Rattus norvegicus

86 known processes

Ctsl1

cathepsin L1

(Aliases: Ctsl,CATHL)

Ctsl1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular catabolic process GO:0044248 295 0.587
response to mechanical stimulus GO:0009612 134 0.374
wound healing GO:0042060 122 0.349
regulation of programmed cell death GO:0043067 341 0.344
response to other organism GO:0051707 220 0.320
catabolic process GO:0009056 351 0.320
response to peptide GO:1901652 292 0.314
response to molecule of bacterial origin GO:0002237 194 0.281
regulation of molecular function GO:0065009 398 0.266
vesicle mediated transport GO:0016192 181 0.264
multicellular organismal catabolic process GO:0044243 2 0.226
oxoacid metabolic process GO:0043436 290 0.220
carboxylic acid metabolic process GO:0019752 289 0.208
response to biotic stimulus GO:0009607 226 0.206
single organism catabolic process GO:0044712 283 0.203
programmed cell death GO:0012501 392 0.192
response to inorganic substance GO:0010035 377 0.188
regulation of catalytic activity GO:0050790 304 0.187
organic substance catabolic process GO:1901575 316 0.187
regulation of vesicle mediated transport GO:0060627 81 0.181
blood coagulation GO:0007596 26 0.173
tissue development GO:0009888 252 0.172
regulation of ion transport GO:0043269 245 0.170
neuron differentiation GO:0030182 368 0.162
response to reactive oxygen species GO:0000302 120 0.159
protein maturation GO:0051604 68 0.159
Mouse
regulation of hemostasis GO:1900046 9 0.159
endocytosis GO:0006897 84 0.157
regulation of apoptotic process GO:0042981 335 0.154
positive regulation of transport GO:0051050 245 0.151
response to external biotic stimulus GO:0043207 221 0.151
carbohydrate derivative metabolic process GO:1901135 346 0.143
lymphocyte activation GO:0046649 43 0.138
response to cytokine GO:0034097 215 0.138
regulation of cell motility GO:2000145 131 0.132
cell motility GO:0048870 202 0.129
macromolecule localization GO:0033036 252 0.123
regulation of protein metabolic process GO:0051246 289 0.120
multicellular organismal homeostasis GO:0048871 49 0.118
Rat
regulation of cellular component organization GO:0051128 368 0.117
Mouse
apoptotic process GO:0006915 381 0.111
brain development GO:0007420 247 0.111
locomotion GO:0040011 237 0.110
response to wounding GO:0009611 254 0.109
positive regulation of catalytic activity GO:0043085 184 0.108
synaptic transmission GO:0007268 235 0.108
cellular response to alcohol GO:0097306 87 0.108
cell type specific apoptotic process GO:0097285 134 0.106
protein complex assembly GO:0006461 263 0.105
anatomical structure morphogenesis GO:0009653 298 0.105
Mouse
cellular response to starvation GO:0009267 27 0.104
regulation of vasculature development GO:1901342 44 0.103
organic acid metabolic process GO:0006082 292 0.100
axon development GO:0061564 96 0.100
cell projection organization GO:0030030 302 0.095
regulation of rna biosynthetic process GO:2001141 381 0.093
regulation of cellular protein metabolic process GO:0032268 267 0.092
regulation of cell proliferation GO:0042127 359 0.092
Mouse
response to hydrogen peroxide GO:0042542 89 0.091
central nervous system development GO:0007417 311 0.091
metal ion transport GO:0030001 289 0.087
single organism intracellular transport GO:1902582 166 0.087
cellular amine metabolic process GO:0044106 38 0.085
neuron apoptotic process GO:0051402 88 0.085
positive regulation of developmental process GO:0051094 283 0.085
localization of cell GO:0051674 202 0.084
sexual reproduction GO:0019953 148 0.083
negative regulation of molecular function GO:0044092 133 0.082
positive regulation of multicellular organismal process GO:0051240 387 0.081
head development GO:0060322 247 0.079
cellular component movement GO:0006928 248 0.078
regeneration GO:0031099 163 0.078
single organism cellular localization GO:1902580 102 0.077
positive regulation of signaling GO:0023056 270 0.076
