Rattus norvegicus

17 known processes

Wfs1

Wolfram syndrome 1 homolog (human)

Wfs1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular component biogenesis GO:0044085 368 0.083
regulation of cell proliferation GO:0042127 359 0.082
regulation of nucleic acid templated transcription GO:1903506 380 0.080
cellular component assembly GO:0022607 360 0.070
cell motility GO:0048870 202 0.069
single organism biosynthetic process GO:0044711 342 0.066
nucleic acid templated transcription GO:0097659 379 0.065
rna metabolic process GO:0016070 406 0.064
carboxylic acid metabolic process GO:0019752 289 0.064
catabolic process GO:0009056 351 0.063
organic acid metabolic process GO:0006082 292 0.063
locomotion GO:0040011 237 0.061
cell cell signaling GO:0007267 335 0.061
organic substance catabolic process GO:1901575 316 0.059
neuron differentiation GO:0030182 368 0.056
protein complex biogenesis GO:0070271 263 0.055
regulation of rna metabolic process GO:0051252 391 0.053
regulation of locomotion GO:0040012 148 0.050
central nervous system development GO:0007417 311 0.050
nucleoside phosphate metabolic process GO:0006753 283 0.049
cell projection organization GO:0030030 302 0.049
oxoacid metabolic process GO:0043436 290 0.049
organonitrogen compound catabolic process GO:1901565 179 0.049
rna biosynthetic process GO:0032774 380 0.048
cellular response to oxygen containing compound GO:1901701 386 0.048
regulation of rna biosynthetic process GO:2001141 381 0.047
carbohydrate derivative metabolic process GO:1901135 346 0.047
response to metal ion GO:0010038 253 0.044
transcription dna templated GO:0006351 377 0.044
macromolecular complex assembly GO:0065003 273 0.044
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.043
protein complex assembly GO:0006461 263 0.041
head development GO:0060322 247 0.040
nucleoside phosphate catabolic process GO:1901292 140 0.040
secretion GO:0046903 307 0.039
neuron projection development GO:0031175 273 0.038
regulation of signal transduction GO:0009966 318 0.038
localization of cell GO:0051674 202 0.037
positive regulation of response to stimulus GO:0048584 285 0.036
response to oxygen levels GO:0070482 265 0.036
anion transport GO:0006820 178 0.035
ion transmembrane transport GO:0034220 365 0.035
regulation of phosphate metabolic process GO:0019220 349 0.035
nucleoside metabolic process GO:0009116 179 0.035
regulation of apoptotic process GO:0042981 335 0.034
carbohydrate derivative catabolic process GO:1901136 147 0.034
nucleobase containing small molecule metabolic process GO:0055086 316 0.034
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.034
positive regulation of phosphorus metabolic process GO:0010562 262 0.032
neuron projection morphogenesis GO:0048812 122 0.032
single organism catabolic process GO:0044712 283 0.032
cellular component movement GO:0006928 248 0.031
regulation of transcription dna templated GO:0006355 374 0.031
regulation of catalytic activity GO:0050790 304 0.031
apoptotic process GO:0006915 381 0.031
ribonucleoside metabolic process GO:0009119 174 0.031
ribose phosphate metabolic process GO:0019693 235 0.031
blood circulation GO:0008015 183 0.030
regulation of cellular ketone metabolic process GO:0010565 27 0.030
lipid metabolic process GO:0006629 283 0.030
cellular ketone metabolic process GO:0042180 51 0.030
purine ribonucleotide catabolic process GO:0009154 136 0.030
purine containing compound catabolic process GO:0072523 138 0.030
regulation of cellular amino acid metabolic process GO:0006521 2 0.029
synaptic transmission GO:0007268 235 0.029
response to nutrient levels GO:0031667 370 0.029
negative regulation of rna biosynthetic process GO:1902679 118 0.029
macromolecular complex subunit organization GO:0043933 339 0.029
purine ribonucleotide metabolic process GO:0009150 227 0.028
organophosphate metabolic process GO:0019637 370 0.028
organic cyclic compound catabolic process GO:1901361 175 0.028
negative regulation of signaling GO:0023057 157 0.028
aromatic compound catabolic process GO:0019439 168 0.028
response to inorganic substance GO:0010035 377 0.028
response to decreased oxygen levels GO:0036293 237 0.028
regulation of cellular component organization GO:0051128 368 0.027
