Rattus norvegicus

25 known processes

Cldn16

claudin 16

(Aliases: Pcln1)

Cldn16 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cation transport GO:0006812 382 0.300
homeostatic process GO:0042592 331 0.226
reproductive process GO:0022414 372 0.177
cellular divalent inorganic cation homeostasis GO:0072503 162 0.172
tissue development GO:0009888 252 0.171
regulation of phosphorus metabolic process GO:0051174 349 0.159
cation transmembrane transport GO:0098655 263 0.145
regulation of molecular function GO:0065009 398 0.140
cellular response to lipid GO:0071396 201 0.134
oxoacid metabolic process GO:0043436 290 0.131
response to inorganic substance GO:0010035 377 0.122
negative regulation of cell death GO:0060548 229 0.114
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.112
inorganic ion transmembrane transport GO:0098660 229 0.109
response to ketone GO:1901654 182 0.109
ion transmembrane transport GO:0034220 365 0.106
divalent inorganic cation homeostasis GO:0072507 165 0.102
positive regulation of cell communication GO:0010647 271 0.101
negative regulation of transport GO:0051051 136 0.089
g protein coupled receptor signaling pathway GO:0007186 242 0.088
regulation of transmembrane transport GO:0034762 122 0.083
positive regulation of cell proliferation GO:0008284 249 0.082
transcription from rna polymerase ii promoter GO:0006366 252 0.080
blood circulation GO:0008015 183 0.079
metal ion transport GO:0030001 289 0.078
positive regulation of cellular biosynthetic process GO:0031328 295 0.078
circulatory system process GO:0003013 183 0.077
regulation of phosphate metabolic process GO:0019220 349 0.072
anatomical structure morphogenesis GO:0009653 298 0.071
cation homeostasis GO:0055080 195 0.070
nitrogen compound transport GO:0071705 229 0.070
cell motility GO:0048870 202 0.068
inorganic cation transmembrane transport GO:0098662 202 0.068
response to estrogen GO:0043627 232 0.068
anion transmembrane transport GO:0098656 77 0.067
organic acid metabolic process GO:0006082 292 0.065
intracellular signal transduction GO:0035556 314 0.064
response to decreased oxygen levels GO:0036293 237 0.064
regulation of catalytic activity GO:0050790 304 0.064
programmed cell death GO:0012501 392 0.062
cellular response to alcohol GO:0097306 87 0.062
cellular component assembly GO:0022607 360 0.062
positive regulation of biosynthetic process GO:0009891 319 0.061
single organism reproductive process GO:0044702 297 0.060
response to oxygen levels GO:0070482 265 0.060
tube development GO:0035295 89 0.058
positive regulation of developmental process GO:0051094 283 0.058
regulation of cellular protein metabolic process GO:0032268 267 0.058
carboxylic acid metabolic process GO:0019752 289 0.057
positive regulation of gene expression GO:0010628 244 0.056
regulation of apoptotic process GO:0042981 335 0.055
calcium mediated signaling GO:0019722 23 0.055
positive regulation of rna metabolic process GO:0051254 203 0.055
head development GO:0060322 247 0.055
response to ethanol GO:0045471 162 0.054
positive regulation of signaling GO:0023056 270 0.053
regulation of nucleic acid templated transcription GO:1903506 380 0.052
regulation of metal ion transport GO:0010959 118 0.052
defense response GO:0006952 194 0.051
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.050
response to cytokine GO:0034097 215 0.049
response to hypoxia GO:0001666 231 0.048
single organism biosynthetic process GO:0044711 342 0.048
regulation of cellular component organization GO:0051128 368 0.048
response to biotic stimulus GO:0009607 226 0.048
positive regulation of transcription dna templated GO:0045893 197 0.048
cellular response to nitrogen compound GO:1901699 210 0.047
dopamine secretion GO:0014046 15 0.047
regulation of locomotion GO:0040012 148 0.047
sensory organ development GO:0007423 74 0.046
regulation of homeostatic process GO:0032844 101 0.045
vesicle mediated transport GO:0016192 181 0.045
positive regulation of cell death GO:0010942 184 0.045
positive regulation of phosphorus metabolic process GO:0010562 262 0.045
circadian rhythm GO:0007623 88 0.045
protein complex subunit organization GO:0071822 302 0.044
