Rattus norvegicus

0 known processes

Loxl3

lysyl oxidase-like 3

Loxl3 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of cellular component organization GO:0051128 368 0.080
regulation of phosphorus metabolic process GO:0051174 349 0.066
positive regulation of multicellular organismal process GO:0051240 387 0.063
regulation of molecular function GO:0065009 398 0.061
macromolecular complex subunit organization GO:0043933 339 0.059
Rat
regulation of phosphate metabolic process GO:0019220 349 0.058
organophosphate metabolic process GO:0019637 370 0.057
nucleotide metabolic process GO:0009117 279 0.053
oxoacid metabolic process GO:0043436 290 0.052
intracellular signal transduction GO:0035556 314 0.050
positive regulation of phosphate metabolic process GO:0045937 262 0.048
programmed cell death GO:0012501 392 0.047
protein complex subunit organization GO:0071822 302 0.046
Rat
carbohydrate derivative metabolic process GO:1901135 346 0.046
regulation of cell differentiation GO:0045595 320 0.044
regulation of nervous system development GO:0051960 264 0.043
anatomical structure morphogenesis GO:0009653 298 0.043
Human
regulation of cell development GO:0060284 263 0.041
cellular component assembly GO:0022607 360 0.041
Rat
protein complex assembly GO:0006461 263 0.041
positive regulation of apoptotic process GO:0043065 154 0.040
cellular response to endogenous stimulus GO:0071495 377 0.040
neuron differentiation GO:0030182 368 0.040
response to oxygen levels GO:0070482 265 0.039
regulation of catalytic activity GO:0050790 304 0.038
organonitrogen compound catabolic process GO:1901565 179 0.038
positive regulation of biosynthetic process GO:0009891 319 0.038
cellular component biogenesis GO:0044085 368 0.037
Rat
aromatic compound catabolic process GO:0019439 168 0.037
mapk cascade GO:0000165 140 0.036
regulation of apoptotic process GO:0042981 335 0.036
organic acid metabolic process GO:0006082 292 0.036
protein complex biogenesis GO:0070271 263 0.036
nucleoside phosphate metabolic process GO:0006753 283 0.035
neuron development GO:0048666 286 0.035
rna metabolic process GO:0016070 406 0.035
Human
purine nucleoside metabolic process GO:0042278 169 0.034
ribonucleotide metabolic process GO:0009259 231 0.033
cellular catabolic process GO:0044248 295 0.033
positive regulation of cell communication GO:0010647 271 0.033
nucleoside triphosphate catabolic process GO:0009143 123 0.031
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.031
response to decreased oxygen levels GO:0036293 237 0.031
positive regulation of cellular component organization GO:0051130 200 0.031
neurological system process GO:0050877 219 0.030
positive regulation of developmental process GO:0051094 283 0.030
purine nucleotide metabolic process GO:0006163 229 0.030
regulation of multicellular organismal development GO:2000026 376 0.030
ribonucleotide catabolic process GO:0009261 136 0.030
positive regulation of molecular function GO:0044093 230 0.030
positive regulation of programmed cell death GO:0043068 157 0.030
positive regulation of phosphorus metabolic process GO:0010562 262 0.030
ribose phosphate metabolic process GO:0019693 235 0.030
circulatory system development GO:0072359 134 0.030
Rat
positive regulation of catalytic activity GO:0043085 184 0.030
ion homeostasis GO:0050801 212 0.030
single organism biosynthetic process GO:0044711 342 0.029
apoptotic process GO:0006915 381 0.029
organelle organization GO:0006996 266 0.029
response to hypoxia GO:0001666 231 0.029
purine ribonucleotide metabolic process GO:0009150 227 0.029
regulation of neuron differentiation GO:0045664 208 0.028
nucleobase containing small molecule metabolic process GO:0055086 316 0.028
positive regulation of phosphorylation GO:0042327 177 0.028
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.028
regulation of protein metabolic process GO:0051246 289 0.028
