Rattus norvegicus

34 known processes

Ppia

peptidylprolyl isomerase A (cyclophilin A)

(Aliases: MGC72881,CYCA)

Ppia biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of nitric oxide synthase activity GO:0050999 8 0.588
response to ketone GO:1901654 182 0.548
regulation of high voltage gated calcium channel activity GO:1901841 3 0.476
positive regulation of camp metabolic process GO:0030816 31 0.457
porphyrin containing compound biosynthetic process GO:0006779 6 0.437
l glutamate import GO:0051938 2 0.402
regulation of monooxygenase activity GO:0032768 8 0.395
regulation of nucleotide biosynthetic process GO:0030808 47 0.371
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.356
adenine nucleotide transport GO:0051503 2 0.345
regulation of transporter activity GO:0032409 50 0.342
regulation of molecular function GO:0065009 398 0.342
positive regulation of phosphate metabolic process GO:0045937 262 0.329
synaptic growth at neuromuscular junction GO:0051124 1 0.305
cellular ketone metabolic process GO:0042180 51 0.288
positive regulation of phosphorus metabolic process GO:0010562 262 0.287
positive regulation of purine nucleotide biosynthetic process GO:1900373 36 0.279
regulation of transmembrane transport GO:0034762 122 0.250
rna metabolic process GO:0016070 406 0.248
positive regulation of molecular function GO:0044093 230 0.246
response to corticosterone GO:0051412 40 0.239
regulation of atp biosynthetic process GO:2001169 2 0.232
positive regulation of monooxygenase activity GO:0032770 5 0.227
regulation of ryanodine sensitive calcium release channel activity GO:0060314 5 0.213
tetrapyrrole biosynthetic process GO:0033014 7 0.211
positive regulation of nucleotide metabolic process GO:0045981 91 0.210
regulation of phosphate metabolic process GO:0019220 349 0.187
nucleoside phosphate biosynthetic process GO:1901293 102 0.179
neurotransmitter uptake GO:0001504 3 0.165
camp biosynthetic process GO:0006171 47 0.156
homeostatic process GO:0042592 331 0.153
cellular response to oxidative stress GO:0034599 76 0.153
regulation of cation channel activity GO:2001257 23 0.152
inorganic cation transmembrane transport GO:0098662 202 0.148
transmembrane transport GO:0055085 412 0.148
regulation of purine nucleotide biosynthetic process GO:1900371 46 0.130
macromolecular complex subunit organization GO:0043933 339 0.130
cation transport GO:0006812 382 0.128
positive regulation of mitochondrial membrane permeability GO:0035794 1 0.127
ribose phosphate metabolic process GO:0019693 235 0.126
peptidyl amino acid modification GO:0018193 126 0.124
Human
nucleic acid templated transcription GO:0097659 379 0.123
ribose phosphate biosynthetic process GO:0046390 87 0.121
regulation of rna metabolic process GO:0051252 391 0.120
positive regulation of nucleotide biosynthetic process GO:0030810 36 0.120
response to oxidative stress GO:0006979 186 0.119
developmental growth GO:0048589 100 0.118
regulation of nucleotide metabolic process GO:0006140 117 0.115
response to corticosteroid GO:0031960 235 0.112
organophosphate biosynthetic process GO:0090407 143 0.106
positive regulation of cyclase activity GO:0031281 15 0.105
pigment biosynthetic process GO:0046148 4 0.103
response to glucocorticoid GO:0051384 223 0.102
ribonucleoside metabolic process GO:0009119 174 0.100
response to amine GO:0014075 46 0.099
organonitrogen compound biosynthetic process GO:1901566 167 0.098
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.092
regulation of cellular ketone metabolic process GO:0010565 27 0.091
protein phosphorylation GO:0006468 345 0.091
response to peptide GO:1901652 292 0.091
response to mineralocorticoid GO:0051385 49 0.086
response to acid chemical GO:0001101 222 0.085
positive regulation of cellular biosynthetic process GO:0031328 295 0.084
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.082
positive regulation of catalytic activity GO:0043085 184 0.082
