Rattus norvegicus

300 known processes

Arrb1

arrestin, beta 1

(Aliases: BARRES)

Arrb1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
cellular response to endogenous stimulus GO:0071495 377 0.433
signal release GO:0023061 145 0.298
regulation of nucleic acid templated transcription GO:1903506 380 0.243
secretion by cell GO:0032940 248 0.176
regulation of hormone secretion GO:0046883 106 0.175
positive regulation of multicellular organismal process GO:0051240 387 0.171
immune system process GO:0002376 204 0.164
response to growth factor GO:0070848 189 0.153
cell cell signaling GO:0007267 335 0.153
cellular response to cytokine stimulus GO:0071345 127 0.148
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.132
embryonic cranial skeleton morphogenesis GO:0048701 2 0.120
neuron differentiation GO:0030182 368 0.119
cellular response to hormone stimulus GO:0032870 247 0.114
response to estrogen GO:0043627 232 0.110
positive regulation of gene expression GO:0010628 244 0.105
response to cytokine GO:0034097 215 0.098
organonitrogen compound catabolic process GO:1901565 179 0.095
cellular response to external stimulus GO:0071496 118 0.095
positive regulation of cell communication GO:0010647 271 0.095
positive regulation of nervous system development GO:0051962 178 0.093
anatomical structure morphogenesis GO:0009653 298 0.091
programmed cell death GO:0012501 392 0.090
secretion GO:0046903 307 0.090
regulation of multicellular organismal development GO:2000026 376 0.090
leukocyte differentiation GO:0002521 30 0.086
regulation of transcription dna templated GO:0006355 374 0.086
cellular response to oxygen containing compound GO:1901701 386 0.086
response to peptide hormone GO:0043434 278 0.082
nucleic acid templated transcription GO:0097659 379 0.077
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.076
regulation of secretion GO:0051046 224 0.073
transcription from rna polymerase ii promoter GO:0006366 252 0.071
positive regulation of secretion GO:0051047 140 0.070
response to reactive oxygen species GO:0000302 120 0.069
muscle system process GO:0003012 115 0.068
carboxylic acid transport GO:0046942 115 0.068
cellular response to insulin stimulus GO:0032869 81 0.068
regulation of cellular localization GO:0060341 263 0.067
response to peptide GO:1901652 292 0.065
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.062
myeloid leukocyte differentiation GO:0002573 20 0.062
regulation of cellular protein metabolic process GO:0032268 267 0.060
cell morphogenesis involved in differentiation GO:0000904 119 0.060
organic acid transport GO:0015849 116 0.059
response to acid chemical GO:0001101 222 0.059
cardiac chamber development GO:0003205 1 0.059
heart morphogenesis GO:0003007 3 0.058
negative regulation of metabolic process GO:0009892 331 0.058
hormone secretion GO:0046879 115 0.058
response to heat GO:0009408 60 0.056
response to oxidative stress GO:0006979 186 0.056
amide transport GO:0042886 105 0.056
jak stat cascade GO:0007259 26 0.056
oxoacid metabolic process GO:0043436 290 0.055
embryonic neurocranium morphogenesis GO:0048702 2 0.054
gastrulation GO:0007369 2 0.054
rna biosynthetic process GO:0032774 380 0.052
forebrain development GO:0030900 98 0.052
neuron development GO:0048666 286 0.051
nitrogen compound transport GO:0071705 229 0.051
cellular component assembly GO:0022607 360 0.051
acid secretion GO:0046717 48 0.051
insulin secretion GO:0030073 69 0.051
embryonic skeletal system morphogenesis GO:0048704 3 0.051
positive regulation of apoptotic process GO:0043065 154 0.050
organic acid metabolic process GO:0006082 292 0.050
response to nutrient levels GO:0031667 370 0.049
regulation of cell projection organization GO:0031344 175 0.049
intracellular signal transduction GO:0035556 314 0.049
rna metabolic process GO:0016070 406 0.049
negative regulation of transcription dna templated GO:0045892 116 0.049
