Rattus norvegicus

107 known processes

Pde3b

phosphodiesterase 3B, cGMP-inhibited

Pde3b biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
transcription dna templated GO:0006351 377 0.154
regulation of rna biosynthetic process GO:2001141 381 0.114
rna biosynthetic process GO:0032774 380 0.114
rna metabolic process GO:0016070 406 0.112
catabolic process GO:0009056 351 0.105
secretion GO:0046903 307 0.092
nitrogen compound transport GO:0071705 229 0.088
organophosphate metabolic process GO:0019637 370 0.087
response to extracellular stimulus GO:0009991 380 0.084
response to nutrient GO:0007584 248 0.083
regulation of rna metabolic process GO:0051252 391 0.082
neuron development GO:0048666 286 0.078
anatomical structure morphogenesis GO:0009653 298 0.077
Human
cellular component movement GO:0006928 248 0.075
positive regulation of transport GO:0051050 245 0.074
regulation of phosphate metabolic process GO:0019220 349 0.071
response to nutrient levels GO:0031667 370 0.071
carboxylic acid metabolic process GO:0019752 289 0.070
cellular catabolic process GO:0044248 295 0.069
positive regulation of signaling GO:0023056 270 0.064
negative regulation of macromolecule metabolic process GO:0010605 260 0.063
tissue development GO:0009888 252 0.063
regulation of ion transport GO:0043269 245 0.061
cellular response to oxygen containing compound GO:1901701 386 0.059
Mouse
cell morphogenesis involved in differentiation GO:0000904 119 0.059
single organism catabolic process GO:0044712 283 0.058
nucleoside phosphate metabolic process GO:0006753 283 0.057
nucleobase containing small molecule metabolic process GO:0055086 316 0.057
single organism reproductive process GO:0044702 297 0.056
Rat
regulation of molecular function GO:0065009 398 0.054
negative regulation of metabolic process GO:0009892 331 0.053
Human
ribose phosphate metabolic process GO:0019693 235 0.052
organic acid metabolic process GO:0006082 292 0.051
cellular response to endogenous stimulus GO:0071495 377 0.051
Mouse
brain development GO:0007420 247 0.051
locomotion GO:0040011 237 0.051
regulation of intracellular signal transduction GO:1902531 218 0.051
aromatic compound catabolic process GO:0019439 168 0.050
regulation of signal transduction GO:0009966 318 0.050
heterocycle catabolic process GO:0046700 167 0.049
cellular component assembly GO:0022607 360 0.049
regulation of phosphorus metabolic process GO:0051174 349 0.048
regulation of nucleic acid templated transcription GO:1903506 380 0.048
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.048
negative regulation of cell death GO:0060548 229 0.047
Rat
purine containing compound metabolic process GO:0072521 253 0.045
regulation of secretion GO:0051046 224 0.043
anion transport GO:0006820 178 0.043
positive regulation of biosynthetic process GO:0009891 319 0.042
regulation of cell proliferation GO:0042127 359 0.042
positive regulation of cell death GO:0010942 184 0.042
purine nucleoside metabolic process GO:0042278 169 0.042
oxoacid metabolic process GO:0043436 290 0.041
cellular response to peptide GO:1901653 133 0.041
Mouse
purine ribonucleoside metabolic process GO:0046128 168 0.040
organic cyclic compound catabolic process GO:1901361 175 0.040
transmembrane transport GO:0055085 412 0.040
positive regulation of cell proliferation GO:0008284 249 0.039
intracellular signal transduction GO:0035556 314 0.039
ribonucleotide catabolic process GO:0009261 136 0.039
response to corticosteroid GO:0031960 235 0.039
purine nucleotide catabolic process GO:0006195 136 0.038
nucleotide metabolic process GO:0009117 279 0.038
organophosphate catabolic process GO:0046434 148 0.038
cation transport GO:0006812 382 0.038
cellular amino acid metabolic process GO:0006520 107 0.038
response to growth factor GO:0070848 189 0.038
response to inorganic substance GO:0010035 377 0.037
central nervous system development GO:0007417 311 0.037
