Rattus norvegicus

0 known processes

Otp

orthopedia homeobox

Otp biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
positive regulation of multicellular organismal process GO:0051240 387 0.355
regulation of phosphate metabolic process GO:0019220 349 0.161
programmed cell death GO:0012501 392 0.150
homeostatic process GO:0042592 331 0.139
positive regulation of cell proliferation GO:0008284 249 0.136
inflammatory response GO:0006954 150 0.130
response to biotic stimulus GO:0009607 226 0.124
regulation of cell differentiation GO:0045595 320 0.123
positive regulation of cell differentiation GO:0045597 217 0.115
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.112
positive regulation of kinase activity GO:0033674 77 0.110
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.107
protein phosphorylation GO:0006468 345 0.095
cation transport GO:0006812 382 0.088
positive regulation of neurogenesis GO:0050769 165 0.085
positive regulation of nervous system development GO:0051962 178 0.084
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.077
regulation of neuron differentiation GO:0045664 208 0.077
reproductive process GO:0022414 372 0.075
secretion by cell GO:0032940 248 0.074
positive regulation of cell development GO:0010720 176 0.072
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.071
organic acid metabolic process GO:0006082 292 0.069
regulation of rna biosynthetic process GO:2001141 381 0.066
response to peptide hormone GO:0043434 278 0.065
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.063
regulation of neurogenesis GO:0050767 247 0.063
cellular amine metabolic process GO:0044106 38 0.062
ion transmembrane transport GO:0034220 365 0.062
regulation of nucleic acid templated transcription GO:1903506 380 0.061
peptidyl tyrosine phosphorylation GO:0018108 72 0.061
intracellular signal transduction GO:0035556 314 0.060
peptidyl amino acid modification GO:0018193 126 0.060
single organism reproductive process GO:0044702 297 0.058
regulation of secretion by cell GO:1903530 208 0.057
regulation of rna metabolic process GO:0051252 391 0.056
positive regulation of phosphate metabolic process GO:0045937 262 0.055
sex differentiation GO:0007548 113 0.051
macromolecule localization GO:0033036 252 0.050
regulation of hormone secretion GO:0046883 106 0.050
defense response GO:0006952 194 0.049
brain renin angiotensin system GO:0002035 3 0.049
negative regulation of cellular biosynthetic process GO:0031327 161 0.048
amine metabolic process GO:0009308 38 0.048
regulation of phosphorylation GO:0042325 248 0.048
positive regulation of cell communication GO:0010647 271 0.048
regulation of cellular component organization GO:0051128 368 0.047
response to peptide GO:1901652 292 0.047
cellular response to oxygen containing compound GO:1901701 386 0.046
cell cell signaling GO:0007267 335 0.046
regulation of cell development GO:0060284 263 0.046
inorganic cation transmembrane transport GO:0098662 202 0.046
metal ion transport GO:0030001 289 0.046
aging GO:0007568 241 0.046
multicellular organism reproduction GO:0032504 233 0.045
secretion GO:0046903 307 0.045
regulation of cellular localization GO:0060341 263 0.045
positive regulation of rna metabolic process GO:0051254 203 0.045
transcription dna templated GO:0006351 377 0.045
regulation of cell proliferation GO:0042127 359 0.045
cellular response to stress GO:0033554 269 0.044
regulation of cell projection organization GO:0031344 175 0.044
multicellular organismal homeostasis GO:0048871 49 0.044
reproductive system development GO:0061458 128 0.043
nucleotide metabolic process GO:0009117 279 0.043
regulation of phosphorus metabolic process GO:0051174 349 0.043
positive regulation of signaling GO:0023056 270 0.042
tissue development GO:0009888 252 0.042
cell projection organization GO:0030030 302 0.041