homeostatic process GO:0042592 331 0.076
Rat
coagulation GO:0050817 28 0.074
multicellular organism reproduction GO:0032504 233 0.074
negative regulation of programmed cell death GO:0043069 183 0.074
amine metabolic process GO:0009308 38 0.073
neuron projection development GO:0031175 273 0.073
blood vessel morphogenesis GO:0048514 58 0.073
response to lipopolysaccharide GO:0032496 191 0.072
cellular component biogenesis GO:0044085 368 0.071
regulation of body fluid levels GO:0050878 90 0.071
developmental growth GO:0048589 100 0.069
glycosyl compound catabolic process GO:1901658 126 0.067
neuron projection morphogenesis GO:0048812 122 0.066
regulation of signal transduction GO:0009966 318 0.065
negative regulation of cell death GO:0060548 229 0.065
regulation of neuron differentiation GO:0045664 208 0.064
membrane organization GO:0061024 94 0.063
negative regulation of response to wounding GO:1903035 23 0.061
negative regulation of apoptotic process GO:0043066 181 0.061
positive regulation of nervous system development GO:0051962 178 0.060
autophagy GO:0006914 19 0.060
positive regulation of molecular function GO:0044093 230 0.059
reproductive process GO:0022414 372 0.059
cellular component assembly GO:0022607 360 0.059
glycosyl compound metabolic process GO:1901657 182 0.059
single organism membrane organization GO:0044802 74 0.057
ribonucleoside triphosphate metabolic process GO:0009199 141 0.057
cell projection morphogenesis GO:0048858 123 0.056
positive regulation of response to stimulus GO:0048584 285 0.056
regulation of wound healing GO:0061041 14 0.056
regulation of locomotion GO:0040012 148 0.055
single organism reproductive process GO:0044702 297 0.054
regulation of immunoglobulin production GO:0002637 4 0.053
positive regulation of cell communication GO:0010647 271 0.052
cellular response to endogenous stimulus GO:0071495 377 0.052
cell activation GO:0001775 97 0.052
response to oxidative stress GO:0006979 186 0.052
angiogenesis GO:0001525 53 0.052
cellular response to organic cyclic compound GO:0071407 202 0.051
receptor mediated endocytosis GO:0006898 42 0.051
protein targeting GO:0006605 61 0.051
protein localization to membrane GO:0072657 36 0.051
macromolecular complex assembly GO:0065003 273 0.050
monovalent inorganic cation transport GO:0015672 172 0.050
response to nutrient levels GO:0031667 370 0.049
purine containing compound catabolic process GO:0072523 138 0.048
reproductive structure development GO:0048608 128 0.048
tube development GO:0035295 89 0.047
protein complex biogenesis GO:0070271 263 0.046
growth GO:0040007 165 0.046
epithelium development GO:0060429 96 0.046
response to hypoxia GO:0001666 231 0.046
single fertilization GO:0007338 3 0.046
cellular macromolecule localization GO:0070727 122 0.045
negative regulation of cell proliferation GO:0008285 119 0.045
Mouse
regulation of cellular amine metabolic process GO:0033238 8 0.044
positive regulation of neuron differentiation GO:0045666 126 0.044
response to peptide hormone GO:0043434 278 0.044
negative regulation of transport GO:0051051 136 0.044
inorganic cation transmembrane transport GO:0098662 202 0.044
monocarboxylic acid metabolic process GO:0032787 152 0.043
protein processing GO:0016485 68 0.042
Mouse
amide transport GO:0042886 105 0.042
epithelial cell differentiation GO:0030855 71 0.042
anatomical structure formation involved in morphogenesis GO:0048646 83 0.042
response to bacterium GO:0009617 200 0.042
ion transmembrane transport GO:0034220 365 0.041
immune effector process GO:0002252 53 0.040
organic cyclic compound catabolic process GO:1901361 175 0.040
gliogenesis GO:0042063 93 0.040
neuron death GO:0070997 127 0.040
positive regulation of cell proliferation GO:0008284 249 0.039
defense response GO:0006952 194 0.039
positive regulation of cell differentiation GO:0045597 217 0.039
positive regulation of cell motility GO:2000147 97 0.039
