Rattus norvegicus

0 known processes

Hcn4

hyperpolarization activated cyclic nucleotide-gated potassium channel 4

Hcn4 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
inorganic cation transmembrane transport GO:0098662 202 0.454
Human
regulation of multicellular organismal development GO:2000026 376 0.255
cation transmembrane transport GO:0098655 263 0.250
Human Mouse Rat
positive regulation of cell proliferation GO:0008284 249 0.247
brain development GO:0007420 247 0.181
Rat
neurological system process GO:0050877 219 0.180
cellular cation homeostasis GO:0030003 180 0.172
Rat
heart contraction GO:0060047 57 0.156
Human Mouse Rat
response to estrogen GO:0043627 232 0.140
regulation of heart contraction GO:0008016 48 0.138
Human Mouse Rat
regulation of ion transport GO:0043269 245 0.132
Human
response to cytokine GO:0034097 215 0.130
cellular divalent inorganic cation homeostasis GO:0072503 162 0.128
Rat
metal ion homeostasis GO:0055065 186 0.124
Rat
cellular ion homeostasis GO:0006873 184 0.124
Rat
cell cell signaling GO:0007267 335 0.123
anatomical structure morphogenesis GO:0009653 298 0.113
localization of cell GO:0051674 202 0.112
cytosolic calcium ion homeostasis GO:0051480 140 0.106
Rat
locomotion GO:0040011 237 0.105
cell projection organization GO:0030030 302 0.104
regulation of synaptic transmission GO:0050804 141 0.102
cellular component movement GO:0006928 248 0.101
ion transmembrane transport GO:0034220 365 0.101
Human Mouse Rat
neuron projection development GO:0031175 273 0.096
secretion GO:0046903 307 0.095
regulation of cell development GO:0060284 263 0.095
cellular response to oxygen containing compound GO:1901701 386 0.094
Human
defense response GO:0006952 194 0.093
regulation of nervous system development GO:0051960 264 0.092
regulation of membrane potential GO:0042391 110 0.091
Human
regulation of signal transduction GO:0009966 318 0.086
cellular homeostasis GO:0019725 252 0.086
Rat
nucleic acid templated transcription GO:0097659 379 0.085
synaptic transmission GO:0007268 235 0.084
regulation of cell proliferation GO:0042127 359 0.084
positive regulation of cellular biosynthetic process GO:0031328 295 0.083
sensory perception of pain GO:0019233 73 0.082
negative regulation of multicellular organismal process GO:0051241 203 0.082
chemical homeostasis GO:0048878 292 0.081
Rat
secretion by cell GO:0032940 248 0.080
metal ion transport GO:0030001 289 0.080
Human
response to other organism GO:0051707 220 0.079
axon development GO:0061564 96 0.078
negative regulation of transport GO:0051051 136 0.077
cellular chemical homeostasis GO:0055082 247 0.076
Rat
regulation of neurogenesis GO:0050767 247 0.074
positive regulation of nervous system development GO:0051962 178 0.074
response to metal ion GO:0010038 253 0.073
positive regulation of response to stimulus GO:0048584 285 0.072
regulation of phosphate metabolic process GO:0019220 349 0.071
homeostatic process GO:0042592 331 0.071
Rat
circulatory system development GO:0072359 134 0.071
neuron death GO:0070997 127 0.070
cation transport GO:0006812 382 0.070
Human Mouse Rat
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.069
positive regulation of biosynthetic process GO:0009891 319 0.069
regulation of neuron differentiation GO:0045664 208 0.068
ion homeostasis GO:0050801 212 0.066
Rat
cell migration GO:0016477 197 0.065
inorganic ion transmembrane transport GO:0098660 229 0.064
Human
positive regulation of cell differentiation GO:0045597 217 0.063
positive regulation of neurogenesis GO:0050769 165 0.063
organ morphogenesis GO:0009887 75 0.063
response to external biotic stimulus GO:0043207 221 0.061
neuron differentiation GO:0030182 368 0.060
regulation of blood pressure GO:0008217 83 0.059
divalent inorganic cation homeostasis GO:0072507 165 0.058
Rat
regulation of nucleic acid templated transcription GO:1903506 380 0.058
action potential GO:0001508 54 0.057