positive regulation of phosphate metabolic process GO:0045937 262 0.027
cell migration GO:0016477 197 0.027
regulation of cell development GO:0060284 263 0.027
transcription from rna polymerase ii promoter GO:0006366 252 0.027
tissue development GO:0009888 252 0.027
cellular catabolic process GO:0044248 295 0.027
purine nucleotide catabolic process GO:0006195 136 0.027
anterior posterior pattern specification GO:0009952 1 0.027
nucleobase containing compound catabolic process GO:0034655 152 0.027
response to peptide hormone GO:0043434 278 0.027
transmembrane transport GO:0055085 412 0.026
brain development GO:0007420 247 0.026
protein oligomerization GO:0051259 191 0.026
circulatory system process GO:0003013 183 0.026
regulation of hormone levels GO:0010817 187 0.026
response to growth factor GO:0070848 189 0.026
signal release GO:0023061 145 0.026
negative regulation of cell communication GO:0010648 158 0.026
cellular amino acid metabolic process GO:0006520 107 0.025
monocarboxylic acid metabolic process GO:0032787 152 0.025
purine nucleotide metabolic process GO:0006163 229 0.025
homeostatic process GO:0042592 331 0.025
purine nucleoside triphosphate metabolic process GO:0009144 141 0.025
regulation of nervous system development GO:0051960 264 0.025
regulation of catabolic process GO:0009894 113 0.025
nucleotide metabolic process GO:0009117 279 0.025
chemical homeostasis GO:0048878 292 0.025
positive regulation of biosynthetic process GO:0009891 319 0.025
regulation of phosphorus metabolic process GO:0051174 349 0.025
protein complex subunit organization GO:0071822 302 0.025
inorganic cation transmembrane transport GO:0098662 202 0.025
negative regulation of metabolic process GO:0009892 331 0.024
purine ribonucleoside metabolic process GO:0046128 168 0.024
purine nucleoside metabolic process GO:0042278 169 0.024
positive regulation of signaling GO:0023056 270 0.024
negative regulation of rna metabolic process GO:0051253 123 0.024
positive regulation of cellular biosynthetic process GO:0031328 295 0.024
response to extracellular stimulus GO:0009991 380 0.024
regulation of anatomical structure size GO:0090066 135 0.024
regulation of secretion GO:0051046 224 0.023
response to estrogen GO:0043627 232 0.023
nucleoside triphosphate metabolic process GO:0009141 144 0.023
secretion by cell GO:0032940 248 0.023
regulation of cellular catabolic process GO:0031329 101 0.023
amine metabolic process GO:0009308 38 0.022
nucleotide catabolic process GO:0009166 139 0.022
glycosyl compound metabolic process GO:1901657 182 0.022
ribonucleotide metabolic process GO:0009259 231 0.022
positive regulation of developmental process GO:0051094 283 0.022
positive regulation of neurogenesis GO:0050769 165 0.022
purine containing compound metabolic process GO:0072521 253 0.022
regulation of cellular localization GO:0060341 263 0.022
reproductive process GO:0022414 372 0.022
glycosyl compound catabolic process GO:1901658 126 0.022
ribonucleoside catabolic process GO:0042454 126 0.021
regulation of cell motility GO:2000145 131 0.021
positive regulation of multicellular organismal process GO:0051240 387 0.021
positive regulation of molecular function GO:0044093 230 0.021
negative regulation of biosynthetic process GO:0009890 168 0.021
regulation of secretion by cell GO:1903530 208 0.021
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.021
negative regulation of gene expression GO:0010629 199 0.021
regulation of molecular function GO:0065009 398 0.021
regulation of protein metabolic process GO:0051246 289 0.021
negative regulation of cell proliferation GO:0008285 119 0.021
response to nutrient GO:0007584 248 0.021
positive regulation of cell differentiation GO:0045597 217 0.021
negative regulation of nucleic acid templated transcription GO:1903507 117 0.021
single organism cellular localization GO:1902580 102 0.020
cellular lipid metabolic process GO:0044255 208 0.020
gland development GO:0048732 155 0.020
regulation of ion transport GO:0043269 245 0.020
response to acid chemical GO:0001101 222 0.020
multicellular organism growth GO:0035264 1 0.020
regulation of phosphorylation GO:0042325 248 0.020