neurological system process GO:0050877 219 0.044
cellular ion homeostasis GO:0006873 184 0.044
regulation of multicellular organismal development GO:2000026 376 0.044
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.043
chemical homeostasis GO:0048878 292 0.042
regulation of ion transport GO:0043269 245 0.042
response to extracellular stimulus GO:0009991 380 0.042
cell morphogenesis involved in differentiation GO:0000904 119 0.042
positive regulation of multicellular organismal process GO:0051240 387 0.042
secretion by cell GO:0032940 248 0.042
regulation of cell differentiation GO:0045595 320 0.041
protein complex biogenesis GO:0070271 263 0.041
response to corticosteroid GO:0031960 235 0.041
inflammatory response GO:0006954 150 0.040
metal ion homeostasis GO:0055065 186 0.040
positive regulation of rna biosynthetic process GO:1902680 197 0.040
transmembrane transport GO:0055085 412 0.039
calcium ion homeostasis GO:0055074 162 0.039
positive regulation of molecular function GO:0044093 230 0.038
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.038
response to nutrient levels GO:0031667 370 0.038
multi organism reproductive process GO:0044703 262 0.037
rna metabolic process GO:0016070 406 0.037
aging GO:0007568 241 0.037
regulation of rna biosynthetic process GO:2001141 381 0.037
macromolecular complex subunit organization GO:0043933 339 0.037
divalent inorganic cation transport GO:0072511 134 0.036
negative regulation of biosynthetic process GO:0009890 168 0.036
negative regulation of gene expression GO:0010629 199 0.036
regulation of transcription dna templated GO:0006355 374 0.036
cellular homeostasis GO:0019725 252 0.036
regulation of protein metabolic process GO:0051246 289 0.035
halogenated hydrocarbon metabolic process GO:0042197 4 0.035
epithelium development GO:0060429 96 0.035
transcription dna templated GO:0006351 377 0.034
lipid metabolic process GO:0006629 283 0.034
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.034
cellular response to organic cyclic compound GO:0071407 202 0.034
positive regulation of cell differentiation GO:0045597 217 0.034
adenylate cyclase inhibiting g protein coupled receptor signaling pathway GO:0007193 19 0.034
ossification GO:0001503 70 0.034
regulation of protein modification process GO:0031399 194 0.033
negative regulation of macromolecule metabolic process GO:0010605 260 0.033
regulation of programmed cell death GO:0043067 341 0.033
regulation of ion transmembrane transport GO:0034765 121 0.032
macromolecular complex assembly GO:0065003 273 0.032
regulation of phosphorylation GO:0042325 248 0.032
positive regulation of apoptotic process GO:0043065 154 0.031
ion homeostasis GO:0050801 212 0.031
dopamine transport GO:0015872 18 0.031
cellular component biogenesis GO:0044085 368 0.031
amine metabolic process GO:0009308 38 0.031
positive regulation of programmed cell death GO:0043068 157 0.031
response to acid chemical GO:0001101 222 0.031
sodium ion transport GO:0006814 82 0.031
cellular amine metabolic process GO:0044106 38 0.030
regulation of rna metabolic process GO:0051252 391 0.030
positive regulation of synaptic transmission GO:0050806 62 0.030
cardiovascular system development GO:0072358 134 0.030
regulation of smooth muscle cell proliferation GO:0048660 75 0.030
catecholamine secretion GO:0050432 33 0.029
rna biosynthetic process GO:0032774 380 0.029
rhythmic process GO:0048511 156 0.029
regulation of hormone levels GO:0010817 187 0.029
localization of cell GO:0051674 202 0.029
oligopeptide transport GO:0006857 4 0.028
organic hydroxy compound transport GO:0015850 77 0.028
cellular response to hormone stimulus GO:0032870 247 0.028
response to ammonium ion GO:0060359 71 0.028
response to amine GO:0014075 46 0.028
organ formation GO:0048645 3 0.027
central nervous system development GO:0007417 311 0.027
negative regulation of rna biosynthetic process GO:1902679 118 0.027
positive regulation of cellular component organization GO:0051130 200 0.027
cellular response to oxygen levels GO:0071453 60 0.026
protein complex assembly GO:0006461 263 0.026
cytosolic calcium ion homeostasis GO:0051480 140 0.026
regulation of cellular amine metabolic process GO:0033238 8 0.026
