Rattus norvegicus

24 known processes

Sigmar1

sigma non-opioid intracellular receptor 1

(Aliases: Oprs1)

Sigmar1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular lipid metabolic process GO:0044255 208 0.249
lipid metabolic process GO:0006629 283 0.190
oxoacid metabolic process GO:0043436 290 0.118
organic acid metabolic process GO:0006082 292 0.096
small molecule biosynthetic process GO:0044283 124 0.090
carboxylic acid metabolic process GO:0019752 289 0.086
regulation of cellular component organization GO:0051128 368 0.082
single organism biosynthetic process GO:0044711 342 0.075
aging GO:0007568 241 0.072
response to peptide GO:1901652 292 0.072
negative regulation of metabolic process GO:0009892 331 0.068
reproductive process GO:0022414 372 0.066
response to inorganic substance GO:0010035 377 0.064
response to peptide hormone GO:0043434 278 0.061
lipid biosynthetic process GO:0008610 128 0.059
neuron differentiation GO:0030182 368 0.058
organic substance catabolic process GO:1901575 316 0.056
cation transport GO:0006812 382 0.056
programmed cell death GO:0012501 392 0.056
response to nutrient levels GO:0031667 370 0.055
single organism reproductive process GO:0044702 297 0.049
negative regulation of cellular metabolic process GO:0031324 281 0.049
rna biosynthetic process GO:0032774 380 0.049
brain development GO:0007420 247 0.048
carbohydrate derivative metabolic process GO:1901135 346 0.048
secretion by cell GO:0032940 248 0.047
negative regulation of macromolecule metabolic process GO:0010605 260 0.046
central nervous system development GO:0007417 311 0.044
cellular component movement GO:0006928 248 0.044
multicellular organismal reproductive process GO:0048609 233 0.043
head development GO:0060322 247 0.042
regulation of apoptotic process GO:0042981 335 0.041
regulation of molecular function GO:0065009 398 0.041
cellular response to lipid GO:0071396 201 0.041
response to purine containing compound GO:0014074 126 0.040
regulation of neuron differentiation GO:0045664 208 0.040
response to estrogen GO:0043627 232 0.039
organophosphate metabolic process GO:0019637 370 0.039
regulation of phosphorus metabolic process GO:0051174 349 0.037
neurological system process GO:0050877 219 0.037
intracellular signal transduction GO:0035556 314 0.037
transcription dna templated GO:0006351 377 0.036
negative regulation of apoptotic process GO:0043066 181 0.036
cellular response to oxygen containing compound GO:1901701 386 0.036
response to extracellular stimulus GO:0009991 380 0.036
immune system process GO:0002376 204 0.035
multicellular organism reproduction GO:0032504 233 0.035
apoptotic process GO:0006915 381 0.035
regulation of nucleic acid templated transcription GO:1903506 380 0.035
positive regulation of transport GO:0051050 245 0.034
regulation of transcription dna templated GO:0006355 374 0.034
regulation of protein metabolic process GO:0051246 289 0.034
positive regulation of biosynthetic process GO:0009891 319 0.034
single organism catabolic process GO:0044712 283 0.034
amine metabolic process GO:0009308 38 0.034
regulation of cell differentiation GO:0045595 320 0.033
response to nutrient GO:0007584 248 0.033
regulation of programmed cell death GO:0043067 341 0.033
regulation of cellular localization GO:0060341 263 0.033
negative regulation of cell death GO:0060548 229 0.033
cellular component biogenesis GO:0044085 368 0.032
response to biotic stimulus GO:0009607 226 0.032
muscle structure development GO:0061061 87 0.032
regulation of cell development GO:0060284 263 0.032
cell cell signaling GO:0007267 335 0.031
phospholipid metabolic process GO:0006644 61 0.031
reproduction GO:0000003 245 0.031
organic hydroxy compound metabolic process GO:1901615 115 0.031
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.031
secretion GO:0046903 307 0.031
neuron projection development GO:0031175 273 0.031
regulation of phosphate metabolic process GO:0019220 349 0.031
regulation of catalytic activity GO:0050790 304 0.030
multi organism reproductive process GO:0044703 262 0.030