positive regulation of cell death GO:0010942 184 0.028
cell projection organization GO:0030030 302 0.028
nucleic acid templated transcription GO:0097659 379 0.028
Human
single organism catabolic process GO:0044712 283 0.028
biological adhesion GO:0022610 110 0.027
ras protein signal transduction GO:0007265 29 0.027
ribonucleoside metabolic process GO:0009119 174 0.027
catabolic process GO:0009056 351 0.027
protein oligomerization GO:0051259 191 0.027
regulation of signal transduction GO:0009966 318 0.027
negative regulation of signaling GO:0023057 157 0.027
regulation of neurogenesis GO:0050767 247 0.027
protein phosphorylation GO:0006468 345 0.026
cellular lipid metabolic process GO:0044255 208 0.025
regulation of intracellular signal transduction GO:1902531 218 0.025
macromolecular complex assembly GO:0065003 273 0.025
purine containing compound metabolic process GO:0072521 253 0.025
positive regulation of cell proliferation GO:0008284 249 0.025
regulation of response to stress GO:0080134 126 0.025
heart morphogenesis GO:0003007 3 0.025
cell morphogenesis GO:0000902 142 0.025
Human
purine ribonucleotide catabolic process GO:0009154 136 0.024
heterocycle catabolic process GO:0046700 167 0.024
regulation of hydrolase activity GO:0051336 143 0.024
aging GO:0007568 241 0.024
head development GO:0060322 247 0.024
carboxylic acid metabolic process GO:0019752 289 0.024
purine ribonucleoside metabolic process GO:0046128 168 0.023
regulation of cellular protein metabolic process GO:0032268 267 0.023
homeostatic process GO:0042592 331 0.023
secretion GO:0046903 307 0.023
positive regulation of cell differentiation GO:0045597 217 0.023
organic substance catabolic process GO:1901575 316 0.023
tissue development GO:0009888 252 0.023
Human
positive regulation of nervous system development GO:0051962 178 0.023
cellular homeostasis GO:0019725 252 0.023
regulation of mapk cascade GO:0043408 116 0.023
regulation of cell projection organization GO:0031344 175 0.023
regulation of phosphorylation GO:0042325 248 0.022
regulation of neuron projection development GO:0010975 161 0.022
regulation of programmed cell death GO:0043067 341 0.022
cellular amine metabolic process GO:0044106 38 0.022
regulation of transcription dna templated GO:0006355 374 0.022
Human
purine nucleoside catabolic process GO:0006152 124 0.022
negative regulation of developmental process GO:0051093 125 0.022
nucleoside metabolic process GO:0009116 179 0.022
purine ribonucleoside catabolic process GO:0046130 124 0.022
brain development GO:0007420 247 0.022
macromolecule localization GO:0033036 252 0.021
negative regulation of response to stimulus GO:0048585 155 0.021
positive regulation of protein metabolic process GO:0051247 178 0.021
positive regulation of cellular biosynthetic process GO:0031328 295 0.021
positive regulation of cell projection organization GO:0031346 111 0.021
regulation of protein modification process GO:0031399 194 0.021
ribonucleoside triphosphate metabolic process GO:0009199 141 0.021
negative regulation of multicellular organismal process GO:0051241 203 0.021
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.021
small gtpase mediated signal transduction GO:0007264 36 0.021
rna biosynthetic process GO:0032774 380 0.021
Human
nucleobase containing compound catabolic process GO:0034655 152 0.021
regulation of nucleic acid templated transcription GO:1903506 380 0.021
Human
organic cyclic compound catabolic process GO:1901361 175 0.021
positive regulation of signaling GO:0023056 270 0.020
cellular cation homeostasis GO:0030003 180 0.020
positive regulation of rna metabolic process GO:0051254 203 0.020
single organism organelle organization GO:1902589 180 0.020
positive regulation of transcription dna templated GO:0045893 197 0.020
response to peptide hormone GO:0043434 278 0.020
