Rattus norvegicus

0 known processes

Sh2b1

SH2B adaptor protein 1

(Aliases: Sh2bpsm1,Sh2-b,Sh2b)

Sh2b1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of nucleic acid templated transcription GO:1903506 380 0.276
transcription dna templated GO:0006351 377 0.181
intracellular signal transduction GO:0035556 314 0.176
regulation of rna biosynthetic process GO:2001141 381 0.156
regulation of phosphorus metabolic process GO:0051174 349 0.149
nucleic acid templated transcription GO:0097659 379 0.134
rna biosynthetic process GO:0032774 380 0.133
regulation of rna metabolic process GO:0051252 391 0.130
positive regulation of signal transduction GO:0009967 175 0.129
regulation of transcription dna templated GO:0006355 374 0.125
regulation of signal transduction GO:0009966 318 0.125
rna metabolic process GO:0016070 406 0.123
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.122
regulation of intracellular signal transduction GO:1902531 218 0.118
positive regulation of gene expression GO:0010628 244 0.104
regulation of cellular localization GO:0060341 263 0.098
mapk cascade GO:0000165 140 0.091
transcription from rna polymerase ii promoter GO:0006366 252 0.091
protein phosphorylation GO:0006468 345 0.088
positive regulation of transcription dna templated GO:0045893 197 0.087
negative regulation of macromolecule metabolic process GO:0010605 260 0.082
regulation of mapk cascade GO:0043408 116 0.078
regulation of phosphorylation GO:0042325 248 0.073
regulation of phosphate metabolic process GO:0019220 349 0.072
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.070
regulation of canonical wnt signaling pathway GO:0060828 4 0.069
heart morphogenesis GO:0003007 3 0.066
positive regulation of signaling GO:0023056 270 0.066
negative regulation of transcription dna templated GO:0045892 116 0.065
positive regulation of rna metabolic process GO:0051254 203 0.062
negative regulation of cellular metabolic process GO:0031324 281 0.062
tissue development GO:0009888 252 0.062
positive regulation of intracellular signal transduction GO:1902533 138 0.058
positive regulation of transferase activity GO:0051347 81 0.057
regulation of protein modification process GO:0031399 194 0.056
positive regulation of response to stimulus GO:0048584 285 0.056
protein complex biogenesis GO:0070271 263 0.053
neurological system process GO:0050877 219 0.053
cellular response to endogenous stimulus GO:0071495 377 0.053
signal transduction by phosphorylation GO:0023014 144 0.052
regulation of system process GO:0044057 208 0.051
establishment of tissue polarity GO:0007164 2 0.051
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.051
positive regulation of phosphorus metabolic process GO:0010562 262 0.050
positive regulation of biosynthetic process GO:0009891 319 0.049
organelle organization GO:0006996 266 0.049
protein localization GO:0008104 191 0.047
positive regulation of protein metabolic process GO:0051247 178 0.047
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.047
negative regulation of cell communication GO:0010648 158 0.046
protein transport GO:0015031 132 0.046
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.045
enzyme linked receptor protein signaling pathway GO:0007167 116 0.045
negative regulation of nucleic acid templated transcription GO:1903507 117 0.045
positive regulation of phosphorylation GO:0042327 177 0.045
multi multicellular organism process GO:0044706 138 0.044
negative regulation of rna metabolic process GO:0051253 123 0.044
negative regulation of gene expression GO:0010629 199 0.044
negative regulation of signaling GO:0023057 157 0.044
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.044
negative regulation of rna biosynthetic process GO:1902679 118 0.040
positive regulation of secretion by cell GO:1903532 128 0.040
negative regulation of cellular biosynthetic process GO:0031327 161 0.040
positive regulation of nucleic acid templated transcription GO:1903508 197 0.040
mesoderm development GO:0007498 2 0.039
negative regulation of signal transduction GO:0009968 83 0.039