chemical homeostasis GO:0048878 292 0.037
Mouse
regulation of transcription dna templated GO:0006355 374 0.037
single organism biosynthetic process GO:0044711 342 0.037
protein complex assembly GO:0006461 263 0.037
cellular component biogenesis GO:0044085 368 0.036
neuron differentiation GO:0030182 368 0.036
homeostatic process GO:0042592 331 0.036
Mouse
neuron projection development GO:0031175 273 0.035
nucleic acid templated transcription GO:0097659 379 0.035
purine nucleotide metabolic process GO:0006163 229 0.035
aging GO:0007568 241 0.035
divalent metal ion transport GO:0070838 132 0.035
ion transmembrane transport GO:0034220 365 0.035
regulation of protein metabolic process GO:0051246 289 0.035
ribonucleotide metabolic process GO:0009259 231 0.035
secretion by cell GO:0032940 248 0.035
cellular nitrogen compound catabolic process GO:0044270 163 0.034
response to estrogen GO:0043627 232 0.034
positive regulation of phosphate metabolic process GO:0045937 262 0.034
positive regulation of gene expression GO:0010628 244 0.034
purine nucleoside triphosphate metabolic process GO:0009144 141 0.034
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.034
response to acid chemical GO:0001101 222 0.033
positive regulation of cellular biosynthetic process GO:0031328 295 0.033
ribonucleoside triphosphate metabolic process GO:0009199 141 0.033
cell projection organization GO:0030030 302 0.033
positive regulation of developmental process GO:0051094 283 0.033
nucleoside triphosphate catabolic process GO:0009143 123 0.033
nucleotide catabolic process GO:0009166 139 0.033
cellular ketone metabolic process GO:0042180 51 0.032
multi organism reproductive process GO:0044703 262 0.032
Rat
regulation of cellular protein metabolic process GO:0032268 267 0.032
cellular response to peptide hormone stimulus GO:0071375 120 0.031
Mouse
purine ribonucleotide catabolic process GO:0009154 136 0.031
carbohydrate derivative metabolic process GO:1901135 346 0.031
positive regulation of nucleic acid templated transcription GO:1903508 197 0.031
organic substance catabolic process GO:1901575 316 0.030
regulation of apoptotic process GO:0042981 335 0.030
Rat
cell projection morphogenesis GO:0048858 123 0.030
reproduction GO:0000003 245 0.029
Rat
cellular response to organonitrogen compound GO:0071417 197 0.029
Mouse
regulation of cellular ketone metabolic process GO:0010565 27 0.029
cellular chemical homeostasis GO:0055082 247 0.029
cellular cation homeostasis GO:0030003 180 0.029
response to mechanical stimulus GO:0009612 134 0.029
carbohydrate derivative catabolic process GO:1901136 147 0.029
positive regulation of cell communication GO:0010647 271 0.029
glycosyl compound catabolic process GO:1901658 126 0.029
positive regulation of cellular protein metabolic process GO:0032270 167 0.029
positive regulation of multicellular organismal process GO:0051240 387 0.029
positive regulation of rna biosynthetic process GO:1902680 197 0.028
defense response GO:0006952 194 0.028
positive regulation of rna metabolic process GO:0051254 203 0.028
sensory perception GO:0007600 101 0.028
purine ribonucleoside catabolic process GO:0046130 124 0.028
negative regulation of cellular metabolic process GO:0031324 281 0.028
positive regulation of cellular component organization GO:0051130 200 0.027
organelle organization GO:0006996 266 0.027
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.027
monocarboxylic acid metabolic process GO:0032787 152 0.027
glycosyl compound metabolic process GO:1901657 182 0.027
cell motility GO:0048870 202 0.027
regulation of cell development GO:0060284 263 0.027
positive regulation of secretion by cell GO:1903532 128 0.027
response to glucocorticoid GO:0051384 223 0.027
neuron projection morphogenesis GO:0048812 122 0.027
regulation of multicellular organismal development GO:2000026 376 0.026
Human
regulation of neuron differentiation GO:0045664 208 0.026