negative regulation of transcription dna templated GO:0045892 116 0.020
organophosphate catabolic process GO:0046434 148 0.020
regulation of neurogenesis GO:0050767 247 0.020
forebrain development GO:0030900 98 0.020
cellular amine metabolic process GO:0044106 38 0.020
cellular response to nitrogen compound GO:1901699 210 0.020
neuron development GO:0048666 286 0.020
programmed cell death GO:0012501 392 0.020
organic anion transport GO:0015711 132 0.020
negative regulation of macromolecule metabolic process GO:0010605 260 0.020
response to peptide GO:1901652 292 0.020
regulation of programmed cell death GO:0043067 341 0.020
nucleoside triphosphate catabolic process GO:0009143 123 0.020
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.020
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.020
regulation of neuron differentiation GO:0045664 208 0.020
regulation of cell differentiation GO:0045595 320 0.020
regeneration GO:0031099 163 0.019
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.019
positive regulation of catabolic process GO:0009896 78 0.019
positive regulation of protein metabolic process GO:0051247 178 0.019
negative regulation of cellular biosynthetic process GO:0031327 161 0.019
macromolecule localization GO:0033036 252 0.019
oxidation reduction process GO:0055114 304 0.019
inorganic ion transmembrane transport GO:0098660 229 0.019
cell morphogenesis GO:0000902 142 0.019
aging GO:0007568 241 0.019
positive regulation of cell development GO:0010720 176 0.019
organic acid transport GO:0015849 116 0.019
regulation of cellular amine metabolic process GO:0033238 8 0.019
small gtpase mediated signal transduction GO:0007264 36 0.019
cation transport GO:0006812 382 0.019
protein transport GO:0015031 132 0.019
cell projection morphogenesis GO:0048858 123 0.019
positive regulation of cell proliferation GO:0008284 249 0.019
positive regulation of protein phosphorylation GO:0001934 135 0.018
anion transmembrane transport GO:0098656 77 0.018
ribonucleotide catabolic process GO:0009261 136 0.018
regulation of intracellular signal transduction GO:1902531 218 0.018
response to monosaccharide GO:0034284 159 0.018
regulation of nucleotide metabolic process GO:0006140 117 0.018
nitrogen compound transport GO:0071705 229 0.018
positive regulation of cell communication GO:0010647 271 0.018
guanosine containing compound metabolic process GO:1901068 74 0.018
heterocycle catabolic process GO:0046700 167 0.018
single organism organelle organization GO:1902589 180 0.018
multicellular organism reproduction GO:0032504 233 0.018
intracellular transport GO:0046907 185 0.017
response to external biotic stimulus GO:0043207 221 0.017
developmental process involved in reproduction GO:0003006 159 0.017
heart morphogenesis GO:0003007 3 0.017
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.017
multi organism reproductive process GO:0044703 262 0.017
intracellular signal transduction GO:0035556 314 0.017
rhythmic process GO:0048511 156 0.017
single organism reproductive process GO:0044702 297 0.017
response to toxic substance GO:0009636 133 0.017
regulation of protein modification process GO:0031399 194 0.017
regulation of multicellular organismal development GO:2000026 376 0.017
cellular component morphogenesis GO:0032989 155 0.017
regulation of cell migration GO:0030334 128 0.017
cardiac chamber development GO:0003205 1 0.017
cellular response to hormone stimulus GO:0032870 247 0.017
axon development GO:0061564 96 0.017
response to glucose GO:0009749 136 0.017
regulation of protein phosphorylation GO:0001932 183 0.017
regulation of cellular protein metabolic process GO:0032268 267 0.016
regulation of cellular component movement GO:0051270 150 0.016
monovalent inorganic cation transport GO:0015672 172 0.016
regulation of purine nucleotide catabolic process GO:0033121 65 0.016
positive regulation of gene expression GO:0010628 244 0.016
response to ketone GO:1901654 182 0.016
positive regulation of nervous system development GO:0051962 178 0.016
cellular response to endogenous stimulus GO:0071495 377 0.016
peptide secretion GO:0002790 86 0.016
response to carbohydrate GO:0009743 183 0.016
neurological system process GO:0050877 219 0.016
