous stimulus GO:0071495 377 0.048
carbohydrate derivative metabolic process GO:1901135 346 0.048
cellular response to cytokine stimulus GO:0071345 127 0.048
positive regulation of protein phosphorylation GO:0001934 135 0.048
defense response GO:0006952 194 0.047
Human Mouse
cellular component assembly GO:0022607 360 0.046
positive regulation of rna metabolic process GO:0051254 203 0.046
negative regulation of macromolecule metabolic process GO:0010605 260 0.045
cellular response to peptide GO:1901653 133 0.045
programmed cell death GO:0012501 392 0.045
cellular component biogenesis GO:0044085 368 0.044
nucleotide metabolic process GO:0009117 279 0.044
regulation of cellular protein metabolic process GO:0032268 267 0.042
positive regulation of mesenchymal cell proliferation GO:0002053 4 0.042
response to peptide GO:1901652 292 0.042
positive regulation of phosphorus metabolic process GO:0010562 262 0.042
cellular response to hormone stimulus GO:0032870 247 0.040
regulation of cellular amino acid metabolic process GO:0006521 2 0.040
developmental process involved in reproduction GO:0003006 159 0.039
organophosphate metabolic process GO:0019637 370 0.039
single organism biosynthetic process GO:0044711 342 0.039
regulation of phosphorylation GO:0042325 248 0.039
liver development GO:0001889 90 0.038
regulation of cellular amine metabolic process GO:0033238 8 0.038
regulation of cell differentiation GO:0045595 320 0.037
regulation of intracellular signal transduction GO:1902531 218 0.037
Human
negative regulation of cellular metabolic process GO:0031324 281 0.036
cellular response to stress GO:0033554 269 0.036
regulation of cell proliferation GO:0042127 359 0.036
positive regulation of nucleic acid templated transcription GO:1903508 197 0.036
central nervous system development GO:0007417 311 0.036
macromolecular complex subunit organization GO:0043933 339 0.035
nucleoside phosphate metabolic process GO:0006753 283 0.035
inflammatory response GO:0006954 150 0.035
brain development GO:0007420 247 0.035
neuron development GO:0048666 286 0.034
intracellular signal transduction GO:0035556 314 0.034
Human
negative regulation of apoptotic process GO:0043066 181 0.034
regulation of cellular ketone metabolic process GO:0010565 27 0.034
organelle organization GO:0006996 266 0.034
cellular amine metabolic process GO:0044106 38 0.034
cellular ketone metabolic process GO:0042180 51 0.034
positive regulation of transcription dna templated GO:0045893 197 0.033
gland development GO:0048732 155 0.033
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.033
regulation of cellular component organization GO:0051128 368 0.033
neuron differentiation GO:0030182 368 0.033
positive regulation of cell proliferation GO:0008284 249 0.033
cellular amino acid metabolic process GO:0006520 107 0.033
regeneration GO:0031099 163 0.033
purine containing compound metabolic process GO:0072521 253 0.033
purine nucleotide metabolic process GO:0006163 229 0.032
cellular response to insulin stimulus GO:0032869 81 0.032
regulation of signal transduction GO:0009966 318 0.032
Human
localization of cell GO:0051674 202 0.032
regulation of immune system process GO:0002682 123 0.031
amine metabolic process GO:0009308 38 0.031
cellular response to organonitrogen compound GO:0071417 197 0.031
positive regulation of multicellular organismal process GO:0051240 387 0.031
neuron projection development GO:0031175 273 0.031
cellular response to oxygen containing compound GO:1901701 386 0.030
positive regulation of response to stimulus GO:0048584 285 0.030
Human
cellular response to peptide hormone stimulus GO:0071375 120 0.029
catabolic process GO:0009056 351 0.029
purine nucleoside metabolic process GO:0042278 169 0.029
secretion GO:0046903 307 0.029
regulation of mesenchymal cell proliferation GO:0010464 4 0.029
nucleobase containing small molecule metabolic process GO:0055086 316 0.028
macromolecular complex assembly GO:0065003 273 0.028
homeostatic process GO:0042592 331 0.028
regulation of catalytic activity GO:0050790 304 0.028
regulation of programmed cell death GO:0043067 341 0.028
response to cytokine GO:0034097 215 0.028
positive regulation of protein modification process GO:0031401 142 0.027
response to ethanol GO:0045471 162 0.027