central nervous system development GO:0007417 311 0.019
amine metabolic process GO:0009308 38 0.019
positive regulation of response to stimulus GO:0048584 285 0.019
carbohydrate derivative catabolic process GO:1901136 147 0.019
response to acid chemical GO:0001101 222 0.019
glycosyl compound catabolic process GO:1901658 126 0.019
positive regulation of gene expression GO:0010628 244 0.019
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.019
chemical homeostasis GO:0048878 292 0.019
purine containing compound catabolic process GO:0072523 138 0.019
cell cell signaling GO:0007267 335 0.019
negative regulation of cellular metabolic process GO:0031324 281 0.019
Human
nucleoside phosphate catabolic process GO:1901292 140 0.019
protein localization GO:0008104 191 0.019
positive regulation of neuron differentiation GO:0045666 126 0.019
negative regulation of metabolic process GO:0009892 331 0.019
Human
positive regulation of protein modification process GO:0031401 142 0.018
response to oxidative stress GO:0006979 186 0.018
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.018
g protein coupled receptor signaling pathway GO:0007186 242 0.018
action potential GO:0001508 54 0.018
purine nucleoside triphosphate catabolic process GO:0009146 122 0.018
monocarboxylic acid metabolic process GO:0032787 152 0.018
transcription dna templated GO:0006351 377 0.018
Human
neuron projection development GO:0031175 273 0.018
cellular chemical homeostasis GO:0055082 247 0.018
cellular amino acid metabolic process GO:0006520 107 0.018
organophosphate catabolic process GO:0046434 148 0.018
regulation of rna metabolic process GO:0051252 391 0.018
Human
cytoskeleton organization GO:0007010 111 0.018
fatty acid metabolic process GO:0006631 99 0.018
positive regulation of cell development GO:0010720 176 0.018
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.018
protein heterooligomerization GO:0051291 89 0.018
regulation of rna biosynthetic process GO:2001141 381 0.018
Human
cellular response to organic cyclic compound GO:0071407 202 0.018
positive regulation of protein phosphorylation GO:0001934 135 0.018
positive regulation of neurogenesis GO:0050769 165 0.018
cell adhesion GO:0007155 110 0.017
negative regulation of macromolecule metabolic process GO:0010605 260 0.017
Human
regulation of cellular amino acid metabolic process GO:0006521 2 0.017
forebrain development GO:0030900 98 0.017
organonitrogen compound biosynthetic process GO:1901566 167 0.017
ribonucleoside triphosphate catabolic process GO:0009203 122 0.017
transmembrane transport GO:0055085 412 0.017
developmental process involved in reproduction GO:0003006 159 0.017
ribonucleoside catabolic process GO:0042454 126 0.017
nucleoside triphosphate metabolic process GO:0009141 144 0.017
regulation of cellular ketone metabolic process GO:0010565 27 0.017
nucleotide catabolic process GO:0009166 139 0.017
defense response GO:0006952 194 0.016
glycosyl compound metabolic process GO:1901657 182 0.016
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.016
lipid metabolic process GO:0006629 283 0.016
regulation of cell proliferation GO:0042127 359 0.016
cellular nitrogen compound catabolic process GO:0044270 163 0.016
cellular response to hormone stimulus GO:0032870 247 0.016
positive regulation of nucleic acid templated transcription GO:1903508 197 0.016
cellular response to oxygen containing compound GO:1901701 386 0.016
positive regulation of intracellular signal transduction GO:1902533 138 0.016
gastrulation GO:0007369 2 0.016
response to extracellular stimulus GO:0009991 380 0.016
reproductive process GO:0022414 372 0.016
cardiovascular system development GO:0072358 134 0.016
Rat
response to estrogen GO:0043627 232 0.016
multicellular organism reproduction GO:0032504 233 0.016
regulation of kinase activity GO:0043549 117 0.016
