Rattus norvegicus

21 known processes

Rock1

Rho-associated coiled-coil containing protein kinase 1

(Aliases: P160Rock)

Rock1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
homeostatic process GO:0042592 331 0.136
reproductive process GO:0022414 372 0.116
Fly
cellular response to oxygen containing compound GO:1901701 386 0.115
organelle organization GO:0006996 266 0.091
organ morphogenesis GO:0009887 75 0.089
Fly
cell type specific apoptotic process GO:0097285 134 0.085
Mouse
rna metabolic process GO:0016070 406 0.080
regulation of cell proliferation GO:0042127 359 0.079
regulation of secretion by cell GO:1903530 208 0.078
cellular component assembly GO:0022607 360 0.078
Mouse Fly
epithelium development GO:0060429 96 0.078
Human Mouse Fly
transcription dna templated GO:0006351 377 0.078
protein complex subunit organization GO:0071822 302 0.077
Fly
response to estradiol GO:0032355 164 0.075
protein complex biogenesis GO:0070271 263 0.074
regulation of rna metabolic process GO:0051252 391 0.072
multi organism reproductive process GO:0044703 262 0.071
Fly
cellular component movement GO:0006928 248 0.070
Human Mouse Rat Fly
response to inorganic substance GO:0010035 377 0.069
regulation of rna biosynthetic process GO:2001141 381 0.068
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.068
transcription from rna polymerase ii promoter GO:0006366 252 0.067
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.066
positive regulation of biosynthetic process GO:0009891 319 0.066
reproduction GO:0000003 245 0.063
Fly
response to estrogen GO:0043627 232 0.062
nitrogen compound transport GO:0071705 229 0.061
regulation of cell development GO:0060284 263 0.061
Fly
cellular response to peptide GO:1901653 133 0.061
locomotion GO:0040011 237 0.057
Human Mouse Rat
intracellular signal transduction GO:0035556 314 0.056
cell migration GO:0016477 197 0.055
Human Mouse Rat
single organism reproductive process GO:0044702 297 0.055
Fly
cellular homeostasis GO:0019725 252 0.055
anatomical structure morphogenesis GO:0009653 298 0.054
Human Mouse Fly
carbohydrate derivative biosynthetic process GO:1901137 124 0.054
reproductive system development GO:0061458 128 0.054
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.054
divalent inorganic cation transport GO:0072511 134 0.053
macromolecular complex assembly GO:0065003 273 0.052
negative regulation of macromolecule metabolic process GO:0010605 260 0.051
regulation of cellular component organization GO:0051128 368 0.051
Mouse Fly
rna biosynthetic process GO:0032774 380 0.051
regulation of hormone levels GO:0010817 187 0.050
neuron differentiation GO:0030182 368 0.050
Fly
multicellular organism reproduction GO:0032504 233 0.050
Fly
secretion by cell GO:0032940 248 0.049
muscle structure development GO:0061061 87 0.049
regulation of neuron differentiation GO:0045664 208 0.048
Fly
eye morphogenesis GO:0048592 4 0.048
Fly
brain development GO:0007420 247 0.048
macromolecule localization GO:0033036 252 0.047
Fly
cellular response to endogenous stimulus GO:0071495 377 0.047
cation transport GO:0006812 382 0.046
cell cycle GO:0007049 101 0.046
Fly
cellular response to stress GO:0033554 269 0.046
peptide hormone secretion GO:0030072 84 0.046
cellular catabolic process GO:0044248 295 0.045
protein complex assembly GO:0006461 263 0.045
gamete generation GO:0007276 124 0.045
Fly
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.045
positive regulation of cyclic nucleotide metabolic process GO:0030801 37 0.044
regulation of membrane potential GO:0042391 110 0.043
response to hypoxia GO:0001666 231 0.043
divalent inorganic cation homeostasis GO:0072507 165 0.043
response to peptide GO:1901652 292 0.042
