Rattus norvegicus

205 known processes

Men1

multiple endocrine neoplasia 1

(Aliases: MGC114329,menin)

Men1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of rna biosynthetic process GO:2001141 381 0.162
regulation of rna metabolic process GO:0051252 391 0.110
regulation of nucleic acid templated transcription GO:1903506 380 0.097
regulation of transcription dna templated GO:0006355 374 0.097
negative regulation of cellular metabolic process GO:0031324 281 0.090
cellular response to endogenous stimulus GO:0071495 377 0.088
positive regulation of rna metabolic process GO:0051254 203 0.086
negative regulation of gene expression GO:0010629 199 0.085
cellular response to hormone stimulus GO:0032870 247 0.071
rna metabolic process GO:0016070 406 0.061
cellular response to organonitrogen compound GO:0071417 197 0.059
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.058
cellular response to peptide GO:1901653 133 0.058
neurological system process GO:0050877 219 0.057
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.055
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.054
negative regulation of cellular biosynthetic process GO:0031327 161 0.054
regulation of cell proliferation GO:0042127 359 0.053
positive regulation of biosynthetic process GO:0009891 319 0.053
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.051
negative regulation of metabolic process GO:0009892 331 0.051
positive regulation of rna biosynthetic process GO:1902680 197 0.051
cell cell signaling GO:0007267 335 0.051
lipid metabolic process GO:0006629 283 0.050
rna biosynthetic process GO:0032774 380 0.049
organophosphate metabolic process GO:0019637 370 0.048
apoptotic process GO:0006915 381 0.047
transcription dna templated GO:0006351 377 0.046
nucleic acid templated transcription GO:0097659 379 0.046
regulation of cellular localization GO:0060341 263 0.045
multi multicellular organism process GO:0044706 138 0.045
peptidyl amino acid modification GO:0018193 126 0.042
regulation of molecular function GO:0065009 398 0.041
positive regulation of transcription dna templated GO:0045893 197 0.039
positive regulation of programmed cell death GO:0043068 157 0.039
regulation of synaptic transmission GO:0050804 141 0.038
cellular response to oxygen containing compound GO:1901701 386 0.038
proteolysis GO:0006508 175 0.037
multi organism reproductive process GO:0044703 262 0.036
cellular macromolecule localization GO:0070727 122 0.036
single organism reproductive process GO:0044702 297 0.036
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.035
negative regulation of cell communication GO:0010648 158 0.035
regulation of cellular protein metabolic process GO:0032268 267 0.033
positive regulation of cell death GO:0010942 184 0.032
protein localization GO:0008104 191 0.032
transcription from rna polymerase ii promoter GO:0006366 252 0.032
cellular response to peptide hormone stimulus GO:0071375 120 0.031
negative regulation of protein metabolic process GO:0051248 114 0.031
response to extracellular stimulus GO:0009991 380 0.030
negative regulation of macromolecule metabolic process GO:0010605 260 0.030
negative regulation of biosynthetic process GO:0009890 168 0.030
response to peptide GO:1901652 292 0.030
positive regulation of cellular biosynthetic process GO:0031328 295 0.030
protein transport GO:0015031 132 0.029
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.029
cellular response to stress GO:0033554 269 0.029
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.028
reproductive process GO:0022414 372 0.028
cellular ketone metabolic process GO:0042180 51 0.027
positive regulation of phosphate metabolic process GO:0045937 262 0.027
positive regulation of apoptotic process GO:0043065 154 0.027
regulation of cellular ketone metabolic process GO:0010565 27 0.027
immune system process GO:0002376 204 0.027
positive regulation of transport GO:0051050 245 0.027
carbohydrate derivative metabolic process GO:1901135 346 0.026
cellular response to external stimulus GO:0071496 118 0.026
synaptic transmission GO:0007268 235 0.026
positive regulation of cell proliferation GO:0008284 249 0.025
programmed cell death GO:0012501 392 0.025
positive regulation of secretion by cell GO:1903532 128 0.025
defense response GO:0006952 194 0.024
positive regulation of nucleic acid templated transcription GO:1903508 197 0.024
cellular chemical homeostasis GO:0055082 247 0.024
regulation of phosphate metabolic process GO:0019220 349 0.024
response to growth factor GO:0070848 189 0.023
regulation of membrane potential GO:0042391 110 0.023
regulation of apoptotic process GO:0042981 335 0.023
cellular response to cytokine stimulus GO:0071345 127 0.023
cellular response to nitrogen compound GO:1901699 210 0.022
calcium ion homeostasis GO:0055074 162 0.022
regulation of catalytic activity GO:0050790 304 0.022
response to acid chemical GO:0001101 222 0.022
positive regulation of molecular function GO:0044093 230 0.022
single organism behavior GO:0044708 130 0.022
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.022
