Rattus norvegicus

0 known processes

Pdia6

protein disulfide isomerase family A, member 6

(Aliases: Txndc7,CaBP1,P5)

Pdia6 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of apoptotic process GO:0042981 335 0.683
cellular response to topologically incorrect protein GO:0035967 3 0.499
programmed cell death GO:0012501 392 0.458
chaperone mediated protein folding GO:0061077 6 0.325
positive regulation of cell development GO:0010720 176 0.280
protein folding GO:0006457 12 0.276
er associated ubiquitin dependent protein catabolic process GO:0030433 1 0.273
apoptotic process GO:0006915 381 0.247
regulation of phosphate metabolic process GO:0019220 349 0.242
protein phosphorylation GO:0006468 345 0.221
response to purine containing compound GO:0014074 126 0.209
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 27 0.201
regulation of phosphorus metabolic process GO:0051174 349 0.192
establishment of protein localization GO:0045184 141 0.192
positive regulation of protein modification process GO:0031401 142 0.154
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.153
positive regulation of multicellular organismal process GO:0051240 387 0.148
response to peptide GO:1901652 292 0.140
positive regulation of phosphate metabolic process GO:0045937 262 0.139
multicellular organism growth GO:0035264 1 0.137
response to endoplasmic reticulum stress GO:0034976 10 0.134
positive regulation of signaling GO:0023056 270 0.129
negative regulation of programmed cell death GO:0043069 183 0.122
response to atp GO:0033198 13 0.120
central nervous system development GO:0007417 311 0.114
pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 3 0.113
response to nutrient levels GO:0031667 370 0.112
positive regulation of phosphorus metabolic process GO:0010562 262 0.110
negative regulation of metabolic process GO:0009892 331 0.107
regulation of hydrolase activity GO:0051336 143 0.107
cerebellar purkinje cell layer development GO:0021680 2 0.101
single organism carbohydrate metabolic process GO:0044723 118 0.097
regulation of molecular function GO:0065009 398 0.096
positive regulation of cell death GO:0010942 184 0.092
cellular response to unfolded protein GO:0034620 2 0.090
macromolecular complex subunit organization GO:0043933 339 0.085
positive regulation of cellular biosynthetic process GO:0031328 295 0.085
regulation of immune system process GO:0002682 123 0.084
regulation of signal transduction GO:0009966 318 0.083
positive regulation of programmed cell death GO:0043068 157 0.083
regulation of cell migration GO:0030334 128 0.082
positive regulation of developmental process GO:0051094 283 0.081
positive regulation of cell morphogenesis involved in differentiation GO:0010770 41 0.080
transmembrane transport GO:0055085 412 0.078
regulation of cellular protein metabolic process GO:0032268 267 0.076
negative regulation of cell death GO:0060548 229 0.075
protein complex subunit organization GO:0071822 302 0.074
regulation of cell differentiation GO:0045595 320 0.073
cellular response to stress GO:0033554 269 0.072
regulation of programmed cell death GO:0043067 341 0.070
head development GO:0060322 247 0.070
positive regulation of apoptotic signaling pathway GO:2001235 6 0.067
response to organophosphorus GO:0046683 102 0.067
regulation of phosphorylation GO:0042325 248 0.066
proteolysis GO:0006508 175 0.065
positive regulation of cellular protein metabolic process GO:0032270 167 0.064
protein complex assembly GO:0006461 263 0.064
protein complex biogenesis GO:0070271 263 0.064
pyrimidine ribonucleotide biosynthetic process GO:0009220 5 0.063
response to toxic substance GO:0009636 133 0.063
response to extracellular stimulus GO:0009991 380 0.063
positive regulation of protein phosphorylation GO:0001934 135 0.061
response to amine GO:0014075 46 0.060
negative regulation of apoptotic process GO:0043066 181 0.060
positive regulation of cellular component organization GO:0051130 200 0.059
hindbrain morphogenesis GO:0021575 2 0.056