metal ion transport GO:0030001 289 0.030
response to wounding GO:0009611 254 0.030
behavior GO:0007610 205 0.029
cellular response to stress GO:0033554 269 0.029
cellular response to endogenous stimulus GO:0071495 377 0.029
neuron development GO:0048666 286 0.029
regulation of cellular protein metabolic process GO:0032268 267 0.029
regulation of cell growth GO:0001558 85 0.029
protein phosphorylation GO:0006468 345 0.029
catabolic process GO:0009056 351 0.028
response to metal ion GO:0010038 253 0.028
isoprenoid metabolic process GO:0006720 45 0.028
synaptic transmission GO:0007268 235 0.028
regulation of synaptic transmission GO:0050804 141 0.028
organophosphate biosynthetic process GO:0090407 143 0.027
chemical homeostasis GO:0048878 292 0.027
growth GO:0040007 165 0.027
cell growth GO:0016049 104 0.027
circulatory system process GO:0003013 183 0.026
homeostatic process GO:0042592 331 0.026
organonitrogen compound biosynthetic process GO:1901566 167 0.026
cell projection organization GO:0030030 302 0.026
cellular response to cytokine stimulus GO:0071345 127 0.026
regulation of secretion GO:0051046 224 0.026
response to vitamin GO:0033273 131 0.026
regulation of multicellular organismal development GO:2000026 376 0.026
ion homeostasis GO:0050801 212 0.026
cation homeostasis GO:0055080 195 0.025
cellular amine metabolic process GO:0044106 38 0.025
negative regulation of programmed cell death GO:0043069 183 0.025
cellular amino acid metabolic process GO:0006520 107 0.025
response to external biotic stimulus GO:0043207 221 0.025
positive regulation of multicellular organismal process GO:0051240 387 0.025
defense response GO:0006952 194 0.025
positive regulation of response to stimulus GO:0048584 285 0.025
regulation of intracellular signal transduction GO:1902531 218 0.025
tissue development GO:0009888 252 0.024
positive regulation of phosphate metabolic process GO:0045937 262 0.024
cell motility GO:0048870 202 0.024
alcohol metabolic process GO:0006066 77 0.024
positive regulation of cell differentiation GO:0045597 217 0.024
regulation of system process GO:0044057 208 0.024
small gtpase mediated signal transduction GO:0007264 36 0.024
sexual reproduction GO:0019953 148 0.024
negative regulation of protein metabolic process GO:0051248 114 0.024
cellular response to organic cyclic compound GO:0071407 202 0.024
rna metabolic process GO:0016070 406 0.023
eye morphogenesis GO:0048592 4 0.023
monocarboxylic acid metabolic process GO:0032787 152 0.023
reproductive structure development GO:0048608 128 0.023
nucleic acid templated transcription GO:0097659 379 0.023
response to bacterium GO:0009617 200 0.023
gamete generation GO:0007276 124 0.023
gland development GO:0048732 155 0.023
regulation of cell projection organization GO:0031344 175 0.022
cellular catabolic process GO:0044248 295 0.022
negative regulation of nucleic acid templated transcription GO:1903507 117 0.022
regulation of hormone levels GO:0010817 187 0.022
cellular component assembly GO:0022607 360 0.022
regulation of rna biosynthetic process GO:2001141 381 0.022
metal ion homeostasis GO:0055065 186 0.022
inflammatory response GO:0006954 150 0.022
circulatory system development GO:0072359 134 0.022
response to corticosteroid GO:0031960 235 0.022
locomotion GO:0040011 237 0.021
blood circulation GO:0008015 183 0.021
regulation of nervous system development GO:0051960 264 0.021
neuron death GO:0070997 127 0.021
carboxylic acid biosynthetic process GO:0046394 83 0.021
spermatogenesis GO:0007283 99 0.021
cellular calcium ion homeostasis GO:0006874 160 0.021
anatomical structure morphogenesis GO:0009653 298 0.021
heart morphogenesis GO:0003007 3 0.021
positive regulation of cellular biosynthetic process GO:0031328 295 0.021
regulation of rna metabolic process GO:0051252 391 0.020
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.020
cellular homeostasis GO:0019725 252 0.020
response to molecule of bacterial origin GO:0002237 194 0.020
organic acid transport GO:0015849 116 0.020