regulation of secretion GO:0051046 224 0.022
positive regulation of gene expression GO:0010628 244 0.021
vesicle mediated transport GO:0016192 181 0.021
regulation of smooth muscle cell proliferation GO:0048660 75 0.021
protein modification by small protein conjugation GO:0032446 31 0.021
endocytosis GO:0006897 84 0.021
intracellular signal transduction GO:0035556 314 0.020
purine ribonucleotide metabolic process GO:0009150 227 0.020
inflammatory response GO:0006954 150 0.020
reproduction GO:0000003 245 0.020
cell type specific apoptotic process GO:0097285 134 0.020
regulation of programmed cell death GO:0043067 341 0.020
ribonucleotide metabolic process GO:0009259 231 0.019
protein complex assembly GO:0006461 263 0.019
response to peptide hormone GO:0043434 278 0.019
organophosphate catabolic process GO:0046434 148 0.019
positive regulation of catalytic activity GO:0043085 184 0.018
negative regulation of nucleic acid templated transcription GO:1903507 117 0.018
regulation of secretion by cell GO:1903530 208 0.018
sexual reproduction GO:0019953 148 0.018
regulation of locomotion GO:0040012 148 0.018
establishment of protein localization GO:0045184 141 0.018
regulation of protein metabolic process GO:0051246 289 0.018
ion homeostasis GO:0050801 212 0.018
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.018
regulation of lipid metabolic process GO:0019216 68 0.017
regulation of cell differentiation GO:0045595 320 0.017
sensory perception GO:0007600 101 0.017
regulation of neurogenesis GO:0050767 247 0.017
response to hypoxia GO:0001666 231 0.017
negative regulation of rna metabolic process GO:0051253 123 0.017
response to inorganic substance GO:0010035 377 0.017
regulation of anatomical structure size GO:0090066 135 0.017
behavior GO:0007610 205 0.016
single organism carbohydrate metabolic process GO:0044723 118 0.016
anion transmembrane transport GO:0098656 77 0.016
positive regulation of cellular component organization GO:0051130 200 0.016
response to retinoic acid GO:0032526 63 0.016
regulation of protein modification process GO:0031399 194 0.016
glucose metabolic process GO:0006006 52 0.016
cation homeostasis GO:0055080 195 0.016
protein oligomerization GO:0051259 191 0.016
cellular component assembly GO:0022607 360 0.016
negative regulation of cellular component organization GO:0051129 83 0.016
intracellular transport GO:0046907 185 0.016
cellular ion homeostasis GO:0006873 184 0.016
macromolecule localization GO:0033036 252 0.016
negative regulation of signaling GO:0023057 157 0.016
regulation of protein targeting GO:1903533 28 0.016
response to carbohydrate GO:0009743 183 0.016
negative regulation of cellular protein metabolic process GO:0032269 106 0.016
regulation of cell cycle GO:0051726 73 0.016
lipid biosynthetic process GO:0008610 128 0.016
cytoplasmic transport GO:0016482 115 0.015
macromolecular complex subunit organization GO:0043933 339 0.015
regulation of nucleotide metabolic process GO:0006140 117 0.015
regulation of phosphorus metabolic process GO:0051174 349 0.015
regulation of cell projection organization GO:0031344 175 0.015
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.015
cellular lipid metabolic process GO:0044255 208 0.015
cognition GO:0050890 92 0.015
signal release GO:0023061 145 0.015
synaptic growth at neuromuscular junction GO:0051124 1 0.015
regulation of cellular amino acid metabolic process GO:0006521 2 0.015
neuron projection development GO:0031175 273 0.015
chemical homeostasis GO:0048878 292 0.015
response to glucocorticoid GO:0051384 223 0.015
cellular amine metabolic process GO:0044106 38 0.015
single organism intracellular transport GO:1902582 166 0.015
regulation of multicellular organismal development GO:2000026 376 0.015
female pregnancy GO:0007565 122 0.015
negative regulation of molecular function GO:0044092 133 0.015
positive regulation of cell projection organization GO:0031346 111 0.015
single organism biosynthetic process GO:0044711 342 0.015
central nervous system development GO:0007417 311 0.015
nucleotide metabolic process GO:0009117 279 0.015
amine metabolic process GO:0009308 38 0.015
single organism cellular localization GO:1902580 102 0.014
cell projection organization GO:0030030 302 0.014
secretion by cell GO:0032940 248 0.014
response to nutrient GO:0007584 248 0.014
regulation of neuron differentiation GO:0045664 208 0.014
cellular response to growth factor stimulus GO:0071363 162 0.014
negative regulation of rna biosynthetic process GO:1902679 118 0.014
localization of cell GO:0051674 202 0.014
ribose phosphate metabolic process GO:0019693 235 0.014
multicellular organism reproduction GO:0032504 233 0.014
response to nutrient levels GO:0031667 370 0.014
metal ion homeostasis GO:0055065 186 0.014
fertilization GO:0009566 3 0.013
nucleoside phosphate metabolic process GO:0006753 283 0.013
chromatin assembly or disassembly GO:0006333 1 0.013
divalent inorganic cation homeostasis GO:0072507 165 0.013
response to cytokine GO:0034097 215 0.013
cellular component movement GO:0006928 248 0.013