female sex differentiation GO:0046660 59 0.042
negative regulation of signaling GO:0023057 157 0.042
response to decreased oxygen levels GO:0036293 237 0.041
response to oxidative stress GO:0006979 186 0.041
localization of cell GO:0051674 202 0.040
Human Mouse Rat
negative regulation of multicellular organismal process GO:0051241 203 0.040
Human
positive regulation of cellular component organization GO:0051130 200 0.039
Mouse Fly
multicellular organismal reproductive process GO:0048609 233 0.039
Fly
central nervous system development GO:0007417 311 0.038
negative regulation of gene expression GO:0010629 199 0.038
response to corticosteroid GO:0031960 235 0.038
regulation of hormone secretion GO:0046883 106 0.038
cellular component biogenesis GO:0044085 368 0.038
Mouse Fly
developmental process involved in reproduction GO:0003006 159 0.037
Fly
development of primary female sexual characteristics GO:0046545 56 0.037
regulation of nucleic acid templated transcription GO:1903506 380 0.037
signal release GO:0023061 145 0.036
cell motility GO:0048870 202 0.035
Human Mouse Rat
negative regulation of metabolic process GO:0009892 331 0.035
response to glucose GO:0009749 136 0.035
carbohydrate homeostasis GO:0033500 75 0.035
positive regulation of transcription dna templated GO:0045893 197 0.034
regulation of cellular localization GO:0060341 263 0.033
cellular chemical homeostasis GO:0055082 247 0.033
regulation of transcription dna templated GO:0006355 374 0.033
head development GO:0060322 247 0.033
reproductive structure development GO:0048608 128 0.032
organophosphate metabolic process GO:0019637 370 0.032
positive regulation of gene expression GO:0010628 244 0.032
response to glucocorticoid GO:0051384 223 0.032
cell projection organization GO:0030030 302 0.032
Mouse Fly
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.031
carbohydrate metabolic process GO:0005975 130 0.031
response to luteinizing hormone GO:0034699 5 0.031
cellular response to hormone stimulus GO:0032870 247 0.031
response to monosaccharide GO:0034284 159 0.031
cellular component morphogenesis GO:0032989 155 0.031
Mouse Fly
positive regulation of response to stimulus GO:0048584 285 0.031
Fly
apoptotic process GO:0006915 381 0.030
Mouse
response to ketone GO:1901654 182 0.030
ion homeostasis GO:0050801 212 0.030
regulation of neuron apoptotic process GO:0043523 83 0.030
Mouse
response to anoxia GO:0034059 4 0.030
cation homeostasis GO:0055080 195 0.030
positive regulation of rna metabolic process GO:0051254 203 0.030
neuron projection development GO:0031175 273 0.030
Fly
response to oxygen levels GO:0070482 265 0.029
positive regulation of cell proliferation GO:0008284 249 0.029
positive regulation of cell communication GO:0010647 271 0.029
nucleic acid templated transcription GO:0097659 379 0.029
macromolecular complex subunit organization GO:0043933 339 0.029
Fly
regulation of cell differentiation GO:0045595 320 0.029
Human Fly
neuron death GO:0070997 127 0.029
Mouse
negative regulation of cellular metabolic process GO:0031324 281 0.028
single organism carbohydrate metabolic process GO:0044723 118 0.028
cellular response to corticosteroid stimulus GO:0071384 69 0.028
cellular response to steroid hormone stimulus GO:0071383 93 0.027
calcium ion homeostasis GO:0055074 162 0.027
tissue development GO:0009888 252 0.027
Human Mouse Fly
male mating behavior GO:0060179 3 0.026
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.026
sex differentiation GO:0007548 113 0.026
g protein coupled receptor signaling pathway GO:0007186 242 0.026
regulation of intracellular signal transduction GO:1902531 218 0.026
Rat
dna metabolic process GO:0006259 96 0.026
purine nucleotide metabolic process GO:0006163 229 0.026
