Rattus norvegicus

186 known processes

Il2

interleukin 2

Il2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
positive regulation of multicellular organismal process GO:0051240 387 0.295
regulation of cell proliferation GO:0042127 359 0.238
response to extracellular stimulus GO:0009991 380 0.194
cellular response to endogenous stimulus GO:0071495 377 0.172
regulation of locomotion GO:0040012 148 0.163
response to lipopolysaccharide GO:0032496 191 0.153
positive regulation of cell proliferation GO:0008284 249 0.148
response to nutrient GO:0007584 248 0.134
regeneration GO:0031099 163 0.130
response to nutrient levels GO:0031667 370 0.129
programmed cell death GO:0012501 392 0.123
response to estrogen GO:0043627 232 0.122
cellular chemical homeostasis GO:0055082 247 0.121
positive regulation of developmental process GO:0051094 283 0.118
cellular response to hormone stimulus GO:0032870 247 0.114
response to cytokine GO:0034097 215 0.112
response to molecule of bacterial origin GO:0002237 194 0.106
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.101
organic acid metabolic process GO:0006082 292 0.099
regulation of cellular protein metabolic process GO:0032268 267 0.094
cellular amino acid metabolic process GO:0006520 107 0.093
homeostatic process GO:0042592 331 0.088
reproductive process GO:0022414 372 0.088
negative regulation of response to stimulus GO:0048585 155 0.085
cellular response to cytokine stimulus GO:0071345 127 0.084
cellular response to stress GO:0033554 269 0.083
response to peptide hormone GO:0043434 278 0.080
aging GO:0007568 241 0.077
cellular response to organic cyclic compound GO:0071407 202 0.070
response to oxidative stress GO:0006979 186 0.070
response to ketone GO:1901654 182 0.069
positive regulation of phosphorylation GO:0042327 177 0.067
cellular catabolic process GO:0044248 295 0.067
cytosolic calcium ion homeostasis GO:0051480 140 0.067
regulation of phosphate metabolic process GO:0019220 349 0.066
amine metabolic process GO:0009308 38 0.066
positive regulation of phosphate metabolic process GO:0045937 262 0.065
positive regulation of transport GO:0051050 245 0.065
regulation of signal transduction GO:0009966 318 0.065
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.064
negative regulation of macromolecule metabolic process GO:0010605 260 0.062
response to external biotic stimulus GO:0043207 221 0.061
regulation of protein metabolic process GO:0051246 289 0.061
regulation of phosphorus metabolic process GO:0051174 349 0.061
single organism reproductive process GO:0044702 297 0.060
regulation of multicellular organismal development GO:2000026 376 0.059
regulation of neuron death GO:1901214 115 0.059
regulation of anatomical structure morphogenesis GO:0022603 141 0.058
central nervous system development GO:0007417 311 0.057
cell migration GO:0016477 197 0.056
positive regulation of cellular amine metabolic process GO:0033240 3 0.055
response to vitamin GO:0033273 131 0.055
positive regulation of cell differentiation GO:0045597 217 0.051
cellular ion homeostasis GO:0006873 184 0.051
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.050
regulation of nervous system development GO:0051960 264 0.050
cellular cation homeostasis GO:0030003 180 0.050
cellular component movement GO:0006928 248 0.049
cell cell signaling GO:0007267 335 0.049
female sex differentiation GO:0046660 59 0.048
positive regulation of protein metabolic process GO:0051247 178 0.048
defense response GO:0006952 194 0.047
response to acid chemical GO:0001101 222 0.047
cellular homeostasis GO:0019725 252 0.047
hormone metabolic process GO:0042445 69 0.046
cellular response to oxygen containing compound GO:1901701 386 0.046
multi organism reproductive process GO:0044703 262 0.045
negative regulation of gene expression GO:0010629 199 0.045
positive regulation of catalytic activity GO:0043085 184 0.045
regulation of cell differentiation GO:0045595 320 0.045
response to other organism GO:0051707 220 0.045
steroid metabolic process GO:0008202 73 0.044
positive regulation of signal transduction GO:0009967 175 0.044
cellular metal ion homeostasis GO:0006875 172 0.043
cell motility GO:0048870 202 0.043
response to oxygen levels GO:0070482 265 0.043
positive regulation of cell communication GO:0010647 271 0.042