positive regulation of transcription dna templated GO:0045893 197 0.041
hormone secretion GO:0046879 115 0.040
response to cytokine GO:0034097 215 0.040
negative regulation of cellular metabolic process GO:0031324 281 0.039
response to nutrient levels GO:0031667 370 0.039
positive regulation of phosphorylation GO:0042327 177 0.039
response to wounding GO:0009611 254 0.038
positive regulation of biosynthetic process GO:0009891 319 0.038
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.038
neuron differentiation GO:0030182 368 0.038
response to external biotic stimulus GO:0043207 221 0.037
regulation of growth GO:0040008 105 0.037
divalent metal ion transport GO:0070838 132 0.037
vitamin d metabolic process GO:0042359 4 0.036
protein transport GO:0015031 132 0.036
establishment of protein localization GO:0045184 141 0.036
nucleic acid templated transcription GO:0097659 379 0.036
regulation of protein modification process GO:0031399 194 0.036
regulation of cellular amine metabolic process GO:0033238 8 0.035
cellular ketone metabolic process GO:0042180 51 0.035
positive regulation of rna biosynthetic process GO:1902680 197 0.035
positive regulation of developmental process GO:0051094 283 0.035
positive regulation of cellular biosynthetic process GO:0031328 295 0.034
regulation of cellular amino acid metabolic process GO:0006521 2 0.034
positive regulation of phosphorus metabolic process GO:0010562 262 0.034
response to oxygen levels GO:0070482 265 0.034
response to alkaloid GO:0043279 132 0.034
negative regulation of metabolic process GO:0009892 331 0.034
regulation of transcription dna templated GO:0006355 374 0.033
negative regulation of transcription dna templated GO:0045892 116 0.033
lymphocyte activation GO:0046649 43 0.032
positive regulation of immune system process GO:0002684 90 0.032
single organism intracellular transport GO:1902582 166 0.032
response to estrogen GO:0043627 232 0.032
response to radiation GO:0009314 137 0.032
regulation of apoptotic process GO:0042981 335 0.031
negative regulation of developmental process GO:0051093 125 0.031
neuron projection development GO:0031175 273 0.031
positive regulation of secretion GO:0051047 140 0.031
multicellular organismal reproductive process GO:0048609 233 0.031
cellular homeostasis GO:0019725 252 0.030
nucleobase containing small molecule metabolic process GO:0055086 316 0.030
cellular response to lipid GO:0071396 201 0.030
response to corticosteroid GO:0031960 235 0.030
regulation of catalytic activity GO:0050790 304 0.030
gamete generation GO:0007276 124 0.030
mapk cascade GO:0000165 140 0.030
carbohydrate derivative metabolic process GO:1901135 346 0.029
regulation of neuron projection development GO:0010975 161 0.029
response to extracellular stimulus GO:0009991 380 0.029
protein maturation GO:0051604 68 0.028
regulation of leukocyte activation GO:0002694 45 0.028
positive regulation of neuron differentiation GO:0045666 126 0.028
immune response GO:0006955 104 0.028
cerebral cortex tangential migration GO:0021800 1 0.028
regulation of protein metabolic process GO:0051246 289 0.028
regulation of transmembrane transport GO:0034762 122 0.027
regulation of molecular function GO:0065009 398 0.027
regulation of homeostatic process GO:0032844 101 0.027
reproduction GO:0000003 245 0.027
development of primary sexual characteristics GO:0045137 107 0.027
response to molecule of bacterial origin GO:0002237 194 0.027
regulation of cellular protein metabolic process GO:0032268 267 0.026
growth GO:0040007 165 0.026
positive regulation of transport GO:0051050 245 0.026
neuron development GO:0048666 286 0.026
response to oxidative stress GO:0006979 186 0.026
multi organism reproductive process GO:0044703 262 0.026
negative regulation of rna biosynthetic process GO:1902679 118 0.026
positive regulation of nucleic acid templated transcription GO:1903508 197 0.025
