Rattus norvegicus

0 known processes

Ddx58

DEAD (Asp-Glu-Ala-Asp) box polypeptide 58

Ddx58 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of mesenchymal cell proliferation GO:0010464 4 0.254
mesenchymal cell proliferation GO:0010463 4 0.120
cellular response to peptide hormone stimulus GO:0071375 120 0.107
regulation of rna metabolic process GO:0051252 391 0.089
response to lipopolysaccharide GO:0032496 191 0.085
response to nutrient levels GO:0031667 370 0.080
rna metabolic process GO:0016070 406 0.077
regulation of multicellular organismal development GO:2000026 376 0.077
response to extracellular stimulus GO:0009991 380 0.077
transcription from rna polymerase ii promoter GO:0006366 252 0.076
jak stat cascade GO:0007259 26 0.064
rna biosynthetic process GO:0032774 380 0.063
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.061
regulation of phosphate metabolic process GO:0019220 349 0.056
regulation of satellite cell proliferation GO:0014842 1 0.056
oxoacid metabolic process GO:0043436 290 0.056
regulation of phosphorus metabolic process GO:0051174 349 0.055
defense response GO:0006952 194 0.052
response to peptide hormone GO:0043434 278 0.052
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.050
response to molecule of bacterial origin GO:0002237 194 0.050
response to peptide GO:1901652 292 0.050
aging GO:0007568 241 0.050
positive regulation of gene expression GO:0010628 244 0.050
negative regulation of macromolecule metabolic process GO:0010605 260 0.048
negative regulation of cell communication GO:0010648 158 0.047
negative regulation of kidney development GO:0090185 2 0.045
negative regulation of multicellular organismal process GO:0051241 203 0.045
epithelial cell differentiation involved in kidney development GO:0035850 3 0.045
intracellular signal transduction GO:0035556 314 0.044
negative regulation of rna metabolic process GO:0051253 123 0.044
nucleotide metabolic process GO:0009117 279 0.044
regulation of nucleic acid templated transcription GO:1903506 380 0.043
regulation of transcription dna templated GO:0006355 374 0.043
response to nutrient GO:0007584 248 0.043
response to mechanical stimulus GO:0009612 134 0.042
nucleoside phosphate metabolic process GO:0006753 283 0.042
cellular response to oxygen containing compound GO:1901701 386 0.041
organophosphate metabolic process GO:0019637 370 0.041
transcription dna templated GO:0006351 377 0.041
purine containing compound biosynthetic process GO:0072522 85 0.039
regulation of rna biosynthetic process GO:2001141 381 0.038
negative regulation of metabolic process GO:0009892 331 0.038
positive regulation of phosphorus metabolic process GO:0010562 262 0.037
negative regulation of cellular biosynthetic process GO:0031327 161 0.037
positive regulation of mesenchymal cell proliferation GO:0002053 4 0.037
negative regulation of gene expression GO:0010629 199 0.037
nucleoside phosphate biosynthetic process GO:1901293 102 0.037
carboxylic acid metabolic process GO:0019752 289 0.036
positive regulation of atp biosynthetic process GO:2001171 2 0.035
regulation of cell differentiation GO:0045595 320 0.035
regulation of cellular component organization GO:0051128 368 0.035
regulation of phosphorylation GO:0042325 248 0.035
positive regulation of phosphate metabolic process GO:0045937 262 0.035
nucleic acid templated transcription GO:0097659 379 0.034
negative regulation of cellular metabolic process GO:0031324 281 0.034
organic acid metabolic process GO:0006082 292 0.034
cellular component movement GO:0006928 248 0.033
regulation of cell development GO:0060284 263 0.033
reproductive process GO:0022414 372 0.033
nucleobase containing small molecule metabolic process GO:0055086 316 0.033
purine containing compound metabolic process GO:0072521 253 0.033
development of primary sexual characteristics GO:0045137 107 0.033
cellular response to hormone stimulus GO:0032870 247 0.033
response to other organism GO:0051707 220 0.033
negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003340 2 0.031