metal ion transport GO:0030001 289 0.080
regulation of calcium ion transmembrane transport GO:1903169 18 0.080
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.079
single organism organelle organization GO:1902589 180 0.076
regulation of rna biosynthetic process GO:2001141 381 0.076
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.074
cation transmembrane transport GO:0098655 263 0.073
organelle organization GO:0006996 266 0.073
Human
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.072
ribonucleotide metabolic process GO:0009259 231 0.071
cellular component assembly GO:0022607 360 0.071
positive regulation of biosynthetic process GO:0009891 319 0.071
cellular component biogenesis GO:0044085 368 0.069
nucleotide metabolic process GO:0009117 279 0.069
carbohydrate derivative biosynthetic process GO:1901137 124 0.069
negative regulation of metabolic process GO:0009892 331 0.064
negative regulation of rna biosynthetic process GO:1902679 118 0.062
cellular response to oxygen containing compound GO:1901701 386 0.062
regulation of cyclic nucleotide metabolic process GO:0030799 51 0.062
regulation of cellular amine metabolic process GO:0033238 8 0.062
positive regulation of camp biosynthetic process GO:0030819 28 0.062
positive regulation of developmental process GO:0051094 283 0.062
regulation of catalytic activity GO:0050790 304 0.061
adult locomotory behavior GO:0008344 4 0.061
organophosphate metabolic process GO:0019637 370 0.057
positive regulation of kinase activity GO:0033674 77 0.057
dna metabolic process GO:0006259 96 0.057
negative regulation of cellular biosynthetic process GO:0031327 161 0.057
positive regulation of multicellular organismal process GO:0051240 387 0.057
ion transmembrane transport GO:0034220 365 0.056
catabolic process GO:0009056 351 0.056
cyclic purine nucleotide metabolic process GO:0052652 62 0.055
regulation of transmembrane transporter activity GO:0022898 49 0.055
amino acid transport GO:0006865 70 0.055
nucleotide biosynthetic process GO:0009165 98 0.054
cellular chemical homeostasis GO:0055082 247 0.053
immune system process GO:0002376 204 0.053
ribonucleoside triphosphate metabolic process GO:0009199 141 0.052
regulation of nucleic acid templated transcription GO:1903506 380 0.050
multi organism reproductive process GO:0044703 262 0.050
regulation of neuron apoptotic process GO:0043523 83 0.050
regulation of phosphorus metabolic process GO:0051174 349 0.050
purine ribonucleotide metabolic process GO:0009150 227 0.049
positive regulation of protein phosphorylation GO:0001934 135 0.049
positive regulation of atp biosynthetic process GO:2001171 2 0.049
regulation of cellular amino acid metabolic process GO:0006521 2 0.048
regulation of cellular component organization GO:0051128 368 0.048
neuron apoptotic process GO:0051402 88 0.048
positive regulation of cellular amine metabolic process GO:0033240 3 0.048
cyclic nucleotide metabolic process GO:0009187 80 0.048
positive regulation of nitric oxide synthase activity GO:0051000 5 0.047
camp metabolic process GO:0046058 63 0.047
negative regulation of biosynthetic process GO:0009890 168 0.047
organic acid transport GO:0015849 116 0.047
positive regulation of transferase activity GO:0051347 81 0.047
inorganic ion transmembrane transport GO:0098660 229 0.046
rna biosynthetic process GO:0032774 380 0.046
purine ribonucleotide biosynthetic process GO:0009152 81 0.045
regulation of transcription dna templated GO:0006355 374 0.045
negative regulation of macromolecule metabolic process GO:0010605 260 0.045
intracellular signal transduction GO:0035556 314 0.045
response to peptide hormone GO:0043434 278 0.045
neuron projection development GO:0031175 273 0.044
membrane organization GO:0061024 94 0.044
chemical homeostasis GO:0048878 292 0.044
regulation of calcium ion transmembrane transporter activity GO:1901019 17 0.044
