Rattus norvegicus

27 known processes

Akr7a3

aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)

(Aliases: Akr7a1,Afar)

Akr7a3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
chlorinated hydrocarbon metabolic process GO:0042196 4 0.402
response to inorganic substance GO:0010035 377 0.254
cellular response to lipid GO:0071396 201 0.193
cellular response to peptide GO:1901653 133 0.187
response to acid chemical GO:0001101 222 0.182
carboxylic acid metabolic process GO:0019752 289 0.172
organic acid metabolic process GO:0006082 292 0.169
response to corticosteroid GO:0031960 235 0.168
cellular response to hormone stimulus GO:0032870 247 0.149
cellular amino acid metabolic process GO:0006520 107 0.143
oxoacid metabolic process GO:0043436 290 0.141
cellular component assembly GO:0022607 360 0.140
response to nutrient GO:0007584 248 0.139
response to nutrient levels GO:0031667 370 0.129
response to carbohydrate GO:0009743 183 0.119
cellular response to peptide hormone stimulus GO:0071375 120 0.116
response to glucocorticoid GO:0051384 223 0.114
cellular response to endogenous stimulus GO:0071495 377 0.113
monocarboxylic acid metabolic process GO:0032787 152 0.111
cellular response to oxygen containing compound GO:1901701 386 0.109
response to xenobiotic stimulus GO:0009410 23 0.106
response to biotic stimulus GO:0009607 226 0.105
response to hypoxia GO:0001666 231 0.104
response to ethanol GO:0045471 162 0.104
response to transition metal nanoparticle GO:1990267 122 0.102
cellular catabolic process GO:0044248 295 0.101
response to metal ion GO:0010038 253 0.101
cellular response to steroid hormone stimulus GO:0071383 93 0.100
xenobiotic catabolic process GO:0042178 7 0.098
response to external biotic stimulus GO:0043207 221 0.097
liver development GO:0001889 90 0.093
response to extracellular stimulus GO:0009991 380 0.093
response to estrogen GO:0043627 232 0.093
regulation of apoptotic process GO:0042981 335 0.092
cellular response to organic cyclic compound GO:0071407 202 0.082
cellular response to nitrogen compound GO:1901699 210 0.081
hepaticobiliary system development GO:0061008 90 0.079
response to insulin GO:0032868 133 0.079
response to lipopolysaccharide GO:0032496 191 0.078
cellular response to organonitrogen compound GO:0071417 197 0.075
aging GO:0007568 241 0.075
cellular amide metabolic process GO:0043603 44 0.073
regulation of molecular function GO:0065009 398 0.072
organic anion transport GO:0015711 132 0.070
gland development GO:0048732 155 0.070
secretion by cell GO:0032940 248 0.068
regulation of programmed cell death GO:0043067 341 0.067
response to bacterium GO:0009617 200 0.065
cellular component biogenesis GO:0044085 368 0.065
catabolic process GO:0009056 351 0.063
response to peptide GO:1901652 292 0.063
lipid metabolic process GO:0006629 283 0.063
response to toxic substance GO:0009636 133 0.062
apoptotic process GO:0006915 381 0.061
macromolecular complex subunit organization GO:0043933 339 0.060
central nervous system development GO:0007417 311 0.060
protein complex assembly GO:0006461 263 0.060
cellular response to insulin stimulus GO:0032869 81 0.059
negative regulation of metabolic process GO:0009892 331 0.059
single organism biosynthetic process GO:0044711 342 0.059
organelle organization GO:0006996 266 0.059
multi organism reproductive process GO:0044703 262 0.059
response to wounding GO:0009611 254 0.057
anatomical structure morphogenesis GO:0009653 298 0.057
response to other organism GO:0051707 220 0.057
response to peptide hormone GO:0043434 278 0.056
cellular modified amino acid metabolic process GO:0006575 61 0.056
cellular response to glucocorticoid stimulus GO:0071385 68 0.054
fatty acid metabolic process GO:0006631 99 0.053
halogenated hydrocarbon metabolic process GO:0042197 4 0.052
response to estradiol GO:0032355 164 0.051
response to oxidative stress GO:0006979 186 0.048