ribonucleoside triphosphate catabolic process GO:0009203 122 0.026
calcium ion homeostasis GO:0055074 162 0.026
nucleoside phosphate catabolic process GO:1901292 140 0.026
negative regulation of apoptotic process GO:0043066 181 0.026
Rat
regulation of cell differentiation GO:0045595 320 0.026
macromolecular complex assembly GO:0065003 273 0.026
ribonucleoside metabolic process GO:0009119 174 0.026
endocytosis GO:0006897 84 0.026
urogenital system development GO:0001655 78 0.025
cellular metal ion homeostasis GO:0006875 172 0.025
metal ion transport GO:0030001 289 0.025
circulatory system development GO:0072359 134 0.025
Human
carbohydrate metabolic process GO:0005975 130 0.025
purine nucleoside triphosphate catabolic process GO:0009146 122 0.025
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.024
circulatory system process GO:0003013 183 0.024
purine ribonucleotide metabolic process GO:0009150 227 0.024
regulation of cellular component organization GO:0051128 368 0.024
cellular response to lipid GO:0071396 201 0.024
nucleoside catabolic process GO:0009164 126 0.024
positive regulation of transcription dna templated GO:0045893 197 0.024
cell part morphogenesis GO:0032990 123 0.024
cellular response to nitrogen compound GO:1901699 210 0.024
Mouse
regulation of phosphorylation GO:0042325 248 0.024
growth GO:0040007 165 0.024
protein phosphorylation GO:0006468 345 0.024
nucleoside triphosphate metabolic process GO:0009141 144 0.024
response to wounding GO:0009611 254 0.023
head development GO:0060322 247 0.023
cell cell signaling GO:0007267 335 0.023
regulation of programmed cell death GO:0043067 341 0.023
Rat
response to peptide hormone GO:0043434 278 0.023
Mouse
positive regulation of response to stimulus GO:0048584 285 0.023
cellular homeostasis GO:0019725 252 0.023
purine nucleoside catabolic process GO:0006152 124 0.023
cellular calcium ion homeostasis GO:0006874 160 0.023
apoptotic process GO:0006915 381 0.023
Rat
regulation of catalytic activity GO:0050790 304 0.023
cellular response to stress GO:0033554 269 0.023
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.023
regulation of cellular amino acid metabolic process GO:0006521 2 0.022
programmed cell death GO:0012501 392 0.022
Rat
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.022
hormone transport GO:0009914 121 0.022
regulation of metal ion transport GO:0010959 118 0.022
negative regulation of cellular protein metabolic process GO:0032269 106 0.022
regulation of secretion by cell GO:1903530 208 0.022
negative regulation of programmed cell death GO:0043069 183 0.022
Rat
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.021
insulin like growth factor receptor signaling pathway GO:0048009 3 0.021
cellular amine metabolic process GO:0044106 38 0.021
positive regulation of molecular function GO:0044093 230 0.021
regulation of system process GO:0044057 208 0.021
regulation of lipid metabolic process GO:0019216 68 0.021
Human
negative regulation of gene expression GO:0010629 199 0.021
regulation of hormone levels GO:0010817 187 0.021
organonitrogen compound catabolic process GO:1901565 179 0.021
positive regulation of secretion GO:0051047 140 0.021
regulation of transmembrane transport GO:0034762 122 0.021
regulation of catabolic process GO:0009894 113 0.021
Human
neurological system process GO:0050877 219 0.020
single organism carbohydrate metabolic process GO:0044723 118 0.020
organic acid transport GO:0015849 116 0.020
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.020
cellular response to insulin stimulus GO:0032869 81 0.020
Mouse
positive regulation of phosphorus metabolic process GO:0010562 262 0.020
cellular response to organic cyclic compound GO:0071407 202 0.020
cofactor metabolic process GO:0051186 95 0.020
axon development GO:0061564 96 0.020
regulation of cell projection organization GO:0031344 175 0.020
