Rattus norvegicus

5 known processes

Sost

sclerosteosis

Sost biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
establishment of organ orientation GO:0048561 1 0.439
establishment of anatomical structure orientation GO:0048560 1 0.129
positive regulation of signaling GO:0023056 270 0.114
regulation of cell differentiation GO:0045595 320 0.110
positive regulation of cell differentiation GO:0045597 217 0.110
apoptotic process GO:0006915 381 0.109
positive regulation of multicellular organismal process GO:0051240 387 0.107
transcription from rna polymerase ii promoter GO:0006366 252 0.105
positive regulation of transcription dna templated GO:0045893 197 0.101
homeostatic process GO:0042592 331 0.092
chemical homeostasis GO:0048878 292 0.086
tube development GO:0035295 89 0.084
positive regulation of cellular component organization GO:0051130 200 0.077
positive regulation of gene expression GO:0010628 244 0.076
regulation of apoptotic process GO:0042981 335 0.074
regulation of cell proliferation GO:0042127 359 0.069
response to bacterium GO:0009617 200 0.068
organonitrogen compound biosynthetic process GO:1901566 167 0.068
cellular ion homeostasis GO:0006873 184 0.068
response to molecule of bacterial origin GO:0002237 194 0.068
regulation of multicellular organismal development GO:2000026 376 0.067
regulation of nucleic acid templated transcription GO:1903506 380 0.065
negative regulation of cell death GO:0060548 229 0.063
mapk cascade GO:0000165 140 0.062
positive regulation of nervous system development GO:0051962 178 0.062
regulation of cellular component organization GO:0051128 368 0.061
positive regulation of cell proliferation GO:0008284 249 0.061
neuron development GO:0048666 286 0.060
divalent inorganic cation homeostasis GO:0072507 165 0.058
cytosolic calcium ion homeostasis GO:0051480 140 0.057
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.057
rna biosynthetic process GO:0032774 380 0.055
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.053
cellular chemical homeostasis GO:0055082 247 0.052
cellular response to stress GO:0033554 269 0.049
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.049
inorganic ion transmembrane transport GO:0098660 229 0.049
single organism reproductive process GO:0044702 297 0.049
calcium ion homeostasis GO:0055074 162 0.049
lymphoid progenitor cell differentiation GO:0002320 2 0.049
regulation of cell development GO:0060284 263 0.048
positive regulation of biosynthetic process GO:0009891 319 0.048
programmed cell death GO:0012501 392 0.048
negative regulation of transcription dna templated GO:0045892 116 0.048
single organism biosynthetic process GO:0044711 342 0.047
neurological system process GO:0050877 219 0.047
regulation of catalytic activity GO:0050790 304 0.047
cellular homeostasis GO:0019725 252 0.046
rna metabolic process GO:0016070 406 0.045
positive regulation of developmental process GO:0051094 283 0.045
negative regulation of macromolecule metabolic process GO:0010605 260 0.045
transcription dna templated GO:0006351 377 0.045
negative regulation of cellular metabolic process GO:0031324 281 0.044
organ morphogenesis GO:0009887 75 0.044
regulation of transcription dna templated GO:0006355 374 0.044
defense response GO:0006952 194 0.044
regulation of hormone levels GO:0010817 187 0.043
negative regulation of metabolic process GO:0009892 331 0.043
positive regulation of phosphate metabolic process GO:0045937 262 0.042
nitrogen compound transport GO:0071705 229 0.041
regulation of molecular function GO:0065009 398 0.040
cellular divalent inorganic cation homeostasis GO:0072503 162 0.040
cellular component assembly GO:0022607 360 0.039
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.039
positive regulation of phosphorylation GO:0042327 177 0.039
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.039
positive regulation of cell development GO:0010720 176 0.038