apoptotic process GO:0006915 381 0.042
positive regulation of cellular biosynthetic process GO:0031328 295 0.042
inflammatory response GO:0006954 150 0.042
metal ion homeostasis GO:0055065 186 0.042
response to peptide GO:1901652 292 0.041
regulation of catalytic activity GO:0050790 304 0.041
cation homeostasis GO:0055080 195 0.040
response to bacterium GO:0009617 200 0.040
neuron development GO:0048666 286 0.040
localization of cell GO:0051674 202 0.040
divalent inorganic cation homeostasis GO:0072507 165 0.040
gland development GO:0048732 155 0.040
single organism biosynthetic process GO:0044711 342 0.039
cellular divalent inorganic cation homeostasis GO:0072503 162 0.039
cellular amine metabolic process GO:0044106 38 0.039
female gonad development GO:0008585 53 0.039
nitrogen compound transport GO:0071705 229 0.039
organic substance catabolic process GO:1901575 316 0.038
multicellular organismal reproductive process GO:0048609 233 0.038
carbohydrate derivative metabolic process GO:1901135 346 0.038
regulation of cellular component movement GO:0051270 150 0.038
protein phosphorylation GO:0006468 345 0.037
purine nucleoside catabolic process GO:0006152 124 0.037
response to reactive oxygen species GO:0000302 120 0.037
positive regulation of cell development GO:0010720 176 0.036
regulation of stress activated protein kinase signaling cascade GO:0070302 23 0.036
purine nucleoside metabolic process GO:0042278 169 0.036
response to corticosteroid GO:0031960 235 0.036
response to decreased oxygen levels GO:0036293 237 0.035
regulation of response to stress GO:0080134 126 0.035
aromatic compound catabolic process GO:0019439 168 0.035
response to glucocorticoid GO:0051384 223 0.035
g protein coupled receptor signaling pathway GO:0007186 242 0.035
positive regulation of phosphorus metabolic process GO:0010562 262 0.035
epithelial cell proliferation GO:0050673 54 0.035
response to ethanol GO:0045471 162 0.034
regulation of response to external stimulus GO:0032101 106 0.034
organophosphate metabolic process GO:0019637 370 0.034
oxoacid metabolic process GO:0043436 290 0.033
rhythmic process GO:0048511 156 0.033
multicellular organism reproduction GO:0032504 233 0.033
positive regulation of molecular function GO:0044093 230 0.033
nucleic acid templated transcription GO:0097659 379 0.033
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.033
single organism catabolic process GO:0044712 283 0.033
tissue development GO:0009888 252 0.032
cellular component biogenesis GO:0044085 368 0.032
cellular response to oxidative stress GO:0034599 76 0.032
cellular lipid metabolic process GO:0044255 208 0.031
regulation of epithelial cell proliferation GO:0050678 49 0.031
proteolysis GO:0006508 175 0.031
calcium ion transport GO:0006816 131 0.031
response to amino acid GO:0043200 75 0.030
catabolic process GO:0009056 351 0.030
positive regulation of nervous system development GO:0051962 178 0.029
response to dexamethasone GO:0071548 49 0.029
reproduction GO:0000003 245 0.029
regulation of transcription dna templated GO:0006355 374 0.029
cellular calcium ion homeostasis GO:0006874 160 0.029
negative regulation of metabolic process GO:0009892 331 0.029
intracellular signal transduction GO:0035556 314 0.029
regulation of rna biosynthetic process GO:2001141 381 0.029
response to inorganic substance GO:0010035 377 0.028
protein complex subunit organization GO:0071822 302 0.028
organonitrogen compound catabolic process GO:1901565 179 0.028
positive regulation of protein modification process GO:0031401 142 0.028
anatomical structure morphogenesis GO:0009653 298 0.027
carboxylic acid metabolic process GO:0019752 289 0.027
behavior GO:0007610 205 0.027
regulation of programmed cell death GO:0043067 341 0.027
cellular response to nitrogen compound GO:1901699 210 0.027
regulation of g protein coupled receptor protein signaling pathway GO:0008277 28 0.027
response to activity GO:0014823 73 0.027
comma shaped body morphogenesis GO:0072049 2 0.026
organophosphate biosynthetic process GO:0090407 143 0.026
response to temperature stimulus GO:0009266 94 0.026
ribose phosphate metabolic process GO:0019693 235 0.026
positive regulation of blood circulation GO:1903524 65 0.025
positive regulation of response to stimulus GO:0048584 285 0.025
