Rattus norvegicus

63 known processes

Pck1

phosphoenolpyruvate carboxykinase 1 (soluble)

(Aliases: Pepck,PEPCK-C,GTP,PCK,MGC93820,RATPEPCK)

Pck1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
oxoacid metabolic process GO:0043436 290 0.483
cellular catabolic process GO:0044248 295 0.305
organic acid metabolic process GO:0006082 292 0.272
catabolic process GO:0009056 351 0.236
alpha amino acid metabolic process GO:1901605 71 0.220
carboxylic acid metabolic process GO:0019752 289 0.209
response to corticosteroid GO:0031960 235 0.208
Rat
aromatic amino acid family catabolic process GO:0009074 7 0.183
single organism catabolic process GO:0044712 283 0.155
response to acid chemical GO:0001101 222 0.143
response to peptide GO:1901652 292 0.138
Human
response to monosaccharide GO:0034284 159 0.138
Rat
positive regulation of transport GO:0051050 245 0.134
Rat
response to carbohydrate GO:0009743 183 0.131
Rat
chemical homeostasis GO:0048878 292 0.128
oxidation reduction process GO:0055114 304 0.124
Rat
response to inorganic substance GO:0010035 377 0.124
regulation of response to external stimulus GO:0032101 106 0.124
acylglycerol metabolic process GO:0006639 21 0.104
nitrogen compound transport GO:0071705 229 0.098
Rat
aromatic compound catabolic process GO:0019439 168 0.090
cellular response to hormone stimulus GO:0032870 247 0.088
monocarboxylic acid metabolic process GO:0032787 152 0.087
cellular amino acid metabolic process GO:0006520 107 0.084
regulation of response to stress GO:0080134 126 0.084
cellular metal ion homeostasis GO:0006875 172 0.075
cellular response to organic cyclic compound GO:0071407 202 0.069
nucleobase containing small molecule metabolic process GO:0055086 316 0.069
Rat
small molecule catabolic process GO:0044282 59 0.067
macromolecular complex assembly GO:0065003 273 0.066
cellular chemical homeostasis GO:0055082 247 0.066
Rat
organic substance catabolic process GO:1901575 316 0.066
response to peptide hormone GO:0043434 278 0.065
Human
homeostatic process GO:0042592 331 0.065
cation transport GO:0006812 382 0.065
glycerolipid metabolic process GO:0046486 67 0.061
response to glucocorticoid GO:0051384 223 0.060
Rat
defense response GO:0006952 194 0.059
organic acid catabolic process GO:0016054 49 0.057
protein homooligomerization GO:0051260 91 0.055
long chain fatty acid metabolic process GO:0001676 32 0.055
cellular response to oxygen containing compound GO:1901701 386 0.054
Rat
liver development GO:0001889 90 0.054
transmembrane transport GO:0055085 412 0.053
g protein coupled receptor signaling pathway GO:0007186 242 0.053
wnt signaling pathway calcium modulating pathway GO:0007223 1 0.053
organ regeneration GO:0031100 101 0.053
blood circulation GO:0008015 183 0.053
organic cyclic compound catabolic process GO:1901361 175 0.051
carbohydrate derivative catabolic process GO:1901136 147 0.051
cellular response to peptide GO:1901653 133 0.050
cellular modified amino acid metabolic process GO:0006575 61 0.050
response to hexose GO:0009746 144 0.050
Rat
organonitrogen compound catabolic process GO:1901565 179 0.050
multi organism reproductive process GO:0044703 262 0.050
fatty acid metabolic process GO:0006631 99 0.049
cellular component biogenesis GO:0044085 368 0.049
carbohydrate derivative metabolic process GO:1901135 346 0.049
reproductive process GO:0022414 372 0.049
response to glucose GO:0009749 136 0.047
Rat
response to antibiotic GO:0046677 39 0.046
alpha amino acid catabolic process GO:1901606 20 0.046
alkaloid metabolic process GO:0009820 3 0.045