anatomical structure morphogenesis GO:0009653 298 0.038
positive regulation of nucleic acid templated transcription GO:1903508 197 0.038
cell projection morphogenesis GO:0048858 123 0.038
negative regulation of biosynthetic process GO:0009890 168 0.036
positive regulation of rna metabolic process GO:0051254 203 0.036
regulation of nervous system development GO:0051960 264 0.036
positive regulation of cellular biosynthetic process GO:0031328 295 0.036
regulation of neurogenesis GO:0050767 247 0.035
cellular component biogenesis GO:0044085 368 0.035
protein complex assembly GO:0006461 263 0.035
organophosphate biosynthetic process GO:0090407 143 0.035
peptide biosynthetic process GO:0043043 3 0.035
macromolecular complex subunit organization GO:0043933 339 0.034
positive regulation of cell communication GO:0010647 271 0.034
response to inorganic substance GO:0010035 377 0.034
regulation of neuron differentiation GO:0045664 208 0.034
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.034
response to oxidative stress GO:0006979 186 0.034
cellular calcium ion homeostasis GO:0006874 160 0.033
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.033
nucleobase containing small molecule metabolic process GO:0055086 316 0.033
response to estrogen GO:0043627 232 0.032
cell projection organization GO:0030030 302 0.032
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.032
positive regulation of response to stimulus GO:0048584 285 0.032
carbohydrate derivative metabolic process GO:1901135 346 0.032
choline transport GO:0015871 4 0.031
neuron differentiation GO:0030182 368 0.031
response to extracellular stimulus GO:0009991 380 0.031
regulation of rna metabolic process GO:0051252 391 0.031
positive regulation of molecular function GO:0044093 230 0.030
multicellular organismal reproductive process GO:0048609 233 0.030
purine ribonucleotide metabolic process GO:0009150 227 0.030
response to other organism GO:0051707 220 0.030
secretion by cell GO:0032940 248 0.029
response to external biotic stimulus GO:0043207 221 0.029
organophosphate metabolic process GO:0019637 370 0.029
regulation of rna biosynthetic process GO:2001141 381 0.029
response to wounding GO:0009611 254 0.029
regulation of phosphate metabolic process GO:0019220 349 0.029
inflammatory response GO:0006954 150 0.029
cation homeostasis GO:0055080 195 0.029
negative regulation of rna metabolic process GO:0051253 123 0.028
regulation of myeloid cell differentiation GO:0045637 12 0.028
cell part morphogenesis GO:0032990 123 0.028
negative regulation of rna biosynthetic process GO:1902679 118 0.027
regulation of programmed cell death GO:0043067 341 0.027
ribonucleotide metabolic process GO:0009259 231 0.027
positive regulation of programmed cell death GO:0043068 157 0.027
regulation of organelle organization GO:0033043 80 0.027
carboxylic acid transport GO:0046942 115 0.027
nucleic acid templated transcription GO:0097659 379 0.027
positive regulation of phosphorus metabolic process GO:0010562 262 0.026
digestive system development GO:0055123 41 0.026
protein complex subunit organization GO:0071822 302 0.026
response to biotic stimulus GO:0009607 226 0.025
organic anion transport GO:0015711 132 0.025
protein complex biogenesis GO:0070271 263 0.025
positive regulation of intracellular signal transduction GO:1902533 138 0.025
regulation of mapk cascade GO:0043408 116 0.024
reproductive system development GO:0061458 128 0.024
anterior posterior pattern specification GO:0009952 1 0.024
protein homooligomerization GO:0051260 91 0.024
positive regulation of neuron differentiation GO:0045666 126 0.023
positive regulation of signal transduction GO:0009967 175 0.023
cell morphogenesis GO:0000902 142 0.023
carboxylic acid metabolic process GO:0019752 289 0.023
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.023
response to oxygen levels GO:0070482 265 0.022