regulation of secretion GO:0051046 224 0.057
regulation of neuron projection development GO:0010975 161 0.057
rna metabolic process GO:0016070 406 0.057
dicarboxylic acid transport GO:0006835 34 0.057
neuron development GO:0048666 286 0.056
regulation of growth GO:0040008 105 0.056
sensory perception GO:0007600 101 0.055
detection of stimulus GO:0051606 24 0.054
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.053
response to nutrient levels GO:0031667 370 0.053
immune system process GO:0002376 204 0.052
signal transduction by phosphorylation GO:0023014 144 0.052
positive regulation of signal transduction GO:0009967 175 0.052
regulation of cell differentiation GO:0045595 320 0.051
muscle contraction GO:0006936 88 0.051
transmission of nerve impulse GO:0019226 42 0.051
organic anion transport GO:0015711 132 0.051
amine metabolic process GO:0009308 38 0.049
rna biosynthetic process GO:0032774 380 0.049
cellular component morphogenesis GO:0032989 155 0.048
programmed cell death GO:0012501 392 0.047
intracellular signal transduction GO:0035556 314 0.046
regulation of rna biosynthetic process GO:2001141 381 0.046
positive regulation of phosphorylation GO:0042327 177 0.046
response to inorganic substance GO:0010035 377 0.044
response to decreased oxygen levels GO:0036293 237 0.044
development of primary sexual characteristics GO:0045137 107 0.044
cellular response to lipid GO:0071396 201 0.044
regulation of transcription dna templated GO:0006355 374 0.044
regulation of locomotion GO:0040012 148 0.043
positive regulation of signaling GO:0023056 270 0.043
cell projection morphogenesis GO:0048858 123 0.043
multi organism reproductive process GO:0044703 262 0.042
muscle system process GO:0003012 115 0.042
negative regulation of signaling GO:0023057 157 0.041
regulation of g protein coupled receptor protein signaling pathway GO:0008277 28 0.041
positive regulation of secretion by cell GO:1903532 128 0.041
positive regulation of multicellular organismal process GO:0051240 387 0.041
Rat
regulation of rna metabolic process GO:0051252 391 0.041
response to peptide hormone GO:0043434 278 0.041
cellular amine metabolic process GO:0044106 38 0.041
response to peptide GO:1901652 292 0.041
reproductive process GO:0022414 372 0.041
tissue development GO:0009888 252 0.040
regulation of apoptotic process GO:0042981 335 0.040
response to oxygen levels GO:0070482 265 0.038
organic substance catabolic process GO:1901575 316 0.038
regulation of secretion by cell GO:1903530 208 0.038
cellular response to stress GO:0033554 269 0.037
organelle organization GO:0006996 266 0.037
positive regulation of protein metabolic process GO:0051247 178 0.037
regulation of intracellular signal transduction GO:1902531 218 0.037
single organism biosynthetic process GO:0044711 342 0.036
regulation of programmed cell death GO:0043067 341 0.036
monovalent inorganic cation transport GO:0015672 172 0.036
Human
positive regulation of epithelial cell proliferation GO:0050679 32 0.036
response to extracellular stimulus GO:0009991 380 0.036
regulation of cellular component organization GO:0051128 368 0.036
negative regulation of cell communication GO:0010648 158 0.036
negative regulation of ion transport GO:0043271 51 0.035
developmental growth involved in morphogenesis GO:0060560 33 0.035
positive regulation of developmental process GO:0051094 283 0.035
positive regulation of catalytic activity GO:0043085 184 0.035
cellular response to hormone stimulus GO:0032870 247 0.035
cardiovascular system development GO:0072358 134 0.035
regulation of muscle system process GO:0090257 79 0.035
response to lipopolysaccharide GO:0032496 191 0.035
behavior GO:0007610 205 0.034
negative regulation of cellular biosynthetic process GO:0031327 161 0.034
oxoacid metabolic process GO:0043436 290 0.034
regulation of system process GO:0044057 208 0.034
Human Mouse Rat