response to monosaccharide GO:0034284 159 0.019
macromolecule localization GO:0033036 252 0.019
cellular component morphogenesis GO:0032989 155 0.019
response to ethanol GO:0045471 162 0.019
protein localization GO:0008104 191 0.019
ribonucleoside catabolic process GO:0042454 126 0.019
transcription from rna polymerase ii promoter GO:0006366 252 0.019
multicellular organismal reproductive process GO:0048609 233 0.019
Rat
ion homeostasis GO:0050801 212 0.019
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.019
regulation of transporter activity GO:0032409 50 0.019
regulation of nucleotide catabolic process GO:0030811 65 0.019
positive regulation of catalytic activity GO:0043085 184 0.019
regulation of peptide hormone secretion GO:0090276 80 0.019
gtp catabolic process GO:0006184 71 0.019
lipid biosynthetic process GO:0008610 128 0.019
enzyme linked receptor protein signaling pathway GO:0007167 116 0.019
cellular ion homeostasis GO:0006873 184 0.019
response to carbohydrate GO:0009743 183 0.019
response to oxygen levels GO:0070482 265 0.019
positive regulation of phosphorylation GO:0042327 177 0.019
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.019
positive regulation of neuron differentiation GO:0045666 126 0.019
organonitrogen compound biosynthetic process GO:1901566 167 0.019
regulation of nervous system development GO:0051960 264 0.019
cellular divalent inorganic cation homeostasis GO:0072503 162 0.019
response to glucose GO:0009749 136 0.019
tube development GO:0035295 89 0.019
hormone secretion GO:0046879 115 0.019
amine metabolic process GO:0009308 38 0.018
divalent inorganic cation transport GO:0072511 134 0.018
purine containing compound catabolic process GO:0072523 138 0.018
regeneration GO:0031099 163 0.018
positive regulation of protein modification process GO:0031401 142 0.018
negative regulation of signaling GO:0023057 157 0.018
calcium ion transport GO:0006816 131 0.018
cell migration GO:0016477 197 0.018
dephosphorylation GO:0016311 98 0.018
regulation of hormone secretion GO:0046883 106 0.018
positive regulation of protein metabolic process GO:0051247 178 0.018
regulation of cellular localization GO:0060341 263 0.018
positive regulation of hormone secretion GO:0046887 65 0.018
regulation of hydrolase activity GO:0051336 143 0.018
inflammatory response GO:0006954 150 0.018
cell morphogenesis GO:0000902 142 0.018
positive regulation of nucleotide metabolic process GO:0045981 91 0.018
positive regulation of intracellular signal transduction GO:1902533 138 0.017
divalent inorganic cation homeostasis GO:0072507 165 0.017
regulation of protein modification process GO:0031399 194 0.017
response to oxidative stress GO:0006979 186 0.017
regulation of anatomical structure morphogenesis GO:0022603 141 0.017
Human
reproductive process GO:0022414 372 0.017
Rat
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.017
positive regulation of protein phosphorylation GO:0001934 135 0.017
negative regulation of transport GO:0051051 136 0.017
positive regulation of neurogenesis GO:0050769 165 0.017
protein oligomerization GO:0051259 191 0.017
gamete generation GO:0007276 124 0.017
Rat
response to hypoxia GO:0001666 231 0.017
regulation of neuron projection development GO:0010975 161 0.017
protein complex subunit organization GO:0071822 302 0.017
response to hexose GO:0009746 144 0.017
guanosine containing compound metabolic process GO:1901068 74 0.017
lipid metabolic process GO:0006629 283 0.016
protein complex biogenesis GO:0070271 263 0.016
developmental process involved in reproduction GO:0003006 159 0.016
Rat
regulation of cellular catabolic process GO:0031329 101 0.016
cell growth GO:0016049 104 0.016
cation homeostasis GO:0055080 195 0.016
positive regulation of cellular amine metabolic process GO:0033240 3 0.016
multicellular organism reproduction GO:0032504 233 0.016
Rat
organophosphate biosynthetic process GO:0090407 143 0.016