regulation of neuron projection development GO:0010975 161 0.016
positive regulation of cellular amine metabolic process GO:0033240 3 0.016
positive regulation of signal transduction GO:0009967 175 0.016
negative regulation of transport GO:0051051 136 0.016
response to purine containing compound GO:0014074 126 0.016
ras protein signal transduction GO:0007265 29 0.016
positive regulation of transport GO:0051050 245 0.016
positive regulation of gtpase activity GO:0043547 47 0.016
regulation of hydrolase activity GO:0051336 143 0.016
positive regulation of neuron differentiation GO:0045666 126 0.015
negative regulation of cellular metabolic process GO:0031324 281 0.015
axis specification GO:0009798 4 0.015
cation transmembrane transport GO:0098655 263 0.015
response to estradiol GO:0032355 164 0.015
lipid biosynthetic process GO:0008610 128 0.015
positive regulation of cell death GO:0010942 184 0.015
positive regulation of locomotion GO:0040017 102 0.015
response to hypoxia GO:0001666 231 0.015
cellular response to growth factor stimulus GO:0071363 162 0.015
cellular response to organic cyclic compound GO:0071407 202 0.015
cellular nitrogen compound catabolic process GO:0044270 163 0.015
response to wounding GO:0009611 254 0.015
cellular response to lipid GO:0071396 201 0.015
cellular homeostasis GO:0019725 252 0.015
multicellular organismal reproductive process GO:0048609 233 0.015
action potential GO:0001508 54 0.015
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.015
lipid modification GO:0030258 52 0.015
response to mechanical stimulus GO:0009612 134 0.015
response to camp GO:0051591 91 0.015
regulation of body fluid levels GO:0050878 90 0.014
regulation of purine nucleotide metabolic process GO:1900542 115 0.014
single organism behavior GO:0044708 130 0.014
response to organophosphorus GO:0046683 102 0.014
defense response GO:0006952 194 0.014
positive regulation of phosphorylation GO:0042327 177 0.014
regulation of gtp catabolic process GO:0033124 58 0.014
cellular response to external stimulus GO:0071496 118 0.014
regulation of peptide hormone secretion GO:0090276 80 0.014
regulation of peptide transport GO:0090087 87 0.014
regulation of synaptic transmission GO:0050804 141 0.014
carbohydrate metabolic process GO:0005975 130 0.014
reproduction GO:0000003 245 0.014
nucleoside catabolic process GO:0009164 126 0.014
regulation of nucleoside metabolic process GO:0009118 66 0.014
anatomical structure morphogenesis GO:0009653 298 0.014
response to retinoic acid GO:0032526 63 0.014
response to biotic stimulus GO:0009607 226 0.014
purine nucleoside catabolic process GO:0006152 124 0.013
glycogen metabolic process GO:0005977 23 0.013
carboxylic acid transport GO:0046942 115 0.013
positive regulation of rna metabolic process GO:0051254 203 0.013
response to hexose GO:0009746 144 0.013
appendage morphogenesis GO:0035107 4 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.013
positive regulation of transcription dna templated GO:0045893 197 0.013
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.013
negative regulation of response to stimulus GO:0048585 155 0.013
cellular protein localization GO:0034613 122 0.013
telencephalon development GO:0021537 62 0.013
insulin like growth factor receptor signaling pathway GO:0048009 3 0.013
response to interleukin 1 GO:0070555 55 0.013
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.013
positive regulation of catalytic activity GO:0043085 184 0.013
peptidyl amino acid modification GO:0018193 126 0.013
regulation of peptide secretion GO:0002791 82 0.013
regulation of system process GO:0044057 208 0.013
positive regulation of cellular component organization GO:0051130 200 0.013
peptide transport GO:0015833 97 0.013
sexual reproduction GO:0019953 148 0.013
regulation of canonical wnt signaling pathway GO:0060828 4 0.013
response to glucocorticoid GO:0051384 223 0.013
embryonic pattern specification GO:0009880 1 0.013
positive regulation of nucleic acid templated transcription GO:1903508 197 0.013
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.012
ovulation cycle GO:0042698 67 0.012
response to bacterium GO:0009617 200 0.012