neuromuscular synaptic transmission GO:0007274 2 0.056
cellular response to endogenous stimulus GO:0071495 377 0.054
positive regulation of biosynthetic process GO:0009891 319 0.054
positive regulation of phosphorylation GO:0042327 177 0.053
positive regulation of cell projection organization GO:0031346 111 0.053
cellular response to organic cyclic compound GO:0071407 202 0.053
cellular response to organonitrogen compound GO:0071417 197 0.052
pyrimidine ribonucleoside triphosphate biosynthetic process GO:0009209 2 0.052
positive regulation of response to stimulus GO:0048584 285 0.050
cellular protein catabolic process GO:0044257 19 0.050
maintenance of protein location GO:0045185 7 0.050
regulation of cell development GO:0060284 263 0.047
intracellular transport GO:0046907 185 0.046
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.046
single organism biosynthetic process GO:0044711 342 0.046
negative regulation of cell communication GO:0010648 158 0.044
regulation of cell proliferation GO:0042127 359 0.043
regulation of protein modification process GO:0031399 194 0.043
positive regulation of neurogenesis GO:0050769 165 0.043
positive regulation of apoptotic process GO:0043065 154 0.043
posttranscriptional regulation of gene expression GO:0010608 37 0.043
positive regulation of signal transduction GO:0009967 175 0.042
positive regulation of neuron projection development GO:0010976 99 0.041
catabolic process GO:0009056 351 0.040
positive regulation of protein metabolic process GO:0051247 178 0.040
positive regulation of cell differentiation GO:0045597 217 0.039
regulation of catalytic activity GO:0050790 304 0.039
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.039
cellular ketone metabolic process GO:0042180 51 0.038
cellular component assembly GO:0022607 360 0.038
protein localization to organelle GO:0033365 57 0.037
response to oxygen levels GO:0070482 265 0.037
regulation of kinase activity GO:0043549 117 0.036
regulation of cellular component organization GO:0051128 368 0.036
dephosphorylation GO:0016311 98 0.036
macromolecule localization GO:0033036 252 0.035
reproductive process GO:0022414 372 0.035
regulation of interleukin 6 production GO:0032675 12 0.035
apoptotic signaling pathway GO:0097190 27 0.035
response to estrogen GO:0043627 232 0.034
macromolecular complex assembly GO:0065003 273 0.034
oxoacid metabolic process GO:0043436 290 0.034
chemosensory behavior GO:0007635 2 0.034
positive regulation of cyclic nucleotide biosynthetic process GO:0030804 34 0.033
endoplasmic reticulum unfolded protein response GO:0030968 2 0.033
microtubule organizing center organization GO:0031023 1 0.033
neurological system process GO:0050877 219 0.033
response to tumor cell GO:0002347 4 0.033
cellular macromolecule catabolic process GO:0044265 29 0.033
chemical homeostasis GO:0048878 292 0.032
regulation of protein metabolic process GO:0051246 289 0.032
proteolysis involved in cellular protein catabolic process GO:0051603 19 0.031
response to ketone GO:1901654 182 0.031
peptidyl amino acid modification GO:0018193 126 0.031
somatic stem cell division GO:0048103 2 0.031
positive regulation of gene expression GO:0010628 244 0.031
urogenital system development GO:0001655 78 0.031
regulation of protein transport GO:0051223 68 0.030
multicellular organismal reproductive process GO:0048609 233 0.030
regulation of nervous system development GO:0051960 264 0.030
organic acid metabolic process GO:0006082 292 0.029
positive regulation of locomotion GO:0040017 102 0.029
secretion by cell GO:0032940 248 0.029
positive regulation of cellular component movement GO:0051272 102 0.029
pyrimidine nucleoside triphosphate metabolic process GO:0009147 4 0.028
rna biosynthetic process GO:0032774 380 0.028
cellular amine metabolic process GO:0044106 38 0.028
positive regulation of protein transport GO:0051222 41 0.028
positive regulation of neuron differentiation GO:0045666 126 0.028
response to peptide hormone GO:0043434 278 0.028