nucleoside phosphate metabolic process GO:0006753 283 0.044
Rat
response to growth factor GO:0070848 189 0.044
head development GO:0060322 247 0.044
epoxygenase p450 pathway GO:0019373 1 0.044
heterocycle catabolic process GO:0046700 167 0.044
circulatory system process GO:0003013 183 0.043
response to metal ion GO:0010038 253 0.043
regulation of cellular ketone metabolic process GO:0010565 27 0.041
protein complex assembly GO:0006461 263 0.041
cell adhesion GO:0007155 110 0.041
lipid transport GO:0006869 61 0.041
cellular response to peptide hormone stimulus GO:0071375 120 0.040
cellular ketone metabolic process GO:0042180 51 0.039
cellular response to insulin stimulus GO:0032869 81 0.039
cellular nitrogen compound catabolic process GO:0044270 163 0.038
regulation of cell growth GO:0001558 85 0.038
cellular response to abiotic stimulus GO:0071214 85 0.038
multi multicellular organism process GO:0044706 138 0.037
isoprenoid metabolic process GO:0006720 45 0.037
organophosphate metabolic process GO:0019637 370 0.036
Rat
regulation of peptide secretion GO:0002791 82 0.035
Rat
hepaticobiliary system development GO:0061008 90 0.035
regulation of cellular component organization GO:0051128 368 0.035
ion transmembrane transport GO:0034220 365 0.035
response to sulfur dioxide GO:0010477 3 0.034
cellular response to nitrogen compound GO:1901699 210 0.034
vitamin d receptor signaling pathway GO:0070561 1 0.034
exogenous drug catabolic process GO:0042738 1 0.033
response to estrogen GO:0043627 232 0.033
cellular ion homeostasis GO:0006873 184 0.033
gland development GO:0048732 155 0.033
response to nutrient GO:0007584 248 0.033
protein complex subunit organization GO:0071822 302 0.032
response to organophosphorus GO:0046683 102 0.032
central nervous system development GO:0007417 311 0.032
cellular response to hexose stimulus GO:0071331 65 0.032
Rat
organic acid biosynthetic process GO:0016053 83 0.032
cellular component assembly GO:0022607 360 0.031
glucose homeostasis GO:0042593 75 0.031
carbohydrate homeostasis GO:0033500 75 0.030
dicarboxylic acid metabolic process GO:0043648 42 0.030
brain development GO:0007420 247 0.030
aromatic amino acid family metabolic process GO:0009072 9 0.030
placenta development GO:0001890 22 0.030
protein complex biogenesis GO:0070271 263 0.030
cell growth GO:0016049 104 0.029
aging GO:0007568 241 0.029
hormone secretion GO:0046879 115 0.029
Rat
response to biotic stimulus GO:0009607 226 0.029
cellular homeostasis GO:0019725 252 0.028
Rat
positive regulation of signaling GO:0023056 270 0.028
Rat
regulation of catabolic process GO:0009894 113 0.028
cellular response to endogenous stimulus GO:0071495 377 0.028
protein oligomerization GO:0051259 191 0.027
response to reactive oxygen species GO:0000302 120 0.027
regulation of protein metabolic process GO:0051246 289 0.027
neutral lipid metabolic process GO:0006638 21 0.027
purine nucleoside metabolic process GO:0042278 169 0.026
regulation of cellular catabolic process GO:0031329 101 0.026
regulation of immunoglobulin production GO:0002637 4 0.026
reproductive system development GO:0061458 128 0.025
response to hypoxia GO:0001666 231 0.025
amine metabolic process GO:0009308 38 0.025
response to xenobiotic stimulus GO:0009410 23 0.025
terpenoid metabolic process GO:0006721 37 0.025
response to ionizing radiation GO:0010212 59 0.025
response to extracellular stimulus GO:0009991 380 0.025
cellular lipid metabolic process GO:0044255 208 0.025
positive regulation of the force of heart contraction by epinephrine norepinephrine GO:0001997 2 0.025