locomotion GO:0040011 237 0.013
secretion GO:0046903 307 0.013
cellular metal ion homeostasis GO:0006875 172 0.013
response to mechanical stimulus GO:0009612 134 0.013
regulation of cell growth GO:0001558 85 0.013
ion transmembrane transport GO:0034220 365 0.013
hexose metabolic process GO:0019318 58 0.013
response to decreased oxygen levels GO:0036293 237 0.013
anatomical structure morphogenesis GO:0009653 298 0.013
cellular protein localization GO:0034613 122 0.013
rhythmic process GO:0048511 156 0.013
gamete generation GO:0007276 124 0.013
carbohydrate metabolic process GO:0005975 130 0.013
response to toxic substance GO:0009636 133 0.013
positive regulation of phosphorus metabolic process GO:0010562 262 0.012
regulation of phosphorylation GO:0042325 248 0.012
negative regulation of transport GO:0051051 136 0.012
cellular response to organic cyclic compound GO:0071407 202 0.012
regulation of cellular component biogenesis GO:0044087 86 0.012
phospholipid metabolic process GO:0006644 61 0.012
protein targeting GO:0006605 61 0.012
muscle cell proliferation GO:0033002 84 0.012
cell motility GO:0048870 202 0.012
cellular cation homeostasis GO:0030003 180 0.012
protein phosphorylation GO:0006468 345 0.012
guanosine containing compound metabolic process GO:1901068 74 0.012
regulation of nervous system development GO:0051960 264 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.012
positive regulation of signaling GO:0023056 270 0.012
cation transport GO:0006812 382 0.012
regulation of kinase activity GO:0043549 117 0.012
carbohydrate derivative biosynthetic process GO:1901137 124 0.012
response to wounding GO:0009611 254 0.012
purine nucleoside metabolic process GO:0042278 169 0.012
cytosolic calcium ion homeostasis GO:0051480 140 0.011
acid secretion GO:0046717 48 0.011
cellular divalent inorganic cation homeostasis GO:0072503 162 0.011
lipid storage GO:0019915 1 0.011
neuron differentiation GO:0030182 368 0.011
negative regulation of nervous system development GO:0051961 79 0.011
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.011
cellular response to acid chemical GO:0071229 75 0.011
learning or memory GO:0007611 90 0.011
cellular response to lipid GO:0071396 201 0.011
cellular response to extracellular stimulus GO:0031668 73 0.011
nucleobase containing small molecule metabolic process GO:0055086 316 0.011
head development GO:0060322 247 0.011
positive regulation of cell development GO:0010720 176 0.011
maintenance of location GO:0051235 17 0.011
homeostatic process GO:0042592 331 0.011
regulation of intracellular transport GO:0032386 65 0.011
negative regulation of innate immune response GO:0045824 4 0.011
regulation of canonical wnt signaling pathway GO:0060828 4 0.011
regulation of cellular amine metabolic process GO:0033238 8 0.011
intracellular protein transport GO:0006886 79 0.011
forebrain development GO:0030900 98 0.011
regulation of dendrite development GO:0050773 59 0.011
response to hexose GO:0009746 144 0.011
circadian rhythm GO:0007623 88 0.011
purine nucleotide catabolic process GO:0006195 136 0.011
nitrogen compound transport GO:0071705 229 0.011
response to glucose GO:0009749 136 0.011
axonogenesis GO:0007409 71 0.011
regulation of immune response GO:0050776 55 0.011
response to corticosteroid GO:0031960 235 0.010
negative regulation of multicellular organismal process GO:0051241 203 0.010
positive regulation of response to stimulus GO:0048584 285 0.010
protein complex subunit organization GO:0071822 302 0.010
oxoacid metabolic process GO:0043436 290 0.010
organic substance catabolic process GO:1901575 316 0.010
catabolic process GO:0009056 351 0.010
ribonucleoside monophosphate metabolic process GO:0009161 88 0.010
positive regulation of cellular amine metabolic process GO:0033240 3 0.010
anion transport GO:0006820 178 0.010
transmembrane transport GO:0055085 412 0.010
regulation of cell development GO:0060284 263 0.010
neuron death GO:0070997 127 0.010
glycosyl compound catabolic process GO:1901658 126 0.010
regulation of immune system process GO:0002682 123 0.010
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.010
organelle organization GO:0006996 266 0.010
enzyme linked receptor protein signaling pathway GO:0007167 116 0.010
protein complex biogenesis GO:0070271 263 0.010
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.010
positive regulation of developmental process GO:0051094 283 0.010
organic acid metabolic process GO:0006082 292 0.010
chromosome organization GO:0051276 36 0.010
calcium ion transport GO:0006816 131 0.010
regulation of neuron projection development GO:0010975 161 0.010
cellular response to insulin stimulus GO:0032869 81 0.010
regulation of signal transduction GO:0009966 318 0.010

Men1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.024
nervous system disease DOID:863 0 0.024
gastrointestinal system cancer DOID:3119 0 0.012
cancer DOID:162 0 0.012
disease of cellular proliferation DOID:14566 0 0.012
organ system cancer DOID:0050686 0 0.012
disease of metabolism DOID:0014667 0 0.010