regulation of response to wounding GO:1903034 69 0.039
carbohydrate derivative catabolic process GO:1901136 147 0.038
regulation of cell differentiation GO:0045595 320 0.038
regulation of cellular localization GO:0060341 263 0.037
striated muscle tissue development GO:0014706 58 0.037
chemical homeostasis GO:0048878 292 0.037
transmembrane transport GO:0055085 412 0.036
cell migration GO:0016477 197 0.036
cellular response to glucocorticoid stimulus GO:0071385 68 0.036
regulation of hydrolase activity GO:0051336 143 0.036
positive regulation of signal transduction GO:0009967 175 0.036
nucleoside triphosphate metabolic process GO:0009141 144 0.036
regulation of multicellular organismal development GO:2000026 376 0.036
intracellular protein transport GO:0006886 79 0.036
protein oligomerization GO:0051259 191 0.036
cellular amino acid metabolic process GO:0006520 107 0.035
hemostasis GO:0007599 26 0.035
fertilization GO:0009566 3 0.035
regulation of neuron projection development GO:0010975 161 0.035
proteolysis GO:0006508 175 0.035
purine ribonucleotide catabolic process GO:0009154 136 0.034
cellular ketone metabolic process GO:0042180 51 0.034
ribonucleotide catabolic process GO:0009261 136 0.034
regulation of immune response GO:0050776 55 0.034
negative regulation of multicellular organismal process GO:0051241 203 0.034
regulation of cell development GO:0060284 263 0.034
nucleotide metabolic process GO:0009117 279 0.034
cellular protein localization GO:0034613 122 0.033
regulation of cellular component movement GO:0051270 150 0.033
cation transport GO:0006812 382 0.033
aging GO:0007568 241 0.033
regulation of anatomical structure morphogenesis GO:0022603 141 0.033
blood vessel development GO:0001568 69 0.033
neuron development GO:0048666 286 0.033
positive regulation of cellular component organization GO:0051130 200 0.033
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.032
regulation of phosphorylation GO:0042325 248 0.032
nucleotide catabolic process GO:0009166 139 0.032
peptidyl tyrosine modification GO:0018212 72 0.032
muscle tissue development GO:0060537 58 0.032
negative regulation of metabolic process GO:0009892 331 0.032
regulation of endocytosis GO:0030100 42 0.032
cellular response to oxygen containing compound GO:1901701 386 0.032
organonitrogen compound catabolic process GO:1901565 179 0.031
negative regulation of hemostasis GO:1900047 6 0.031
purine ribonucleotide metabolic process GO:0009150 227 0.031
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.031
intracellular transport GO:0046907 185 0.031
cell junction organization GO:0034330 21 0.031
positive regulation of cell migration GO:0030335 96 0.030
negative regulation of macromolecule metabolic process GO:0010605 260 0.030
response to estrogen GO:0043627 232 0.030
epithelial cell migration GO:0010631 19 0.030
rubidium ion transport GO:0035826 1 0.029
regulation of intracellular signal transduction GO:1902531 218 0.029
heterocycle catabolic process GO:0046700 167 0.029
negative regulation of response to stimulus GO:0048585 155 0.029
cellular response to external stimulus GO:0071496 118 0.029
autophagic cell death GO:0048102 4 0.028
positive regulation of programmed cell death GO:0043068 157 0.028
purine ribonucleoside catabolic process GO:0046130 124 0.028
cell cell signaling GO:0007267 335 0.028
nucleoside catabolic process GO:0009164 126 0.028
receptor internalization GO:0031623 14 0.028
cellular response to growth factor stimulus GO:0071363 162 0.028
purine nucleotide catabolic process GO:0006195 136 0.027
rna metabolic process GO:0016070 406 0.027
positive regulation of cellular amine metabolic process GO:0033240 3 0.027
positive regulation of phosphate metabolic process GO:0045937 262 0.027
nucleoside phosphate catabolic process GO:1901292 140 0.026
negative regulation of humoral immune response GO:0002921 4 0.026