hormone secretion GO:0046879 115 0.026
cellular divalent inorganic cation homeostasis GO:0072503 162 0.026
regulation of multicellular organismal development GO:2000026 376 0.025
Human Fly
regulation of cellular protein metabolic process GO:0032268 267 0.025
Fly
alternative mrna splicing via spliceosome GO:0000380 4 0.025
chemical homeostasis GO:0048878 292 0.025
immune system process GO:0002376 204 0.025
Human
regulation of immune system process GO:0002682 123 0.024
positive regulation of nucleotide biosynthetic process GO:0030810 36 0.024
divalent metal ion transport GO:0070838 132 0.024
negative regulation of nucleic acid templated transcription GO:1903507 117 0.024
synaptic growth at neuromuscular junction GO:0051124 1 0.024
negative regulation of cellular biosynthetic process GO:0031327 161 0.024
negative regulation of cell death GO:0060548 229 0.024
Mouse
regulation of neuron projection development GO:0010975 161 0.023
Fly
muscle tissue development GO:0060537 58 0.023
neuron apoptotic process GO:0051402 88 0.023
Mouse
response to carbohydrate GO:0009743 183 0.023
cell cycle process GO:0022402 57 0.023
Fly
positive regulation of secretion GO:0051047 140 0.023
cellular response to lipid GO:0071396 201 0.023
response to hexose GO:0009746 144 0.023
regulation of secretion GO:0051046 224 0.023
regulation of cell projection organization GO:0031344 175 0.022
Fly
positive regulation of nucleotide metabolic process GO:0045981 91 0.022
biological adhesion GO:0022610 110 0.022
Human Mouse Fly
regulation of cell migration GO:0030334 128 0.022
negative regulation of response to stimulus GO:0048585 155 0.022
negative regulation of transport GO:0051051 136 0.022
Fly
peptide secretion GO:0002790 86 0.022
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.021
mapk cascade GO:0000165 140 0.021
behavior GO:0007610 205 0.021
carbohydrate derivative metabolic process GO:1901135 346 0.021
cellular carbohydrate metabolic process GO:0044262 72 0.021
synaptic transmission GO:0007268 235 0.021
positive regulation of cell development GO:0010720 176 0.021
female gonad development GO:0008585 53 0.021
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.021
cell morphogenesis GO:0000902 142 0.021
Mouse Fly
positive regulation of signaling GO:0023056 270 0.021
positive regulation of cellular biosynthetic process GO:0031328 295 0.021
neurological system process GO:0050877 219 0.021
protein oligomerization GO:0051259 191 0.020
positive regulation of nucleic acid templated transcription GO:1903508 197 0.020
purine nucleotide biosynthetic process GO:0006164 83 0.020
regulation of neuron death GO:1901214 115 0.020
Mouse
regulation of peptide hormone secretion GO:0090276 80 0.020
regulation of ion transport GO:0043269 245 0.020
regulation of carbohydrate metabolic process GO:0006109 41 0.020
sympathetic nervous system development GO:0048485 1 0.020
lipid metabolic process GO:0006629 283 0.020
calcium ion transport GO:0006816 131 0.019
ras protein signal transduction GO:0007265 29 0.019
forebrain development GO:0030900 98 0.019
axis specification GO:0009798 4 0.019
Fly
negative regulation of transcription dna templated GO:0045892 116 0.019
regulation of cellular catabolic process GO:0031329 101 0.019
positive regulation of signal transduction GO:0009967 175 0.019
glucose homeostasis GO:0042593 75 0.019
cellular ion homeostasis GO:0006873 184 0.019
positive regulation of calcium ion transport GO:0051928 36 0.019
regulation of nervous system development GO:0051960 264 0.019
Fly
cellular metal ion homeostasis GO:0006875 172 0.019
regulation of homeostatic process GO:0032844 101 0.019
regulation of programmed cell death GO:0043067 341 0.019
Mouse
cellular response to peptide hormone stimulus GO:0071375 120 0.019