sodium ion transmembrane transport GO:0035725 67 0.025
positive regulation of jak stat cascade GO:0046427 19 0.025
jak stat cascade GO:0007259 26 0.025
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.025
regulation of signal transduction GO:0009966 318 0.025
positive regulation of cellular protein metabolic process GO:0032270 167 0.025
single organism biosynthetic process GO:0044711 342 0.025
negative regulation of multicellular organismal process GO:0051241 203 0.025
negative regulation of apoptotic process GO:0043066 181 0.025
regeneration GO:0031099 163 0.025
regulation of immune system process GO:0002682 123 0.025
regulation of kinase activity GO:0043549 117 0.025
lymphoid progenitor cell differentiation GO:0002320 2 0.025
single organism organelle organization GO:1902589 180 0.025
negative regulation of gene expression GO:0010629 199 0.025
protein localization GO:0008104 191 0.024
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.024
cellular response to biotic stimulus GO:0071216 59 0.024
positive regulation of cytokine production GO:0001819 42 0.024
negative regulation of rna metabolic process GO:0051253 123 0.024
anatomical structure homeostasis GO:0060249 29 0.024
regulation of hormone levels GO:0010817 187 0.024
carboxylic acid metabolic process GO:0019752 289 0.024
cellular amino acid metabolic process GO:0006520 107 0.023
positive regulation of protein modification process GO:0031401 142 0.023
ion homeostasis GO:0050801 212 0.023
chemical homeostasis GO:0048878 292 0.023
cell activation GO:0001775 97 0.023
negative regulation of macromolecule metabolic process GO:0010605 260 0.023
ribose phosphate biosynthetic process GO:0046390 87 0.023
intramembranous ossification GO:0001957 1 0.023
muscle system process GO:0003012 115 0.023
positive regulation of response to stimulus GO:0048584 285 0.023
female pregnancy GO:0007565 122 0.023
regulation of nervous system development GO:0051960 264 0.023
cell type specific apoptotic process GO:0097285 134 0.023
response to hexose GO:0009746 144 0.022
peptide biosynthetic process GO:0043043 3 0.022
action potential GO:0001508 54 0.022
cellular response to growth factor stimulus GO:0071363 162 0.022
regulation of locomotion GO:0040012 148 0.022
transcription from rna polymerase ii promoter GO:0006366 252 0.022
regulation of system process GO:0044057 208 0.022
response to reactive oxygen species GO:0000302 120 0.022
positive regulation of protein kinase activity GO:0045860 73 0.022
cyclic nucleotide biosynthetic process GO:0009190 63 0.022
rna metabolic process GO:0016070 406 0.022
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.022
cellular response to peptide hormone stimulus GO:0071375 120 0.022
positive regulation of catalytic activity GO:0043085 184 0.022
regulation of programmed cell death GO:0043067 341 0.021
response to metal ion GO:0010038 253 0.021
positive regulation of molecular function GO:0044093 230 0.021
positive regulation of signal transduction GO:0009967 175 0.021
positive regulation of cellular amine metabolic process GO:0033240 3 0.021
inorganic ion transmembrane transport GO:0098660 229 0.021
negative regulation of transport GO:0051051 136 0.021
leukocyte activation GO:0045321 76 0.021
male gonad development GO:0008584 59 0.021
monovalent inorganic cation transport GO:0015672 172 0.021
oxoacid metabolic process GO:0043436 290 0.021
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.020
proteolysis GO:0006508 175 0.020
cellular ion homeostasis GO:0006873 184 0.020
regulation of cellular ketone metabolic process GO:0010565 27 0.020
protein complex subunit organization GO:0071822 302 0.020
g protein coupled receptor signaling pathway GO:0007186 242 0.020
positive regulation of protein metabolic process GO:0051247 178 0.020
cellular component movement GO:0006928 248 0.020
protein autophosphorylation GO:0046777 66 0.020