organic anion transport GO:0015711 132 0.048
hormone transport GO:0009914 121 0.047
single organism reproductive process GO:0044702 297 0.047
regulation of apoptotic process GO:0042981 335 0.047
cytokine mediated signaling pathway GO:0019221 43 0.046
positive regulation of cellular component organization GO:0051130 200 0.046
Rat
regulation of cellular amine metabolic process GO:0033238 8 0.046
regulation of rna metabolic process GO:0051252 391 0.045
response to nutrient GO:0007584 248 0.044
response to other organism GO:0051707 220 0.044
multicellular organism reproduction GO:0032504 233 0.044
positive regulation of biosynthetic process GO:0009891 319 0.043
myeloid cell differentiation GO:0030099 22 0.043
response to organophosphorus GO:0046683 102 0.043
glandular epithelial cell differentiation GO:0002067 4 0.042
response to estradiol GO:0032355 164 0.042
cellular catabolic process GO:0044248 295 0.041
cell part morphogenesis GO:0032990 123 0.041
aging GO:0007568 241 0.041
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.041
positive regulation of rna metabolic process GO:0051254 203 0.041
response to hexose GO:0009746 144 0.040
regulation of nervous system development GO:0051960 264 0.039
response to monosaccharide GO:0034284 159 0.038
cellular ketone metabolic process GO:0042180 51 0.037
peptide secretion GO:0002790 86 0.037
cellular response to organonitrogen compound GO:0071417 197 0.037
response to carbohydrate GO:0009743 183 0.037
cerebral cortex tangential migration GO:0021800 1 0.036
negative regulation of developmental process GO:0051093 125 0.036
carboxylic acid metabolic process GO:0019752 289 0.036
brain development GO:0007420 247 0.036
Rat
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.036
regulation of hormone levels GO:0010817 187 0.036
regulation of secretion by cell GO:1903530 208 0.035
neuron projection development GO:0031175 273 0.035
cellular homeostasis GO:0019725 252 0.035
tissue development GO:0009888 252 0.034
camera type eye development GO:0043010 48 0.034
response to inorganic substance GO:0010035 377 0.034
cellular component movement GO:0006928 248 0.034
actin filament based process GO:0030029 86 0.033
negative regulation of nucleic acid templated transcription GO:1903507 117 0.033
mesoderm development GO:0007498 2 0.032
reactive nitrogen species metabolic process GO:2001057 1 0.032
regulation of mesenchymal cell proliferation GO:0010464 4 0.031
regulation of cell proliferation GO:0042127 359 0.031
negative regulation of signaling GO:0023057 157 0.031
cell morphogenesis GO:0000902 142 0.031
single organism biosynthetic process GO:0044711 342 0.031
monocarboxylic acid metabolic process GO:0032787 152 0.031
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.031
regulation of cellular ketone metabolic process GO:0010565 27 0.031
signal transduction by phosphorylation GO:0023014 144 0.031
regulation of rna biosynthetic process GO:2001141 381 0.031
peptide hormone secretion GO:0030072 84 0.031
regulation of neurogenesis GO:0050767 247 0.031
glutamate secretion GO:0014047 19 0.031
nucleobase containing small molecule metabolic process GO:0055086 316 0.031
regulation of cell differentiation GO:0045595 320 0.030
positive regulation of developmental process GO:0051094 283 0.030
lipid metabolic process GO:0006629 283 0.029
telencephalon development GO:0021537 62 0.029
dicarboxylic acid transport GO:0006835 34 0.029
cellular chemical homeostasis GO:0055082 247 0.029
negative regulation of cellular metabolic process GO:0031324 281 0.028
alpha amino acid metabolic process GO:1901605 71 0.028
morphogenesis of embryonic epithelium GO:0016331 3 0.028
regulation of peptide secretion GO:0002791 82 0.028
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.028
negative regulation of cell differentiation GO:0045596 99 0.028
single organism carbohydrate metabolic process GO:0044723 118 0.028