regeneration GO:0031099 163 0.025
secretion GO:0046903 307 0.024
Rat
regulation of response to wounding GO:1903034 69 0.024
trichloroethylene metabolic process GO:0018979 1 0.024
regulation of defense response GO:0031347 68 0.024
response to vitamin GO:0033273 131 0.024
peptide hormone secretion GO:0030072 84 0.024
Rat
folic acid containing compound metabolic process GO:0006760 10 0.023
choline transport GO:0015871 4 0.023
purine nucleoside triphosphate catabolic process GO:0009146 122 0.023
ion homeostasis GO:0050801 212 0.023
multicellular organism reproduction GO:0032504 233 0.023
response to wounding GO:0009611 254 0.023
regulation of wound healing GO:0061041 14 0.023
cellular amine metabolic process GO:0044106 38 0.022
response to toxic substance GO:0009636 133 0.022
multicellular organismal reproductive process GO:0048609 233 0.022
regulation of body fluid levels GO:0050878 90 0.022
glycosyl compound metabolic process GO:1901657 182 0.022
cellular cation homeostasis GO:0030003 180 0.022
lipid metabolic process GO:0006629 283 0.022
regulation of cellular amine metabolic process GO:0033238 8 0.022
response to ketone GO:1901654 182 0.022
regulation of cellular amino acid metabolic process GO:0006521 2 0.021
response to bacterium GO:0009617 200 0.021
peptide transport GO:0015833 97 0.021
Rat
peptide secretion GO:0002790 86 0.020
Rat
steroid biosynthetic process GO:0006694 48 0.020
ribonucleoside metabolic process GO:0009119 174 0.020
negative regulation of transport GO:0051051 136 0.020
nucleoside triphosphate metabolic process GO:0009141 144 0.020
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.020
purine ribonucleoside metabolic process GO:0046128 168 0.020
small molecule biosynthetic process GO:0044283 124 0.020
glycogen metabolic process GO:0005977 23 0.020
response to estradiol GO:0032355 164 0.020
neural crest cell migration GO:0001755 1 0.020
glutamine family amino acid metabolic process GO:0009064 15 0.020
response to dexamethasone GO:0071548 49 0.020
regulation of cellular response to stress GO:0080135 49 0.019
response to nutrient levels GO:0031667 370 0.019
immune system process GO:0002376 204 0.019
ras protein signal transduction GO:0007265 29 0.019
organonitrogen compound biosynthetic process GO:1901566 167 0.019
biological adhesion GO:0022610 110 0.019
single organism biosynthetic process GO:0044711 342 0.019
macromolecular complex subunit organization GO:0043933 339 0.019
positive regulation of catabolic process GO:0009896 78 0.019
maternal process involved in female pregnancy GO:0060135 38 0.019
reproduction GO:0000003 245 0.019
divalent inorganic cation homeostasis GO:0072507 165 0.018
hormone transport GO:0009914 121 0.018
Rat
purine containing compound metabolic process GO:0072521 253 0.018
negative regulation of programmed cell death GO:0043069 183 0.018
regulation of synaptic transmission GO:0050804 141 0.018
protein phosphorylation GO:0006468 345 0.018
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 27 0.018
nucleoside catabolic process GO:0009164 126 0.018
cellular amino acid catabolic process GO:0009063 21 0.018
organophosphate catabolic process GO:0046434 148 0.018
telencephalon development GO:0021537 62 0.018
response to oxygen levels GO:0070482 265 0.018
insecticide metabolic process GO:0017143 4 0.018
organic hydroxy compound transport GO:0015850 77 0.018
positive regulation of blood coagulation GO:0030194 4 0.018
nucleobase containing compound catabolic process GO:0034655 152 0.017
hemostasis GO:0007599 26 0.017