response to antibiotic GO:0046677 39 0.027
regulation of neurogenesis GO:0050767 247 0.027
positive regulation of nervous system development GO:0051962 178 0.027
er nucleus signaling pathway GO:0006984 3 0.027
cell motility GO:0048870 202 0.026
cellular amino acid metabolic process GO:0006520 107 0.025
positive regulation of molecular function GO:0044093 230 0.025
response to hypoxia GO:0001666 231 0.025
negative regulation of rna biosynthetic process GO:1902679 118 0.025
cellular response to drug GO:0035690 30 0.025
regulation of cellular ketone metabolic process GO:0010565 27 0.024
regulation of growth GO:0040008 105 0.024
mast cell migration GO:0097531 4 0.024
response to inorganic substance GO:0010035 377 0.024
response to acid chemical GO:0001101 222 0.024
negative regulation of macromolecule metabolic process GO:0010605 260 0.023
carbohydrate derivative biosynthetic process GO:1901137 124 0.023
synaptic vesicle endocytosis GO:0048488 4 0.023
intracellular signal transduction GO:0035556 314 0.023
response to fatty acid GO:0070542 65 0.022
cellular response to oxygen containing compound GO:1901701 386 0.022
regeneration GO:0031099 163 0.022
organic hydroxy compound metabolic process GO:1901615 115 0.022
regulation of secretion GO:0051046 224 0.022
response to camp GO:0051591 91 0.022
salivary gland development GO:0007431 3 0.022
cyclic purine nucleotide metabolic process GO:0052652 62 0.022
response to fungus GO:0009620 8 0.021
response to other organism GO:0051707 220 0.021
pyrimidine ribonucleotide metabolic process GO:0009218 5 0.021
calcium ion homeostasis GO:0055074 162 0.021
cellular catabolic process GO:0044248 295 0.021
response to nutrient GO:0007584 248 0.021
response to external biotic stimulus GO:0043207 221 0.021
cellular component biogenesis GO:0044085 368 0.021
positive regulation of growth GO:0045927 55 0.021
regulation of nucleotide biosynthetic process GO:0030808 47 0.020
cellular lipid metabolic process GO:0044255 208 0.020
negative regulation of gene expression GO:0010629 199 0.020
cellular divalent inorganic cation homeostasis GO:0072503 162 0.020
motor neuron axon guidance GO:0008045 1 0.020
maintenance of location GO:0051235 17 0.020
proteasomal protein catabolic process GO:0010498 8 0.020
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 2 0.020
regulation of protein heterodimerization activity GO:0043497 1 0.020
modification dependent protein catabolic process GO:0019941 14 0.020
regulation of protein phosphorylation GO:0001932 183 0.020
transcription dna templated GO:0006351 377 0.020
calcium ion transport GO:0006816 131 0.019
regulation of cellular amine metabolic process GO:0033238 8 0.019
secretion GO:0046903 307 0.019
response to unfolded protein GO:0006986 6 0.019
regulation of rna metabolic process GO:0051252 391 0.019
cellular response to peptide GO:1901653 133 0.019
protein homooligomerization GO:0051260 91 0.019
carbohydrate derivative metabolic process GO:1901135 346 0.019
regulation of multicellular organismal development GO:2000026 376 0.018
organelle organization GO:0006996 266 0.018
regulation of triglyceride biosynthetic process GO:0010866 4 0.018
multicellular organismal homeostasis GO:0048871 49 0.018
toxin transport GO:1901998 3 0.018
regulation of epithelial cell differentiation GO:0030856 12 0.018
regulation of apoptotic signaling pathway GO:2001233 13 0.018
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.018
protein targeting to membrane GO:0006612 11 0.018
taxis GO:0042330 67 0.017
maintenance of protein location in cell GO:0032507 7 0.017
cellular amide metabolic process GO:0043603 44 0.017
response to biotic stimulus GO:0009607 226 0.017
growth GO:0040007 165 0.017
regulation of calcium ion transport GO:0051924 77 0.017
nucleoside phosphate metabolic process GO:0006753 283 0.017
response to testosterone GO:0033574 55 0.017
immunoglobulin secretion GO:0048305 1 0.017
organophosphate metabolic process GO:0019637 370 0.017