motor neuron axon guidance GO:0008045 1 0.019
endocrine process GO:0050886 32 0.019
muscle contraction GO:0006936 88 0.019
developmental process involved in reproduction GO:0003006 159 0.019
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.019
ossification GO:0001503 70 0.019
cellular component morphogenesis GO:0032989 155 0.019
apoptotic process GO:0006915 381 0.019
cytokine production GO:0001816 61 0.019
cellular chemical homeostasis GO:0055082 247 0.019
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.019
positive regulation of humoral immune response GO:0002922 2 0.019
rna biosynthetic process GO:0032774 380 0.019
sexual reproduction GO:0019953 148 0.019
organophosphate metabolic process GO:0019637 370 0.019
regulation of mapk cascade GO:0043408 116 0.019
gliogenesis GO:0042063 93 0.019
neurological system process GO:0050877 219 0.018
regulation of establishment of protein localization GO:0070201 69 0.018
negative regulation of nucleic acid templated transcription GO:1903507 117 0.018
intracellular transport GO:0046907 185 0.018
regulation of protein phosphorylation GO:0001932 183 0.018
negative regulation of biosynthetic process GO:0009890 168 0.018
organic acid transport GO:0015849 116 0.018
brain development GO:0007420 247 0.018
spermatogenesis GO:0007283 99 0.018
anatomical structure morphogenesis GO:0009653 298 0.017
sensory perception GO:0007600 101 0.017
positive regulation of protein phosphorylation GO:0001934 135 0.017
cellular catabolic process GO:0044248 295 0.017
ribose phosphate metabolic process GO:0019693 235 0.017
regulation of ion transmembrane transport GO:0034765 121 0.017
single organism catabolic process GO:0044712 283 0.017
cellular calcium ion homeostasis GO:0006874 160 0.017
regulation of hydrolase activity GO:0051336 143 0.017
reproductive structure development GO:0048608 128 0.017
response to temperature stimulus GO:0009266 94 0.017
enzyme linked receptor protein signaling pathway GO:0007167 116 0.017
regulation of ion transport GO:0043269 245 0.017
regulation of multicellular organismal development GO:2000026 376 0.017
organonitrogen compound biosynthetic process GO:1901566 167 0.017
positive regulation of intracellular signal transduction GO:1902533 138 0.017
negative regulation of cell differentiation GO:0045596 99 0.017
cellular response to interleukin 1 GO:0071347 37 0.017
carbohydrate derivative biosynthetic process GO:1901137 124 0.016
positive regulation of cellular component organization GO:0051130 200 0.016
positive regulation of secretion by cell GO:1903532 128 0.016
response to retinoic acid GO:0032526 63 0.016
regulation of secretion GO:0051046 224 0.016
potassium ion transport GO:0006813 97 0.016
single organism cellular localization GO:1902580 102 0.016
neuron death GO:0070997 127 0.016
response to lipopolysaccharide GO:0032496 191 0.016
activation of cysteine type endopeptidase activity GO:0097202 4 0.015
protein complex biogenesis GO:0070271 263 0.015
regulation of cytokine production GO:0001817 56 0.015
positive regulation of cell projection organization GO:0031346 111 0.015
organic hydroxy compound metabolic process GO:1901615 115 0.015
cell growth GO:0016049 104 0.015
positive regulation of apoptotic process GO:0043065 154 0.015
positive regulation of programmed cell death GO:0043068 157 0.015
catabolic process GO:0009056 351 0.015
lipid metabolic process GO:0006629 283 0.015
synaptic transmission GO:0007268 235 0.015
regulation of protein transport GO:0051223 68 0.015
ribonucleotide biosynthetic process GO:0009260 85 0.015
positive regulation of transferase activity GO:0051347 81 0.015
sodium ion transport GO:0006814 82 0.015
regulation of response to stress GO:0080134 126 0.015
head development GO:0060322 247 0.015
regulation of peptide secretion GO:0002791 82 0.015
positive regulation of cell death GO:0010942 184 0.015