positive regulation of protein phosphorylation GO:0001934 135 0.025
brain development GO:0007420 247 0.025
regulation of intracellular signal transduction GO:1902531 218 0.025
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.025
cell type specific apoptotic process GO:0097285 134 0.025
positive regulation of biosynthetic process GO:0009891 319 0.025
positive regulation of cellular protein metabolic process GO:0032270 167 0.024
anatomical structure formation involved in morphogenesis GO:0048646 83 0.024
negative regulation of developmental process GO:0051093 125 0.024
negative regulation of neuron death GO:1901215 69 0.024
positive regulation of intracellular signal transduction GO:1902533 138 0.024
nucleoside metabolic process GO:0009116 179 0.024
response to growth factor GO:0070848 189 0.024
regulation of homeostatic process GO:0032844 101 0.024
response to metal ion GO:0010038 253 0.024
immune system process GO:0002376 204 0.024
ribonucleotide metabolic process GO:0009259 231 0.023
regulation of cellular amine metabolic process GO:0033238 8 0.023
purine nucleotide metabolic process GO:0006163 229 0.023
purine ribonucleotide metabolic process GO:0009150 227 0.023
regulation of molecular function GO:0065009 398 0.023
glycosyl compound metabolic process GO:1901657 182 0.023
synapse organization GO:0050808 46 0.023
lipid metabolic process GO:0006629 283 0.023
cellular response to lipid GO:0071396 201 0.023
response to insulin GO:0032868 133 0.023
negative regulation of cellular metabolic process GO:0031324 281 0.023
response to biotic stimulus GO:0009607 226 0.023
cytokine mediated signaling pathway GO:0019221 43 0.023
purine ribonucleoside metabolic process GO:0046128 168 0.023
purine containing compound metabolic process GO:0072521 253 0.023
negative regulation of rna biosynthetic process GO:1902679 118 0.023
cognition GO:0050890 92 0.022
regulation of ion transport GO:0043269 245 0.022
macromolecule localization GO:0033036 252 0.022
regulation of phosphorylation GO:0042325 248 0.022
cellular ketone metabolic process GO:0042180 51 0.022
regulation of cell motility GO:2000145 131 0.022
response to alkaloid GO:0043279 132 0.022
synaptic growth at neuromuscular junction GO:0051124 1 0.021
leukocyte cell cell adhesion GO:0007159 4 0.021
carbohydrate derivative biosynthetic process GO:1901137 124 0.021
blood vessel development GO:0001568 69 0.021
cell activation GO:0001775 97 0.021
signal transduction by phosphorylation GO:0023014 144 0.021
circulatory system development GO:0072359 134 0.021
blood circulation GO:0008015 183 0.021
regulation of blood circulation GO:1903522 110 0.021
response to hypoxia GO:0001666 231 0.021
nucleobase containing small molecule metabolic process GO:0055086 316 0.021
negative regulation of cellular protein metabolic process GO:0032269 106 0.020
purine nucleoside triphosphate metabolic process GO:0009144 141 0.020
stress activated protein kinase signaling cascade GO:0031098 37 0.020
respiratory system development GO:0060541 45 0.020
positive regulation of cell death GO:0010942 184 0.020
regulation of cellular amino acid metabolic process GO:0006521 2 0.020
nucleoside phosphate metabolic process GO:0006753 283 0.020
response to camp GO:0051591 91 0.020
metal ion transport GO:0030001 289 0.020
response to carbohydrate GO:0009743 183 0.020
female pregnancy GO:0007565 122 0.020
immune response GO:0006955 104 0.019
transcription dna templated GO:0006351 377 0.019
cellular response to glucocorticoid stimulus GO:0071385 68 0.019
response to wounding GO:0009611 254 0.019
regulation of mapk cascade GO:0043408 116 0.019
regulation of metal ion transport GO:0010959 118 0.019
positive regulation of signaling GO:0023056 270 0.019
organ regeneration GO:0031100 101 0.019
rna metabolic process GO:0016070 406 0.019
regulation of cellular localization GO:0060341 263 0.019
endoplasmic reticulum to cytosol transport GO:1903513 4 0.018
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002859 1 0.018
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.018
positive regulation of neurogenesis GO:0050769 165 0.018
negative regulation of cell communication GO:0010648 158 0.018
multicellular organismal homeostasis GO:0048871 49 0.017
tube development GO:0035295 89 0.017