multicellular organismal reproductive process GO:0048609 233 0.027
epithelial cell differentiation involved in kidney development GO:0035850 3 0.027
head development GO:0060322 247 0.027
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.027
cellular response to organic cyclic compound GO:0071407 202 0.026
multicellular organism reproduction GO:0032504 233 0.026
negative regulation of nucleic acid templated transcription GO:1903507 117 0.026
positive regulation of molecular function GO:0044093 230 0.026
Human
apoptotic process GO:0006915 381 0.026
reproductive structure development GO:0048608 128 0.025
hepaticobiliary system development GO:0061008 90 0.025
negative regulation of cell death GO:0060548 229 0.024
response to hypoxia GO:0001666 231 0.024
positive regulation of cellular protein metabolic process GO:0032270 167 0.024
ribonucleoside metabolic process GO:0009119 174 0.024
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.024
establishment of protein localization GO:0045184 141 0.024
negative regulation of gene expression GO:0010629 199 0.024
negative regulation of rna metabolic process GO:0051253 123 0.024
nucleoside metabolic process GO:0009116 179 0.024
jak stat cascade GO:0007259 26 0.024
response to interleukin 1 GO:0070555 55 0.023
multicellular organism growth GO:0035264 1 0.023
intracellular transport GO:0046907 185 0.023
negative regulation of cellular biosynthetic process GO:0031327 161 0.023
glycosyl compound metabolic process GO:1901657 182 0.023
reproduction GO:0000003 245 0.023
purine ribonucleotide metabolic process GO:0009150 227 0.023
ribose phosphate metabolic process GO:0019693 235 0.023
regulation of cellular component movement GO:0051270 150 0.023
positive regulation of developmental process GO:0051094 283 0.023
protein complex biogenesis GO:0070271 263 0.023
negative regulation of transcription dna templated GO:0045892 116 0.022
mapk cascade GO:0000165 140 0.022
positive regulation of smooth muscle cell proliferation GO:0048661 51 0.022
cellular component movement GO:0006928 248 0.022
regulation of protein kinase activity GO:0045859 105 0.022
cellular response to lipid GO:0071396 201 0.022
positive regulation of transport GO:0051050 245 0.022
protein complex subunit organization GO:0071822 302 0.022
carbohydrate derivative biosynthetic process GO:1901137 124 0.022
gonad development GO:0008406 104 0.022
positive regulation of phosphorylation GO:0042327 177 0.022
response to external biotic stimulus GO:0043207 221 0.022
purine ribonucleoside metabolic process GO:0046128 168 0.022
development of primary sexual characteristics GO:0045137 107 0.022
positive regulation of cell communication GO:0010647 271 0.022
Human
negative regulation of biosynthetic process GO:0009890 168 0.021
carbohydrate metabolic process GO:0005975 130 0.021
peptidyl amino acid modification GO:0018193 126 0.021
sex differentiation GO:0007548 113 0.021
embryonic pattern specification GO:0009880 1 0.021
regulation of response to stress GO:0080134 126 0.021
positive regulation of protein metabolic process GO:0051247 178 0.021
response to molecule of bacterial origin GO:0002237 194 0.020
cellular lipid metabolic process GO:0044255 208 0.020
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.020
positive regulation of cellular amine metabolic process GO:0033240 3 0.020
negative regulation of cell differentiation GO:0045596 99 0.020
single organism catabolic process GO:0044712 283 0.020
negative regulation of multicellular organismal process GO:0051241 203 0.020
regulation of transferase activity GO:0051338 123 0.020
aromatic compound catabolic process GO:0019439 168 0.020
tissue development GO:0009888 252 0.019
positive regulation of cell differentiation GO:0045597 217 0.019
organonitrogen compound biosynthetic process GO:1901566 167 0.019
reactive oxygen species biosynthetic process GO:1903409 8 0.019
negative regulation of rna biosynthetic process GO:1902679 118 0.019
regulation of cell development GO:0060284 263 0.019
response to growth factor GO:0070848 189 0.019
response to insulin GO:0032868 133 0.019
response to decreased oxygen levels GO:0036293 237 0.019
lipid metabolic process GO:0006629 283 0.019
negative regulation of programmed cell death GO:0043069 183 0.019