multicellular organismal reproductive process GO:0048609 233 0.026
ribose phosphate metabolic process GO:0019693 235 0.026
regulation of cellular ketone metabolic process GO:0010565 27 0.026
intracellular signal transduction GO:0035556 314 0.026
muscle structure development GO:0061061 87 0.025
regulation of transcription dna templated GO:0006355 374 0.025
cellular response to nitrogen compound GO:1901699 210 0.025
negative regulation of endopeptidase activity GO:0010951 36 0.025
regulation of immune system process GO:0002682 123 0.025
positive regulation of cell development GO:0010720 176 0.025
multi organism reproductive process GO:0044703 262 0.025
muscle organ development GO:0007517 50 0.025
ribonucleotide metabolic process GO:0009259 231 0.025
response to glucose GO:0009749 136 0.024
regulation of secretion GO:0051046 224 0.024
nucleobase containing compound catabolic process GO:0034655 152 0.024
positive regulation of locomotion GO:0040017 102 0.024
reproduction GO:0000003 245 0.024
cellular divalent inorganic cation homeostasis GO:0072503 162 0.024
regulation of rna metabolic process GO:0051252 391 0.024
regulation of response to stress GO:0080134 126 0.023
response to estradiol GO:0032355 164 0.023
regulation of cellular amino acid metabolic process GO:0006521 2 0.023
immune system process GO:0002376 204 0.023
macromolecular complex subunit organization GO:0043933 339 0.023
cellular protein catabolic process GO:0044257 19 0.023
establishment of protein localization GO:0045184 141 0.023
cellular modified amino acid metabolic process GO:0006575 61 0.023
axonogenesis GO:0007409 71 0.023
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.022
multi multicellular organism process GO:0044706 138 0.022
ameboidal type cell migration GO:0001667 26 0.022
cell adhesion GO:0007155 110 0.022
aromatic compound catabolic process GO:0019439 168 0.022
regulation of blood coagulation GO:0030193 9 0.022
purine nucleotide metabolic process GO:0006163 229 0.022
nucleoside triphosphate catabolic process GO:0009143 123 0.022
acute inflammatory response GO:0002526 58 0.022
cellular response to nutrient levels GO:0031669 60 0.021
protein phosphorylation GO:0006468 345 0.021
regulation of epithelial cell migration GO:0010632 17 0.021
negative regulation of protein maturation GO:1903318 47 0.021
respiratory system development GO:0060541 45 0.021
secretion GO:0046903 307 0.021
regulation of catabolic process GO:0009894 113 0.021
single organism carbohydrate metabolic process GO:0044723 118 0.021
purine nucleoside metabolic process GO:0042278 169 0.021
response to extracellular stimulus GO:0009991 380 0.021
dna conformation change GO:0071103 10 0.021
protein complex subunit organization GO:0071822 302 0.020
response to growth factor GO:0070848 189 0.020
cellular response to stress GO:0033554 269 0.020
cellular response to extracellular stimulus GO:0031668 73 0.020
positive regulation of cell projection organization GO:0031346 111 0.020
protein transport GO:0015031 132 0.020
collagen catabolic process GO:0030574 2 0.020
adult locomotory behavior GO:0008344 4 0.020
transcription from rna polymerase ii promoter GO:0006366 252 0.020
regulation of protein phosphorylation GO:0001932 183 0.020
negative regulation of peptidase activity GO:0010466 38 0.020
regulation of angiogenesis GO:0045765 39 0.020
secretion by cell GO:0032940 248 0.020
positive regulation of apoptotic process GO:0043065 154 0.020
cellular homeostasis GO:0019725 252 0.020
cellular response to organonitrogen compound GO:0071417 197 0.019
positive regulation of neurogenesis GO:0050769 165 0.019
metal ion homeostasis GO:0055065 186 0.019
regulation of nervous system development GO:0051960 264 0.019
ribonucleoside triphosphate catabolic process GO:0009203 122 0.019
cell part morphogenesis GO:0032990 123 0.019
cellular response to oxidative stress GO:0034599 76 0.019