positive regulation of peptide hormone secretion GO:0090277 50 0.019
regulation of anatomical structure morphogenesis GO:0022603 141 0.019
Human Fly
vesicle mediated transport GO:0016192 181 0.018
response to metal ion GO:0010038 253 0.018
regulation of phosphate metabolic process GO:0019220 349 0.018
Fly
catabolic process GO:0009056 351 0.018
negative regulation of cellular protein metabolic process GO:0032269 106 0.018
positive regulation of rna biosynthetic process GO:1902680 197 0.018
cellular response to nitrogen compound GO:1901699 210 0.018
protein localization GO:0008104 191 0.018
Fly
cell adhesion GO:0007155 110 0.018
Human Mouse
regulation of system process GO:0044057 208 0.018
insulin secretion GO:0030073 69 0.018
heart morphogenesis GO:0003007 3 0.018
positive regulation of transport GO:0051050 245 0.018
negative regulation of cell communication GO:0010648 158 0.018
secretion GO:0046903 307 0.018
defecation GO:0030421 1 0.018
positive regulation of catalytic activity GO:0043085 184 0.017
positive regulation of neuron differentiation GO:0045666 126 0.017
transmission of nerve impulse GO:0019226 42 0.017
cellular response to hexose stimulus GO:0071331 65 0.017
aging GO:0007568 241 0.017
reactive oxygen species metabolic process GO:0072593 37 0.017
negative regulation of protein metabolic process GO:0051248 114 0.017
protein heterooligomerization GO:0051291 89 0.017
single organism cellular localization GO:1902580 102 0.017
response to radiation GO:0009314 137 0.017
single organism behavior GO:0044708 130 0.017
actin filament based process GO:0030029 86 0.017
Mouse Rat Fly
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.017
sexual reproduction GO:0019953 148 0.017
Fly
regulation of behavior GO:0050795 61 0.017
response to nutrient levels GO:0031667 370 0.016
small gtpase mediated signal transduction GO:0007264 36 0.016
tube development GO:0035295 89 0.016
Fly
hormone biosynthetic process GO:0042446 25 0.016
single organism intracellular transport GO:1902582 166 0.016
positive regulation of ion transport GO:0043270 94 0.016
response to ethanol GO:0045471 162 0.016
response to vitamin GO:0033273 131 0.016
cellular response to organic cyclic compound GO:0071407 202 0.016
positive regulation of developmental process GO:0051094 283 0.016
positive regulation of secretion by cell GO:1903532 128 0.016
regulation of molecular function GO:0065009 398 0.016
positive regulation of behavior GO:0048520 38 0.016
regulation of cell motility GO:2000145 131 0.016
female mating behavior GO:0060180 6 0.015
leukocyte activation GO:0045321 76 0.015
regulation of apoptotic process GO:0042981 335 0.015
Mouse
cellular macromolecule localization GO:0070727 122 0.015
Fly
cellular response to glucose stimulus GO:0071333 65 0.015
cellular ketone metabolic process GO:0042180 51 0.015
neuron development GO:0048666 286 0.015
Fly
purine ribonucleotide biosynthetic process GO:0009152 81 0.015
cellular calcium ion homeostasis GO:0006874 160 0.015
nucleotide metabolic process GO:0009117 279 0.015
epithelial cell differentiation GO:0030855 71 0.015
Human Mouse Fly
regulation of peptide secretion GO:0002791 82 0.015
response to cytokine GO:0034097 215 0.015
growth GO:0040007 165 0.015
Fly
single organism organelle organization GO:1902589 180 0.015
Mouse Rat Fly
positive regulation of molecular function GO:0044093 230 0.015
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.015
response to ionizing radiation GO:0010212 59 0.015
regulation of blood vessel size GO:0050880 89 0.015
regulation of peptide transport GO:0090087 87 0.015
positive regulation of camp metabolic process GO:0030816 31 0.015
regulation of anatomical structure size GO:0090066 135 0.015