amide biosynthetic process GO:0043604 10 0.022
response to hypoxia GO:0001666 231 0.022
positive regulation of rna biosynthetic process GO:1902680 197 0.022
catabolic process GO:0009056 351 0.022
negative regulation of cellular biosynthetic process GO:0031327 161 0.022
neuron projection development GO:0031175 273 0.021
regulation of phosphorylation GO:0042325 248 0.021
central nervous system development GO:0007417 311 0.021
response to lipopolysaccharide GO:0032496 191 0.021
respiratory system development GO:0060541 45 0.021
regulation of phosphorus metabolic process GO:0051174 349 0.021
cation transport GO:0006812 382 0.021
regulation of transferase activity GO:0051338 123 0.021
response to decreased oxygen levels GO:0036293 237 0.021
alcohol metabolic process GO:0006066 77 0.021
cation transmembrane transport GO:0098655 263 0.021
cellular response to endogenous stimulus GO:0071495 377 0.021
organic acid transport GO:0015849 116 0.020
regulation of signal transduction GO:0009966 318 0.020
metanephric s shaped body morphogenesis GO:0072284 2 0.020
regulation of membrane potential GO:0042391 110 0.020
tissue development GO:0009888 252 0.020
axis specification GO:0009798 4 0.020
response to growth factor GO:0070848 189 0.020
developmental induction GO:0031128 2 0.019
negative regulation of apoptotic process GO:0043066 181 0.019
negative regulation of multicellular organismal process GO:0051241 203 0.019
negative regulation of programmed cell death GO:0043069 183 0.019
nucleoside phosphate metabolic process GO:0006753 283 0.019
regulation of ion transmembrane transport GO:0034765 121 0.019
morphogenesis of embryonic epithelium GO:0016331 3 0.019
positive regulation of cellular protein metabolic process GO:0032270 167 0.019
protein phosphorylation GO:0006468 345 0.019
secretion GO:0046903 307 0.019
glucose metabolic process GO:0006006 52 0.019
mesoderm development GO:0007498 2 0.018
sensory organ development GO:0007423 74 0.018
regulation of cell projection organization GO:0031344 175 0.018
mechanoreceptor differentiation GO:0042490 2 0.018
neuron projection morphogenesis GO:0048812 122 0.018
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.018
g protein coupled receptor signaling pathway GO:0007186 242 0.018
cellular amide metabolic process GO:0043603 44 0.018
epithelium development GO:0060429 96 0.018
monovalent inorganic cation transport GO:0015672 172 0.018
negative regulation of cell communication GO:0010648 158 0.018
purine containing compound metabolic process GO:0072521 253 0.018
ion homeostasis GO:0050801 212 0.017
ribose phosphate biosynthetic process GO:0046390 87 0.017
regulation of neuron projection development GO:0010975 161 0.017
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.017
pancreatic stellate cell proliferation GO:0072343 2 0.017
positive regulation of neurogenesis GO:0050769 165 0.017
cellular component morphogenesis GO:0032989 155 0.017
amino acid transport GO:0006865 70 0.017
negative regulation of nucleic acid templated transcription GO:1903507 117 0.017
reproductive process GO:0022414 372 0.017
positive regulation of protein phosphorylation GO:0001934 135 0.017
rhythmic process GO:0048511 156 0.017
negative regulation of growth GO:0045926 37 0.017
metal ion homeostasis GO:0055065 186 0.017
anion transport GO:0006820 178 0.017
macromolecular complex assembly GO:0065003 273 0.017
developmental process involved in reproduction GO:0003006 159 0.017
cell cell signaling GO:0007267 335 0.017
embryo development GO:0009790 49 0.017
cardiovascular system development GO:0072358 134 0.017
response to cytokine GO:0034097 215 0.017
reproduction GO:0000003 245 0.017
amine metabolic process GO:0009308 38 0.016
cellular response to oxygen containing compound GO:1901701 386 0.016
organelle organization GO:0006996 266 0.016
peptidyl amino acid modification GO:0018193 126 0.016
cellular response to growth factor stimulus GO:0071363 162 0.016