regulation of protein modification process GO:0031399 194 0.019
gtp catabolic process GO:0006184 71 0.019
negative regulation of protein processing GO:0010955 47 0.019
vasculature development GO:0001944 70 0.019
negative regulation of immune response GO:0050777 15 0.019
monosaccharide metabolic process GO:0005996 61 0.018
regulation of immune effector process GO:0002697 32 0.018
response to monosaccharide GO:0034284 159 0.018
negative regulation of response to external stimulus GO:0032102 37 0.018
endosomal transport GO:0016197 14 0.018
negative regulation of gene expression GO:0010629 199 0.018
cell cell junction organization GO:0045216 20 0.018
negative regulation of neutrophil apoptotic process GO:0033030 3 0.018
cellular response to hormone stimulus GO:0032870 247 0.018
regulation of cell migration GO:0030334 128 0.018
cellular nitrogen compound catabolic process GO:0044270 163 0.018
carboxylic acid transport GO:0046942 115 0.018
protein localization GO:0008104 191 0.017
regulation of phagocytosis GO:0050764 13 0.017
negative regulation of protein metabolic process GO:0051248 114 0.017
inflammatory response GO:0006954 150 0.017
nucleoside phosphate metabolic process GO:0006753 283 0.017
carbohydrate metabolic process GO:0005975 130 0.017
regulation of defense response GO:0031347 68 0.017
cell junction assembly GO:0034329 18 0.017
negative regulation of signaling GO:0023057 157 0.017
regulation of membrane potential GO:0042391 110 0.017
translation GO:0006412 35 0.017
regulation of phosphate metabolic process GO:0019220 349 0.016
response to axon injury GO:0048678 59 0.016
spermatogenesis GO:0007283 99 0.016
circulatory system development GO:0072359 134 0.016
regulation of leukocyte activation GO:0002694 45 0.016
nerve development GO:0021675 11 0.016
response to acid chemical GO:0001101 222 0.016
organic anion transport GO:0015711 132 0.016
gamete generation GO:0007276 124 0.016
gastrulation GO:0007369 2 0.016
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.016
nitrogen compound transport GO:0071705 229 0.016
regulation of synaptic transmission GO:0050804 141 0.015
organophosphate catabolic process GO:0046434 148 0.015
establishment of vesicle localization GO:0051650 31 0.015
regulation of cellular catabolic process GO:0031329 101 0.015
divalent inorganic cation homeostasis GO:0072507 165 0.015
cation homeostasis GO:0055080 195 0.015
cellular component morphogenesis GO:0032989 155 0.015
macroautophagy GO:0016236 4 0.015
neuromuscular synaptic transmission GO:0007274 2 0.015
regulation of metal ion transport GO:0010959 118 0.015
positive regulation of phosphorus metabolic process GO:0010562 262 0.015
response to oxygen levels GO:0070482 265 0.015
cellular chemical homeostasis GO:0055082 247 0.015
regulation of protein processing GO:0070613 50 0.015
positive regulation of angiogenesis GO:0045766 28 0.015
protein activation cascade GO:0072376 12 0.015
negative regulation of cell communication GO:0010648 158 0.015
regulation of response to external stimulus GO:0032101 106 0.015
cytoplasmic transport GO:0016482 115 0.014
cardiovascular system development GO:0072358 134 0.014
calcium ion transport GO:0006816 131 0.014
response to starvation GO:0042594 59 0.014
male gamete generation GO:0048232 99 0.014
regulation of protein maturation GO:1903317 50 0.014
dna metabolic process GO:0006259 96 0.014
positive regulation of neuron projection development GO:0010976 99 0.014
vascular endothelial growth factor signaling pathway GO:0038084 4 0.014
ribonucleoside catabolic process GO:0042454 126 0.014
positive regulation of rna biosynthetic process GO:1902680 197 0.014
cellular response to camp GO:0071320 26 0.014
cellular lipid metabolic process GO:0044255 208 0.014
cellular response to hydrogen peroxide GO:0070301 42 0.014
gland development GO:0048732 155 0.014
purine nucleoside catabolic process GO:0006152 124 0.014