organophosphate biosynthetic process GO:0090407 143 0.026
cellular cation homeostasis GO:0030003 180 0.026
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.026
response to other organism GO:0051707 220 0.026
catecholamine transport GO:0051937 37 0.026
regulation of cellular localization GO:0060341 263 0.025
positive regulation of nucleic acid templated transcription GO:1903508 197 0.025
regulation of membrane potential GO:0042391 110 0.025
ribonucleotide metabolic process GO:0009259 231 0.025
cellular ketone metabolic process GO:0042180 51 0.024
neuron projection development GO:0031175 273 0.024
cellular response to organonitrogen compound GO:0071417 197 0.024
cellular amino acid metabolic process GO:0006520 107 0.024
organophosphate metabolic process GO:0019637 370 0.024
cellular response to stress GO:0033554 269 0.024
organic cyclic compound catabolic process GO:1901361 175 0.024
response to lipopolysaccharide GO:0032496 191 0.024
response to monosaccharide GO:0034284 159 0.024
nucleic acid templated transcription GO:0097659 379 0.024
cellular chemical homeostasis GO:0055082 247 0.023
cellular response to oxygen containing compound GO:1901701 386 0.023
response to estradiol GO:0032355 164 0.023
response to metal ion GO:0010038 253 0.022
female pregnancy GO:0007565 122 0.022
positive regulation of intracellular signal transduction GO:1902533 138 0.022
regulation of blood circulation GO:1903522 110 0.022
monovalent inorganic cation transport GO:0015672 172 0.022
multi multicellular organism process GO:0044706 138 0.022
response to molecule of bacterial origin GO:0002237 194 0.022
neuron differentiation GO:0030182 368 0.022
regulation of transferase activity GO:0051338 123 0.022
cellular metal ion homeostasis GO:0006875 172 0.022
positive regulation of protein phosphorylation GO:0001934 135 0.021
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.021
response to external biotic stimulus GO:0043207 221 0.021
positive regulation of nervous system development GO:0051962 178 0.021
regulation of cellular amino acid metabolic process GO:0006521 2 0.021
response to glucocorticoid GO:0051384 223 0.021
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.021
positive regulation of phosphorylation GO:0042327 177 0.020
response to bacterium GO:0009617 200 0.020
regulation of cellular ketone metabolic process GO:0010565 27 0.020
negative regulation of programmed cell death GO:0043069 183 0.020
divalent metal ion transport GO:0070838 132 0.020
negative regulation of apoptotic process GO:0043066 181 0.020
positive regulation of organelle organization GO:0010638 48 0.020
sodium ion transmembrane transport GO:0035725 67 0.020
cellular response to acid chemical GO:0071229 75 0.019
regulation of catecholamine secretion GO:0050433 32 0.019
brain development GO:0007420 247 0.019
positive regulation of growth GO:0045927 55 0.019
antibiotic transport GO:0042891 2 0.019
response to nutrient GO:0007584 248 0.019
response to histamine GO:0034776 3 0.019
vasculature development GO:0001944 70 0.019
cellular response to drug GO:0035690 30 0.019
sexual reproduction GO:0019953 148 0.019
regulation of secretion by cell GO:1903530 208 0.019
positive regulation of mapk cascade GO:0043410 92 0.018
response to wounding GO:0009611 254 0.018
epithelial cell differentiation GO:0030855 71 0.018
carbohydrate derivative biosynthetic process GO:1901137 124 0.018
locomotion GO:0040011 237 0.018
membrane organization GO:0061024 94 0.018
positive regulation of transport GO:0051050 245 0.018
phospholipid metabolic process GO:0006644 61 0.018
regulation of vasculature development GO:1901342 44 0.018
negative regulation of transcription dna templated GO:0045892 116 0.018
regulation of signal transduction GO:0009966 318 0.018
cellular component movement GO:0006928 248 0.018
purine containing compound metabolic process GO:0072521 253 0.017
apoptotic process GO:0006915 381 0.017
negative regulation of cellular biosynthetic process GO:0031327 161 0.017
protein phosphorylation GO:0006468 345 0.017
negative regulation of multicellular organismal process GO:0051241 203 0.017
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.017