cell morphogenesis involved in differentiation GO:0000904 119 0.016
behavior GO:0007610 205 0.016
regulation of intracellular signal transduction GO:1902531 218 0.016
positive regulation of cell death GO:0010942 184 0.016
regulation of sodium ion transmembrane transporter activity GO:2000649 4 0.016
circadian rhythm GO:0007623 88 0.016
s shaped body morphogenesis GO:0072050 2 0.016
comma shaped body morphogenesis GO:0072049 2 0.016
coronary vasculature morphogenesis GO:0060977 3 0.016
myeloid leukocyte differentiation GO:0002573 20 0.015
purine nucleotide metabolic process GO:0006163 229 0.015
positive regulation of protein metabolic process GO:0051247 178 0.015
ion transmembrane transport GO:0034220 365 0.015
monocarboxylic acid transport GO:0015718 52 0.015
tube formation GO:0035148 3 0.015
potassium ion transmembrane transport GO:0071805 71 0.015
signal transduction by phosphorylation GO:0023014 144 0.015
response to estradiol GO:0032355 164 0.015
protein oligomerization GO:0051259 191 0.015
intracellular signal transduction GO:0035556 314 0.015
multicellular organism reproduction GO:0032504 233 0.015
hexose metabolic process GO:0019318 58 0.015
negative regulation of transcription regulatory region dna binding GO:2000678 2 0.015
inorganic cation transmembrane transport GO:0098662 202 0.015
organic hydroxy compound metabolic process GO:1901615 115 0.014
vitamin d receptor signaling pathway GO:0070561 1 0.014
ribose phosphate metabolic process GO:0019693 235 0.014
intracellular receptor signaling pathway GO:0030522 35 0.014
smooth muscle cell proliferation GO:0048659 77 0.014
tissue morphogenesis GO:0048729 22 0.014
muscle cell proliferation GO:0033002 84 0.014
muscle tissue morphogenesis GO:0060415 1 0.014
immune system process GO:0002376 204 0.014
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.014
positive regulation of phagocytosis engulfment GO:0060100 4 0.014
adult locomotory behavior GO:0008344 4 0.014
positive regulation of mapk cascade GO:0043410 92 0.014
nucleotide metabolic process GO:0009117 279 0.014
hair cell differentiation GO:0035315 2 0.014
locomotion GO:0040011 237 0.014
heart development GO:0007507 72 0.014
cellular catabolic process GO:0044248 295 0.013
gonad development GO:0008406 104 0.013
dendrite development GO:0016358 72 0.013
locomotor rhythm GO:0045475 1 0.013
positive regulation of catalytic activity GO:0043085 184 0.013
response to alkaloid GO:0043279 132 0.013
urogenital system development GO:0001655 78 0.013
negative regulation of transport GO:0051051 136 0.013
regulation of system process GO:0044057 208 0.013
single organism behavior GO:0044708 130 0.013
regeneration GO:0031099 163 0.013
retina morphogenesis in camera type eye GO:0060042 1 0.013
enzyme linked receptor protein signaling pathway GO:0007167 116 0.013
regulation of cellular amine metabolic process GO:0033238 8 0.013
muscle contraction GO:0006936 88 0.013
embryonic skeletal system morphogenesis GO:0048704 3 0.013
regulation of transcription regulatory region dna binding GO:2000677 4 0.013
cellular cation homeostasis GO:0030003 180 0.013
epithelial cell proliferation GO:0050673 54 0.012
organic acid metabolic process GO:0006082 292 0.012
regulation of fat cell proliferation GO:0070344 1 0.012
cellular response to abiotic stimulus GO:0071214 85 0.012
dendrite morphogenesis GO:0048813 43 0.012
amide transport GO:0042886 105 0.012
cellular response to external stimulus GO:0071496 118 0.012
multi organism reproductive process GO:0044703 262 0.012
regulation of growth GO:0040008 105 0.012
ventral spinal cord development GO:0021517 3 0.012
regulation of endocytosis GO:0030100 42 0.012
regulation of neuron death GO:1901214 115 0.012
negative regulation of signaling GO:0023057 157 0.012
cellular amine metabolic process GO:0044106 38 0.012
regulation of protein phosphorylation GO:0001932 183 0.012