macromolecule catabolic process GO:0009057 58 0.017
positive regulation of protein kinase activity GO:0045860 73 0.017
hippocampus development GO:0021766 30 0.017
protein oligomerization GO:0051259 191 0.017
positive regulation of cellular component biogenesis GO:0044089 55 0.017
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 3 0.016
pyrimidine containing compound metabolic process GO:0072527 20 0.016
carboxylic acid metabolic process GO:0019752 289 0.016
regulation of intracellular transport GO:0032386 65 0.016
purine ribonucleotide metabolic process GO:0009150 227 0.016
activation of cysteine type endopeptidase activity GO:0097202 4 0.016
cellular calcium ion homeostasis GO:0006874 160 0.016
cellular response to lipid GO:0071396 201 0.016
cellular response to cytokine stimulus GO:0071345 127 0.016
tissue development GO:0009888 252 0.016
multicellular organism reproduction GO:0032504 233 0.016
enzyme linked receptor protein signaling pathway GO:0007167 116 0.016
cytoplasmic transport GO:0016482 115 0.016
aging GO:0007568 241 0.016
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.015
brain development GO:0007420 247 0.015
localization of cell GO:0051674 202 0.015
cellular response to extracellular stimulus GO:0031668 73 0.015
skeletal system development GO:0001501 41 0.015
positive regulation of transport GO:0051050 245 0.015
regulation of canonical wnt signaling pathway GO:0060828 4 0.015
limbic system development GO:0021761 38 0.015
regulation of cellular amino acid metabolic process GO:0006521 2 0.015
cell migration GO:0016477 197 0.015
developmental growth GO:0048589 100 0.015
cellular response to nutrient levels GO:0031669 60 0.015
regulation of rna biosynthetic process GO:2001141 381 0.014
regulation of ion homeostasis GO:2000021 63 0.014
cation homeostasis GO:0055080 195 0.014
response to decreased oxygen levels GO:0036293 237 0.014
regulation of cellular component biogenesis GO:0044087 86 0.014
positive regulation of epithelial cell differentiation GO:0030858 6 0.014
negative regulation of phosphate metabolic process GO:0045936 80 0.014
regulation of cyclic nucleotide biosynthetic process GO:0030802 45 0.014
cation transport GO:0006812 382 0.014
positive regulation of nucleic acid templated transcription GO:1903508 197 0.014
negative regulation of cell differentiation GO:0045596 99 0.014
regulation of transferase activity GO:0051338 123 0.014
cytokine production GO:0001816 61 0.014
antigen processing and presentation of peptide antigen via mhc class i GO:0002474 1 0.014
centrosome organization GO:0051297 1 0.014
regulation of response to tumor cell GO:0002834 3 0.014
epithelial cell proliferation GO:0050673 54 0.014
positive regulation of rna metabolic process GO:0051254 203 0.014
cytosolic calcium ion homeostasis GO:0051480 140 0.014
amine metabolic process GO:0009308 38 0.014
telencephalon development GO:0021537 62 0.014
response to bacterium GO:0009617 200 0.014
positive regulation of cellular amine metabolic process GO:0033240 3 0.014
ctp metabolic process GO:0046036 1 0.013
ion homeostasis GO:0050801 212 0.013
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 1 0.013
regulation of purine nucleotide biosynthetic process GO:1900371 46 0.013
response to cytokine GO:0034097 215 0.013
regulation of nucleic acid templated transcription GO:1903506 380 0.013
protein localization GO:0008104 191 0.013
positive regulation of phagocytosis GO:0050766 9 0.013
spermatogenesis GO:0007283 99 0.013
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 10 0.013
cellular protein localization GO:0034613 122 0.013
regulation of neuron projection development GO:0010975 161 0.013
immune system process GO:0002376 204 0.013
nucleotide phosphorylation GO:0046939 8 0.013
renal system development GO:0072001 67 0.013
lipid metabolic process GO:0006629 283 0.013
positive regulation of purine nucleotide biosynthetic process GO:1900373 36 0.013
regulation of behavior GO:0050795 61 0.013
cell adhesion GO:0007155 110 0.013