regulation of molecular function GO:0065009 398 0.034
inflammatory response GO:0006954 150 0.034
defecation GO:0030421 1 0.033
positive regulation of cell development GO:0010720 176 0.033
positive regulation of intracellular signal transduction GO:1902533 138 0.033
cell morphogenesis GO:0000902 142 0.032
positive regulation of molecular function GO:0044093 230 0.031
epithelial cell proliferation GO:0050673 54 0.031
regulation of peptide transport GO:0090087 87 0.031
response to calcium ion GO:0051592 59 0.031
response to acid chemical GO:0001101 222 0.031
regulation of phosphorylation GO:0042325 248 0.031
response to growth factor GO:0070848 189 0.030
cellular metal ion homeostasis GO:0006875 172 0.030
Rat
cellular response to drug GO:0035690 30 0.030
regulation of blood circulation GO:1903522 110 0.030
Human Mouse Rat
negative regulation of developmental process GO:0051093 125 0.029
cellular amino acid metabolic process GO:0006520 107 0.029
regulation of cellular amine metabolic process GO:0033238 8 0.029
organic hydroxy compound metabolic process GO:1901615 115 0.029
regulation of defecation GO:2000292 1 0.029
developmental growth GO:0048589 100 0.029
response to estradiol GO:0032355 164 0.029
negative regulation of secretion by cell GO:1903531 72 0.029
carboxylic acid transport GO:0046942 115 0.029
synaptic transmission cholinergic GO:0007271 11 0.028
anterior posterior pattern specification GO:0009952 1 0.028
heart process GO:0003015 57 0.028
Human Mouse Rat
growth GO:0040007 165 0.028
enzyme linked receptor protein signaling pathway GO:0007167 116 0.028
positive regulation of phosphate metabolic process GO:0045937 262 0.028
developmental process involved in reproduction GO:0003006 159 0.028
actin filament based process GO:0030029 86 0.027
regulation of peptide hormone secretion GO:0090276 80 0.027
anion transport GO:0006820 178 0.027
circulatory system process GO:0003013 183 0.027
Human Mouse Rat
apoptotic process GO:0006915 381 0.026
positive regulation of nucleic acid templated transcription GO:1903508 197 0.026
blood circulation GO:0008015 183 0.026
Human Mouse Rat
positive regulation of cellular component organization GO:0051130 200 0.026
potassium ion transport GO:0006813 97 0.026
Human
cation homeostasis GO:0055080 195 0.026
Rat
organic acid metabolic process GO:0006082 292 0.026
cellular component biogenesis GO:0044085 368 0.026
Rat
negative regulation of cellular component organization GO:0051129 83 0.026
protein complex subunit organization GO:0071822 302 0.025
Rat
response to mechanical stimulus GO:0009612 134 0.025
response to molecule of bacterial origin GO:0002237 194 0.025
regulation of cellular protein metabolic process GO:0032268 267 0.025
multicellular organism reproduction GO:0032504 233 0.025
regulation of homeostatic process GO:0032844 101 0.025
micturition GO:0060073 4 0.025
cellular component assembly GO:0022607 360 0.025
Rat
protein phosphorylation GO:0006468 345 0.025
motor neuron axon guidance GO:0008045 1 0.025
axonogenesis GO:0007409 71 0.025
neuron projection morphogenesis GO:0048812 122 0.025
amino acid transport GO:0006865 70 0.025
negative regulation of programmed cell death GO:0043069 183 0.024
positive regulation of cellular amine metabolic process GO:0033240 3 0.024
single organism organelle organization GO:1902589 180 0.024
regulation of phosphorus metabolic process GO:0051174 349 0.024
regulation of behavior GO:0050795 61 0.024
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.024
transcription dna templated GO:0006351 377 0.024
cellular ketone metabolic process GO:0042180 51 0.024
negative regulation of neuron differentiation GO:0045665 62 0.024
organic acid transport GO:0015849 116 0.023
response to biotic stimulus GO:0009607 226 0.023
positive regulation of leukocyte activation GO:0002696 30 0.023
positive regulation of synaptic transmission GO:0050806 62 0.023