heme biosynthetic process GO:0006783 4 0.043
cell part morphogenesis GO:0032990 123 0.043
regulation of programmed cell death GO:0043067 341 0.043
cellular response to endogenous stimulus GO:0071495 377 0.043
negative regulation of cell death GO:0060548 229 0.043
cell redox homeostasis GO:0045454 1 0.042
synaptic transmission GO:0007268 235 0.042
hair follicle development GO:0001942 2 0.041
calcium ion transport GO:0006816 131 0.041
regulation of purine nucleotide metabolic process GO:1900542 115 0.041
regulation of cellular localization GO:0060341 263 0.041
Human
neuron development GO:0048666 286 0.040
transcription dna templated GO:0006351 377 0.040
single organism biosynthetic process GO:0044711 342 0.040
regulation of membrane potential GO:0042391 110 0.040
positive regulation of transport GO:0051050 245 0.040
Human
macromolecular complex assembly GO:0065003 273 0.039
positive regulation of cyclic nucleotide biosynthetic process GO:0030804 34 0.039
circulatory system process GO:0003013 183 0.038
regulation of intracellular transport GO:0032386 65 0.038
response to thyroxine GO:0097068 3 0.038
retinal metabolic process GO:0042574 3 0.036
purine nucleotide transport GO:0015865 3 0.036
regulation of cyclic nucleotide biosynthetic process GO:0030802 45 0.036
positive regulation of cyclic nucleotide metabolic process GO:0030801 37 0.035
multicellular organismal homeostasis GO:0048871 49 0.034
positive regulation of phosphorylation GO:0042327 177 0.034
nuclear transport GO:0051169 49 0.034
hippocampus development GO:0021766 30 0.034
negative regulation of cellular metabolic process GO:0031324 281 0.034
ion homeostasis GO:0050801 212 0.033
cellular homeostasis GO:0019725 252 0.033
nucleoside phosphate metabolic process GO:0006753 283 0.033
regulation of neuron death GO:1901214 115 0.033
neuron projection morphogenesis GO:0048812 122 0.033
negative regulation of gene expression GO:0010629 199 0.033
carboxylic acid transport GO:0046942 115 0.033
divalent metal ion transport GO:0070838 132 0.033
negative regulation of transcription dna templated GO:0045892 116 0.033
anatomical structure homeostasis GO:0060249 29 0.032
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.032
defense response GO:0006952 194 0.031
regulation of cell development GO:0060284 263 0.031
peptidyl serine phosphorylation GO:0018105 33 0.031
organic substance catabolic process GO:1901575 316 0.031
growth GO:0040007 165 0.030
dicarboxylic acid transport GO:0006835 34 0.030
cellular lipid metabolic process GO:0044255 208 0.030
norepinephrine metabolic process GO:0042415 3 0.030
cofactor transport GO:0051181 5 0.030
positive regulation of transporter activity GO:0032411 14 0.030
positive regulation of ion transport GO:0043270 94 0.029
positive regulation of cell differentiation GO:0045597 217 0.029
purine containing compound metabolic process GO:0072521 253 0.029
regulation of camp biosynthetic process GO:0030817 38 0.029
protein import into nucleus GO:0006606 35 0.029
ribonucleoside triphosphate biosynthetic process GO:0009201 7 0.028
regulation of mitochondrial membrane permeability GO:0046902 5 0.028
regulation of cell proliferation GO:0042127 359 0.028
regulation of phosphorylation GO:0042325 248 0.028
positive regulation of cell proliferation GO:0008284 249 0.028
glycosyl compound biosynthetic process GO:1901659 25 0.027
inflammatory response GO:0006954 150 0.027
response to monosaccharide GO:0034284 159 0.027
striated muscle contraction GO:0006941 44 0.027
multicellular organism reproduction GO:0032504 233 0.027
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.027
nucleoside transport GO:0015858 8 0.027
neuron differentiation GO:0030182 368 0.027
cellular calcium ion homeostasis GO:0006874 160 0.027
salivary gland development GO:0007431 3 0.026
purine nucleotide biosynthetic process GO:0006164 83 0.026
positive regulation of protein metabolic process GO:0051247 178 0.026