macromolecule catabolic process GO:0009057 58 0.013
mesodermal cell differentiation GO:0048333 1 0.013
cell substrate adhesion GO:0031589 29 0.013
cell matrix adhesion GO:0007160 19 0.013
regulation of phosphorus metabolic process GO:0051174 349 0.013
reactive oxygen species metabolic process GO:0072593 37 0.013
leukocyte activation GO:0045321 76 0.013
response to glucocorticoid GO:0051384 223 0.013
positive regulation of protein modification process GO:0031401 142 0.013
response to decreased oxygen levels GO:0036293 237 0.012
dendrite development GO:0016358 72 0.012
cellular response to reactive oxygen species GO:0034614 55 0.012
signal release GO:0023061 145 0.012
protein homooligomerization GO:0051260 91 0.012
receptor metabolic process GO:0043112 18 0.012
sensory perception GO:0007600 101 0.012
regulation of peptidase activity GO:0052547 55 0.012
regulation of neuron death GO:1901214 115 0.012
cell chemotaxis GO:0060326 31 0.012
regulation of protein transport GO:0051223 68 0.012
response to camp GO:0051591 91 0.012
neurological system process GO:0050877 219 0.012
regulation of cell activation GO:0050865 50 0.012
gtp metabolic process GO:0046039 72 0.012
positive regulation of cell junction assembly GO:1901890 2 0.012
calcium ion homeostasis GO:0055074 162 0.012
regulation of lymphocyte proliferation GO:0050670 26 0.012
exocytosis GO:0006887 60 0.012
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.012
regulation of leukocyte proliferation GO:0070663 26 0.011
guanosine containing compound metabolic process GO:1901068 74 0.011
positive regulation of immune system process GO:0002684 90 0.011
sperm egg recognition GO:0035036 1 0.011
positive regulation of gene expression GO:0010628 244 0.011
hexose metabolic process GO:0019318 58 0.011
ribonucleoside metabolic process GO:0009119 174 0.011
cellular response to vascular endothelial growth factor stimulus GO:0035924 6 0.011
purine ribonucleoside metabolic process GO:0046128 168 0.011
positive regulation of catabolic process GO:0009896 78 0.011
negative regulation of cellular metabolic process GO:0031324 281 0.011
enzyme linked receptor protein signaling pathway GO:0007167 116 0.011
ion homeostasis GO:0050801 212 0.011
anion transport GO:0006820 178 0.011
rna biosynthetic process GO:0032774 380 0.011
sensory perception of bitter taste GO:0050913 4 0.011
regulation of calcium ion transport GO:0051924 77 0.011
antigen processing and presentation of exogenous peptide antigen via mhc class ii GO:0019886 1 0.011
positive regulation of transcription dna templated GO:0045893 197 0.011
ras protein signal transduction GO:0007265 29 0.011
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.011
cellular response to corticosteroid stimulus GO:0071384 69 0.011
regulation of phospholipase activity GO:0010517 12 0.010
cellular response to ketone GO:1901655 51 0.010
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.010
neuron projection regeneration GO:0031102 35 0.010
activation of phospholipase d activity GO:0031584 2 0.010
regulation of receptor internalization GO:0002090 6 0.010
regulation of anatomical structure size GO:0090066 135 0.010
response to metal ion GO:0010038 253 0.010
endothelium development GO:0003158 12 0.010
response to hexose GO:0009746 144 0.010
cellular calcium ion homeostasis GO:0006874 160 0.010
urogenital system development GO:0001655 78 0.010
small gtpase mediated signal transduction GO:0007264 36 0.010
negative regulation of proteolysis GO:0045861 41 0.010
digestive tract development GO:0048565 39 0.010
negative regulation of wound healing GO:0061045 8 0.010

Ctsl1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.051
nervous system disease DOID:863 0 0.051
musculoskeletal system disease DOID:17 0 0.047
central nervous system disease DOID:331 0 0.027
epilepsy syndrome DOID:1826 0 0.015
brain disease DOID:936 0 0.015
electroclinical syndrome DOID:0050701 0 0.013