embryonic skeletal system development GO:0048706 3 0.028
embryonic pattern specification GO:0009880 1 0.028
hematopoietic or lymphoid organ development GO:0048534 36 0.028
axon development GO:0061564 96 0.027
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.027
positive regulation of cellular biosynthetic process GO:0031328 295 0.027
positive regulation of transcription dna templated GO:0045893 197 0.027
head development GO:0060322 247 0.027
Rat
eye morphogenesis GO:0048592 4 0.027
regulation of protein metabolic process GO:0051246 289 0.026
aromatic compound catabolic process GO:0019439 168 0.026
single organism catabolic process GO:0044712 283 0.026
regulation of neuron differentiation GO:0045664 208 0.026
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.026
cellular response to peptide hormone stimulus GO:0071375 120 0.026
response to radiation GO:0009314 137 0.026
Fly
inorganic ion transmembrane transport GO:0098660 229 0.026
rhythmic process GO:0048511 156 0.025
monosaccharide metabolic process GO:0005996 61 0.025
cellular component morphogenesis GO:0032989 155 0.025
cellular amino acid metabolic process GO:0006520 107 0.025
cell projection organization GO:0030030 302 0.025
negative regulation of cellular biosynthetic process GO:0031327 161 0.025
biological adhesion GO:0022610 110 0.025
transcription dna templated GO:0006351 377 0.025
organic substance catabolic process GO:1901575 316 0.025
hemopoiesis GO:0030097 34 0.025
circadian rhythm GO:0007623 88 0.024
negative regulation of rna metabolic process GO:0051253 123 0.024
regulation of cell development GO:0060284 263 0.024
regulation of peptide hormone secretion GO:0090276 80 0.024
regulation of peptide transport GO:0090087 87 0.024
cellular protein localization GO:0034613 122 0.024
cellular response to growth factor stimulus GO:0071363 162 0.024
regulation of homeostatic process GO:0032844 101 0.024
ribonucleoside metabolic process GO:0009119 174 0.024
regulation of programmed cell death GO:0043067 341 0.024
protein complex assembly GO:0006461 263 0.024
cell growth GO:0016049 104 0.024
sympathetic nervous system development GO:0048485 1 0.023
chemical homeostasis GO:0048878 292 0.023
dna metabolic process GO:0006259 96 0.023
Rat
response to ketone GO:1901654 182 0.023
response to mechanical stimulus GO:0009612 134 0.023
positive regulation of calcium ion transport GO:0051928 36 0.023
Rat
regulation of protein phosphorylation GO:0001932 183 0.023
cellular response to organic cyclic compound GO:0071407 202 0.022
membrane organization GO:0061024 94 0.022
response to extracellular stimulus GO:0009991 380 0.022
anion transport GO:0006820 178 0.022
negative regulation of rna biosynthetic process GO:1902679 118 0.022
macromolecular complex subunit organization GO:0043933 339 0.022
organophosphate metabolic process GO:0019637 370 0.022
development of primary sexual characteristics GO:0045137 107 0.022
cellular response to extracellular stimulus GO:0031668 73 0.022
chemosensory behavior GO:0007635 2 0.022
amino acid transport GO:0006865 70 0.022
gonad development GO:0008406 104 0.022
cell cycle checkpoint GO:0000075 2 0.021
monovalent inorganic cation transport GO:0015672 172 0.021
amine metabolic process GO:0009308 38 0.021
negative regulation of cell communication GO:0010648 158 0.021
regulation of neuron projection development GO:0010975 161 0.021
negative regulation of calcium ion transport into cytosol GO:0010523 4 0.021
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.021
positive regulation of peptide hormone secretion GO:0090277 50 0.021
actin cytoskeleton organization GO:0030036 73 0.021
catabolic process GO:0009056 351 0.020
immune system development GO:0002520 41 0.020
glucose homeostasis GO:0042593 75 0.020
negative regulation of neuron differentiation GO:0045665 62 0.020
