Rattus norvegicus

126 known processes

Ddit4

DNA-damage-inducible transcript 4

(Aliases: Rtp801)

Ddit4 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
negative regulation of cellular metabolic process GO:0031324 281 0.177
transcription dna templated GO:0006351 377 0.139
regulation of apoptotic process GO:0042981 335 0.132
transcription from rna polymerase ii promoter GO:0006366 252 0.115
nucleic acid templated transcription GO:0097659 379 0.107
cation transport GO:0006812 382 0.098
regulation of intracellular signal transduction GO:1902531 218 0.094
regulation of protein metabolic process GO:0051246 289 0.090
regulation of rna metabolic process GO:0051252 391 0.089
negative regulation of macromolecule metabolic process GO:0010605 260 0.084
rna biosynthetic process GO:0032774 380 0.082
negative regulation of metabolic process GO:0009892 331 0.082
regulation of nucleic acid templated transcription GO:1903506 380 0.082
rna metabolic process GO:0016070 406 0.078
regulation of rna biosynthetic process GO:2001141 381 0.074
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.072
single organism reproductive process GO:0044702 297 0.071
macromolecule localization GO:0033036 252 0.069
negative regulation of signaling GO:0023057 157 0.069
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.066
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.065
regulation of cellular protein metabolic process GO:0032268 267 0.062
intracellular signal transduction GO:0035556 314 0.060
organic substance catabolic process GO:1901575 316 0.057
cellular response to stress GO:0033554 269 0.056
negative regulation of apoptotic process GO:0043066 181 0.054
cellular response to oxygen containing compound GO:1901701 386 0.054
regulation of programmed cell death GO:0043067 341 0.053
negative regulation of cell death GO:0060548 229 0.053
positive regulation of humoral immune response GO:0002922 2 0.052
programmed cell death GO:0012501 392 0.052
peptide biosynthetic process GO:0043043 3 0.050
regulation of catalytic activity GO:0050790 304 0.049
metal ion transport GO:0030001 289 0.048
positive regulation of biosynthetic process GO:0009891 319 0.047
amine metabolic process GO:0009308 38 0.047
negative regulation of response to stimulus GO:0048585 155 0.046
homeostatic process GO:0042592 331 0.046
regulation of molecular function GO:0065009 398 0.045
negative regulation of nucleic acid templated transcription GO:1903507 117 0.045
response to peptide GO:1901652 292 0.045
anion transport GO:0006820 178 0.044
apoptotic process GO:0006915 381 0.044
reproductive process GO:0022414 372 0.044
signal transduction by phosphorylation GO:0023014 144 0.043
protein localization GO:0008104 191 0.043
organic anion transport GO:0015711 132 0.042
positive regulation of rna metabolic process GO:0051254 203 0.041
multicellular organism reproduction GO:0032504 233 0.041
nitrogen compound transport GO:0071705 229 0.039
regulation of phosphate metabolic process GO:0019220 349 0.039
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.039
cell type specific apoptotic process GO:0097285 134 0.037
organonitrogen compound biosynthetic process GO:1901566 167 0.037
regulation of phosphorus metabolic process GO:0051174 349 0.036
negative regulation of multicellular organismal process GO:0051241 203 0.035
regulation of signal transduction GO:0009966 318 0.035
organic acid metabolic process GO:0006082 292 0.034
d amino acid transport GO:0042940 1 0.034
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.034
positive regulation of gene expression GO:0010628 244 0.034
regulation of response to stress GO:0080134 126 0.033
entrainment of circadian clock GO:0009649 3 0.033
cellular response to hormone stimulus GO:0032870 247 0.033
regulation of transcription dna templated GO:0006355 374 0.032
positive regulation of transcription dna templated GO:0045893 197 0.032