g protein coupled receptor signaling pathway GO:0007186 242 0.039
regulation of transferase activity GO:0051338 123 0.039
regulation of kinase activity GO:0043549 117 0.039
regulation of multicellular organismal development GO:2000026 376 0.039
positive regulation of molecular function GO:0044093 230 0.038
regulation of molecular function GO:0065009 398 0.038
homeostatic process GO:0042592 331 0.037
locomotion GO:0040011 237 0.037
macromolecule localization GO:0033036 252 0.036
secretion GO:0046903 307 0.036
positive regulation of cellular biosynthetic process GO:0031328 295 0.036
anterior posterior pattern specification GO:0009952 1 0.036
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.036
tube development GO:0035295 89 0.036
regulation of cellular protein metabolic process GO:0032268 267 0.036
single organism reproductive process GO:0044702 297 0.035
immune system process GO:0002376 204 0.035
positive regulation of multicellular organismal process GO:0051240 387 0.035
cellular component movement GO:0006928 248 0.035
cellular component assembly GO:0022607 360 0.034
positive regulation of phosphate metabolic process GO:0045937 262 0.034
regulation of cell differentiation GO:0045595 320 0.034
central nervous system development GO:0007417 311 0.034
amine metabolic process GO:0009308 38 0.034
positive regulation of transport GO:0051050 245 0.034
positive regulation of cellular protein metabolic process GO:0032270 167 0.034
positive regulation of protein phosphorylation GO:0001934 135 0.034
negative regulation of metabolic process GO:0009892 331 0.033
cellular amino acid metabolic process GO:0006520 107 0.032
renal system development GO:0072001 67 0.032
negative regulation of protein metabolic process GO:0051248 114 0.032
negative regulation of cell differentiation GO:0045596 99 0.032
digestive system development GO:0055123 41 0.032
neuron projection development GO:0031175 273 0.032
cellular response to oxygen containing compound GO:1901701 386 0.031
positive regulation of neurogenesis GO:0050769 165 0.031
regulation of protein metabolic process GO:0051246 289 0.031
response to metal ion GO:0010038 253 0.031
transforming growth factor beta receptor signaling pathway GO:0007179 18 0.031
cell adhesion GO:0007155 110 0.031
cell morphogenesis involved in differentiation GO:0000904 119 0.031
positive regulation of nervous system development GO:0051962 178 0.031
response to wounding GO:0009611 254 0.030
cell cell signaling GO:0007267 335 0.030
cellular component biogenesis GO:0044085 368 0.030
cellular response to lipid GO:0071396 201 0.030
proteolysis GO:0006508 175 0.030
positive regulation of mapk cascade GO:0043410 92 0.029
negative regulation of multicellular organismal process GO:0051241 203 0.029
peptidyl amino acid modification GO:0018193 126 0.029
secretion by cell GO:0032940 248 0.028
regulation of protein phosphorylation GO:0001932 183 0.028
positive regulation of protein modification process GO:0031401 142 0.028
positive regulation of cellular component organization GO:0051130 200 0.028
neuron development GO:0048666 286 0.028
regulation of protein kinase activity GO:0045859 105 0.028
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.027
regulation of cell proliferation GO:0042127 359 0.027
catabolic process GO:0009056 351 0.027
establishment of protein localization GO:0045184 141 0.027
positive regulation of kinase activity GO:0033674 77 0.026
protein complex assembly GO:0006461 263 0.026
cell projection organization GO:0030030 302 0.026
axon development GO:0061564 96 0.026
neuron differentiation GO:0030182 368 0.026
cellular amine metabolic process GO:0044106 38 0.026
response to growth factor GO:0070848 189 0.026
motor neuron axon guidance GO:0008045 1 0.026
regulation of cellular amino acid metabolic process GO:0006521 2 0.025
regulation of map kinase activity GO:0043405 53 0.025
positive regulation of protein kinase activity GO:0045860 73 0.025
reproductive system development GO:0061458 128 0.025
positive regulation of map kinase activity GO:0043406 46 0.025