negative regulation of multicellular organismal process GO:0051241 203 0.017
purine ribonucleotide catabolic process GO:0009154 136 0.017
regulation of protein phosphorylation GO:0001932 183 0.017
heart morphogenesis GO:0003007 3 0.017
protein localization GO:0008104 191 0.017
arachidonic acid metabolic process GO:0019369 20 0.017
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.017
cellular response to organonitrogen compound GO:0071417 197 0.017
divalent inorganic cation transport GO:0072511 134 0.016
cofactor metabolic process GO:0051186 95 0.016
Rat
regulation of coagulation GO:0050818 11 0.016
cellular response to carbohydrate stimulus GO:0071322 72 0.016
Rat
ribose phosphate metabolic process GO:0019693 235 0.016
nucleoside metabolic process GO:0009116 179 0.016
spermatogenesis GO:0007283 99 0.016
positive regulation of cellular component organization GO:0051130 200 0.016
cellular response to monosaccharide stimulus GO:0071326 67 0.016
Rat
nucleoside phosphate catabolic process GO:1901292 140 0.016
neuron differentiation GO:0030182 368 0.016
locomotion GO:0040011 237 0.016
coagulation GO:0050817 28 0.016
regulation of cellular component movement GO:0051270 150 0.016
regulation of locomotion GO:0040012 148 0.016
nucleotide catabolic process GO:0009166 139 0.016
female pregnancy GO:0007565 122 0.015
regulation of extracellular matrix constituent secretion GO:0003330 2 0.015
positive regulation of cellular amine metabolic process GO:0033240 3 0.015
apoptotic process GO:0006915 381 0.015
response to oxidative stress GO:0006979 186 0.015
carboxylic acid catabolic process GO:0046395 49 0.015
positive regulation of immunoglobulin production GO:0002639 4 0.015
hepatocyte proliferation GO:0072574 3 0.015
positive regulation of response to stimulus GO:0048584 285 0.015
positive regulation of insulin secretion GO:0032024 36 0.015
Rat
negative regulation of neuron differentiation GO:0045665 62 0.014
response to fatty acid GO:0070542 65 0.014
purine nucleotide catabolic process GO:0006195 136 0.014
lipid storage GO:0019915 1 0.014
regulation of multicellular organismal development GO:2000026 376 0.014
response to osmotic stress GO:0006970 42 0.014
cellular response to stress GO:0033554 269 0.014
membrane organization GO:0061024 94 0.014
regulation of hormone levels GO:0010817 187 0.014
Rat
positive regulation of peptide secretion GO:0002793 52 0.014
Rat
positive regulation of multicellular organismal process GO:0051240 387 0.014
extracellular matrix constituent secretion GO:0070278 4 0.014
response to transition metal nanoparticle GO:1990267 122 0.014
negative regulation of cardiac muscle tissue development GO:0055026 3 0.014
small gtpase mediated signal transduction GO:0007264 36 0.014
regulation of cytokine biosynthetic process GO:0042035 3 0.014
monocarboxylic acid transport GO:0015718 52 0.014
negative regulation of cell death GO:0060548 229 0.014
anion transport GO:0006820 178 0.014
purine nucleoside triphosphate metabolic process GO:0009144 141 0.014
reactive oxygen species metabolic process GO:0072593 37 0.014
negative regulation of organ growth GO:0046621 3 0.014
cation homeostasis GO:0055080 195 0.014
cellular calcium ion homeostasis GO:0006874 160 0.014
pyridine containing compound metabolic process GO:0072524 32 0.014
Rat
regulation of blood circulation GO:1903522 110 0.014
negative regulation of protein metabolic process GO:0051248 114 0.014
negative regulation of innate immune response GO:0045824 4 0.014
reactive nitrogen species metabolic process GO:2001057 1 0.014