regulation of cellular amino acid metabolic process GO:0006521 2 0.032
positive regulation of nucleic acid templated transcription GO:1903508 197 0.032
negative regulation of rna biosynthetic process GO:1902679 118 0.031
regulation of cellular amine metabolic process GO:0033238 8 0.031
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.031
cellular response to endogenous stimulus GO:0071495 377 0.031
negative regulation of biosynthetic process GO:0009890 168 0.031
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.030
negative regulation of phosphorus metabolic process GO:0010563 80 0.030
neuron death GO:0070997 127 0.030
carbohydrate derivative metabolic process GO:1901135 346 0.030
monovalent inorganic cation transport GO:0015672 172 0.030
anatomical structure morphogenesis GO:0009653 298 0.029
circadian regulation of gene expression GO:0032922 3 0.029
carboxylic acid transport GO:0046942 115 0.029
cellular ion homeostasis GO:0006873 184 0.029
response to inorganic substance GO:0010035 377 0.028
negative regulation of molecular function GO:0044092 133 0.028
amide transport GO:0042886 105 0.028
cellular amine metabolic process GO:0044106 38 0.028
single organism biosynthetic process GO:0044711 342 0.028
positive regulation of rna biosynthetic process GO:1902680 197 0.028
regulation of p38mapk cascade GO:1900744 1 0.027
sterol transport GO:0015918 6 0.027
organic acid transport GO:0015849 116 0.027
negative regulation of immune system process GO:0002683 39 0.027
defense response GO:0006952 194 0.027
cellular cation homeostasis GO:0030003 180 0.027
organelle organization GO:0006996 266 0.026
regulation of cellular localization GO:0060341 263 0.026
negative regulation of gene expression GO:0010629 199 0.025
positive regulation of transport GO:0051050 245 0.025
single organism organelle organization GO:1902589 180 0.025
protein phosphorylation GO:0006468 345 0.025
positive regulation of cell death GO:0010942 184 0.025
regulation of cellular ketone metabolic process GO:0010565 27 0.025
organophosphate metabolic process GO:0019637 370 0.025
macromolecular complex subunit organization GO:0043933 339 0.025
nucleoside metabolic process GO:0009116 179 0.025
amide biosynthetic process GO:0043604 10 0.024
amino acid transport GO:0006865 70 0.024
secretion GO:0046903 307 0.024
axis specification GO:0009798 4 0.024
response to radiation GO:0009314 137 0.024
regulation of multicellular organismal development GO:2000026 376 0.023
negative regulation of phosphate metabolic process GO:0045936 80 0.023
nucleobase containing small molecule metabolic process GO:0055086 316 0.023
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.022
nucleobase containing compound catabolic process GO:0034655 152 0.022
vesicle mediated transport GO:0016192 181 0.022
cellular ketone metabolic process GO:0042180 51 0.022
oxoacid metabolic process GO:0043436 290 0.022
cellular chemical homeostasis GO:0055082 247 0.022
response to reactive oxygen species GO:0000302 120 0.022
regulation of phosphorylation GO:0042325 248 0.022
catabolic process GO:0009056 351 0.022
sexual reproduction GO:0019953 148 0.022
neuron differentiation GO:0030182 368 0.022
ribose phosphate metabolic process GO:0019693 235 0.022
purine containing compound metabolic process GO:0072521 253 0.022
cation homeostasis GO:0055080 195 0.022
regulation of cell proliferation GO:0042127 359 0.021
purine nucleotide catabolic process GO:0006195 136 0.021
cell cell signaling GO:0007267 335 0.021
negative regulation of cellular biosynthetic process GO:0031327 161 0.021
cellular response to nitrogen compound GO:1901699 210 0.021
chemical homeostasis GO:0048878 292 0.021
cellular amino acid metabolic process GO:0006520 107 0.021
regulation of peptide transport GO:0090087 87 0.021
nucleoside phosphate metabolic process GO:0006753 283 0.021