angiogenesis involved in coronary vascular morphogenesis GO:0060978 3 0.012
growth GO:0040007 165 0.012
regulation of leukocyte differentiation GO:1902105 20 0.012
regulation of lipid metabolic process GO:0019216 68 0.012
oxoacid metabolic process GO:0043436 290 0.012
camera type eye morphogenesis GO:0048593 2 0.012
cellular response to reactive oxygen species GO:0034614 55 0.011
monosaccharide metabolic process GO:0005996 61 0.011
response to monosaccharide GO:0034284 159 0.011
neuron fate commitment GO:0048663 4 0.011
cell cell signaling involved in cell fate commitment GO:0045168 2 0.011
regulation of pancreatic stellate cell proliferation GO:2000229 2 0.011
positive regulation of neuron projection development GO:0010976 99 0.011
organ formation GO:0048645 3 0.011
positive regulation of transport GO:0051050 245 0.011
inner ear morphogenesis GO:0042472 1 0.011
transmembrane transport GO:0055085 412 0.011
multicellular organismal homeostasis GO:0048871 49 0.011
negative regulation of molecular function GO:0044092 133 0.011
negative regulation of collagen biosynthetic process GO:0032966 4 0.011
heart morphogenesis GO:0003007 3 0.011
leukocyte proliferation GO:0070661 29 0.011
regulation of phagocytosis engulfment GO:0060099 4 0.011
carbohydrate derivative biosynthetic process GO:1901137 124 0.011
regulation of response to external stimulus GO:0032101 106 0.011
regulation of protein modification process GO:0031399 194 0.011
embryonic pattern specification GO:0009880 1 0.011
regulation of secretion by cell GO:1903530 208 0.011
regulation of metal ion transport GO:0010959 118 0.011
regulation of cell cycle GO:0051726 73 0.011
nucleotide biosynthetic process GO:0009165 98 0.011
lung development GO:0030324 43 0.011
reproductive structure development GO:0048608 128 0.011
head development GO:0060322 247 0.011
regulation of cellular ketone metabolic process GO:0010565 27 0.011
respiratory tube development GO:0030323 43 0.011
positive regulation of protein modification process GO:0031401 142 0.011
single organism catabolic process GO:0044712 283 0.011
epithelial tube formation GO:0072175 3 0.011
response to hexose GO:0009746 144 0.011
lipid biosynthetic process GO:0008610 128 0.010
positive regulation of apoptotic process GO:0043065 154 0.010
glucose homeostasis GO:0042593 75 0.010
positive regulation of transferase activity GO:0051347 81 0.010
sterol homeostasis GO:0055092 3 0.010
glycosyl compound metabolic process GO:1901657 182 0.010
mitotic cell cycle GO:0000278 49 0.010
negative regulation of cell development GO:0010721 82 0.010
negative regulation of cell growth GO:0030308 33 0.010
positive regulation of endocytosis GO:0045807 28 0.010
response to reactive oxygen species GO:0000302 120 0.010
metal ion transport GO:0030001 289 0.010
response to glucose GO:0009749 136 0.010
regulation of kinase activity GO:0043549 117 0.010
wound healing GO:0042060 122 0.010
kidney development GO:0001822 67 0.010
response to nicotine GO:0035094 51 0.010
regulation of cellular amino acid metabolic process GO:0006521 2 0.010
purine nucleoside metabolic process GO:0042278 169 0.010
auditory receptor cell differentiation GO:0042491 2 0.010
hematopoietic progenitor cell differentiation GO:0002244 2 0.010
organ induction GO:0001759 1 0.010
cellular response to cytokine stimulus GO:0071345 127 0.010

Sost disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 0 0.057
disease of anatomical entity DOID:7 0 0.057
nervous system disease DOID:863 0 0.057
retinal disease DOID:5679 0 0.027
retinal degeneration DOID:8466 0 0.027
retinitis pigmentosa DOID:10584 0 0.027
eye and adnexa disease DOID:1492 0 0.027
eye disease DOID:5614 0 0.027
cardiovascular system disease DOID:1287 0 0.019
myopathy DOID:423 0 0.017
muscular disease DOID:0080000 0 0.017
heart disease DOID:114 0 0.017
cardiomyopathy DOID:0050700 0 0.017
musculoskeletal system disease DOID:17 0 0.017
muscle tissue disease DOID:66 0 0.017