nucleobase containing compound catabolic process GO:0034655 152 0.016
gtp metabolic process GO:0046039 72 0.016
cellular response to growth factor stimulus GO:0071363 162 0.016
negative regulation of cellular biosynthetic process GO:0031327 161 0.016
metal ion homeostasis GO:0055065 186 0.016
response to alkaloid GO:0043279 132 0.016
macromolecule catabolic process GO:0009057 58 0.016
inorganic ion transmembrane transport GO:0098660 229 0.016
cellular response to hormone stimulus GO:0032870 247 0.016
Mouse
response to cytokine GO:0034097 215 0.015
muscle structure development GO:0061061 87 0.015
nucleoside metabolic process GO:0009116 179 0.015
cell adhesion GO:0007155 110 0.015
Human
multicellular organism growth GO:0035264 1 0.015
negative regulation of signal transduction GO:0009968 83 0.015
regulation of neurogenesis GO:0050767 247 0.015
positive regulation of peptide hormone secretion GO:0090277 50 0.015
guanosine containing compound catabolic process GO:1901069 71 0.015
regulation of protein localization GO:0032880 81 0.015
response to decreased oxygen levels GO:0036293 237 0.015
positive regulation of neuron projection development GO:0010976 99 0.015
organic anion transport GO:0015711 132 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.014
heart development GO:0007507 72 0.014
cellular response to cytokine stimulus GO:0071345 127 0.014
regulation of homeostatic process GO:0032844 101 0.014
regulation of cell growth GO:0001558 85 0.014
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.014
response to molecule of bacterial origin GO:0002237 194 0.014
regulation of membrane potential GO:0042391 110 0.014
vesicle mediated transport GO:0016192 181 0.014
amine transport GO:0015837 57 0.014
alpha amino acid metabolic process GO:1901605 71 0.014
regulation of nucleoside metabolic process GO:0009118 66 0.014
localization of cell GO:0051674 202 0.014
response to metal ion GO:0010038 253 0.014
gland development GO:0048732 155 0.014
positive regulation of cell differentiation GO:0045597 217 0.014
regulation of anatomical structure size GO:0090066 135 0.014
eye morphogenesis GO:0048592 4 0.014
positive regulation of catabolic process GO:0009896 78 0.014
g protein coupled receptor signaling pathway GO:0007186 242 0.013
signal release GO:0023061 145 0.013
response to other organism GO:0051707 220 0.013
intracellular transport GO:0046907 185 0.013
regulation of ion transmembrane transporter activity GO:0032412 48 0.013
response to estradiol GO:0032355 164 0.013
regulation of ion transmembrane transport GO:0034765 121 0.013
muscle cell proliferation GO:0033002 84 0.013
regulation of purine nucleotide catabolic process GO:0033121 65 0.013
negative regulation of protein metabolic process GO:0051248 114 0.013
kidney development GO:0001822 67 0.013
peptide secretion GO:0002790 86 0.013
blood circulation GO:0008015 183 0.013
regulation of fat cell differentiation GO:0045598 3 0.013
monosaccharide metabolic process GO:0005996 61 0.013
cellular protein localization GO:0034613 122 0.013
positive regulation of signal transduction GO:0009967 175 0.013
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.013
positive regulation of programmed cell death GO:0043068 157 0.013
ribonucleoside monophosphate metabolic process GO:0009161 88 0.013
peptidyl amino acid modification GO:0018193 126 0.013
regulation of blood circulation GO:1903522 110 0.013
dna metabolic process GO:0006259 96 0.013
ossification GO:0001503 70 0.013
negative regulation of biosynthetic process GO:0009890 168 0.013
monovalent inorganic cation transport GO:0015672 172 0.013
carbohydrate derivative biosynthetic process GO:1901137 124 0.012
positive regulation of nucleoside metabolic process GO:0045979 55 0.012
hepaticobiliary system development GO:0061008 90 0.012
response to ketone GO:1901654 182 0.012
positive regulation of nervous system development GO:0051962 178 0.012