regulation of multicellular organismal development GO:2000026 376 0.026
aging GO:0007568 241 0.026
negative regulation of response to stimulus GO:0048585 155 0.025
single organism behavior GO:0044708 130 0.025
cell projection organization GO:0030030 302 0.025
regulation of ion transmembrane transporter activity GO:0032412 48 0.025
organelle localization GO:0051640 55 0.025
regulation of mitochondrion organization GO:0010821 7 0.025
positive regulation of cellular protein metabolic process GO:0032270 167 0.025
amine metabolic process GO:0009308 38 0.025
cellular response to stress GO:0033554 269 0.024
nucleobase containing small molecule metabolic process GO:0055086 316 0.024
reproduction GO:0000003 245 0.024
negative regulation of rna metabolic process GO:0051253 123 0.024
cellular response to peptide GO:1901653 133 0.024
jak stat cascade GO:0007259 26 0.024
divalent inorganic cation transport GO:0072511 134 0.023
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.023
nitrogen compound transport GO:0071705 229 0.023
second messenger mediated signaling GO:0019932 51 0.023
blood circulation GO:0008015 183 0.023
collecting duct development GO:0072044 1 0.023
response to inorganic substance GO:0010035 377 0.022
taxis GO:0042330 67 0.022
immune response GO:0006955 104 0.022
mitochondrial calcium ion homeostasis GO:0051560 3 0.022
calcium ion transmembrane transport GO:0070588 70 0.021
positive regulation of protein modification process GO:0031401 142 0.021
regulation of camp metabolic process GO:0030814 43 0.021
response to mechanical stimulus GO:0009612 134 0.021
negative regulation of neuron apoptotic process GO:0043524 45 0.021
anion transport GO:0006820 178 0.021
purine ribonucleoside metabolic process GO:0046128 168 0.021
regulation of protein modification process GO:0031399 194 0.020
carbohydrate derivative metabolic process GO:1901135 346 0.020
purine nucleoside metabolic process GO:0042278 169 0.020
organic anion transport GO:0015711 132 0.020
terpenoid metabolic process GO:0006721 37 0.020
multicellular organismal reproductive process GO:0048609 233 0.020
negative regulation of transport GO:0051051 136 0.019
purine nucleotide metabolic process GO:0006163 229 0.019
adp transport GO:0015866 1 0.019
cell morphogenesis GO:0000902 142 0.019
neuron death GO:0070997 127 0.019
l amino acid import GO:0043092 5 0.019
positive regulation of nucleic acid templated transcription GO:1903508 197 0.018
cell activation GO:0001775 97 0.018
peptidyl serine modification GO:0018209 34 0.018
neurotransmitter transport GO:0006836 42 0.018
programmed cell death GO:0012501 392 0.018
cell cell signaling GO:0007267 335 0.018
tetrapyrrole metabolic process GO:0033013 11 0.018
cellular amino acid metabolic process GO:0006520 107 0.018
axon development GO:0061564 96 0.017
response to hexose GO:0009746 144 0.017
ribonucleotide biosynthetic process GO:0009260 85 0.017
regulation of protein kinase activity GO:0045859 105 0.017
protein import into nucleus translocation GO:0000060 9 0.016
head development GO:0060322 247 0.016
ctp biosynthetic process GO:0006241 1 0.016
nucleoside metabolic process GO:0009116 179 0.016
positive regulation of lyase activity GO:0051349 15 0.016
organic acid metabolic process GO:0006082 292 0.016
cyclic nucleotide biosynthetic process GO:0009190 63 0.016
response to glucose GO:0009749 136 0.016
regulation of ion transmembrane transport GO:0034765 121 0.016
regulation of immune system process GO:0002682 123 0.016
establishment of neuroblast polarity GO:0045200 1 0.016
purine ribonucleoside biosynthetic process GO:0046129 21 0.015
rho protein signal transduction GO:0007266 11 0.015
regulation of ion transport GO:0043269 245 0.015
central nervous system development GO:0007417 311 0.015
protein complex subunit organization GO:0071822 302 0.015
alditol metabolic process GO:0019400 4 0.015
cation homeostasis GO:0055080 195 0.015