nucleoside monophosphate metabolic process GO:0009123 93 0.021
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.020
negative regulation of signal transduction GO:0009968 83 0.020
lipid transport GO:0006869 61 0.020
negative regulation of programmed cell death GO:0043069 183 0.020
positive regulation of multicellular organismal process GO:0051240 387 0.020
positive regulation of protein metabolic process GO:0051247 178 0.020
negative regulation of cellular protein metabolic process GO:0032269 106 0.020
multicellular organismal reproductive process GO:0048609 233 0.020
cytoplasmic sequestering of protein GO:0051220 3 0.020
multi organism reproductive process GO:0044703 262 0.020
positive regulation of response to stimulus GO:0048584 285 0.020
regulation of cellular component organization GO:0051128 368 0.020
regulation of cellular catabolic process GO:0031329 101 0.020
cellular nitrogen compound catabolic process GO:0044270 163 0.019
regulation of homeostatic process GO:0032844 101 0.019
regulation of immune system process GO:0002682 123 0.019
protein autophosphorylation GO:0046777 66 0.019
negative regulation of transport GO:0051051 136 0.019
regulation of body fluid levels GO:0050878 90 0.019
lipid storage GO:0019915 1 0.019
response to muramyl dipeptide GO:0032495 1 0.019
cytoplasmic transport GO:0016482 115 0.019
positive regulation of cellular protein metabolic process GO:0032270 167 0.019
regulation of cell differentiation GO:0045595 320 0.019
single organism intracellular transport GO:1902582 166 0.019
positive regulation of cellular biosynthetic process GO:0031328 295 0.019
maintenance of location GO:0051235 17 0.019
regulation of defense response GO:0031347 68 0.019
purine ribonucleotide metabolic process GO:0009150 227 0.019
photoperiodism GO:0009648 4 0.019
protein complex subunit organization GO:0071822 302 0.019
carbohydrate derivative catabolic process GO:1901136 147 0.018
negative regulation of developmental process GO:0051093 125 0.018
single organism catabolic process GO:0044712 283 0.018
cellular catabolic process GO:0044248 295 0.018
nuclear transport GO:0051169 49 0.018
negative regulation of protein metabolic process GO:0051248 114 0.018
intracellular receptor signaling pathway GO:0030522 35 0.018
intracellular transport GO:0046907 185 0.017
nucleoside catabolic process GO:0009164 126 0.017
peptide transport GO:0015833 97 0.017
reproduction GO:0000003 245 0.017
regulation of metal ion transport GO:0010959 118 0.017
cellular response to organonitrogen compound GO:0071417 197 0.017
transmembrane transport GO:0055085 412 0.017
protein targeting GO:0006605 61 0.017
negative regulation of rna metabolic process GO:0051253 123 0.016
positive regulation of cellular component organization GO:0051130 200 0.016
central nervous system development GO:0007417 311 0.016
lipid metabolic process GO:0006629 283 0.016
hormone transport GO:0009914 121 0.016
circulatory system process GO:0003013 183 0.016
cellular response to oxidative stress GO:0034599 76 0.016
metal ion homeostasis GO:0055065 186 0.016
positive regulation of apoptotic process GO:0043065 154 0.016
growth GO:0040007 165 0.016
nucleotide metabolic process GO:0009117 279 0.016
multicellular organism growth GO:0035264 1 0.016
tissue development GO:0009888 252 0.016
regulation of response to external stimulus GO:0032101 106 0.016
posttranscriptional regulation of gene expression GO:0010608 37 0.016
regulation of anatomical structure size GO:0090066 135 0.016
positive regulation of cell projection organization GO:0031346 111 0.016
positive regulation of programmed cell death GO:0043068 157 0.016
positive regulation of signal transduction GO:0009967 175 0.016
positive regulation of cellular amine metabolic process GO:0033240 3 0.016
mapk cascade GO:0000165 140 0.016
regulation of protein transport GO:0051223 68 0.016