regulation of calcium ion transport GO:0051924 77 0.015
sequestering of calcium ion GO:0051208 8 0.015
hormone metabolic process GO:0042445 69 0.015
positive regulation of cellular amine metabolic process GO:0033240 3 0.015
cellular response to alcohol GO:0097306 87 0.015
proteolysis GO:0006508 175 0.015
cytoplasmic transport GO:0016482 115 0.014
cellular cation homeostasis GO:0030003 180 0.014
regulation of catalytic activity GO:0050790 304 0.014
single organism biosynthetic process GO:0044711 342 0.014
maintenance of location GO:0051235 17 0.014
Fly
nucleobase containing small molecule metabolic process GO:0055086 316 0.014
response to growth factor GO:0070848 189 0.014
regulation of phosphorus metabolic process GO:0051174 349 0.014
Fly
dephosphorylation GO:0016311 98 0.014
exploration behavior GO:0035640 1 0.014
cellular amino acid metabolic process GO:0006520 107 0.014
developmental growth GO:0048589 100 0.014
Fly
negative regulation of secretion GO:0051048 82 0.014
positive regulation of purine nucleotide biosynthetic process GO:1900373 36 0.014
gonad development GO:0008406 104 0.014
cellular response to insulin stimulus GO:0032869 81 0.014
regulation of dna metabolic process GO:0051052 60 0.014
establishment of protein localization GO:0045184 141 0.014
Fly
nucleoside phosphate metabolic process GO:0006753 283 0.014
positive regulation of intracellular signal transduction GO:1902533 138 0.014
anterior posterior pattern specification GO:0009952 1 0.014
meiotic cell cycle process GO:1903046 3 0.014
embryonic pattern specification GO:0009880 1 0.014
chromosome organization GO:0051276 36 0.014
oxidation reduction process GO:0055114 304 0.014
muscle cell differentiation GO:0042692 52 0.014
purine nucleoside triphosphate metabolic process GO:0009144 141 0.014
rhythmic process GO:0048511 156 0.014
development of primary sexual characteristics GO:0045137 107 0.013
circulatory system development GO:0072359 134 0.013
Human
negative regulation of biosynthetic process GO:0009890 168 0.013
regulation of defense response GO:0031347 68 0.013
positive regulation of hormone secretion GO:0046887 65 0.013
kidney development GO:0001822 67 0.013
amide transport GO:0042886 105 0.013
positive regulation of cell migration GO:0030335 96 0.013
metal ion transport GO:0030001 289 0.013
organ regeneration GO:0031100 101 0.013
circulatory system process GO:0003013 183 0.013
male gamete generation GO:0048232 99 0.013
dendrite development GO:0016358 72 0.013
regulation of nucleotide metabolic process GO:0006140 117 0.013
negative regulation of secretion by cell GO:1903531 72 0.013
organophosphate biosynthetic process GO:0090407 143 0.013
purine containing compound biosynthetic process GO:0072522 85 0.013
regulation of response to external stimulus GO:0032101 106 0.013
multi multicellular organism process GO:0044706 138 0.013
cell activation GO:0001775 97 0.013
cellular response to external stimulus GO:0071496 118 0.013
cell cycle checkpoint GO:0000075 2 0.013
programmed cell death GO:0012501 392 0.013
Mouse
erk1 and erk2 cascade GO:0070371 48 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.012
b cell differentiation GO:0030183 2 0.012
steroid metabolic process GO:0008202 73 0.012
deoxyribose phosphate metabolic process GO:0019692 9 0.012
regulation of protein metabolic process GO:0051246 289 0.012
Fly
camera type eye morphogenesis GO:0048593 2 0.012
regulation of protein serine threonine kinase activity GO:0071900 64 0.012
response to nutrient GO:0007584 248 0.012
spermatogenesis GO:0007283 99 0.012
positive regulation of locomotion GO:0040017 102 0.012
smooth muscle cell apoptotic process GO:0034390 7 0.012
regulation of small gtpase mediated signal transduction GO:0051056 48 0.012