positive regulation of transport GO:0051050 245 0.016
regulation of response to external stimulus GO:0032101 106 0.016
cellular ketone metabolic process GO:0042180 51 0.016
positive regulation of transferase activity GO:0051347 81 0.016
localization of cell GO:0051674 202 0.016
nucleoside catabolic process GO:0009164 126 0.015
positive regulation of signal transduction GO:0009967 175 0.015
regulation of cellular localization GO:0060341 263 0.015
positive regulation of rna biosynthetic process GO:1902680 197 0.015
regulation of protein phosphorylation GO:0001932 183 0.015
response to cytokine GO:0034097 215 0.015
response to growth factor GO:0070848 189 0.015
multi organism reproductive process GO:0044703 262 0.015
single organism reproductive process GO:0044702 297 0.015
positive regulation of cellular protein metabolic process GO:0032270 167 0.015
cellular response to stress GO:0033554 269 0.015
negative regulation of cell differentiation GO:0045596 99 0.015
negative regulation of cell development GO:0010721 82 0.015
positive regulation of neuron projection development GO:0010976 99 0.015
negative regulation of nervous system development GO:0051961 79 0.015
negative regulation of rna biosynthetic process GO:1902679 118 0.015
Human
positive regulation of mapk cascade GO:0043410 92 0.015
response to inorganic substance GO:0010035 377 0.015
negative regulation of molecular function GO:0044092 133 0.014
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.014
neuronal action potential GO:0019228 35 0.014
negative regulation of cell communication GO:0010648 158 0.014
cellular metal ion homeostasis GO:0006875 172 0.014
regulation of secretion by cell GO:1903530 208 0.014
regulation of cell morphogenesis GO:0022604 77 0.014
transmission of nerve impulse GO:0019226 42 0.014
response to alkaloid GO:0043279 132 0.014
divalent inorganic cation homeostasis GO:0072507 165 0.014
actin filament based process GO:0030029 86 0.014
regeneration GO:0031099 163 0.013
wound healing GO:0042060 122 0.013
Rat
cellular calcium ion homeostasis GO:0006874 160 0.013
regulation of anatomical structure morphogenesis GO:0022603 141 0.013
anterior posterior pattern specification GO:0009952 1 0.013
chromosome segregation GO:0007059 2 0.013
cation homeostasis GO:0055080 195 0.013
response to wounding GO:0009611 254 0.013
Rat
response to metal ion GO:0010038 253 0.013
guanosine containing compound catabolic process GO:1901069 71 0.013
carbohydrate derivative biosynthetic process GO:1901137 124 0.013
purine nucleotide catabolic process GO:0006195 136 0.013
multicellular organismal reproductive process GO:0048609 233 0.013
dna metabolic process GO:0006259 96 0.013
negative regulation of cellular biosynthetic process GO:0031327 161 0.013
Human
morphogenesis of embryonic epithelium GO:0016331 3 0.013
positive regulation of cellular component biogenesis GO:0044089 55 0.013
cellular response to growth factor stimulus GO:0071363 162 0.013
limb morphogenesis GO:0035108 4 0.013
negative regulation of gene expression GO:0010629 199 0.013
Human
proteolysis GO:0006508 175 0.013
learning or memory GO:0007611 90 0.013
response to peptide GO:1901652 292 0.013
axis specification GO:0009798 4 0.013
cellular divalent inorganic cation homeostasis GO:0072503 162 0.013
cell cell signaling involved in cell fate commitment GO:0045168 2 0.013
response to nutrient levels GO:0031667 370 0.013
metal ion transport GO:0030001 289 0.012
cytosolic calcium ion homeostasis GO:0051480 140 0.012
positive regulation of protein kinase activity GO:0045860 73 0.012
epithelium development GO:0060429 96 0.012
salivary gland development GO:0007431 3 0.012
reproduction GO:0000003 245 0.012
metal ion homeostasis GO:0055065 186 0.012
cellular ion homeostasis GO:0006873 184 0.012
regulation of cellular amine metabolic process GO:0033238 8 0.012
behavior GO:0007610 205 0.012