eye morphogenesis GO:0048592 4 0.019
organophosphate biosynthetic process GO:0090407 143 0.019
response to radiation GO:0009314 137 0.019
response to inorganic substance GO:0010035 377 0.019
cellular response to oxidative stress GO:0034599 76 0.019
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.019
gliogenesis GO:0042063 93 0.018
axis specification GO:0009798 4 0.018
locomotion GO:0040011 237 0.018
Human Mouse
anterior posterior pattern specification GO:0009952 1 0.018
response to nutrient levels GO:0031667 370 0.018
response to nutrient GO:0007584 248 0.018
positive regulation of signaling GO:0023056 270 0.018
Human
response to mechanical stimulus GO:0009612 134 0.018
regulation of apoptotic process GO:0042981 335 0.018
leukocyte differentiation GO:0002521 30 0.018
nucleoside catabolic process GO:0009164 126 0.017
anatomical structure morphogenesis GO:0009653 298 0.017
cellular chemical homeostasis GO:0055082 247 0.017
purine nucleoside triphosphate metabolic process GO:0009144 141 0.017
multi organism reproductive process GO:0044703 262 0.017
camera type eye morphogenesis GO:0048593 2 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.017
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.017
regulation of kinase activity GO:0043549 117 0.017
biological adhesion GO:0022610 110 0.017
regulation of smooth muscle cell proliferation GO:0048660 75 0.017
ribonucleoside monophosphate metabolic process GO:0009161 88 0.017
protein complex assembly GO:0006461 263 0.016
positive regulation of signal transduction GO:0009967 175 0.016
Human
response to metal ion GO:0010038 253 0.016
nucleoside phosphate biosynthetic process GO:1901293 102 0.016
cellular catabolic process GO:0044248 295 0.016
nucleotide biosynthetic process GO:0009165 98 0.016
negative regulation of immune system process GO:0002683 39 0.016
cellular response to reactive oxygen species GO:0034614 55 0.016
cellular nitrogen compound catabolic process GO:0044270 163 0.016
single organism carbohydrate metabolic process GO:0044723 118 0.016
hormone secretion GO:0046879 115 0.016
muscle cell proliferation GO:0033002 84 0.016
single organism intracellular transport GO:1902582 166 0.016
enzyme linked receptor protein signaling pathway GO:0007167 116 0.015
response to ketone GO:1901654 182 0.015
mesenchymal cell proliferation GO:0010463 4 0.015
cytoplasmic transport GO:0016482 115 0.015
ribonucleoside triphosphate metabolic process GO:0009199 141 0.015
secretion by cell GO:0032940 248 0.015
positive regulation of mapk cascade GO:0043410 92 0.015
response to other organism GO:0051707 220 0.015
cell morphogenesis involved in differentiation GO:0000904 119 0.015
cellular homeostasis GO:0019725 252 0.015
response to extracellular stimulus GO:0009991 380 0.015
response to hexose GO:0009746 144 0.015
positive regulation of cell development GO:0010720 176 0.015
female pregnancy GO:0007565 122 0.015
cellular calcium ion homeostasis GO:0006874 160 0.015
negative regulation of signaling GO:0023057 157 0.015
single organism organelle organization GO:1902589 180 0.015
organic substance catabolic process GO:1901575 316 0.015
ribonucleotide metabolic process GO:0009259 231 0.015
regulation of canonical wnt signaling pathway GO:0060828 4 0.015
dna metabolic process GO:0006259 96 0.015
organic cyclic compound catabolic process GO:1901361 175 0.015
aging GO:0007568 241 0.015
positive regulation of protein kinase activity GO:0045860 73 0.015
regulation of metanephros development GO:0072215 4 0.014
macromolecule localization GO:0033036 252 0.014
nucleoside triphosphate metabolic process GO:0009141 144 0.014
cellular component morphogenesis GO:0032989 155 0.014
ras protein signal transduction GO:0007265 29 0.014
motor neuron axon guidance GO:0008045 1 0.014
small gtpase mediated signal transduction GO:0007264 36 0.014
purine ribonucleotide biosynthetic process GO:0009152 81 0.014
nucleotide catabolic process GO:0009166 139 0.014
purine nucleoside monophosphate metabolic process GO:0009126 84 0.014
cell projection organization GO:0030030 302 0.014
cell motility GO:0048870 202 0.014
mesoderm development GO:0007498 2 0.014
regulation of catabolic process GO:0009894 113 0.014
response to carbohydrate GO:0009743 183 0.014
gastrulation GO:0007369 2 0.014