Rat
ribose phosphate metabolic process GO:0019693 235 0.012
gastrulation GO:0007369 2 0.012
Fly
positive regulation of endothelial cell migration GO:0010595 4 0.012
dna integrity checkpoint GO:0031570 2 0.012
heart development GO:0007507 72 0.012
positive regulation of neurogenesis GO:0050769 165 0.012
ribonucleotide biosynthetic process GO:0009260 85 0.012
positive regulation of phosphorylation GO:0042327 177 0.011
cardiovascular system development GO:0072358 134 0.011
Human
regulation of catabolic process GO:0009894 113 0.011
negative regulation of rna metabolic process GO:0051253 123 0.011
cell cell signaling GO:0007267 335 0.011
cellular response to carbohydrate stimulus GO:0071322 72 0.011
urogenital system development GO:0001655 78 0.011
cytosolic calcium ion homeostasis GO:0051480 140 0.011
sensory perception GO:0007600 101 0.011
negative regulation of neuron death GO:1901215 69 0.011
Mouse
cellular response to abiotic stimulus GO:0071214 85 0.011
cellular lipid metabolic process GO:0044255 208 0.011
response to reactive oxygen species GO:0000302 120 0.011
nucleoside phosphate biosynthetic process GO:1901293 102 0.011
regulation of cellular ketone metabolic process GO:0010565 27 0.011
mrna metabolic process GO:0016071 20 0.011
regulation of cellular amino acid metabolic process GO:0006521 2 0.011
artery development GO:0060840 3 0.011
regulation of map kinase activity GO:0043405 53 0.011
regulation of phosphorylation GO:0042325 248 0.011
Fly
hormone transport GO:0009914 121 0.011
regulation of purine nucleotide metabolic process GO:1900542 115 0.011
metal ion homeostasis GO:0055065 186 0.011
regulation of body fluid levels GO:0050878 90 0.011
limbic system development GO:0021761 38 0.011
sequestering of metal ion GO:0051238 9 0.011
mitotic cell cycle process GO:1903047 35 0.011
Fly
organ formation GO:0048645 3 0.011
regulation of tube size GO:0035150 89 0.011
positive regulation of cyclic nucleotide biosynthetic process GO:0030804 34 0.011
response to extracellular stimulus GO:0009991 380 0.011
protein targeting GO:0006605 61 0.011
negative regulation of luteinizing hormone secretion GO:0033685 4 0.011
regulation of signal transduction GO:0009966 318 0.011
Rat Fly
regulation of insulin secretion GO:0050796 65 0.011
positive regulation of neuron apoptotic process GO:0043525 33 0.010
cellular response to monosaccharide stimulus GO:0071326 67 0.010
regulation of lipid metabolic process GO:0019216 68 0.010
response to fatty acid GO:0070542 65 0.010
peptide transport GO:0015833 97 0.010
cell growth GO:0016049 104 0.010
cell morphogenesis involved in differentiation GO:0000904 119 0.010
Mouse Fly
amine metabolic process GO:0009308 38 0.010
positive regulation of cell differentiation GO:0045597 217 0.010
cellular glucose homeostasis GO:0001678 66 0.010
regulation of sodium ion transmembrane transporter activity GO:2000649 4 0.010
digestive system development GO:0055123 41 0.010
Fly
cellular response to growth factor stimulus GO:0071363 162 0.010
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 51 0.010

Rock1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.029
disease of cellular proliferation DOID:14566 0 0.029
gastrointestinal system cancer DOID:3119 0 0.022
organ system cancer DOID:0050686 0 0.022
retinal disease DOID:5679 0 0.022
sensory system disease DOID:0050155 0 0.022
disease of anatomical entity DOID:7 0 0.022
eye and adnexa disease DOID:1492 0 0.022
nervous system disease DOID:863 0 0.022
eye disease DOID:5614 0 0.022
disease of metabolism DOID:0014667 0 0.014
colon carcinoma DOID:1520 0 0.014
large intestine cancer DOID:5672 0 0.014
colon cancer DOID:219 0 0.014
intestinal cancer DOID:10155 0 0.014
colorectal cancer DOID:9256 0 0.014