cellular amine metabolic process GO:0044106 38 0.031
regulation of signal transduction GO:0009966 318 0.031
response to cytokine GO:0034097 215 0.031
regulation of protein metabolic process GO:0051246 289 0.030
positive regulation of biosynthetic process GO:0009891 319 0.030
negative regulation of biosynthetic process GO:0009890 168 0.029
response to insulin GO:0032868 133 0.029
cellular response to peptide GO:1901653 133 0.029
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.028
negative regulation of transcription dna templated GO:0045892 116 0.028
cellular response to endogenous stimulus GO:0071495 377 0.028
single organism biosynthetic process GO:0044711 342 0.028
negative regulation of cell differentiation GO:0045596 99 0.028
cellular response to organonitrogen compound GO:0071417 197 0.028
amine metabolic process GO:0009308 38 0.027
regulation of metanephros development GO:0072215 4 0.027
cellular response to lipid GO:0071396 201 0.027
negative regulation of cell death GO:0060548 229 0.027
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.027
purine ribonucleoside metabolic process GO:0046128 168 0.027
positive regulation of rna metabolic process GO:0051254 203 0.026
cellular amino acid metabolic process GO:0006520 107 0.026
regulation of cellular amino acid metabolic process GO:0006521 2 0.026
cytokine mediated signaling pathway GO:0019221 43 0.026
positive regulation of multicellular organismal process GO:0051240 387 0.026
gland development GO:0048732 155 0.026
negative regulation of developmental process GO:0051093 125 0.025
regulation of cellular protein metabolic process GO:0032268 267 0.025
negative regulation of protein metabolic process GO:0051248 114 0.025
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.025
ion homeostasis GO:0050801 212 0.025
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.025
cellular response to nitrogen compound GO:1901699 210 0.025
ribose phosphate biosynthetic process GO:0046390 87 0.025
blood circulation GO:0008015 183 0.024
purine nucleotide metabolic process GO:0006163 229 0.024
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.024
circulatory system process GO:0003013 183 0.024
positive regulation of developmental process GO:0051094 283 0.024
response to decreased oxygen levels GO:0036293 237 0.024
metanephric mesenchymal cell differentiation GO:0072162 1 0.024
nucleotide biosynthetic process GO:0009165 98 0.024
cellular response to growth factor stimulus GO:0071363 162 0.024
organelle organization GO:0006996 266 0.024
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.024
positive regulation of cell proliferation GO:0008284 249 0.024
regulation of cellular ketone metabolic process GO:0010565 27 0.023
metanephric epithelium development GO:0072207 4 0.023
multicellular organism reproduction GO:0032504 233 0.023
purine ribonucleotide metabolic process GO:0009150 227 0.023
mammary gland involution GO:0060056 5 0.023
protein phosphorylation GO:0006468 345 0.023
negative regulation of signaling GO:0023057 157 0.023
cellular chemical homeostasis GO:0055082 247 0.023
positive regulation of skeletal muscle cell proliferation GO:0014858 2 0.022
regulation of intracellular signal transduction GO:1902531 218 0.022
neuron differentiation GO:0030182 368 0.022
response to vitamin GO:0033273 131 0.022
mesenchymal to epithelial transition GO:0060231 3 0.022
positive regulation of cellular biosynthetic process GO:0031328 295 0.022
response to external biotic stimulus GO:0043207 221 0.022
ribonucleoside biosynthetic process GO:0042455 25 0.022
cell differentiation involved in metanephros development GO:0072202 1 0.022
positive regulation of transcription dna templated GO:0045893 197 0.022
central nervous system development GO:0007417 311 0.021
organophosphate biosynthetic process GO:0090407 143 0.021
negative regulation of neuron death GO:1901215 69 0.021
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.021
skeletal muscle satellite cell proliferation GO:0014841 1 0.021
carbohydrate derivative metabolic process GO:1901135 346 0.021