establishment of protein localization GO:0045184 141 0.015
purine nucleoside triphosphate catabolic process GO:0009146 122 0.015
regulation of hormone levels GO:0010817 187 0.015
neurological system process GO:0050877 219 0.015
secretion by cell GO:0032940 248 0.015
cellular homeostasis GO:0019725 252 0.015
positive regulation of immune system process GO:0002684 90 0.015
ras protein signal transduction GO:0007265 29 0.015
cytoplasmic sequestering of transcription factor GO:0042994 3 0.015
signal release GO:0023061 145 0.015
regulation of cellular response to stress GO:0080135 49 0.015
organic cyclic compound catabolic process GO:1901361 175 0.015
regulation of protein modification process GO:0031399 194 0.015
purine containing compound catabolic process GO:0072523 138 0.015
aromatic compound catabolic process GO:0019439 168 0.015
negative regulation of nf kappab transcription factor activity GO:0032088 4 0.015
regulation of secretion GO:0051046 224 0.014
dna metabolic process GO:0006259 96 0.014
response to wounding GO:0009611 254 0.014
hormone secretion GO:0046879 115 0.014
ribonucleotide metabolic process GO:0009259 231 0.014
positive regulation of catalytic activity GO:0043085 184 0.014
p38mapk cascade GO:0038066 1 0.014
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 11 0.014
purine ribonucleoside catabolic process GO:0046130 124 0.014
cellular component assembly GO:0022607 360 0.014
gamete generation GO:0007276 124 0.014
negative regulation of intracellular signal transduction GO:1902532 38 0.014
regulation of protein localization GO:0032880 81 0.014
cholesterol efflux GO:0033344 1 0.014
organonitrogen compound catabolic process GO:1901565 179 0.014
purine nucleoside metabolic process GO:0042278 169 0.014
regulation of blood circulation GO:1903522 110 0.014
lymphocyte homeostasis GO:0002260 2 0.014
response to extracellular stimulus GO:0009991 380 0.014
neuron projection development GO:0031175 273 0.014
organic hydroxy compound transport GO:0015850 77 0.014
erythrocyte differentiation GO:0030218 1 0.014
cellular divalent inorganic cation homeostasis GO:0072503 162 0.013
nucleoside phosphate catabolic process GO:1901292 140 0.013
immune system process GO:0002376 204 0.013
regulation of system process GO:0044057 208 0.013
negative regulation of transcription dna templated GO:0045892 116 0.013
divalent inorganic cation homeostasis GO:0072507 165 0.013
protein transport GO:0015031 132 0.013
cardiovascular system development GO:0072358 134 0.013
proteolysis GO:0006508 175 0.013
protein complex biogenesis GO:0070271 263 0.013
cellular metal ion homeostasis GO:0006875 172 0.013
positive regulation of phosphorus metabolic process GO:0010562 262 0.013
cellular component movement GO:0006928 248 0.013
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.013
regulation of kinase activity GO:0043549 117 0.013
cellular calcium ion homeostasis GO:0006874 160 0.013
nucleotide catabolic process GO:0009166 139 0.013
single organism cellular localization GO:1902580 102 0.013
cell cycle GO:0007049 101 0.012
positive regulation of signaling GO:0023056 270 0.012
positive regulation of cell differentiation GO:0045597 217 0.012
glycosyl compound metabolic process GO:1901657 182 0.012
positive regulation of neurogenesis GO:0050769 165 0.012
neuron development GO:0048666 286 0.012
purine ribonucleoside metabolic process GO:0046128 168 0.012
cellular response to peptide GO:1901653 133 0.012
calcium ion transport GO:0006816 131 0.012
negative regulation of cellular amine metabolic process GO:0033239 3 0.012
steroid hormone mediated signaling pathway GO:0043401 8 0.012
cellular protein localization GO:0034613 122 0.012
small gtpase mediated signal transduction GO:0007264 36 0.012
positive regulation of cell communication GO:0010647 271 0.012
regeneration GO:0031099 163 0.012
regulation of notch signaling pathway GO:0008593 3 0.012