protein complex biogenesis GO:0070271 263 0.020
nitrogen compound transport GO:0071705 229 0.020
organic acid biosynthetic process GO:0016053 83 0.020
positive regulation of phosphorus metabolic process GO:0010562 262 0.020
developmental process involved in reproduction GO:0003006 159 0.020
carboxylic acid transport GO:0046942 115 0.020
negative regulation of signaling GO:0023057 157 0.020
regulation of neuron projection development GO:0010975 161 0.019
cell migration GO:0016477 197 0.019
regulation of cell proliferation GO:0042127 359 0.019
rhythmic process GO:0048511 156 0.019
regulation of secretion by cell GO:1903530 208 0.019
ribose phosphate metabolic process GO:0019693 235 0.019
positive regulation of cell proliferation GO:0008284 249 0.019
response to estradiol GO:0032355 164 0.018
regulation of cell migration GO:0030334 128 0.018
regulation of vesicle mediated transport GO:0060627 81 0.018
cellular metal ion homeostasis GO:0006875 172 0.018
positive regulation of cellular component organization GO:0051130 200 0.018
cellular chemical homeostasis GO:0055082 247 0.018
cellular response to hormone stimulus GO:0032870 247 0.018
cellular ketone metabolic process GO:0042180 51 0.018
male gamete generation GO:0048232 99 0.018
cellular response to nitrogen compound GO:1901699 210 0.018
regulation of blood pressure GO:0008217 83 0.018
protein complex subunit organization GO:0071822 302 0.018
regulation of lipid metabolic process GO:0019216 68 0.018
regulation of cellular amine metabolic process GO:0033238 8 0.017
regulation of neurogenesis GO:0050767 247 0.017
single organism carbohydrate metabolic process GO:0044723 118 0.017
synaptic vesicle endocytosis GO:0048488 4 0.017
negative regulation of cellular biosynthetic process GO:0031327 161 0.017
positive regulation of cellular amine metabolic process GO:0033240 3 0.017
response to camp GO:0051591 91 0.017
response to ketone GO:1901654 182 0.017
localization of cell GO:0051674 202 0.017
alpha amino acid metabolic process GO:1901605 71 0.017
response to radiation GO:0009314 137 0.017
regulation of growth GO:0040008 105 0.017
organelle organization GO:0006996 266 0.017
ion transmembrane transport GO:0034220 365 0.017
response to hypoxia GO:0001666 231 0.017
response to cytokine GO:0034097 215 0.017
heterocycle catabolic process GO:0046700 167 0.017
negative regulation of biosynthetic process GO:0009890 168 0.017
ribonucleotide metabolic process GO:0009259 231 0.017
positive regulation of nucleic acid templated transcription GO:1903508 197 0.016
regulation of cellular amino acid metabolic process GO:0006521 2 0.016
regeneration GO:0031099 163 0.016
g protein coupled receptor signaling pathway GO:0007186 242 0.016
organic anion transport GO:0015711 132 0.016
anion transport GO:0006820 178 0.016
intracellular transport GO:0046907 185 0.016
regulation of ion transport GO:0043269 245 0.016
heart development GO:0007507 72 0.016
macromolecular complex subunit organization GO:0043933 339 0.016
positive regulation of rna biosynthetic process GO:1902680 197 0.016
response to decreased oxygen levels GO:0036293 237 0.016
fatty acid metabolic process GO:0006631 99 0.016
purine nucleoside metabolic process GO:0042278 169 0.016
cell type specific apoptotic process GO:0097285 134 0.016
inorganic ion transmembrane transport GO:0098660 229 0.016
nucleobase containing small molecule metabolic process GO:0055086 316 0.016
ras protein signal transduction GO:0007265 29 0.016
regulation of protein modification process GO:0031399 194 0.016
negative regulation of response to stimulus GO:0048585 155 0.016
positive regulation of apoptotic process GO:0043065 154 0.015
carbohydrate metabolic process GO:0005975 130 0.015
positive regulation of rna metabolic process GO:0051254 203 0.015
cell adhesion GO:0007155 110 0.015
positive regulation of developmental process GO:0051094 283 0.015
organophosphate catabolic process GO:0046434 148 0.015
retina morphogenesis in camera type eye GO:0060042 1 0.015
acute inflammatory response GO:0002526 58 0.015