negative regulation of response to stimulus GO:0048585 155 0.024
cellular response to growth factor stimulus GO:0071363 162 0.024
positive regulation of rna biosynthetic process GO:1902680 197 0.024
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.024
regulation of catalytic activity GO:0050790 304 0.024
positive regulation of cell differentiation GO:0045597 217 0.024
regulation of cell projection organization GO:0031344 175 0.024
negative regulation of transport GO:0051051 136 0.024
tube formation GO:0035148 3 0.024
head development GO:0060322 247 0.024
cardiovascular system development GO:0072358 134 0.023
regulation of smooth muscle cell proliferation GO:0048660 75 0.023
female pregnancy GO:0007565 122 0.023
regulation of nucleotide metabolic process GO:0006140 117 0.023
regulation of protein transport GO:0051223 68 0.023
protein complex subunit organization GO:0071822 302 0.023
gastrulation GO:0007369 2 0.023
positive regulation of protein serine threonine kinase activity GO:0071902 52 0.023
regulation of cellular amine metabolic process GO:0033238 8 0.022
regulation of cell development GO:0060284 263 0.022
regulation of cellular ketone metabolic process GO:0010565 27 0.022
organ morphogenesis GO:0009887 75 0.022
muscle system process GO:0003012 115 0.022
embryonic skeletal system development GO:0048706 3 0.022
response to ketone GO:1901654 182 0.022
negative regulation of developmental process GO:0051093 125 0.022
single organism organelle organization GO:1902589 180 0.022
positive regulation of developmental process GO:0051094 283 0.022
skeletal system development GO:0001501 41 0.022
tube morphogenesis GO:0035239 23 0.021
negative regulation of biosynthetic process GO:0009890 168 0.021
response to estradiol GO:0032355 164 0.021
single organism cellular localization GO:1902580 102 0.021
anatomical structure morphogenesis GO:0009653 298 0.021
reproductive process GO:0022414 372 0.021
synaptic transmission GO:0007268 235 0.021
neuron death GO:0070997 127 0.021
circulatory system process GO:0003013 183 0.021
calcium ion homeostasis GO:0055074 162 0.020
brain development GO:0007420 247 0.020
negative regulation of cellular protein metabolic process GO:0032269 106 0.020
oxoacid metabolic process GO:0043436 290 0.020
organ formation GO:0048645 3 0.020
negative regulation of canonical wnt signaling pathway GO:0090090 4 0.020
regulation of stem cell differentiation GO:2000736 2 0.020
blood circulation GO:0008015 183 0.020
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.020
carboxylic acid metabolic process GO:0019752 289 0.019
organic substance catabolic process GO:1901575 316 0.019
multi organism reproductive process GO:0044703 262 0.019
cellular protein localization GO:0034613 122 0.019
spindle organization GO:0007051 2 0.019
cell type specific apoptotic process GO:0097285 134 0.019
forebrain development GO:0030900 98 0.019
inflammatory response GO:0006954 150 0.019
regulation of cellular catabolic process GO:0031329 101 0.018
cellular response to hormone stimulus GO:0032870 247 0.018
nuclear transport GO:0051169 49 0.018
regulation of embryonic development GO:0045995 2 0.018
mitotic spindle organization GO:0007052 2 0.018
response to cytokine GO:0034097 215 0.018
vesicle mediated transport GO:0016192 181 0.018
ribose phosphate metabolic process GO:0019693 235 0.018
gliogenesis GO:0042063 93 0.018
cellular response to peptide GO:1901653 133 0.018
programmed cell death GO:0012501 392 0.018
epithelium development GO:0060429 96 0.017
regulation of secretion by cell GO:1903530 208 0.017
digestive tract development GO:0048565 39 0.017
macromolecular complex subunit organization GO:0043933 339 0.017
regulation of homeostatic process GO:0032844 101 0.017
cardiac chamber development GO:0003205 1 0.017
carbohydrate derivative metabolic process GO:1901135 346 0.017
positive regulation of cell development GO:0010720 176 0.017
regulation of programmed cell death GO:0043067 341 0.017
circulatory system development GO:0072359 134 0.017