positive regulation of programmed cell death GO:0043068 157 0.012
regulation of blood vessel size GO:0050880 89 0.012
cell cycle GO:0007049 101 0.012
sodium ion transport GO:0006814 82 0.012
reactive nitrogen species metabolic process GO:2001057 1 0.012
gliogenesis GO:0042063 93 0.012
positive regulation of cellular catabolic process GO:0031331 71 0.012
positive regulation of apoptotic process GO:0043065 154 0.012
immune system process GO:0002376 204 0.012
enzyme linked receptor protein signaling pathway GO:0007167 116 0.012
wound healing GO:0042060 122 0.012
cellular macromolecule localization GO:0070727 122 0.012
ribonucleoside triphosphate metabolic process GO:0009199 141 0.012
heart contraction GO:0060047 57 0.012
response to corticosteroid GO:0031960 235 0.012
cell growth GO:0016049 104 0.012
regulation of cell projection organization GO:0031344 175 0.012
protein phosphorylation GO:0006468 345 0.012
monocarboxylic acid transport GO:0015718 52 0.012
regulation of transferase activity GO:0051338 123 0.012
single organism intracellular transport GO:1902582 166 0.012
positive regulation of protein modification process GO:0031401 142 0.012
positive regulation of cellular component movement GO:0051272 102 0.011
response to lipopolysaccharide GO:0032496 191 0.011
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.011
positive regulation of nucleotide metabolic process GO:0045981 91 0.011
cell morphogenesis involved in differentiation GO:0000904 119 0.011
negative regulation of multicellular organismal process GO:0051241 203 0.011
purine nucleoside monophosphate metabolic process GO:0009126 84 0.011
negative regulation of protein import into nucleus translocation GO:0033159 1 0.011
ribonucleoside triphosphate catabolic process GO:0009203 122 0.011
behavior GO:0007610 205 0.011
actin filament based process GO:0030029 86 0.011
neuromuscular synaptic transmission GO:0007274 2 0.011
guanosine containing compound catabolic process GO:1901069 71 0.011
cytoplasmic transport GO:0016482 115 0.011
cell part morphogenesis GO:0032990 123 0.011
heart process GO:0003015 57 0.011
single organism carbohydrate metabolic process GO:0044723 118 0.011
regulation of tube size GO:0035150 89 0.011
response to vitamin GO:0033273 131 0.011
positive regulation of secretion GO:0051047 140 0.011
regulation of transmembrane transport GO:0034762 122 0.011
response to other organism GO:0051707 220 0.011
regulation of neurotransmitter levels GO:0001505 42 0.011
regulation of nucleotide catabolic process GO:0030811 65 0.011
hormone transport GO:0009914 121 0.011
response to starvation GO:0042594 59 0.011
positive regulation of cell motility GO:2000147 97 0.011
regulation of hormone secretion GO:0046883 106 0.011
regulation of small gtpase mediated signal transduction GO:0051056 48 0.011
negative regulation of secretion GO:0051048 82 0.011
insulin secretion GO:0030073 69 0.011
muscle structure development GO:0061061 87 0.011
response to ethanol GO:0045471 162 0.011
regulation of behavior GO:0050795 61 0.010
defense response to gram negative bacterium GO:0050829 3 0.010
regulation of membrane potential GO:0042391 110 0.010
muscle cell proliferation GO:0033002 84 0.010
cellular response to cytokine stimulus GO:0071345 127 0.010
pallium development GO:0021543 42 0.010
camera type eye development GO:0043010 48 0.010
motor neuron axon guidance GO:0008045 1 0.010
response to transition metal nanoparticle GO:1990267 122 0.010
response to cytokine GO:0034097 215 0.010
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.010
embryo development GO:0009790 49 0.010
positive regulation of mapk cascade GO:0043410 92 0.010
negative regulation of signal transduction GO:0009968 83 0.010
peptide hormone secretion GO:0030072 84 0.010
response to reactive oxygen species GO:0000302 120 0.010
rho protein signal transduction GO:0007266 11 0.010

Wfs1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.025
nervous system disease DOID:863 0 0.025
disease of metabolism DOID:0014667 0 0.019
cardiovascular system disease DOID:1287 0 0.017
inherited metabolic disorder DOID:655 0 0.016
musculoskeletal system disease DOID:17 0 0.015
central nervous system disease DOID:331 0 0.011