camp biosynthetic process GO:0006171 47 0.017
regulation of calcium ion transport GO:0051924 77 0.017
regulation of peptide transport GO:0090087 87 0.017
regulation of fat cell differentiation GO:0045598 3 0.017
negative regulation of catalytic activity GO:0043086 103 0.017
response to toxic substance GO:0009636 133 0.017
regulation of sodium ion transmembrane transporter activity GO:2000649 4 0.017
negative regulation of nucleic acid templated transcription GO:1903507 117 0.017
ribose phosphate metabolic process GO:0019693 235 0.017
positive regulation of catalytic activity GO:0043085 184 0.017
growth GO:0040007 165 0.017
second messenger mediated signaling GO:0019932 51 0.017
regulation of growth GO:0040008 105 0.017
micturition GO:0060073 4 0.016
response to nicotine GO:0035094 51 0.016
response to testosterone GO:0033574 55 0.016
multicellular organism reproduction GO:0032504 233 0.016
positive regulation of phosphate metabolic process GO:0045937 262 0.016
response to peptide hormone GO:0043434 278 0.016
ribose phosphate biosynthetic process GO:0046390 87 0.016
mapk cascade GO:0000165 140 0.016
cell adhesion GO:0007155 110 0.016
blood vessel morphogenesis GO:0048514 58 0.016
immune system process GO:0002376 204 0.016
regulation of kinase activity GO:0043549 117 0.016
chemotaxis GO:0006935 66 0.016
multicellular organismal signaling GO:0035637 44 0.016
positive regulation of protein metabolic process GO:0051247 178 0.016
transmission of nerve impulse GO:0019226 42 0.015
connective tissue development GO:0061448 33 0.015
cellular response to glucocorticoid stimulus GO:0071385 68 0.015
negative regulation of rna metabolic process GO:0051253 123 0.015
carbohydrate derivative metabolic process GO:1901135 346 0.015
forebrain development GO:0030900 98 0.015
positive regulation of locomotion GO:0040017 102 0.015
establishment of tissue polarity GO:0007164 2 0.015
hormone transport GO:0009914 121 0.015
bile acid biosynthetic process GO:0006699 3 0.015
amide transport GO:0042886 105 0.015
regulation of system process GO:0044057 208 0.015
regulation of organelle organization GO:0033043 80 0.015
gland development GO:0048732 155 0.015
oxidation reduction process GO:0055114 304 0.014
regulation of blood pressure GO:0008217 83 0.014
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 51 0.014
response to increased oxygen levels GO:0036296 45 0.014
response to hyperoxia GO:0055093 45 0.014
cell morphogenesis GO:0000902 142 0.014
regulation of neuron death GO:1901214 115 0.014
smooth muscle cell proliferation GO:0048659 77 0.014
action potential GO:0001508 54 0.014
eye morphogenesis GO:0048592 4 0.014
positive regulation of epithelial cell proliferation GO:0050679 32 0.014
liver development GO:0001889 90 0.014
regulation of establishment of planar polarity GO:0090175 2 0.014
biological adhesion GO:0022610 110 0.014
nucleobase containing small molecule metabolic process GO:0055086 316 0.014
synaptic transmission glycinergic GO:0060012 2 0.014
reproduction GO:0000003 245 0.014
sequestering of calcium ion GO:0051208 8 0.014
benzene containing compound metabolic process GO:0042537 22 0.014
respiratory system development GO:0060541 45 0.014
acute inflammatory response GO:0002526 58 0.014
multicellular organismal reproductive process GO:0048609 233 0.014
cellular calcium ion homeostasis GO:0006874 160 0.014
cellular lipid metabolic process GO:0044255 208 0.014
response to xenobiotic stimulus GO:0009410 23 0.013
response to mechanical stimulus GO:0009612 134 0.013
regulation of dopamine secretion GO:0014059 15 0.013
circulatory system development GO:0072359 134 0.013
positive regulation of response to stimulus GO:0048584 285 0.013
positive regulation of signal transduction GO:0009967 175 0.013
negative regulation of protein metabolic process GO:0051248 114 0.013
peptidyl amino acid modification GO:0018193 126 0.013
sensory perception GO:0007600 101 0.013
positive regulation of immune system process GO:0002684 90 0.013
neuron development GO:0048666 286 0.013
secretion GO:0046903 307 0.013
regulation of sodium ion transport GO:0002028 21 0.013
erk1 and erk2 cascade GO:0070371 48 0.013
cellular response to endogenous stimulus GO:0071495 377 0.013