amide transport GO:0042886 105 0.014
Rat
regulation of cell development GO:0060284 263 0.013
nucleoside triphosphate catabolic process GO:0009143 123 0.013
embryonic pattern specification GO:0009880 1 0.013
secondary metabolic process GO:0019748 15 0.013
regulation of homotypic cell cell adhesion GO:0034110 4 0.013
positive regulation of defense response GO:0031349 37 0.013
muscle system process GO:0003012 115 0.013
regulation of phosphate metabolic process GO:0019220 349 0.013
regulation of blood coagulation GO:0030193 9 0.013
steroid metabolic process GO:0008202 73 0.013
purine nucleotide metabolic process GO:0006163 229 0.013
signal release GO:0023061 145 0.013
Rat
regulation of hormone secretion GO:0046883 106 0.013
Rat
vascular process in circulatory system GO:0003018 96 0.013
carbohydrate biosynthetic process GO:0016051 42 0.013
cellular protein localization GO:0034613 122 0.013
diterpenoid metabolic process GO:0016101 33 0.013
carboxylic acid transport GO:0046942 115 0.013
behavior GO:0007610 205 0.013
neural crest cell differentiation GO:0014033 2 0.013
tissue development GO:0009888 252 0.013
macromolecule localization GO:0033036 252 0.013
response to calcium ion GO:0051592 59 0.013
regulation of stem cell differentiation GO:2000736 2 0.013
negative regulation of molecular function GO:0044092 133 0.013
halogenated hydrocarbon metabolic process GO:0042197 4 0.013
cellular component movement GO:0006928 248 0.013
positive regulation of cell development GO:0010720 176 0.013
nicotine metabolic process GO:0018933 1 0.013
regulation of telomerase activity GO:0051972 2 0.013
positive regulation of molecular function GO:0044093 230 0.012
ribonucleoside catabolic process GO:0042454 126 0.012
monovalent inorganic cation transport GO:0015672 172 0.012
inflammatory response GO:0006954 150 0.012
decidualization GO:0046697 14 0.012
phenol containing compound biosynthetic process GO:0046189 9 0.012
sulfur compound metabolic process GO:0006790 70 0.012
response to insulin GO:0032868 133 0.012
Human
regulation of cellular localization GO:0060341 263 0.012
Rat
cardiac conduction GO:0061337 2 0.012
macromolecule catabolic process GO:0009057 58 0.012
carboxylic acid biosynthetic process GO:0046394 83 0.012
regulation of apoptotic process GO:0042981 335 0.012
response to ethanol GO:0045471 162 0.012
cellular response to xenobiotic stimulus GO:0071466 19 0.012
negative regulation of developmental process GO:0051093 125 0.012
cellular glucose homeostasis GO:0001678 66 0.012
Rat
regulation of growth GO:0040008 105 0.012
negative regulation of catalytic activity GO:0043086 103 0.012
transmission of nerve impulse GO:0019226 42 0.012
renal response to blood flow involved in circulatory renin angiotensin regulation of systemic arterial blood pressure GO:0001999 1 0.012
regulation of peptide hormone secretion GO:0090276 80 0.012
Rat
response to mineralocorticoid GO:0051385 49 0.011
proteolysis GO:0006508 175 0.011
myelination GO:0042552 39 0.011
unsaturated fatty acid metabolic process GO:0033559 39 0.011
purine ribonucleotide metabolic process GO:0009150 227 0.011
muscle structure development GO:0061061 87 0.011
lipid localization GO:0010876 62 0.011
negative regulation of growth GO:0045926 37 0.011
defense response to gram negative bacterium GO:0050829 3 0.011
cellular response to glucose stimulus GO:0071333 65 0.011
Rat
response to decreased oxygen levels GO:0036293 237 0.011
regulation of catalytic activity GO:0050790 304 0.011
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.011