inflammatory response to antigenic stimulus GO:0002437 18 0.015
regulation of organelle organization GO:0033043 80 0.015
skeletal muscle contraction GO:0003009 17 0.015
purine containing compound biosynthetic process GO:0072522 85 0.015
organ regeneration GO:0031100 101 0.015
regulation of metal ion transport GO:0010959 118 0.015
negative regulation of ion transport GO:0043271 51 0.014
positive regulation of blood pressure by epinephrine norepinephrine GO:0003321 2 0.014
positive regulation of gene expression GO:0010628 244 0.014
organic hydroxy compound biosynthetic process GO:1901617 51 0.014
peptide secretion GO:0002790 86 0.014
response to growth factor GO:0070848 189 0.014
oxidation reduction process GO:0055114 304 0.014
cytoskeleton organization GO:0007010 111 0.014
regulation of sodium ion transport GO:0002028 21 0.014
establishment of anatomical structure orientation GO:0048560 1 0.014
cellular cation homeostasis GO:0030003 180 0.014
macromolecular complex subunit organization GO:0043933 339 0.014
immune system process GO:0002376 204 0.014
positive regulation of neuron projection development GO:0010976 99 0.014
peptidyl tyrosine modification GO:0018212 72 0.014
male sex differentiation GO:0046661 64 0.014
protein complex assembly GO:0006461 263 0.014
cellular response to tumor necrosis factor GO:0071356 46 0.014
negative regulation of cell death GO:0060548 229 0.014
t cell activation GO:0042110 29 0.014
interleukin 18 production GO:0032621 1 0.014
cell morphogenesis involved in differentiation GO:0000904 119 0.014
nucleotide biosynthetic process GO:0009165 98 0.014
neuron apoptotic process GO:0051402 88 0.014
blood circulation GO:0008015 183 0.013
response to glucocorticoid GO:0051384 223 0.013
female gonad development GO:0008585 53 0.013
lipid transport GO:0006869 61 0.013
purine containing compound metabolic process GO:0072521 253 0.013
epithelium development GO:0060429 96 0.013
purine containing compound catabolic process GO:0072523 138 0.013
central nervous system development GO:0007417 311 0.013
positive regulation of mapk cascade GO:0043410 92 0.013
nucleoside metabolic process GO:0009116 179 0.013
negative regulation of nervous system development GO:0051961 79 0.013
response to inorganic substance GO:0010035 377 0.013
tissue homeostasis GO:0001894 28 0.013
regulation of cellular catabolic process GO:0031329 101 0.013
response to nutrient GO:0007584 248 0.013
purine ribonucleotide metabolic process GO:0009150 227 0.013
embryonic appendage morphogenesis GO:0035113 4 0.013
positive regulation of cellular component movement GO:0051272 102 0.013
response to other organism GO:0051707 220 0.013
male gamete generation GO:0048232 99 0.013
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.013
alcohol metabolic process GO:0006066 77 0.012
purine ribonucleotide biosynthetic process GO:0009152 81 0.012
protein processing GO:0016485 68 0.012
response to bacterium GO:0009617 200 0.012
positive regulation of ion transport GO:0043270 94 0.012
regulation of neuron death GO:1901214 115 0.012
positive regulation of phosphatidylinositol 3 kinase activity GO:0043552 2 0.012
response to decreased oxygen levels GO:0036293 237 0.012
hematopoietic progenitor cell differentiation GO:0002244 2 0.012
negative regulation of neurogenesis GO:0050768 78 0.012
nitrogen compound transport GO:0071705 229 0.012
alcohol biosynthetic process GO:0046165 38 0.012
purine nucleoside metabolic process GO:0042278 169 0.012
regulation of jak stat cascade GO:0046425 21 0.012
response to monosaccharide GO:0034284 159 0.012
regulation of systemic arterial blood pressure by circulatory renin angiotensin GO:0001991 4 0.012
negative regulation of programmed cell death GO:0043069 183 0.012
response to molecule of fungal origin GO:0002238 3 0.012
calcium ion homeostasis GO:0055074 162 0.012