positive regulation of phosphorus metabolic process GO:0010562 262 0.023
regulation of cellular localization GO:0060341 263 0.023
response to radiation GO:0009314 137 0.023
regulation of catalytic activity GO:0050790 304 0.023
regulation of cellular component movement GO:0051270 150 0.023
regulation of organic acid transport GO:0032890 35 0.023
epithelium development GO:0060429 96 0.022
regulation of neuron death GO:1901214 115 0.022
positive regulation of secretion GO:0051047 140 0.022
regulation of amino acid transport GO:0051955 25 0.022
anatomical structure formation involved in morphogenesis GO:0048646 83 0.022
eye morphogenesis GO:0048592 4 0.022
catabolic process GO:0009056 351 0.022
response to ethanol GO:0045471 162 0.022
glutamate secretion GO:0014047 19 0.022
cell motility GO:0048870 202 0.022
positive regulation of protein modification process GO:0031401 142 0.022
negative regulation of apoptotic process GO:0043066 181 0.021
calcium ion homeostasis GO:0055074 162 0.021
Rat
negative regulation of cell death GO:0060548 229 0.021
leukocyte activation GO:0045321 76 0.021
transmembrane transport GO:0055085 412 0.021
Human Mouse Rat
negative regulation of nervous system development GO:0051961 79 0.021
steroid metabolic process GO:0008202 73 0.021
response to light stimulus GO:0009416 52 0.021
muscle tissue development GO:0060537 58 0.021
single organism reproductive process GO:0044702 297 0.021
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.021
neuron projection guidance GO:0097485 24 0.020
mapk cascade GO:0000165 140 0.020
regulation of cell migration GO:0030334 128 0.020
negative regulation of cell development GO:0010721 82 0.020
response to bacterium GO:0009617 200 0.020
acid secretion GO:0046717 48 0.020
smooth muscle cell proliferation GO:0048659 77 0.020
response to transition metal nanoparticle GO:1990267 122 0.020
neuropeptide signaling pathway GO:0007218 29 0.020
multicellular organismal signaling GO:0035637 44 0.020
detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 4 0.020
lipid biosynthetic process GO:0008610 128 0.020
regulation of cellular amino acid metabolic process GO:0006521 2 0.019
protein complex biogenesis GO:0070271 263 0.019
Rat
regulation of protein metabolic process GO:0051246 289 0.019
cellular response to growth factor stimulus GO:0071363 162 0.019
negative regulation of macromolecule metabolic process GO:0010605 260 0.019
positive regulation of response to food GO:0032097 3 0.019
regulation of smooth muscle cell proliferation GO:0048660 75 0.019
regulation of cellular ketone metabolic process GO:0010565 27 0.019
retina morphogenesis in camera type eye GO:0060042 1 0.019
regulation of amine transport GO:0051952 54 0.019
sexual reproduction GO:0019953 148 0.019
positive regulation of transcription dna templated GO:0045893 197 0.019
gonad development GO:0008406 104 0.019
detection of chemical stimulus GO:0009593 10 0.019
cytoskeleton organization GO:0007010 111 0.018
cellular response to abiotic stimulus GO:0071214 85 0.018
head development GO:0060322 247 0.018
Rat
positive regulation of cell projection organization GO:0031346 111 0.018
cell morphogenesis involved in differentiation GO:0000904 119 0.018
carbohydrate derivative metabolic process GO:1901135 346 0.018
transcription from rna polymerase ii promoter GO:0006366 252 0.018
regulation of protein modification process GO:0031399 194 0.018
regulation of peptide secretion GO:0002791 82 0.018
nucleoside phosphate metabolic process GO:0006753 283 0.018
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.018
negative regulation of luteinizing hormone secretion GO:0033685 4 0.018
biological adhesion GO:0022610 110 0.017
negative regulation of cell differentiation GO:0045596 99 0.017
muscle structure development GO:0061061 87 0.017
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.017
positive regulation of smooth muscle cell proliferation GO:0048661 51 0.017