response to vitamin GO:0033273 131 0.048
organic acid biosynthetic process GO:0016053 83 0.048
vesicle mediated transport GO:0016192 181 0.048
protein complex subunit organization GO:0071822 302 0.047
single organism organelle organization GO:1902589 180 0.046
cellular lipid metabolic process GO:0044255 208 0.045
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.045
negative regulation of apoptotic process GO:0043066 181 0.044
secretion GO:0046903 307 0.044
organonitrogen compound biosynthetic process GO:1901566 167 0.043
tissue development GO:0009888 252 0.042
regulation of nucleic acid templated transcription GO:1903506 380 0.042
response to nicotine GO:0035094 51 0.041
response to monosaccharide GO:0034284 159 0.041
protein oligomerization GO:0051259 191 0.041
response to ketone GO:1901654 182 0.040
neurological system process GO:0050877 219 0.040
rna biosynthetic process GO:0032774 380 0.040
gliogenesis GO:0042063 93 0.040
anion transport GO:0006820 178 0.039
protein complex biogenesis GO:0070271 263 0.039
insecticide metabolic process GO:0017143 4 0.038
alkaloid metabolic process GO:0009820 3 0.038
circulatory system process GO:0003013 183 0.037
response to oxygen levels GO:0070482 265 0.037
macromolecular complex assembly GO:0065003 273 0.037
glutathione metabolic process GO:0006749 15 0.037
neuron development GO:0048666 286 0.036
negative regulation of cellular metabolic process GO:0031324 281 0.036
cellular ketone metabolic process GO:0042180 51 0.035
circadian rhythm GO:0007623 88 0.034
response to molecule of bacterial origin GO:0002237 194 0.034
transcription dna templated GO:0006351 377 0.034
behavior GO:0007610 205 0.034
response to radiation GO:0009314 137 0.034
response to amino acid GO:0043200 75 0.034
programmed cell death GO:0012501 392 0.033
response to alkaloid GO:0043279 132 0.032
intracellular signal transduction GO:0035556 314 0.032
regulation of phosphate metabolic process GO:0019220 349 0.032
response to decreased oxygen levels GO:0036293 237 0.032
cell part morphogenesis GO:0032990 123 0.031
organophosphate metabolic process GO:0019637 370 0.031
drug transmembrane transport GO:0006855 13 0.031
sulfur compound metabolic process GO:0006790 70 0.031
organ regeneration GO:0031100 101 0.031
cellular component morphogenesis GO:0032989 155 0.031
xenobiotic metabolic process GO:0006805 19 0.031
regulation of hormone levels GO:0010817 187 0.031
carboxylic acid biosynthetic process GO:0046394 83 0.031
regulation of blood vessel size GO:0050880 89 0.031
cell projection organization GO:0030030 302 0.030
positive regulation of cellular biosynthetic process GO:0031328 295 0.030
sensory perception GO:0007600 101 0.030
response to testosterone GO:0033574 55 0.030
benzene containing compound metabolic process GO:0042537 22 0.030
response to herbicide GO:0009635 16 0.030
regulation of rna biosynthetic process GO:2001141 381 0.030
positive regulation of gene expression GO:0010628 244 0.030
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.030
cation transport GO:0006812 382 0.030
cellular modified amino acid biosynthetic process GO:0042398 18 0.029
regulation of rna metabolic process GO:0051252 391 0.029
negative regulation of programmed cell death GO:0043069 183 0.028
isoprenoid metabolic process GO:0006720 45 0.028
cell type specific apoptotic process GO:0097285 134 0.028
macromolecule localization GO:0033036 252 0.028
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.027
endocrine system development GO:0035270 30 0.027
response to growth factor GO:0070848 189 0.027
cellular response to external stimulus GO:0071496 118 0.027
response to epidermal growth factor GO:0070849 18 0.027
nitrogen compound transport GO:0071705 229 0.027
regulation of protein metabolic process GO:0051246 289 0.027
transcription from rna polymerase ii promoter GO:0006366 252 0.027
hormone transport GO:0009914 121 0.027