positive regulation of peptide hormone secretion GO:0090277 50 0.011
Rat
positive regulation of cellular catabolic process GO:0031331 71 0.011
tube development GO:0035295 89 0.011
secretion by cell GO:0032940 248 0.011
Rat
vitamin biosynthetic process GO:0009110 3 0.011
response to insecticide GO:0017085 21 0.011
protein tetramerization GO:0051262 38 0.011
male gamete generation GO:0048232 99 0.011
regulation of programmed cell death GO:0043067 341 0.011
bile acid biosynthetic process GO:0006699 3 0.011
fatty acid oxidation GO:0019395 29 0.011
protein transport GO:0015031 132 0.011
response to low density lipoprotein particle GO:0055098 4 0.011
renal system process GO:0003014 40 0.011
negative regulation of synaptic transmission dopaminergic GO:0032227 4 0.011
ribonucleotide catabolic process GO:0009261 136 0.011
cellular response to oxygen levels GO:0071453 60 0.011
regulation of protein modification process GO:0031399 194 0.011
positive regulation of phosphorus metabolic process GO:0010562 262 0.011
negative regulation of fibrinolysis GO:0051918 2 0.011
monocarboxylic acid biosynthetic process GO:0072330 48 0.011
positive regulation of protein phosphorylation GO:0001934 135 0.011
negative regulation of wound healing GO:0061045 8 0.011
positive regulation of hemostasis GO:1900048 4 0.011
tetrahydrofolate metabolic process GO:0046653 9 0.011
positive regulation of blood circulation GO:1903524 65 0.011
single organism cell adhesion GO:0098602 46 0.011
ribonucleotide metabolic process GO:0009259 231 0.011
reproductive structure development GO:0048608 128 0.011
nucleotide metabolic process GO:0009117 279 0.011
Rat
regulation of phagocytosis engulfment GO:0060099 4 0.011
ribonucleoside monophosphate metabolic process GO:0009161 88 0.010
neurotransmitter uptake GO:0001504 3 0.010
developmental growth GO:0048589 100 0.010
alpha amino acid biosynthetic process GO:1901607 23 0.010
regulation of hemostasis GO:1900046 9 0.010
multicellular organismal signaling GO:0035637 44 0.010
sexual reproduction GO:0019953 148 0.010
negative regulation of cell communication GO:0010648 158 0.010
cellular lipid catabolic process GO:0044242 37 0.010
negative regulation of macromolecule metabolic process GO:0010605 260 0.010
anatomical structure morphogenesis GO:0009653 298 0.010
fat soluble vitamin biosynthetic process GO:0042362 2 0.010
purine ribonucleoside catabolic process GO:0046130 124 0.010
divalent metal ion transport GO:0070838 132 0.010
programmed cell death GO:0012501 392 0.010
meiotic cell cycle process GO:1903046 3 0.010
gamete generation GO:0007276 124 0.010
response to corticosterone GO:0051412 40 0.010
regulation of monooxygenase activity GO:0032768 8 0.010
metal ion homeostasis GO:0055065 186 0.010
regulation of synaptic transmission gabaergic GO:0032228 17 0.010
heart development GO:0007507 72 0.010
ribonucleoside triphosphate catabolic process GO:0009203 122 0.010
sodium ion transport GO:0006814 82 0.010
regulation of cell differentiation GO:0045595 320 0.010

Pck1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.121
nutrition disease DOID:374 0 0.054
acquired metabolic disease DOID:0060158 0 0.054
obesity DOID:9970 0 0.054
overnutrition DOID:654 0 0.054
inherited metabolic disorder DOID:655 0 0.028
disease of anatomical entity DOID:7 0 0.027
urinary system disease DOID:18 0 0.027
kidney disease DOID:557 0 0.021
nervous system disease DOID:863 0 0.021
musculoskeletal system disease DOID:17 0 0.018
connective tissue disease DOID:65 0 0.014
sensory system disease DOID:0050155 0 0.011