regulation of blood pressure GO:0008217 83 0.013
circulatory system process GO:0003013 183 0.013
organonitrogen compound biosynthetic process GO:1901566 167 0.013
negative regulation of multicellular organismal process GO:0051241 203 0.012
negative regulation of molecular function GO:0044092 133 0.012
homeostatic process GO:0042592 331 0.012
regulation of nucleotide metabolic process GO:0006140 117 0.012
organic substance catabolic process GO:1901575 316 0.012
positive regulation of cell motility GO:2000147 97 0.012
cellular response to external stimulus GO:0071496 118 0.012
retinal metabolic process GO:0042574 3 0.012
protein catabolic process GO:0030163 30 0.012
regulation of cell motility GO:2000145 131 0.012
cellular response to transforming growth factor beta stimulus GO:0071560 41 0.012
regulation of membrane potential GO:0042391 110 0.012
dna metabolic process GO:0006259 96 0.012
bone development GO:0060348 25 0.012
regulation of cellular component movement GO:0051270 150 0.012
establishment of protein localization to membrane GO:0090150 16 0.012
negative regulation of transcription dna templated GO:0045892 116 0.012
cellular response to growth factor stimulus GO:0071363 162 0.012
golgi vesicle transport GO:0048193 22 0.012
response to starvation GO:0042594 59 0.012
startle response GO:0001964 2 0.012
developmental process involved in reproduction GO:0003006 159 0.012
response to interleukin 4 GO:0070670 7 0.011
negative regulation of protein metabolic process GO:0051248 114 0.011
positive regulation of protein ubiquitination GO:0031398 3 0.011
regulation of ion transport GO:0043269 245 0.011
nucleobase containing small molecule metabolic process GO:0055086 316 0.011
metal ion homeostasis GO:0055065 186 0.011
cellular response to biotic stimulus GO:0071216 59 0.011
positive regulation of leukocyte activation GO:0002696 30 0.011
keratinocyte differentiation GO:0030216 2 0.011
single organism catabolic process GO:0044712 283 0.011
regulation of camp biosynthetic process GO:0030817 38 0.011
regulation of anatomical structure size GO:0090066 135 0.011
phenol containing compound metabolic process GO:0018958 30 0.011
multi multicellular organism process GO:0044706 138 0.011
regulation of protein localization GO:0032880 81 0.011
ubiquitin dependent protein catabolic process GO:0006511 14 0.011
chromatin organization GO:0006325 34 0.011
response to vitamin GO:0033273 131 0.011
anatomical structure homeostasis GO:0060249 29 0.011
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.011
regulation of cellular localization GO:0060341 263 0.011
regulation of response to external stimulus GO:0032101 106 0.011
muscle cell apoptotic process GO:0010657 30 0.011
regulation of cytokine production GO:0001817 56 0.011
sequestering of calcium ion GO:0051208 8 0.010
extrinsic apoptotic signaling pathway GO:0097191 10 0.010
camp biosynthetic process GO:0006171 47 0.010
rho protein signal transduction GO:0007266 11 0.010
regulation of transcription dna templated GO:0006355 374 0.010
oxidation reduction process GO:0055114 304 0.010
single organism organelle organization GO:1902589 180 0.010
cell chemotaxis GO:0060326 31 0.010
male gamete generation GO:0048232 99 0.010
neuron differentiation GO:0030182 368 0.010
neuromuscular process GO:0050905 2 0.010
positive regulation of lamellipodium organization GO:1902745 4 0.010
response to growth factor GO:0070848 189 0.010
positive regulation of nucleotide biosynthetic process GO:0030810 36 0.010
positive regulation of cell adhesion GO:0045785 30 0.010
retinoic acid receptor signaling pathway GO:0048384 7 0.010

Pdia6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
bone disease DOID:0080001 0 0.037
disease of anatomical entity DOID:7 0 0.037
musculoskeletal system disease DOID:17 0 0.037
connective tissue disease DOID:65 0 0.037
osteochondrodysplasia DOID:2256 0 0.016
bone development disease DOID:0080006 0 0.016
osteogenesis imperfecta DOID:12347 0 0.013