regulation of sodium ion transmembrane transporter activity GO:2000649 4 0.012
divalent inorganic cation homeostasis GO:0072507 165 0.012
metanephric comma shaped body morphogenesis GO:0072278 2 0.012
response to interleukin 1 GO:0070555 55 0.012
axis specification GO:0009798 4 0.012
immune system development GO:0002520 41 0.012
cellular metal ion homeostasis GO:0006875 172 0.012
divalent inorganic cation transport GO:0072511 134 0.012
negative regulation of uterine smooth muscle contraction GO:0070473 2 0.012
positive regulation of cellular catabolic process GO:0031331 71 0.012
response to tumor necrosis factor GO:0034612 56 0.012
positive regulation of hydrolase activity GO:0051345 86 0.012
negative regulation of cell development GO:0010721 82 0.012
cytosolic calcium ion homeostasis GO:0051480 140 0.012
regulation of alternative mrna splicing via spliceosome GO:0000381 2 0.012
cyclic purine nucleotide metabolic process GO:0052652 62 0.011
calcium ion transmembrane transport GO:0070588 70 0.011
regulation of protein kinase activity GO:0045859 105 0.011
insulin secretion GO:0030073 69 0.011
positive regulation of homeostatic process GO:0032846 49 0.011
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.011
cellular response to lipopolysaccharide GO:0071222 55 0.011
sensory perception of pain GO:0019233 73 0.011
regulation of transferase activity GO:0051338 123 0.011
regulation of behavior GO:0050795 61 0.011
regulation of cell cycle GO:0051726 73 0.011
regulation of saliva secretion GO:0046877 3 0.011
regulation of protein localization GO:0032880 81 0.011
regulation of intracellular signal transduction GO:1902531 218 0.011
regulation of interferon gamma production GO:0032649 3 0.011
response to mechanical stimulus GO:0009612 134 0.011
organic hydroxy compound transport GO:0015850 77 0.011
peptide hormone secretion GO:0030072 84 0.011
cellular macromolecule localization GO:0070727 122 0.011
phospholipid metabolic process GO:0006644 61 0.011
amide transport GO:0042886 105 0.011
purine nucleotide metabolic process GO:0006163 229 0.011
keratinocyte migration GO:0051546 2 0.011
signal release GO:0023061 145 0.011
cell cell signaling involved in cell fate commitment GO:0045168 2 0.011
cellular response to organic cyclic compound GO:0071407 202 0.011
regulation of cell morphogenesis GO:0022604 77 0.011
lymphocyte proliferation GO:0046651 29 0.011
neuropeptide signaling pathway GO:0007218 29 0.011
quaternary ammonium group transport GO:0015697 6 0.011
negative regulation of transporter activity GO:0032410 13 0.011
hair cycle GO:0042633 3 0.011
somatostatin receptor signaling pathway GO:0038169 4 0.010
negative regulation of neuron projection development GO:0010977 46 0.010
development of primary male sexual characteristics GO:0046546 59 0.010
fatty acid transport GO:0015908 25 0.010
response to transition metal nanoparticle GO:1990267 122 0.010
hormone transport GO:0009914 121 0.010
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.010
salivary gland development GO:0007431 3 0.010
cardiovascular system development GO:0072358 134 0.010
response to hypoxia GO:0001666 231 0.010
regulation of synaptic transmission GO:0050804 141 0.010
molting cycle GO:0042303 3 0.010
autophagic cell death GO:0048102 4 0.010
positive regulation of interferon gamma production GO:0032729 2 0.010
lipid localization GO:0010876 62 0.010

Otp disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
bone disease DOID:0080001 0 0.039
disease of anatomical entity DOID:7 0 0.039
musculoskeletal system disease DOID:17 0 0.039
connective tissue disease DOID:65 0 0.039
cardiovascular system disease DOID:1287 0 0.038
sensory system disease DOID:0050155 0 0.015
nervous system disease DOID:863 0 0.015
eye and adnexa disease DOID:1492 0 0.013
vascular disease DOID:178 0 0.011
eye disease DOID:5614 0 0.011
bone development disease DOID:0080006 0 0.010