single organism organelle organization GO:1902589 180 0.020
cellular amine metabolic process GO:0044106 38 0.020
small molecule biosynthetic process GO:0044283 124 0.020
ribonucleotide metabolic process GO:0009259 231 0.020
dna replication GO:0006260 37 0.020
regulation of molecular function GO:0065009 398 0.020
cell activation GO:0001775 97 0.020
negative regulation of macromolecule metabolic process GO:0010605 260 0.020
cellular response to peptide GO:1901653 133 0.020
metal ion transport GO:0030001 289 0.020
Rat
olfactory bulb interneuron differentiation GO:0021889 1 0.019
positive regulation of neuron migration GO:2001224 2 0.019
regulation of signal transduction GO:0009966 318 0.019
carbohydrate derivative metabolic process GO:1901135 346 0.019
positive regulation of cell projection organization GO:0031346 111 0.019
leukocyte activation GO:0045321 76 0.019
cellular component biogenesis GO:0044085 368 0.019
response to metal ion GO:0010038 253 0.019
positive regulation of nucleic acid templated transcription GO:1903508 197 0.019
parasympathetic nervous system development GO:0048486 1 0.019
positive regulation of rna biosynthetic process GO:1902680 197 0.019
cell junction organization GO:0034330 21 0.019
muscle tissue morphogenesis GO:0060415 1 0.019
positive regulation of neuron projection development GO:0010976 99 0.019
cellular response to nutrient levels GO:0031669 60 0.018
autonomic nervous system development GO:0048483 3 0.018
cytoskeleton organization GO:0007010 111 0.018
single organism intracellular transport GO:1902582 166 0.018
positive regulation of cell development GO:0010720 176 0.018
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.018
reproductive process GO:0022414 372 0.018
substrate dependent cerebral cortex tangential migration GO:0021825 1 0.018
response to decreased oxygen levels GO:0036293 237 0.018
negative regulation of biosynthetic process GO:0009890 168 0.018
positive regulation of neuron differentiation GO:0045666 126 0.018
reactive oxygen species biosynthetic process GO:1903409 8 0.018
response to glucocorticoid GO:0051384 223 0.018
multicellular organism growth GO:0035264 1 0.018
nucleotide catabolic process GO:0009166 139 0.018
central nervous system development GO:0007417 311 0.017
Rat
lymphocyte activation GO:0046649 43 0.017
ras protein signal transduction GO:0007265 29 0.017
peptide transport GO:0015833 97 0.017
dendrite development GO:0016358 72 0.017
negative regulation of cell cycle phase transition GO:1901988 4 0.017
multicellular organismal reproductive process GO:0048609 233 0.017
ribonucleoside catabolic process GO:0042454 126 0.017
second messenger mediated signaling GO:0019932 51 0.017
purine ribonucleoside metabolic process GO:0046128 168 0.017
g protein coupled receptor signaling pathway GO:0007186 242 0.017
regulation of reactive oxygen species metabolic process GO:2000377 26 0.017
purine nucleotide metabolic process GO:0006163 229 0.017
response to fatty acid GO:0070542 65 0.016
regulation of cytokine production GO:0001817 56 0.016
synaptic transmission GO:0007268 235 0.016
negative regulation of cell development GO:0010721 82 0.016
protein heterooligomerization GO:0051291 89 0.016
regulation of jak stat cascade GO:0046425 21 0.016
organic acid biosynthetic process GO:0016053 83 0.016
positive regulation of hormone secretion GO:0046887 65 0.016
organic hydroxy compound biosynthetic process GO:1901617 51 0.016
cardiac muscle tissue morphogenesis GO:0055008 1 0.016
negative regulation of multicellular organismal process GO:0051241 203 0.016
regulation of synaptic transmission GO:0050804 141 0.016
circulatory system development GO:0072359 134 0.016
tube development GO:0035295 89 0.016
cell substrate adhesion GO:0031589 29 0.016
cellular response to alcohol GO:0097306 87 0.015
response to retinoic acid GO:0032526 63 0.015
response to glucose GO:0009749 136 0.015