response to other organism GO:0051707 220 0.015
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.015
regulation of hormone secretion GO:0046883 106 0.015
cellular nitrogen compound catabolic process GO:0044270 163 0.015
cellular cation homeostasis GO:0030003 180 0.015
positive regulation of intracellular signal transduction GO:1902533 138 0.015
positive regulation of phosphorylation GO:0042327 177 0.015
carbohydrate derivative biosynthetic process GO:1901137 124 0.015
regulation of cellular ketone metabolic process GO:0010565 27 0.015
sulfur compound metabolic process GO:0006790 70 0.015
steroid metabolic process GO:0008202 73 0.015
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.015
reproductive system development GO:0061458 128 0.015
nucleoside phosphate metabolic process GO:0006753 283 0.014
regulation of signal transduction GO:0009966 318 0.014
response to acid chemical GO:0001101 222 0.014
regulation of protein phosphorylation GO:0001932 183 0.014
cofactor metabolic process GO:0051186 95 0.014
negative regulation of transport GO:0051051 136 0.014
negative regulation of cellular protein metabolic process GO:0032269 106 0.014
coenzyme metabolic process GO:0006732 86 0.014
nucleotide metabolic process GO:0009117 279 0.014
purine nucleoside triphosphate catabolic process GO:0009146 122 0.014
regulation of phosphorylation GO:0042325 248 0.014
response to lipopolysaccharide GO:0032496 191 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.014
response to temperature stimulus GO:0009266 94 0.014
positive regulation of secretion by cell GO:1903532 128 0.014
regulation of kinase activity GO:0043549 117 0.014
regulation of neuron apoptotic process GO:0043523 83 0.014
mapk cascade GO:0000165 140 0.014
response to alkaloid GO:0043279 132 0.014
negative regulation of rna biosynthetic process GO:1902679 118 0.014
negative regulation of molecular function GO:0044092 133 0.014
cation transmembrane transport GO:0098655 263 0.014
response to oxidative stress GO:0006979 186 0.014
positive regulation of transcription dna templated GO:0045893 197 0.014
endocytosis GO:0006897 84 0.014
ribonucleoside monophosphate metabolic process GO:0009161 88 0.014
purine containing compound metabolic process GO:0072521 253 0.014
organonitrogen compound catabolic process GO:1901565 179 0.014
response to growth factor GO:0070848 189 0.013
regulation of homeostatic process GO:0032844 101 0.013
aromatic compound catabolic process GO:0019439 168 0.013
dephosphorylation GO:0016311 98 0.013
circadian rhythm GO:0007623 88 0.013
transmembrane transport GO:0055085 412 0.013
muscle organ development GO:0007517 50 0.013
regulation of cellular component movement GO:0051270 150 0.013
response to oxygen levels GO:0070482 265 0.013
positive regulation of molecular function GO:0044093 230 0.013
alpha amino acid biosynthetic process GO:1901607 23 0.013
adult locomotory behavior GO:0008344 4 0.013
response to glucocorticoid GO:0051384 223 0.013
response to hexose GO:0009746 144 0.013
synaptic growth at neuromuscular junction GO:0051124 1 0.013
potassium ion transport GO:0006813 97 0.013
monocarboxylic acid biosynthetic process GO:0072330 48 0.013
regulation of protein kinase activity GO:0045859 105 0.013
steroid biosynthetic process GO:0006694 48 0.013
biological adhesion GO:0022610 110 0.013
camera type eye development GO:0043010 48 0.013
positive regulation of immune system process GO:0002684 90 0.013
cellular amino acid biosynthetic process GO:0008652 32 0.013
nucleoside metabolic process GO:0009116 179 0.013
negative regulation of multicellular organismal process GO:0051241 203 0.013
negative regulation of cell development GO:0010721 82 0.012
regulation of neuron death GO:1901214 115 0.012
camera type eye morphogenesis GO:0048593 2 0.012
negative regulation of neuron death GO:1901215 69 0.012
cellular modified amino acid metabolic process GO:0006575 61 0.012
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.012
sensory organ development GO:0007423 74 0.012