positive regulation of response to external stimulus GO:0032103 51 0.012
brain development GO:0007420 247 0.012
regulation of cell growth GO:0001558 85 0.012
regulation of proteasomal protein catabolic process GO:0061136 4 0.012
head development GO:0060322 247 0.012
g protein coupled receptor signaling pathway GO:0007186 242 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.012
positive regulation of cell proliferation GO:0008284 249 0.012
aging GO:0007568 241 0.012
ion homeostasis GO:0050801 212 0.012
sodium ion transport GO:0006814 82 0.012
heterocycle catabolic process GO:0046700 167 0.012
response to temperature stimulus GO:0009266 94 0.012
regulation of neuron projection development GO:0010975 161 0.012
cytokine production GO:0001816 61 0.012
regulation of catabolic process GO:0009894 113 0.012
response to oxygen levels GO:0070482 265 0.012
positive regulation of developmental process GO:0051094 283 0.011
localization of cell GO:0051674 202 0.011
cell projection organization GO:0030030 302 0.011
regulation of hormone secretion GO:0046883 106 0.011
circadian rhythm GO:0007623 88 0.011
negative regulation of cell differentiation GO:0045596 99 0.011
negative regulation of stress activated protein kinase signaling cascade GO:0070303 4 0.011
ribonucleoside metabolic process GO:0009119 174 0.011
regulation of sodium ion transport GO:0002028 21 0.011
cellular response to lipopolysaccharide GO:0071222 55 0.011
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.011
regulation of immune response GO:0050776 55 0.011
purine nucleoside triphosphate metabolic process GO:0009144 141 0.011
t cell homeostasis GO:0043029 2 0.011
response to nutrient GO:0007584 248 0.011
response to decreased oxygen levels GO:0036293 237 0.011
single organism carbohydrate metabolic process GO:0044723 118 0.011
negative regulation of protein phosphorylation GO:0001933 44 0.011
organophosphate catabolic process GO:0046434 148 0.011
negative regulation of protein modification process GO:0031400 52 0.011
protein import into nucleus GO:0006606 35 0.011
serine transport GO:0032329 4 0.011
membrane organization GO:0061024 94 0.011
innate immune response GO:0045087 35 0.011
response to external biotic stimulus GO:0043207 221 0.011
purine nucleotide metabolic process GO:0006163 229 0.011
macromolecular complex assembly GO:0065003 273 0.011
response to oxidative stress GO:0006979 186 0.011
response to hypoxia GO:0001666 231 0.011
regulation of protein phosphorylation GO:0001932 183 0.011
positive regulation of nervous system development GO:0051962 178 0.011
reproductive system development GO:0061458 128 0.011
spermatogenesis GO:0007283 99 0.011
calcium ion homeostasis GO:0055074 162 0.011
regulation of organelle organization GO:0033043 80 0.011
regulation of protein kinase activity GO:0045859 105 0.011
organophosphate biosynthetic process GO:0090407 143 0.011
peptide hormone secretion GO:0030072 84 0.011
protein localization to organelle GO:0033365 57 0.011
carboxylic acid metabolic process GO:0019752 289 0.010
cytoskeleton organization GO:0007010 111 0.010
single organism membrane organization GO:0044802 74 0.010
peptide metabolic process GO:0006518 32 0.010
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.010
positive regulation of phosphorylation GO:0042327 177 0.010
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.010
regulation of fat cell differentiation GO:0045598 3 0.010
positive regulation of cell development GO:0010720 176 0.010
nucleoside triphosphate catabolic process GO:0009143 123 0.010
positive regulation of intracellular signal transduction GO:1902533 138 0.010
nucleoside triphosphate metabolic process GO:0009141 144 0.010

Ddit4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.013
nervous system disease DOID:863 0 0.013
disease of metabolism DOID:0014667 0 0.010