positive regulation of lymphocyte activation GO:0051251 25 0.015
positive regulation of transport GO:0051050 245 0.015
Rat
response to corticosteroid GO:0031960 235 0.015
organic cyclic compound catabolic process GO:1901361 175 0.015
regulation of catalytic activity GO:0050790 304 0.015
female pregnancy GO:0007565 122 0.015
negative regulation of phosphorus metabolic process GO:0010563 80 0.015
cardiovascular system development GO:0072358 134 0.015
regulation of muscle system process GO:0090257 79 0.015
lymphoid progenitor cell differentiation GO:0002320 2 0.014
cellular divalent inorganic cation homeostasis GO:0072503 162 0.014
regulation of ion transport GO:0043269 245 0.014
Rat
lung development GO:0030324 43 0.014
dendrite morphogenesis GO:0048813 43 0.014
protein complex biogenesis GO:0070271 263 0.014
lens development in camera type eye GO:0002088 13 0.014
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.014
cell adhesion GO:0007155 110 0.014
positive regulation of cell death GO:0010942 184 0.014
cellular response to tumor necrosis factor GO:0071356 46 0.014
calcium ion transport GO:0006816 131 0.014
Rat
action potential GO:0001508 54 0.014
cardiac ventricle development GO:0003231 1 0.014
negative regulation of jak stat cascade GO:0046426 3 0.014
muscle organ morphogenesis GO:0048644 1 0.014
rhythmic synaptic transmission GO:0060024 1 0.014
cell cell junction organization GO:0045216 20 0.014
cellular macromolecule localization GO:0070727 122 0.014
purine nucleoside metabolic process GO:0042278 169 0.014
negative regulation of phosphorylation GO:0042326 57 0.013
regulation of cellular component organization GO:0051128 368 0.013
Rat
positive regulation of cell proliferation GO:0008284 249 0.013
hematopoietic progenitor cell differentiation GO:0002244 2 0.013
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.013
organelle organization GO:0006996 266 0.013
Rat
pro t cell differentiation GO:0002572 1 0.013
cellular response to stress GO:0033554 269 0.013
positive regulation of mesenchymal cell proliferation GO:0002053 4 0.013
intracellular transport GO:0046907 185 0.013
behavior GO:0007610 205 0.013
inflammatory response GO:0006954 150 0.013
cytokine production GO:0001816 61 0.013
positive regulation of jak stat cascade GO:0046427 19 0.013
vesicle organization GO:0016050 29 0.013
eye development GO:0001654 50 0.013
regulation of metal ion transport GO:0010959 118 0.013
Rat
heart development GO:0007507 72 0.013
sexual reproduction GO:0019953 148 0.013
adult locomotory behavior GO:0008344 4 0.013
regulation of amino acid transport GO:0051955 25 0.013
regulation of cellular amino acid metabolic process GO:0006521 2 0.013
response to wounding GO:0009611 254 0.013
spinal cord development GO:0021510 27 0.012
regulation of insulin secretion GO:0050796 65 0.012
cell cycle GO:0007049 101 0.012
muscle contraction GO:0006936 88 0.012
substrate dependent cell migration GO:0006929 1 0.012
regulation of intracellular signal transduction GO:1902531 218 0.012
axis specification GO:0009798 4 0.012
negative regulation of apoptotic process GO:0043066 181 0.012
Rat
cell differentiation involved in kidney development GO:0061005 4 0.012
camera type eye morphogenesis GO:0048593 2 0.012
cell type specific apoptotic process GO:0097285 134 0.012
response to calcium ion GO:0051592 59 0.012
positive regulation of neurogenesis GO:0050769 165 0.012
negative regulation of calcium ion import GO:0090281 2 0.012
kidney epithelium development GO:0072073 19 0.012
organonitrogen compound biosynthetic process GO:1901566 167 0.012
regulation of small gtpase mediated signal transduction GO:0051056 48 0.012
tube formation GO:0035148 3 0.012
negative regulation of nervous system development GO:0051961 79 0.012
l glutamate import GO:0051938 2 0.012
positive regulation of neuron apoptotic process GO:0043525 33 0.012
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.012