hormone secretion GO:0046879 115 0.013
small gtpase mediated signal transduction GO:0007264 36 0.013
positive regulation of secretion GO:0051047 140 0.013
organic hydroxy compound metabolic process GO:1901615 115 0.013
taxis GO:0042330 67 0.013
cell migration GO:0016477 197 0.013
regulation of cellular component movement GO:0051270 150 0.013
protein localization GO:0008104 191 0.013
regulation of blood vessel size GO:0050880 89 0.012
establishment or maintenance of transmembrane electrochemical gradient GO:0010248 1 0.012
negative regulation of molecular function GO:0044092 133 0.012
positive regulation of ion transport GO:0043270 94 0.012
synaptic transmission GO:0007268 235 0.012
regulation of cellular component biogenesis GO:0044087 86 0.012
negative regulation of metabolic process GO:0009892 331 0.012
cellular response to hypoxia GO:0071456 51 0.012
regulation of mapk cascade GO:0043408 116 0.012
monoamine transport GO:0015844 43 0.012
behavior GO:0007610 205 0.012
glutathione transport GO:0034635 2 0.012
negative regulation of neuron death GO:1901215 69 0.012
calcium ion transport GO:0006816 131 0.011
cell projection organization GO:0030030 302 0.011
insulin secretion GO:0030073 69 0.011
positive regulation of smooth muscle cell proliferation GO:0048661 51 0.011
regulation of cell development GO:0060284 263 0.011
peptidyl tyrosine phosphorylation GO:0018108 72 0.011
ras protein signal transduction GO:0007265 29 0.011
neuron death GO:0070997 127 0.011
cyclic nucleotide metabolic process GO:0009187 80 0.011
purine ribonucleotide metabolic process GO:0009150 227 0.011
developmental process involved in reproduction GO:0003006 159 0.011
protein heterooligomerization GO:0051291 89 0.011
establishment of planar polarity GO:0001736 1 0.011
positive regulation of neurogenesis GO:0050769 165 0.011
regulation of cyclic nucleotide metabolic process GO:0030799 51 0.011
single organism membrane organization GO:0044802 74 0.011
single organism catabolic process GO:0044712 283 0.011
intracellular transport GO:0046907 185 0.011
proteolysis GO:0006508 175 0.011
peptide hormone secretion GO:0030072 84 0.011
nucleoside phosphate metabolic process GO:0006753 283 0.011
organelle organization GO:0006996 266 0.011
ribonucleotide biosynthetic process GO:0009260 85 0.011
endocrine system development GO:0035270 30 0.011
negative regulation of secretion GO:0051048 82 0.011
regulation of hydrolase activity GO:0051336 143 0.011
cellular macromolecule localization GO:0070727 122 0.011
multicellular organism growth GO:0035264 1 0.011
negative regulation of cellular protein metabolic process GO:0032269 106 0.011
regulation of anatomical structure size GO:0090066 135 0.011
endocytosis GO:0006897 84 0.011
regulation of neuron projection development GO:0010975 161 0.010
toxin transport GO:1901998 3 0.010
cellular response to growth factor stimulus GO:0071363 162 0.010
regulation of immune system process GO:0002682 123 0.010
regulation of cell migration GO:0030334 128 0.010
maintenance of location GO:0051235 17 0.010
regulation of leukocyte differentiation GO:1902105 20 0.010
positive regulation of cellular protein metabolic process GO:0032270 167 0.010
smooth muscle cell migration GO:0014909 36 0.010
response to antibiotic GO:0046677 39 0.010
spinal cord development GO:0021510 27 0.010
positive regulation of jak stat cascade GO:0046427 19 0.010
regulation of synaptic transmission glutamatergic GO:0051966 26 0.010
retina development in camera type eye GO:0060041 27 0.010
regulation of secretion GO:0051046 224 0.010
inorganic anion transport GO:0015698 41 0.010
regulation of protein phosphorylation GO:0001932 183 0.010
peptide transport GO:0015833 97 0.010
cellular response to peptide GO:1901653 133 0.010
regulation of protein kinase activity GO:0045859 105 0.010
protein oligomerization GO:0051259 191 0.010

Cldn16 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 0 0.052
disease of anatomical entity DOID:7 0 0.052
nervous system disease DOID:863 0 0.052
retinal disease DOID:5679 0 0.020
retinal degeneration DOID:8466 0 0.020
cone rod dystrophy DOID:0050572 0 0.020
eye and adnexa disease DOID:1492 0 0.020
eye disease DOID:5614 0 0.020