positive regulation of nucleic acid templated transcription GO:1903508 197 0.021
hydrogen peroxide metabolic process GO:0042743 13 0.021
protein oligomerization GO:0051259 191 0.021
cellular ketone metabolic process GO:0042180 51 0.020
mesenchymal cell differentiation involved in kidney development GO:0072161 1 0.020
negative regulation of rna biosynthetic process GO:1902679 118 0.020
intracellular transport GO:0046907 185 0.020
negative regulation of metanephros development GO:0072217 2 0.020
positive regulation of response to stimulus GO:0048584 285 0.020
protein complex biogenesis GO:0070271 263 0.020
response to growth factor GO:0070848 189 0.020
ribonucleotide metabolic process GO:0009259 231 0.020
carbohydrate derivative biosynthetic process GO:1901137 124 0.020
regulation of cellular amine metabolic process GO:0033238 8 0.020
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.020
macromolecular complex assembly GO:0065003 273 0.020
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.020
negative regulation of nucleic acid templated transcription GO:1903507 117 0.020
positive regulation of cell communication GO:0010647 271 0.020
positive regulation of signaling GO:0023056 270 0.020
metal ion transport GO:0030001 289 0.020
chemical homeostasis GO:0048878 292 0.019
purine ribonucleoside biosynthetic process GO:0046129 21 0.019
purine nucleotide biosynthetic process GO:0006164 83 0.019
regulation of purine nucleotide metabolic process GO:1900542 115 0.019
cellular response to stress GO:0033554 269 0.018
positive regulation of nucleotide metabolic process GO:0045981 91 0.018
immune response GO:0006955 104 0.018
cell differentiation involved in kidney development GO:0061005 4 0.018
response to oxygen levels GO:0070482 265 0.018
response to ethanol GO:0045471 162 0.018
mesenchymal cell differentiation involved in renal system development GO:2001012 1 0.018
negative regulation of nephron tubule epithelial cell differentiation GO:0072183 1 0.018
regulation of protein phosphorylation GO:0001932 183 0.018
multicellular organismal reproductive process GO:0048609 233 0.018
apoptotic process GO:0006915 381 0.018
multi organism reproductive process GO:0044703 262 0.018
response to estrogen GO:0043627 232 0.018
ribose phosphate metabolic process GO:0019693 235 0.018
kidney morphogenesis GO:0060993 13 0.017
metanephric renal vesicle morphogenesis GO:0072283 3 0.017
smooth muscle cell proliferation GO:0048659 77 0.017
homeostatic process GO:0042592 331 0.017
cellular response to cytokine stimulus GO:0071345 127 0.017
regulation of protein modification process GO:0031399 194 0.017
negative regulation of jak stat cascade GO:0046426 3 0.017
negative regulation of response to stimulus GO:0048585 155 0.017
cellular response to insulin stimulus GO:0032869 81 0.017
regulation of nervous system development GO:0051960 264 0.017
metanephric nephron tubule development GO:0072234 3 0.017
nucleoside monophosphate metabolic process GO:0009123 93 0.017
regulation of anatomical structure morphogenesis GO:0022603 141 0.016
anatomical structure morphogenesis GO:0009653 298 0.016
reactive oxygen species biosynthetic process GO:1903409 8 0.016
regulation of immune system process GO:0002682 123 0.016
regulation of cellular component movement GO:0051270 150 0.016
negative regulation of cellular component organization GO:0051129 83 0.016
regulation of skeletal muscle cell proliferation GO:0014857 2 0.016
negative regulation of cell development GO:0010721 82 0.016
cellular component biogenesis GO:0044085 368 0.016
positive regulation of signal transduction GO:0009967 175 0.016
gonad development GO:0008406 104 0.016
peptidyl amino acid modification GO:0018193 126 0.016
cell proliferation involved in metanephros development GO:0072203 2 0.015
positive regulation of transport GO:0051050 245 0.015
cellular catabolic process GO:0044248 295 0.015
rhythmic process GO:0048511 156 0.015
epithelial cell differentiation GO:0030855 71 0.015
purine nucleoside metabolic process GO:0042278 169 0.015