nucleoside monophosphate metabolic process GO:0009123 93 0.014
protein transport GO:0015031 132 0.014
cellular cation homeostasis GO:0030003 180 0.014
cell part morphogenesis GO:0032990 123 0.014
negative regulation of cell cycle phase transition GO:1901988 4 0.014
ribonucleotide biosynthetic process GO:0009260 85 0.014
smooth muscle cell proliferation GO:0048659 77 0.014
cellular protein localization GO:0034613 122 0.014
bmp signaling pathway GO:0030509 4 0.014
negative regulation of protein metabolic process GO:0051248 114 0.014
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.014
response to oxidative stress GO:0006979 186 0.014
negative regulation of developmental process GO:0051093 125 0.014
peptidyl tyrosine modification GO:0018212 72 0.014
cellular response to growth factor stimulus GO:0071363 162 0.014
response to vitamin GO:0033273 131 0.013
organ regeneration GO:0031100 101 0.013
positive regulation of catalytic activity GO:0043085 184 0.013
defense response to gram positive bacterium GO:0050830 2 0.013
negative regulation of molecular function GO:0044092 133 0.013
positive regulation of secretion by cell GO:1903532 128 0.013
ribose phosphate biosynthetic process GO:0046390 87 0.013
mesenchymal to epithelial transition GO:0060231 3 0.013
regulation of hydrolase activity GO:0051336 143 0.013
response to bacterium GO:0009617 200 0.013
negative regulation of kidney development GO:0090185 2 0.013
purine containing compound biosynthetic process GO:0072522 85 0.013
nucleobase containing compound catabolic process GO:0034655 152 0.013
cell migration GO:0016477 197 0.013
purine nucleoside catabolic process GO:0006152 124 0.013
organophosphate catabolic process GO:0046434 148 0.013
g protein coupled receptor signaling pathway GO:0007186 242 0.013
response to glucose GO:0009749 136 0.013
regulation of multicellular organismal development GO:2000026 376 0.013
regulation of cellular localization GO:0060341 263 0.013
protein localization GO:0008104 191 0.013
glial cell differentiation GO:0010001 65 0.013
ovulation cycle GO:0042698 67 0.013
hematopoietic progenitor cell differentiation GO:0002244 2 0.013
cellular metal ion homeostasis GO:0006875 172 0.013
circulatory system process GO:0003013 183 0.013
purine ribonucleotide catabolic process GO:0009154 136 0.013
regulation of cell migration GO:0030334 128 0.012
regulation of nucleotide metabolic process GO:0006140 117 0.012
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.012
male gonad development GO:0008584 59 0.012
male sex differentiation GO:0046661 64 0.012
cell differentiation involved in kidney development GO:0061005 4 0.012
cofactor metabolic process GO:0051186 95 0.012
cellular carbohydrate metabolic process GO:0044262 72 0.012
regulation of hormone levels GO:0010817 187 0.012
cytokine mediated signaling pathway GO:0019221 43 0.012
urogenital system development GO:0001655 78 0.012
signal release GO:0023061 145 0.012
tube development GO:0035295 89 0.012
positive regulation of cellular component organization GO:0051130 200 0.012
protein oligomerization GO:0051259 191 0.012
alpha beta t cell differentiation GO:0046632 2 0.012
digestive system development GO:0055123 41 0.012
axon development GO:0061564 96 0.012
regulation of cytokine production GO:0001817 56 0.012
cellular ion homeostasis GO:0006873 184 0.012
cell morphogenesis GO:0000902 142 0.012
positive regulation of cellular component movement GO:0051272 102 0.012
positive regulation of intracellular signal transduction GO:1902533 138 0.012
Human
response to estrogen GO:0043627 232 0.012
organonitrogen compound catabolic process GO:1901565 179 0.012
purine nucleotide biosynthetic process GO:0006164 83 0.012
regulation of purine nucleotide metabolic process GO:1900542 115 0.012
regulation of secretion by cell GO:1903530 208 0.012
rhythmic process GO:0048511 156 0.012
single organism membrane organization GO:0044802 74 0.012
response to ionizing radiation GO:0010212 59 0.012
gamete generation GO:0007276 124 0.012
heart morphogenesis GO:0003007 3 0.012
oxidation reduction process GO:0055114 304 0.012
regulation of membrane potential GO:0042391 110 0.012
atp metabolic process GO:0046034 72 0.012
response to reactive oxygen species GO:0000302 120 0.012