response to retinoic acid GO:0032526 63 0.017
leukocyte differentiation GO:0002521 30 0.017
macromolecular complex subunit organization GO:0043933 339 0.017
regulation of cell migration GO:0030334 128 0.017
t helper 1 type immune response GO:0042088 1 0.017
response to hydrogen peroxide GO:0042542 89 0.017
ribonucleoside triphosphate catabolic process GO:0009203 122 0.016
negative regulation of signaling GO:0023057 157 0.016
alcohol metabolic process GO:0006066 77 0.016
organonitrogen compound biosynthetic process GO:1901566 167 0.016
cellular response to growth factor stimulus GO:0071363 162 0.016
cellular component morphogenesis GO:0032989 155 0.016
regulation of hydrolase activity GO:0051336 143 0.016
metanephric s shaped body morphogenesis GO:0072284 2 0.016
regulation of muscle system process GO:0090257 79 0.016
negative regulation of apoptotic process GO:0043066 181 0.016
lung development GO:0030324 43 0.016
positive regulation of cell migration GO:0030335 96 0.016
cell projection organization GO:0030030 302 0.016
s shaped body morphogenesis GO:0072050 2 0.016
regulation of cellular component organization GO:0051128 368 0.016
ribonucleoside metabolic process GO:0009119 174 0.016
negative regulation of response to tumor cell GO:0002835 2 0.016
response to monosaccharide GO:0034284 159 0.016
negative regulation of epithelial cell proliferation GO:0050680 16 0.016
organelle organization GO:0006996 266 0.016
regulation of stress activated mapk cascade GO:0032872 23 0.015
chemical homeostasis GO:0048878 292 0.015
nucleotide metabolic process GO:0009117 279 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.015
positive regulation of epithelial cell proliferation GO:0050679 32 0.015
positive regulation of ion transport GO:0043270 94 0.015
regulation of nucleic acid templated transcription GO:1903506 380 0.015
regulation of response to wounding GO:1903034 69 0.015
vasculature development GO:0001944 70 0.015
circulatory system process GO:0003013 183 0.015
lipid biosynthetic process GO:0008610 128 0.015
organic cyclic compound catabolic process GO:1901361 175 0.015
neuron death GO:0070997 127 0.015
response to estradiol GO:0032355 164 0.015
response to transition metal nanoparticle GO:1990267 122 0.015
smooth muscle cell proliferation GO:0048659 77 0.015
negative regulation of multicellular organismal process GO:0051241 203 0.015
reproductive structure development GO:0048608 128 0.014
carbohydrate derivative catabolic process GO:1901136 147 0.014
development of primary female sexual characteristics GO:0046545 56 0.014
small molecule biosynthetic process GO:0044283 124 0.014
regulation of ion homeostasis GO:2000021 63 0.014
necroptotic process GO:0070266 2 0.014
cation transport GO:0006812 382 0.014
regulation of growth GO:0040008 105 0.014
response to glucose GO:0009749 136 0.014
cellular macromolecule localization GO:0070727 122 0.014
neural precursor cell proliferation GO:0061351 23 0.014
nucleobase containing compound catabolic process GO:0034655 152 0.014
protein processing GO:0016485 68 0.013
adult locomotory behavior GO:0008344 4 0.013
blood vessel morphogenesis GO:0048514 58 0.013
sexual reproduction GO:0019953 148 0.013
cytoplasmic transport GO:0016482 115 0.013
ovulation cycle GO:0042698 67 0.013
circadian rhythm GO:0007623 88 0.013
multi multicellular organism process GO:0044706 138 0.013
regulation of hormone levels GO:0010817 187 0.013
transcription from rna polymerase ii promoter GO:0006366 252 0.013
ribonucleoside triphosphate metabolic process GO:0009199 141 0.013
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.013
renal system development GO:0072001 67 0.013
regulation of cellular ketone metabolic process GO:0010565 27 0.013
mapk cascade GO:0000165 140 0.013
negative regulation of chronic inflammatory response GO:0002677 2 0.013
sequestering of metal ion GO:0051238 9 0.013
regulation of protein maturation GO:1903317 50 0.013
regulation of neurogenesis GO:0050767 247 0.013
eye morphogenesis GO:0048592 4 0.013
regulation of necroptotic process GO:0060544 2 0.013
regulation of reactive oxygen species metabolic process GO:2000377 26 0.013
muscle tissue development GO:0060537 58 0.013
heterocycle catabolic process GO:0046700 167 0.013
response to hexose GO:0009746 144 0.013
calcium mediated signaling GO:0019722 23 0.013