response to camp GO:0051591 91 0.015
cell morphogenesis involved in differentiation GO:0000904 119 0.015
cation transport GO:0006812 382 0.015
response to purine containing compound GO:0014074 126 0.015
muscle cell proliferation GO:0033002 84 0.015
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.015
protein complex subunit organization GO:0071822 302 0.015
cardiovascular system development GO:0072358 134 0.015
response to acid chemical GO:0001101 222 0.015
nucleoside metabolic process GO:0009116 179 0.015
inflammatory response GO:0006954 150 0.015
liver development GO:0001889 90 0.015
divalent metal ion transport GO:0070838 132 0.015
regulation of catalytic activity GO:0050790 304 0.015
neuron development GO:0048666 286 0.015
regulation of apoptotic process GO:0042981 335 0.014
reactive oxygen species metabolic process GO:0072593 37 0.014
metal ion homeostasis GO:0055065 186 0.014
negative regulation of hydrogen peroxide metabolic process GO:0010727 2 0.014
neuron projection development GO:0031175 273 0.014
cellular response to molecule of bacterial origin GO:0071219 56 0.014
ovulation cycle GO:0042698 67 0.014
regulation of neurogenesis GO:0050767 247 0.014
cellular response to nutrient levels GO:0031669 60 0.014
regulation of neuron projection development GO:0010975 161 0.014
positive regulation of cellular amine metabolic process GO:0033240 3 0.014
signal transduction by phosphorylation GO:0023014 144 0.014
response to organophosphorus GO:0046683 102 0.014
positive regulation of growth factor dependent skeletal muscle satellite cell proliferation GO:1902728 1 0.014
transmembrane transport GO:0055085 412 0.014
response to wounding GO:0009611 254 0.014
nucleoside monophosphate biosynthetic process GO:0009124 28 0.014
negative regulation of cellular protein metabolic process GO:0032269 106 0.014
single organism organelle organization GO:1902589 180 0.014
positive regulation of molecular function GO:0044093 230 0.014
neuron death GO:0070997 127 0.014
metanephric tubule development GO:0072170 4 0.014
renal system development GO:0072001 67 0.014
ribonucleoside metabolic process GO:0009119 174 0.013
hepaticobiliary system development GO:0061008 90 0.013
cellular ion homeostasis GO:0006873 184 0.013
positive regulation of nucleoside metabolic process GO:0045979 55 0.013
negative regulation of apoptotic process GO:0043066 181 0.013
developmental process involved in reproduction GO:0003006 159 0.013
acute inflammatory response GO:0002526 58 0.013
response to inorganic substance GO:0010035 377 0.013
purine nucleoside monophosphate metabolic process GO:0009126 84 0.013
reproduction GO:0000003 245 0.013
positive regulation of cell death GO:0010942 184 0.013
regulation of response to stress GO:0080134 126 0.013
regulation of epithelial cell differentiation involved in kidney development GO:2000696 1 0.013
negative regulation of metanephric nephron tubule epithelial cell differentiation GO:0072308 1 0.013
carbohydrate metabolic process GO:0005975 130 0.013
monovalent inorganic cation transport GO:0015672 172 0.013
regulation of molecular function GO:0065009 398 0.013
regulation of protein kinase activity GO:0045859 105 0.013
regulation of reactive oxygen species metabolic process GO:2000377 26 0.013
gastrulation GO:0007369 2 0.013
protein complex assembly GO:0006461 263 0.013
regulation of nucleotide metabolic process GO:0006140 117 0.013
response to corticosteroid GO:0031960 235 0.013
response to bacterium GO:0009617 200 0.013
single organism membrane organization GO:0044802 74 0.012
pattern recognition receptor signaling pathway GO:0002221 9 0.012
cellular component assembly GO:0022607 360 0.012
regulation of programmed cell death GO:0043067 341 0.012
negative regulation of programmed cell death GO:0043069 183 0.012
localization of cell GO:0051674 202 0.012
single organism intracellular transport GO:1902582 166 0.012
ribonucleoside triphosphate metabolic process GO:0009199 141 0.012
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.012
female gonad development GO:0008585 53 0.012