small molecule biosynthetic process GO:0044283 124 0.012
purine nucleoside triphosphate catabolic process GO:0009146 122 0.012
alpha beta t cell activation GO:0046631 3 0.011
renal system development GO:0072001 67 0.011
purine containing compound catabolic process GO:0072523 138 0.011
purine ribonucleoside catabolic process GO:0046130 124 0.011
inner ear receptor cell differentiation GO:0060113 2 0.011
organic hydroxy compound metabolic process GO:1901615 115 0.011
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.011
positive regulation of nucleotide metabolic process GO:0045981 91 0.011
cellular macromolecule localization GO:0070727 122 0.011
ion homeostasis GO:0050801 212 0.011
chemical homeostasis GO:0048878 292 0.011
positive regulation of nucleoside metabolic process GO:0045979 55 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.011
divalent inorganic cation homeostasis GO:0072507 165 0.011
negative regulation of response to stimulus GO:0048585 155 0.011
negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003340 2 0.011
regulation of reactive oxygen species metabolic process GO:2000377 26 0.011
multi multicellular organism process GO:0044706 138 0.011
reactive nitrogen species metabolic process GO:2001057 1 0.011
metanephric tubule development GO:0072170 4 0.011
lipid biosynthetic process GO:0008610 128 0.011
single organism cellular localization GO:1902580 102 0.011
cell adhesion GO:0007155 110 0.011
sexual reproduction GO:0019953 148 0.011
heterocycle catabolic process GO:0046700 167 0.011
positive regulation of cellular catabolic process GO:0031331 71 0.011
response to oxygen levels GO:0070482 265 0.011
organic acid biosynthetic process GO:0016053 83 0.011
response to camp GO:0051591 91 0.011
response to hydrogen peroxide GO:0042542 89 0.011
negative regulation of protein phosphorylation GO:0001933 44 0.011
cation transport GO:0006812 382 0.011
membrane organization GO:0061024 94 0.011
calcium ion homeostasis GO:0055074 162 0.011
metanephric epithelium development GO:0072207 4 0.011
protein homooligomerization GO:0051260 91 0.011
development of primary female sexual characteristics GO:0046545 56 0.011
neuronal action potential GO:0019228 35 0.011
hematopoietic or lymphoid organ development GO:0048534 36 0.011
signal transduction by phosphorylation GO:0023014 144 0.011
nucleoside monophosphate biosynthetic process GO:0009124 28 0.011
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.011
anion transport GO:0006820 178 0.010
positive regulation of programmed cell death GO:0043068 157 0.010
response to tumor necrosis factor GO:0034612 56 0.010
antigen processing and presentation GO:0019882 2 0.010
circulatory system development GO:0072359 134 0.010
blood circulation GO:0008015 183 0.010
positive regulation of cytokine production GO:0001819 42 0.010
salivary gland development GO:0007431 3 0.010
cation homeostasis GO:0055080 195 0.010
purine nucleotide catabolic process GO:0006195 136 0.010
multicellular organismal signaling GO:0035637 44 0.010
neuron projection morphogenesis GO:0048812 122 0.010
regulation of body fluid levels GO:0050878 90 0.010
response to corticosteroid GO:0031960 235 0.010
establishment of tissue polarity GO:0007164 2 0.010
response to monosaccharide GO:0034284 159 0.010
protein targeting GO:0006605 61 0.010
positive regulation of neurogenesis GO:0050769 165 0.010
metal ion homeostasis GO:0055065 186 0.010
forebrain development GO:0030900 98 0.010
regulation of cellular catabolic process GO:0031329 101 0.010
nucleoside phosphate catabolic process GO:1901292 140 0.010
cellular macromolecular complex assembly GO:0034622 58 0.010
hormone transport GO:0009914 121 0.010
leukocyte activation GO:0045321 76 0.010
chemosensory behavior GO:0007635 2 0.010
cardiovascular system development GO:0072358 134 0.010
response to wounding GO:0009611 254 0.010
proteolysis GO:0006508 175 0.010

Trim25 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.014
disease of cellular proliferation DOID:14566 0 0.014
organ system cancer DOID:0050686 0 0.014
disease of anatomical entity DOID:7 0 0.013
nervous system disease DOID:863 0 0.013
disease of metabolism DOID:0014667 0 0.012
primary immunodeficiency disease DOID:612 0 0.011
immune system disease DOID:2914 0 0.011