reactive oxygen species metabolic process GO:0072593 37 0.017
glutamate receptor signaling pathway GO:0007215 43 0.017
cellular response to metal ion GO:0071248 55 0.017
positive regulation of transferase activity GO:0051347 81 0.017
negative regulation of cellular metabolic process GO:0031324 281 0.017
positive regulation of cellular protein metabolic process GO:0032270 167 0.017
negative regulation of secretion GO:0051048 82 0.017
negative regulation of biosynthetic process GO:0009890 168 0.017
positive regulation of protein phosphorylation GO:0001934 135 0.017
multicellular organismal reproductive process GO:0048609 233 0.017
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.017
vesicle mediated transport GO:0016192 181 0.017
positive regulation of rna metabolic process GO:0051254 203 0.017
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.016
nitrogen compound transport GO:0071705 229 0.016
central nervous system development GO:0007417 311 0.016
Rat
regulation of epithelial cell proliferation GO:0050678 49 0.016
positive regulation of cell communication GO:0010647 271 0.016
smooth muscle contraction involved in micturition GO:0060083 1 0.016
organonitrogen compound biosynthetic process GO:1901566 167 0.016
cellular calcium ion homeostasis GO:0006874 160 0.016
Rat
positive regulation of lymphocyte proliferation GO:0050671 20 0.016
response to alkaloid GO:0043279 132 0.016
regulation of heart rate GO:0002027 16 0.016
Human
regulation of cell cycle GO:0051726 73 0.016
calcium ion import GO:0070509 22 0.016
striated muscle contraction GO:0006941 44 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.015
proteolysis GO:0006508 175 0.015
axon guidance GO:0007411 24 0.015
neuronal action potential GO:0019228 35 0.015
protein complex assembly GO:0006461 263 0.015
Rat
regulation of anion transport GO:0044070 43 0.015
positive regulation of programmed cell death GO:0043068 157 0.015
positive regulation of protein kinase activity GO:0045860 73 0.015
nucleotide metabolic process GO:0009117 279 0.015
cell adhesion GO:0007155 110 0.015
regulation of ion homeostasis GO:2000021 63 0.015
regulation of protein kinase activity GO:0045859 105 0.015
regulation of cellular component biogenesis GO:0044087 86 0.015
blood vessel development GO:0001568 69 0.014
muscle cell proliferation GO:0033002 84 0.014
gamete generation GO:0007276 124 0.014
cellular catabolic process GO:0044248 295 0.014
positive regulation of serotonin secretion GO:0014064 1 0.014
nucleobase containing small molecule metabolic process GO:0055086 316 0.014
neuromuscular process GO:0050905 2 0.014
sensory organ development GO:0007423 74 0.014
camera type eye morphogenesis GO:0048593 2 0.014
reproduction GO:0000003 245 0.014
negative regulation of response to stimulus GO:0048585 155 0.014
response to insulin GO:0032868 133 0.014
regulation of mapk cascade GO:0043408 116 0.014
organic cyclic compound catabolic process GO:1901361 175 0.014
macromolecular complex assembly GO:0065003 273 0.013
Rat
cell growth GO:0016049 104 0.013
muscle organ development GO:0007517 50 0.013
rhythmic process GO:0048511 156 0.013
regulation of protein phosphorylation GO:0001932 183 0.013
excretion GO:0007588 24 0.013
hormone transport GO:0009914 121 0.013
ovulation cycle process GO:0022602 50 0.013
regulation of neuron apoptotic process GO:0043523 83 0.013
g protein coupled receptor signaling pathway GO:0007186 242 0.013
positive regulation of neuron projection development GO:0010976 99 0.013
positive regulation of transport GO:0051050 245 0.013
regulation of metal ion transport GO:0010959 118 0.013
anatomical structure homeostasis GO:0060249 29 0.013
peptidyl amino acid modification GO:0018193 126 0.013
immune response GO:0006955 104 0.013
positive regulation of mapk cascade GO:0043410 92 0.013
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.013
steroid biosynthetic process GO:0006694 48 0.013