multicellular organismal reproductive process GO:0048609 233 0.017
regulation of anatomical structure size GO:0090066 135 0.017
positive regulation of catalytic activity GO:0043085 184 0.017
response to inorganic substance GO:0010035 377 0.017
response to glucocorticoid GO:0051384 223 0.017
cellular catabolic process GO:0044248 295 0.017
organic acid metabolic process GO:0006082 292 0.017
behavior GO:0007610 205 0.017
regulation of secretion GO:0051046 224 0.016
response to peptide hormone GO:0043434 278 0.016
ras protein signal transduction GO:0007265 29 0.016
axonogenesis GO:0007409 71 0.016
heart development GO:0007507 72 0.016
positive regulation of cell proliferation GO:0008284 249 0.016
regulation of protein localization GO:0032880 81 0.016
regulation of apoptotic process GO:0042981 335 0.016
gland development GO:0048732 155 0.016
cognition GO:0050890 92 0.016
response to corticosteroid GO:0031960 235 0.016
cellular calcium ion homeostasis GO:0006874 160 0.016
regulation of establishment of protein localization GO:0070201 69 0.016
multicellular organism reproduction GO:0032504 233 0.016
macromolecular complex assembly GO:0065003 273 0.016
wnt signaling pathway planar cell polarity pathway GO:0060071 2 0.016
regulation of neuron projection development GO:0010975 161 0.015
cellular response to organic cyclic compound GO:0071407 202 0.015
positive regulation of programmed cell death GO:0043068 157 0.015
aging GO:0007568 241 0.015
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 27 0.015
response to acid chemical GO:0001101 222 0.015
negative regulation of molecular function GO:0044092 133 0.015
cellular ketone metabolic process GO:0042180 51 0.015
reproductive structure development GO:0048608 128 0.015
cellular response to stress GO:0033554 269 0.015
mechanoreceptor differentiation GO:0042490 2 0.015
cellular component morphogenesis GO:0032989 155 0.015
peptidyl tyrosine phosphorylation GO:0018108 72 0.015
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.015
positive regulation of cellular amine metabolic process GO:0033240 3 0.015
taxis GO:0042330 67 0.015
regulation of anatomical structure morphogenesis GO:0022603 141 0.015
regulation of membrane potential GO:0042391 110 0.015
response to transforming growth factor beta GO:0071559 46 0.014
neuron projection morphogenesis GO:0048812 122 0.014
cytosolic calcium ion homeostasis GO:0051480 140 0.014
glial cell differentiation GO:0010001 65 0.014
purine containing compound metabolic process GO:0072521 253 0.014
metal ion transport GO:0030001 289 0.014
embryonic pattern specification GO:0009880 1 0.014
regulation of protein import into nucleus GO:0042306 24 0.014
purine ribonucleoside metabolic process GO:0046128 168 0.014
regulation of neurogenesis GO:0050767 247 0.014
purine nucleotide metabolic process GO:0006163 229 0.014
cellular macromolecular complex assembly GO:0034622 58 0.014
cell fate determination GO:0001709 2 0.014
embryonic skeletal system morphogenesis GO:0048704 3 0.014
inner ear receptor cell differentiation GO:0060113 2 0.014
cellular response to abiotic stimulus GO:0071214 85 0.014
regulation of establishment of planar polarity GO:0090175 2 0.014
epithelial cell differentiation GO:0030855 71 0.014
positive regulation of synaptic transmission GO:0050806 62 0.014
activation of protein kinase activity GO:0032147 47 0.014
cellular response to organonitrogen compound GO:0071417 197 0.013
nucleosome organization GO:0034728 1 0.013
biological adhesion GO:0022610 110 0.013
cyclic nucleotide metabolic process GO:0009187 80 0.013
cell motility GO:0048870 202 0.013
smooth muscle cell proliferation GO:0048659 77 0.013
salivary gland development GO:0007431 3 0.013
regulation of nervous system development GO:0051960 264 0.013
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.013
synaptic vesicle transport GO:0048489 23 0.013
chromosome organization GO:0051276 36 0.013
cell part morphogenesis GO:0032990 123 0.013
regulation of muscle contraction GO:0006937 53 0.013
reproduction GO:0000003 245 0.013