guanosine containing compound metabolic process GO:1901068 74 0.012
anatomical structure formation involved in morphogenesis GO:0048646 83 0.012
oxidation reduction process GO:0055114 304 0.012
Rat Fly
regulation of cellular component biogenesis GO:0044087 86 0.012
response to ethanol GO:0045471 162 0.012
regulation of protein kinase activity GO:0045859 105 0.012
regulation of canonical wnt signaling pathway GO:0060828 4 0.012
cellular response to acid chemical GO:0071229 75 0.012
gtp catabolic process GO:0006184 71 0.012
eye morphogenesis GO:0048592 4 0.012
positive regulation of kinase activity GO:0033674 77 0.012
response to glucocorticoid GO:0051384 223 0.012
cellular response to nitrogen compound GO:1901699 210 0.012
nitrogen compound transport GO:0071705 229 0.012
regulation of system process GO:0044057 208 0.012
signal transduction by phosphorylation GO:0023014 144 0.012
regulation of nucleotide metabolic process GO:0006140 117 0.012
positive regulation of hydrolase activity GO:0051345 86 0.012
regulation of anatomical structure size GO:0090066 135 0.012
positive regulation of nucleotide metabolic process GO:0045981 91 0.011
cation transport GO:0006812 382 0.011
establishment of protein localization GO:0045184 141 0.011
embryonic appendage morphogenesis GO:0035113 4 0.011
negative regulation of programmed cell death GO:0043069 183 0.011
growth GO:0040007 165 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.011
response to transition metal nanoparticle GO:1990267 122 0.011
negative regulation of biosynthetic process GO:0009890 168 0.011
Human
response to fatty acid GO:0070542 65 0.011
response to corticosteroid GO:0031960 235 0.011
purine nucleoside triphosphate metabolic process GO:0009144 141 0.011
organ formation GO:0048645 3 0.011
protein homooligomerization GO:0051260 91 0.011
immune system process GO:0002376 204 0.011
negative regulation of neurogenesis GO:0050768 78 0.011
regulation of purine nucleotide metabolic process GO:1900542 115 0.011
positive regulation of cellular amine metabolic process GO:0033240 3 0.011
rhythmic process GO:0048511 156 0.011
transcription from rna polymerase ii promoter GO:0006366 252 0.011
response to hexose GO:0009746 144 0.011
organophosphate biosynthetic process GO:0090407 143 0.011
gtp metabolic process GO:0046039 72 0.011
regulation of membrane potential GO:0042391 110 0.011
gamete generation GO:0007276 124 0.011
negative regulation of transcription dna templated GO:0045892 116 0.011
Human
response to vitamin GO:0033273 131 0.011
epithelial cell differentiation GO:0030855 71 0.010
rho protein signal transduction GO:0007266 11 0.010
response to other organism GO:0051707 220 0.010
Rat
regulation of secretion GO:0051046 224 0.010
cellular response to lipid GO:0071396 201 0.010
synaptic transmission GO:0007268 235 0.010
cell morphogenesis involved in differentiation GO:0000904 119 0.010
Human
response to ketone GO:1901654 182 0.010
gland development GO:0048732 155 0.010
organic hydroxy compound metabolic process GO:1901615 115 0.010
cellular response to organonitrogen compound GO:0071417 197 0.010
regulation of embryonic development GO:0045995 2 0.010
regulation of neuron death GO:1901214 115 0.010
tube formation GO:0035148 3 0.010
locomotion GO:0040011 237 0.010
negative regulation of nucleic acid templated transcription GO:1903507 117 0.010
Human
regulation of transferase activity GO:0051338 123 0.010

Loxl3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
nervous system disease DOID:863 0 0.023
disease of anatomical entity DOID:7 0 0.023
bone disease DOID:0080001 0 0.016
connective tissue disease DOID:65 0 0.016
musculoskeletal system disease DOID:17 0 0.016
disease of cellular proliferation DOID:14566 0 0.012
eye and adnexa disease DOID:1492 0 0.011
sensory system disease DOID:0050155 0 0.011
eye disease DOID:5614 0 0.011