lipid metabolic process GO:0006629 283 0.013
cellular response to acid chemical GO:0071229 75 0.013
protein catabolic process GO:0030163 30 0.012
positive regulation of apoptotic process GO:0043065 154 0.012
negative regulation of hormone secretion GO:0046888 46 0.012
striated muscle tissue development GO:0014706 58 0.012
regulation of axonogenesis GO:0050770 37 0.012
adaptation of signaling pathway GO:0023058 10 0.012
cell part morphogenesis GO:0032990 123 0.012
negative regulation of calcium ion import GO:0090281 2 0.012
negative regulation of cell projection organization GO:0031345 50 0.012
dendrite development GO:0016358 72 0.012
forebrain development GO:0030900 98 0.012
amide transport GO:0042886 105 0.012
positive regulation of gene expression GO:0010628 244 0.012
axis specification GO:0009798 4 0.012
regulation of immunoglobulin mediated immune response GO:0002889 2 0.012
actin filament organization GO:0007015 42 0.012
regulation of cell motility GO:2000145 131 0.012
regulation of cellular response to stress GO:0080135 49 0.012
locomotory exploration behavior GO:0035641 1 0.012
regulation of hormone secretion GO:0046883 106 0.012
vasculature development GO:0001944 70 0.012
regulation of neurological system process GO:0031644 43 0.011
heart morphogenesis GO:0003007 3 0.011
regulation of immune system process GO:0002682 123 0.011
positive regulation of kinase activity GO:0033674 77 0.011
regulation of isotype switching GO:0045191 1 0.011
response to fatty acid GO:0070542 65 0.011
regulation of action potential GO:0098900 14 0.011
regulation of cellular catabolic process GO:0031329 101 0.011
positive regulation of cellular component movement GO:0051272 102 0.011
cellular response to peptide hormone stimulus GO:0071375 120 0.011
positive regulation of neuron differentiation GO:0045666 126 0.011
positive regulation of cellular catabolic process GO:0031331 71 0.011
positive regulation of rna biosynthetic process GO:1902680 197 0.011
regulation of kinase activity GO:0043549 117 0.011
negative regulation of neuron death GO:1901215 69 0.011
purine nucleotide metabolic process GO:0006163 229 0.011
response to hypoxia GO:0001666 231 0.011
gliogenesis GO:0042063 93 0.011
negative regulation of chronic inflammatory response GO:0002677 2 0.011
carboxylic acid metabolic process GO:0019752 289 0.011
positive regulation of locomotion GO:0040017 102 0.011
cognition GO:0050890 92 0.011
cellular response to organic cyclic compound GO:0071407 202 0.011
Human
positive regulation of blood circulation GO:1903524 65 0.011
Rat
positive regulation of mononuclear cell proliferation GO:0032946 20 0.011
negative regulation of rna biosynthetic process GO:1902679 118 0.011
regulation of developmental growth GO:0048638 45 0.011
cytoplasmic transport GO:0016482 115 0.010
learning or memory GO:0007611 90 0.010
actin cytoskeleton organization GO:0030036 73 0.010
aging GO:0007568 241 0.010
Rat
regulation of muscle contraction GO:0006937 53 0.010
negative regulation of defecation GO:2000293 1 0.010
regulation of transferase activity GO:0051338 123 0.010
activation of protein kinase activity GO:0032147 47 0.010
response to wounding GO:0009611 254 0.010
positive regulation of cell death GO:0010942 184 0.010
ribonucleoside triphosphate catabolic process GO:0009203 122 0.010
peptide secretion GO:0002790 86 0.010
multicellular organismal response to stress GO:0033555 25 0.010
regulation of anatomical structure morphogenesis GO:0022603 141 0.010
response to activity GO:0014823 73 0.010
regulation of glucose transport GO:0010827 18 0.010

Hcn4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.035
Human
nervous system disease DOID:863 0 0.035
musculoskeletal system disease DOID:17 0 0.032
sensory system disease DOID:0050155 0 0.023
eye and adnexa disease DOID:1492 0 0.023
connective tissue disease DOID:65 0 0.019
eye disease DOID:5614 0 0.013