regulation of peptide transport GO:0090087 87 0.012
response to biotic stimulus GO:0009607 226 0.012
cellular lipid metabolic process GO:0044255 208 0.012
ras protein signal transduction GO:0007265 29 0.012
nucleoside monophosphate metabolic process GO:0009123 93 0.012
protein heterooligomerization GO:0051291 89 0.012
regulation of nucleotide metabolic process GO:0006140 117 0.012
small gtpase mediated signal transduction GO:0007264 36 0.012
organ morphogenesis GO:0009887 75 0.012
nucleotide biosynthetic process GO:0009165 98 0.012
positive regulation of cell projection organization GO:0031346 111 0.012
regulation of proteasomal protein catabolic process GO:0061136 4 0.012
renal system development GO:0072001 67 0.012
negative regulation of transcription dna templated GO:0045892 116 0.012
peptide transport GO:0015833 97 0.012
organ growth GO:0035265 24 0.012
reactive oxygen species metabolic process GO:0072593 37 0.012
neurotransmitter gated ion channel clustering GO:0072578 3 0.011
cellular macromolecule localization GO:0070727 122 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.011
negative regulation of phosphate metabolic process GO:0045936 80 0.011
negative regulation of cell proliferation GO:0008285 119 0.011
respiratory system development GO:0060541 45 0.011
negative regulation of phosphorus metabolic process GO:0010563 80 0.011
cell type specific apoptotic process GO:0097285 134 0.011
response to vitamin GO:0033273 131 0.011
regulation of establishment of protein localization GO:0070201 69 0.011
sexual reproduction GO:0019953 148 0.011
Rat
single organism behavior GO:0044708 130 0.011
carboxylic acid transport GO:0046942 115 0.011
negative regulation of organ growth GO:0046621 3 0.011
sensory perception of pain GO:0019233 73 0.011
regulation of transmembrane transporter activity GO:0022898 49 0.011
regulation of body fluid levels GO:0050878 90 0.011
positive regulation of hydrolase activity GO:0051345 86 0.011
spermatogenesis GO:0007283 99 0.011
response to low density lipoprotein particle GO:0055098 4 0.011
response to peptide GO:1901652 292 0.011
Mouse
regulation of cell migration GO:0030334 128 0.011
palate development GO:0060021 2 0.011
regulation of cellular amine metabolic process GO:0033238 8 0.011
carbohydrate homeostasis GO:0033500 75 0.011
Mouse
cellular response to external stimulus GO:0071496 118 0.011
macromolecular complex subunit organization GO:0043933 339 0.011
negative regulation of heart growth GO:0061117 3 0.011
reproductive system development GO:0061458 128 0.011
positive regulation of growth GO:0045927 55 0.011
cellular response to alcohol GO:0097306 87 0.011
regulation of developmental growth GO:0048638 45 0.011
small molecule biosynthetic process GO:0044283 124 0.011
cellular response to oxygen levels GO:0071453 60 0.011
single organism intracellular transport GO:1902582 166 0.011
cation transmembrane transport GO:0098655 263 0.010
regulation of locomotion GO:0040012 148 0.010
organ regeneration GO:0031100 101 0.010
negative regulation of cardiac muscle cell proliferation GO:0060044 2 0.010
response to testosterone GO:0033574 55 0.010
negative regulation of phosphorylation GO:0042326 57 0.010
positive regulation of isotype switching GO:0045830 1 0.010
steroid metabolic process GO:0008202 73 0.010
mesenchymal cell proliferation GO:0010463 4 0.010
developmental growth GO:0048589 100 0.010
positive regulation of cell development GO:0010720 176 0.010
response to cold GO:0009409 29 0.010
defense response to gram negative bacterium GO:0050829 3 0.010
positive regulation of fat cell differentiation GO:0045600 2 0.010

Pde3b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.047
nervous system disease DOID:863 0 0.047
disease of metabolism DOID:0014667 0 0.029
sensory system disease DOID:0050155 0 0.015
central nervous system disease DOID:331 0 0.011
inherited metabolic disorder DOID:655 0 0.011