cellular carbohydrate metabolic process GO:0044262 72 0.015
dna replication GO:0006260 37 0.015
regulation of transferase activity GO:0051338 123 0.015
apoptotic process GO:0006915 381 0.014
action potential GO:0001508 54 0.014
regulation of metal ion transport GO:0010959 118 0.014
acidic amino acid transport GO:0015800 10 0.014
regulation of signal transduction GO:0009966 318 0.014
response to wounding GO:0009611 254 0.014
calcium mediated signaling GO:0019722 23 0.014
positive regulation of lipid kinase activity GO:0090218 2 0.014
molting cycle GO:0042303 3 0.014
positive regulation of pseudopodium assembly GO:0031274 1 0.013
tube development GO:0035295 89 0.013
positive regulation of intracellular signal transduction GO:1902533 138 0.013
regulation of anatomical structure size GO:0090066 135 0.013
negative regulation of apoptotic process GO:0043066 181 0.013
positive regulation of response to stimulus GO:0048584 285 0.013
gastrulation GO:0007369 2 0.013
sorbitol biosynthetic process GO:0006061 1 0.013
telencephalon development GO:0021537 62 0.013
mitochondrial transport GO:0006839 19 0.013
innate immune response GO:0045087 35 0.013
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.013
cellular response to insulin stimulus GO:0032869 81 0.013
l amino acid transport GO:0015807 21 0.013
cellular divalent inorganic cation homeostasis GO:0072503 162 0.013
multicellular organism growth GO:0035264 1 0.013
negative regulation of mitochondrion organization GO:0010823 2 0.013
endocytosis GO:0006897 84 0.013
single organism catabolic process GO:0044712 283 0.013
positive regulation of nucleoside metabolic process GO:0045979 55 0.013
negative regulation of neuron death GO:1901215 69 0.012
metal ion homeostasis GO:0055065 186 0.012
monovalent inorganic cation transport GO:0015672 172 0.012
regulation of protein phosphorylation GO:0001932 183 0.012
cell growth GO:0016049 104 0.012
regulation of neurotransmitter levels GO:0001505 42 0.012
mitochondrion organization GO:0007005 35 0.012
positive regulation of lamellipodium assembly GO:0010592 4 0.012
cellular component movement GO:0006928 248 0.012
isoprenoid metabolic process GO:0006720 45 0.012
regulation of cellular catabolic process GO:0031329 101 0.012
carboxylic acid metabolic process GO:0019752 289 0.012
spliceosomal complex assembly GO:0000245 2 0.011
single organism intracellular transport GO:1902582 166 0.011
protein oligomerization GO:0051259 191 0.011
regulation of protein metabolic process GO:0051246 289 0.011
purine nucleoside triphosphate biosynthetic process GO:0009145 6 0.011
negative regulation of protein modification by small protein conjugation or removal GO:1903321 4 0.011
regulation of developmental growth GO:0048638 45 0.011
cellular response to organonitrogen compound GO:0071417 197 0.011
single organism membrane organization GO:0044802 74 0.011
regulation of kinase activity GO:0043549 117 0.011
positive regulation of cell communication GO:0010647 271 0.011
anion transmembrane transport GO:0098656 77 0.011
nucleocytoplasmic transport GO:0006913 48 0.011
regulation of blood circulation GO:1903522 110 0.010
response to hydrogen peroxide GO:0042542 89 0.010
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.010
vesicle mediated transport GO:0016192 181 0.010
cellular component morphogenesis GO:0032989 155 0.010
carbohydrate homeostasis GO:0033500 75 0.010
regulation of cyclase activity GO:0031279 21 0.010
heart contraction GO:0060047 57 0.010
pseudopodium assembly GO:0031269 3 0.010
regulation of body fluid levels GO:0050878 90 0.010

Ppia disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
osteochondrodysplasia DOID:2256 0 0.016
bone development disease DOID:0080006 0 0.016
bone disease DOID:0080001 0 0.016
disease of anatomical entity DOID:7 0 0.016
musculoskeletal system disease DOID:17 0 0.016
connective tissue disease DOID:65 0 0.016