vascular process in circulatory system GO:0003018 96 0.012
response to oxidative stress GO:0006979 186 0.012
cation homeostasis GO:0055080 195 0.012
regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003339 2 0.012
cellular protein localization GO:0034613 122 0.012
metanephric nephron tubule epithelial cell differentiation GO:0072257 1 0.012
positive regulation of smooth muscle cell proliferation GO:0048661 51 0.012
tyrosine phosphorylation of stat1 protein GO:0042508 3 0.012
head development GO:0060322 247 0.012
regulation of cell proliferation GO:0042127 359 0.012
regulation of epithelial cell differentiation GO:0030856 12 0.012
cellular divalent inorganic cation homeostasis GO:0072503 162 0.012
negative regulation of reactive oxygen species metabolic process GO:2000378 7 0.012
positive regulation of purine nucleotide biosynthetic process GO:1900373 36 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.012
response to hypoxia GO:0001666 231 0.012
divalent inorganic cation homeostasis GO:0072507 165 0.012
regulation of defense response GO:0031347 68 0.012
kidney development GO:0001822 67 0.012
regulation of nucleotide biosynthetic process GO:0030808 47 0.012
positive regulation of cell differentiation GO:0045597 217 0.011
cellular homeostasis GO:0019725 252 0.011
embryonic pattern specification GO:0009880 1 0.011
immune effector process GO:0002252 53 0.011
positive regulation of phosphorylation GO:0042327 177 0.011
positive regulation of mapk cascade GO:0043410 92 0.011
eye morphogenesis GO:0048592 4 0.011
positive regulation of protein modification process GO:0031401 142 0.011
cellular cation homeostasis GO:0030003 180 0.011
regulation of immune response GO:0050776 55 0.011
organonitrogen compound biosynthetic process GO:1901566 167 0.011
cellular component morphogenesis GO:0032989 155 0.011
reproductive system development GO:0061458 128 0.011
glycosyl compound metabolic process GO:1901657 182 0.011
nucleoside triphosphate metabolic process GO:0009141 144 0.011
proteolysis GO:0006508 175 0.011
kidney mesenchyme development GO:0072074 2 0.011
ribonucleotide biosynthetic process GO:0009260 85 0.011
metanephric mesenchyme development GO:0072075 2 0.011
purine nucleoside biosynthetic process GO:0042451 21 0.011
positive regulation of protein metabolic process GO:0051247 178 0.011
response to estradiol GO:0032355 164 0.011
purine ribonucleotide biosynthetic process GO:0009152 81 0.011
positive regulation of neurogenesis GO:0050769 165 0.011
axis specification GO:0009798 4 0.011
positive regulation of nervous system development GO:0051962 178 0.011
positive regulation of cellular component movement GO:0051272 102 0.011
catabolic process GO:0009056 351 0.011
mapk cascade GO:0000165 140 0.011
secretion GO:0046903 307 0.011
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.011
positive regulation of defense response GO:0031349 37 0.011
purine nucleoside triphosphate metabolic process GO:0009144 141 0.011
cell migration GO:0016477 197 0.011
regulation of smooth muscle cell proliferation GO:0048660 75 0.011
regulation of neuron death GO:1901214 115 0.011
response to vitamin e GO:0033197 24 0.011
appendage morphogenesis GO:0035107 4 0.010
single organism carbohydrate metabolic process GO:0044723 118 0.010
tube development GO:0035295 89 0.010
cellular response to extracellular stimulus GO:0031668 73 0.010
monosaccharide metabolic process GO:0005996 61 0.010
oxidation reduction process GO:0055114 304 0.010
sex differentiation GO:0007548 113 0.010
female pregnancy GO:0007565 122 0.010
cellular response to external stimulus GO:0071496 118 0.010
response to metal ion GO:0010038 253 0.010
ovulation cycle process GO:0022602 50 0.010
positive regulation of cellular protein metabolic process GO:0032270 167 0.010

Ddx58 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.017
disease of anatomical entity DOID:7 0 0.014
nervous system disease DOID:863 0 0.014
musculoskeletal system disease DOID:17 0 0.011
connective tissue disease DOID:65 0 0.011
bone disease DOID:0080001 0 0.011