regulation of synaptic plasticity GO:0048167 70 0.012
protein oligomerization GO:0051259 191 0.012
positive regulation of secretion GO:0051047 140 0.012
positive regulation of cellular component movement GO:0051272 102 0.012
regulation of cell cycle GO:0051726 73 0.012
positive regulation of synaptic vesicle transport GO:1902805 3 0.012
cellular response to growth factor stimulus GO:0071363 162 0.012
muscle tissue development GO:0060537 58 0.012
positive regulation of gene expression GO:0010628 244 0.012
positive regulation of signaling GO:0023056 270 0.012
female pregnancy GO:0007565 122 0.012
macromolecule localization GO:0033036 252 0.012
phospholipid biosynthetic process GO:0008654 29 0.012
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.012
positive regulation of cell development GO:0010720 176 0.012
positive regulation of synaptic transmission GO:0050806 62 0.012
single organism behavior GO:0044708 130 0.012
positive regulation of ion transport GO:0043270 94 0.012
positive regulation of cell communication GO:0010647 271 0.012
organic hydroxy compound transport GO:0015850 77 0.012
negative regulation of cell communication GO:0010648 158 0.012
response to ethanol GO:0045471 162 0.012
cellular divalent inorganic cation homeostasis GO:0072503 162 0.012
purine ribonucleoside metabolic process GO:0046128 168 0.011
inorganic cation transmembrane transport GO:0098662 202 0.011
ribonucleoside catabolic process GO:0042454 126 0.011
transmission of nerve impulse GO:0019226 42 0.011
intermediate filament based process GO:0045103 3 0.011
proteolysis GO:0006508 175 0.011
axon development GO:0061564 96 0.011
glycosyl compound catabolic process GO:1901658 126 0.011
regulation of plasma lipoprotein particle levels GO:0097006 3 0.011
neuron apoptotic process GO:0051402 88 0.011
nucleobase containing compound catabolic process GO:0034655 152 0.011
negative regulation of cell proliferation GO:0008285 119 0.011
negative regulation of rna metabolic process GO:0051253 123 0.011
enzyme linked receptor protein signaling pathway GO:0007167 116 0.011
nucleoside phosphate biosynthetic process GO:1901293 102 0.011
cellular ion homeostasis GO:0006873 184 0.011
forebrain development GO:0030900 98 0.011
molting cycle process GO:0022404 2 0.011
calcium ion homeostasis GO:0055074 162 0.011
positive regulation of protein modification process GO:0031401 142 0.011
regulation of catabolic process GO:0009894 113 0.011
multicellular organismal signaling GO:0035637 44 0.011
action potential GO:0001508 54 0.011
cardiovascular system development GO:0072358 134 0.011
response to mechanical stimulus GO:0009612 134 0.011
development of primary sexual characteristics GO:0045137 107 0.010
regulation of calcium ion transport GO:0051924 77 0.010
regulation of transferase activity GO:0051338 123 0.010
glycosyl compound metabolic process GO:1901657 182 0.010
peptide secretion GO:0002790 86 0.010
ribonucleoside triphosphate metabolic process GO:0009199 141 0.010
motor neuron axon guidance GO:0008045 1 0.010
purine containing compound catabolic process GO:0072523 138 0.010
vasculature development GO:0001944 70 0.010
hair follicle development GO:0001942 2 0.010
response to glucose GO:0009749 136 0.010
nucleoside triphosphate metabolic process GO:0009141 144 0.010
neuronal action potential GO:0019228 35 0.010
cytokine production GO:0001816 61 0.010
regulation of nucleotide metabolic process GO:0006140 117 0.010
sequestering of calcium ion GO:0051208 8 0.010
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.010
regulation of immune system process GO:0002682 123 0.010
gonad development GO:0008406 104 0.010
positive regulation of catalytic activity GO:0043085 184 0.010
divalent metal ion transport GO:0070838 132 0.010
positive regulation of neuron differentiation GO:0045666 126 0.010
regulation of anatomical structure morphogenesis GO:0022603 141 0.010

Sigmar1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.021
nervous system disease DOID:863 0 0.021
disease of metabolism DOID:0014667 0 0.014