central nervous system neuron differentiation GO:0021953 17 0.012
detection of visible light GO:0009584 3 0.012
Fly
female gonad development GO:0008585 53 0.012
response to fibroblast growth factor GO:0071774 29 0.012
regulation of lymphocyte activation GO:0051249 34 0.012
cellular protein complex assembly GO:0043623 44 0.012
positive regulation of secretion by cell GO:1903532 128 0.012
regulation of nitric oxide biosynthetic process GO:0045428 20 0.012
nucleoside phosphate catabolic process GO:1901292 140 0.012
mesonephros development GO:0001823 14 0.012
negative regulation of cellular amine metabolic process GO:0033239 3 0.011
hyperosmotic response GO:0006972 18 0.011
negative regulation of secretion GO:0051048 82 0.011
cellular response to nitrogen compound GO:1901699 210 0.011
erk1 and erk2 cascade GO:0070371 48 0.011
forebrain generation of neurons GO:0021872 8 0.011
heart process GO:0003015 57 0.011
negative regulation of stress activated protein kinase signaling cascade GO:0070303 4 0.011
carboxylic acid biosynthetic process GO:0046394 83 0.011
cellular component maintenance GO:0043954 4 0.011
retina morphogenesis in camera type eye GO:0060042 1 0.011
negative regulation of osteoblast differentiation GO:0045668 2 0.011
regulation of phosphate metabolic process GO:0019220 349 0.011
positive regulation of immune system process GO:0002684 90 0.011
multi organism reproductive process GO:0044703 262 0.011
response to alkaloid GO:0043279 132 0.011
positive regulation of cell differentiation GO:0045597 217 0.011
negative regulation of gene expression GO:0010629 199 0.011
Rat
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.011
response to insulin GO:0032868 133 0.011
developmental process involved in reproduction GO:0003006 159 0.011
nucleotide metabolic process GO:0009117 279 0.011
cardiac conduction GO:0061337 2 0.011
cellular response to lipid GO:0071396 201 0.011
vesicle mediated transport GO:0016192 181 0.011
small gtpase mediated signal transduction GO:0007264 36 0.011
carbohydrate homeostasis GO:0033500 75 0.011
purine nucleoside triphosphate metabolic process GO:0009144 141 0.011
negative regulation of secretion by cell GO:1903531 72 0.010
regulation of embryonic development GO:0045995 2 0.010
pallium development GO:0021543 42 0.010
ion homeostasis GO:0050801 212 0.010
protein phosphorylation GO:0006468 345 0.010
homeostatic process GO:0042592 331 0.010
Fly
cation transmembrane transport GO:0098655 263 0.010
negative regulation of cellular protein metabolic process GO:0032269 106 0.010
purine nucleotide catabolic process GO:0006195 136 0.010
cellular carbohydrate metabolic process GO:0044262 72 0.010
regulation of leukocyte differentiation GO:1902105 20 0.010
response to epidermal growth factor GO:0070849 18 0.010
positive regulation of signaling GO:0023056 270 0.010
positive regulation of neuron death GO:1901216 43 0.010
cell migration GO:0016477 197 0.010
response to anoxia GO:0034059 4 0.010
cellular response to glucose stimulus GO:0071333 65 0.010
response to mineralocorticoid GO:0051385 49 0.010

Arrb1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.069
musculoskeletal system disease DOID:17 0 0.069
connective tissue disease DOID:65 0 0.041
nervous system disease DOID:863 0 0.025
neuropathy DOID:870 0 0.025
gastrointestinal system cancer DOID:3119 0 0.022
cancer DOID:162 0 0.022
disease of cellular proliferation DOID:14566 0 0.022
organ system cancer DOID:0050686 0 0.022
substance related disorder DOID:303 0 0.021
disease of mental health DOID:150 0 0.021
cardiovascular system disease DOID:1287 0 0.021
neuromuscular disease DOID:440 0 0.018
charcot marie tooth disease type 2 DOID:0050539 0 0.016
charcot marie tooth disease DOID:10595 0 0.016
bone disease DOID:0080001 0 0.012
disease of metabolism DOID:0014667 0 0.011
substance dependence DOID:9973 0 0.010