respiratory tube development GO:0030323 43 0.013
positive regulation of rna biosynthetic process GO:1902680 197 0.013
cellular response to steroid hormone stimulus GO:0071383 93 0.012
ion homeostasis GO:0050801 212 0.012
dna integrity checkpoint GO:0031570 2 0.012
growth GO:0040007 165 0.012
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.012
cellular response to abiotic stimulus GO:0071214 85 0.012
divalent metal ion transport GO:0070838 132 0.012
developmental growth GO:0048589 100 0.012
regulation of natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002858 1 0.012
glycerolipid metabolic process GO:0046486 67 0.012
negative regulation of programmed cell death GO:0043069 183 0.012
regulation of neural precursor cell proliferation GO:2000177 16 0.012
cellular response to histamine GO:0071420 3 0.012
response to mechanical stimulus GO:0009612 134 0.012
peptidyl amino acid modification GO:0018193 126 0.012
positive regulation of gene expression GO:0010628 244 0.012
purine nucleoside triphosphate catabolic process GO:0009146 122 0.011
positive regulation of nucleic acid templated transcription GO:1903508 197 0.011
regulation of exit from mitosis GO:0007096 1 0.011
protein oligomerization GO:0051259 191 0.011
monovalent inorganic cation transport GO:0015672 172 0.011
negative regulation of immune system process GO:0002683 39 0.011
regulation of cell development GO:0060284 263 0.011
response to axon injury GO:0048678 59 0.011
regulation of protein phosphorylation GO:0001932 183 0.011
negative regulation of cell death GO:0060548 229 0.011
positive regulation of locomotion GO:0040017 102 0.011
regulation of interferon gamma production GO:0032649 3 0.011
learning or memory GO:0007611 90 0.011
regulation of system process GO:0044057 208 0.011
regulation of blood pressure GO:0008217 83 0.011
nucleoside catabolic process GO:0009164 126 0.011
cellular nitrogen compound catabolic process GO:0044270 163 0.011
muscle cell proliferation GO:0033002 84 0.011
negative regulation of natural killer cell mediated immune response to tumor cell GO:0002856 1 0.011
axis specification GO:0009798 4 0.011
synaptic transmission glycinergic GO:0060012 2 0.011
positive regulation of cellular component movement GO:0051272 102 0.011
neuron differentiation GO:0030182 368 0.011
programmed necrotic cell death GO:0097300 2 0.011
hepaticobiliary system development GO:0061008 90 0.011
response to organophosphorus GO:0046683 102 0.011
response to heat GO:0009408 60 0.011
organ morphogenesis GO:0009887 75 0.011
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.011
intracellular transport GO:0046907 185 0.011
protein localization GO:0008104 191 0.011
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.011
cell cell signaling involved in cell fate commitment GO:0045168 2 0.011
acute phase response GO:0006953 20 0.011
regulation of dna metabolic process GO:0051052 60 0.011
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.011
cell cycle checkpoint GO:0000075 2 0.010
positive regulation of transcription dna templated GO:0045893 197 0.010
hematopoietic progenitor cell differentiation GO:0002244 2 0.010
urogenital system development GO:0001655 78 0.010
regulation of proteolysis GO:0030162 66 0.010
neuron apoptotic process GO:0051402 88 0.010
regulation of systemic arterial blood pressure GO:0003073 30 0.010
cardiovascular system development GO:0072358 134 0.010
positive regulation of smooth muscle cell proliferation GO:0048661 51 0.010
cellular response to reactive oxygen species GO:0034614 55 0.010
palate development GO:0060021 2 0.010
regulation of cd4 positive alpha beta t cell activation GO:2000514 1 0.010
negative regulation of cellular component organization GO:0051129 83 0.010
sequestering of calcium ion GO:0051208 8 0.010
purine ribonucleoside catabolic process GO:0046130 124 0.010
negative regulation of signal transduction GO:0009968 83 0.010
feeding behavior GO:0007631 53 0.010
regulation of purine nucleotide metabolic process GO:1900542 115 0.010
divalent inorganic cation transport GO:0072511 134 0.010
male gamete generation GO:0048232 99 0.010
regulation of calcium ion transport GO:0051924 77 0.010

Il2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.015
nervous system disease DOID:863 0 0.015