muscle organ morphogenesis GO:0048644 1 0.013
localization of cell GO:0051674 202 0.013
protein localization to organelle GO:0033365 57 0.013
protein targeting GO:0006605 61 0.013
nucleotide biosynthetic process GO:0009165 98 0.013
protein oligomerization GO:0051259 191 0.013
rhythmic process GO:0048511 156 0.012
small gtpase mediated signal transduction GO:0007264 36 0.012
protein autophosphorylation GO:0046777 66 0.012
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.012
axis specification GO:0009798 4 0.012
apoptotic process GO:0006915 381 0.012
cell cycle GO:0007049 101 0.012
positive regulation of apoptotic process GO:0043065 154 0.012
response to radiation GO:0009314 137 0.012
chemical homeostasis GO:0048878 292 0.012
macromolecule catabolic process GO:0009057 58 0.012
single organism membrane organization GO:0044802 74 0.012
regulation of nucleocytoplasmic transport GO:0046822 28 0.012
divalent metal ion transport GO:0070838 132 0.012
single organism intracellular transport GO:1902582 166 0.012
single organism behavior GO:0044708 130 0.012
cell morphogenesis GO:0000902 142 0.012
regulation of neuron apoptotic process GO:0043523 83 0.012
non canonical wnt signaling pathway GO:0035567 3 0.011
cardiac ventricle development GO:0003231 1 0.011
cellular response to nitrogen compound GO:1901699 210 0.011
protein import into nucleus GO:0006606 35 0.011
nucleobase containing small molecule metabolic process GO:0055086 316 0.011
positive regulation of neuron differentiation GO:0045666 126 0.011
regulation of protein secretion GO:0050708 28 0.011
negative regulation of cell death GO:0060548 229 0.011
muscle cell proliferation GO:0033002 84 0.011
positive regulation of secretion GO:0051047 140 0.011
cellular macromolecule localization GO:0070727 122 0.011
kidney development GO:0001822 67 0.011
intracellular transport GO:0046907 185 0.011
cellular divalent inorganic cation homeostasis GO:0072503 162 0.011
morphogenesis of embryonic epithelium GO:0016331 3 0.011
cellular response to steroid hormone stimulus GO:0071383 93 0.011
inner ear morphogenesis GO:0042472 1 0.011
cartilage development GO:0051216 22 0.011
regulation of stress activated mapk cascade GO:0032872 23 0.011
nucleocytoplasmic transport GO:0006913 48 0.011
nucleotide metabolic process GO:0009117 279 0.011
regulation of protein serine threonine kinase activity GO:0071900 64 0.011
purine ribonucleotide metabolic process GO:0009150 227 0.011
regulation of b cell differentiation GO:0045577 1 0.011
regulation of blood vessel size GO:0050880 89 0.011
sex differentiation GO:0007548 113 0.011
gtp metabolic process GO:0046039 72 0.011
cytoplasmic transport GO:0016482 115 0.011
cell cell signaling involved in cell fate commitment GO:0045168 2 0.011
response to peptide GO:1901652 292 0.011
cellular response to peptide hormone stimulus GO:0071375 120 0.011
positive regulation of protein transport GO:0051222 41 0.010
regulation of catabolic process GO:0009894 113 0.010
response to dexamethasone GO:0071548 49 0.010
urogenital system development GO:0001655 78 0.010
regulation of response to stress GO:0080134 126 0.010
regulation of fat cell differentiation GO:0045598 3 0.010
peptidyl tyrosine modification GO:0018212 72 0.010
sensory organ development GO:0007423 74 0.010
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.010
protein targeting to nucleus GO:0044744 35 0.010
lipid metabolic process GO:0006629 283 0.010
dephosphorylation GO:0016311 98 0.010
positive regulation of cell projection organization GO:0031346 111 0.010
rna localization GO:0006403 4 0.010
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.010
cellular chemical homeostasis GO:0055082 247 0.010
protein secretion GO:0009306 34 0.010
regulation of ion transport GO:0043269 245 0.010

Sh2b1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.016
disease of cellular proliferation DOID:14566 0 0.016
organ system cancer DOID:0050686 0 0.016
disease of anatomical entity DOID:7 0 0.011
nervous system disease DOID:863 0 0.011
gastrointestinal system cancer DOID:3119 0 0.011