response to purine containing compound GO:0014074 126 0.026
pyridine containing compound metabolic process GO:0072524 32 0.026
peptide metabolic process GO:0006518 32 0.026
rna metabolic process GO:0016070 406 0.026
cellular response to corticosteroid stimulus GO:0071384 69 0.026
response to reactive oxygen species GO:0000302 120 0.026
oxidation reduction process GO:0055114 304 0.026
cellular response to stress GO:0033554 269 0.026
sodium independent organic anion transport GO:0043252 2 0.025
organic hydroxy compound metabolic process GO:1901615 115 0.025
negative regulation of cellular biosynthetic process GO:0031327 161 0.025
regulation of signal transduction GO:0009966 318 0.025
terpenoid metabolic process GO:0006721 37 0.025
multicellular organismal reproductive process GO:0048609 233 0.024
choline transport GO:0015871 4 0.024
response to retinoic acid GO:0032526 63 0.024
negative regulation of developmental process GO:0051093 125 0.024
regulation of intracellular signal transduction GO:1902531 218 0.024
regulation of cellular amine metabolic process GO:0033238 8 0.024
protein phosphorylation GO:0006468 345 0.024
amino acid transport GO:0006865 70 0.024
response to cytokine GO:0034097 215 0.024
regulation of transcription dna templated GO:0006355 374 0.023
amine metabolic process GO:0009308 38 0.023
regeneration GO:0031099 163 0.023
single organism reproductive process GO:0044702 297 0.023
cellular amine metabolic process GO:0044106 38 0.023
regulation of cellular component organization GO:0051128 368 0.022
regulation of cellular protein metabolic process GO:0032268 267 0.022
regulation of tube size GO:0035150 89 0.022
response to hexose GO:0009746 144 0.022
protein autophosphorylation GO:0046777 66 0.022
single organism catabolic process GO:0044712 283 0.022
organic acid transport GO:0015849 116 0.022
negative regulation of cell death GO:0060548 229 0.022
cellular nitrogen compound catabolic process GO:0044270 163 0.021
regulation of catalytic activity GO:0050790 304 0.021
axis specification GO:0009798 4 0.021
neuron differentiation GO:0030182 368 0.021
regulation of cell differentiation GO:0045595 320 0.021
response to mercury ion GO:0046689 15 0.021
cellular chemical homeostasis GO:0055082 247 0.021
single organism behavior GO:0044708 130 0.021
nucleotide metabolic process GO:0009117 279 0.021
steroid metabolic process GO:0008202 73 0.021
organic substance catabolic process GO:1901575 316 0.021
rhythmic process GO:0048511 156 0.021
cell projection morphogenesis GO:0048858 123 0.020
carboxylic acid transport GO:0046942 115 0.020
homeostatic process GO:0042592 331 0.020
immune response GO:0006955 104 0.020
reproductive structure development GO:0048608 128 0.020
response to calcium ion GO:0051592 59 0.020
response to organophosphorus GO:0046683 102 0.020
regulation of cellular amino acid metabolic process GO:0006521 2 0.020
organonitrogen compound catabolic process GO:1901565 179 0.020
regulation of anatomical structure size GO:0090066 135 0.020
regulation of membrane potential GO:0042391 110 0.020
negative regulation of macromolecule metabolic process GO:0010605 260 0.020
positive regulation of transport GO:0051050 245 0.020
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.019
glial cell development GO:0021782 19 0.019
neuron projection morphogenesis GO:0048812 122 0.019
positive regulation of transcription dna templated GO:0045893 197 0.019
cellular response to ketone GO:1901655 51 0.019
head development GO:0060322 247 0.019
nucleoside phosphate metabolic process GO:0006753 283 0.019
response to temperature stimulus GO:0009266 94 0.019
negative regulation of gene expression GO:0010629 199 0.019
response to tumor necrosis factor GO:0034612 56 0.019
aromatic compound catabolic process GO:0019439 168 0.019
ion transmembrane transport GO:0034220 365 0.019
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.019
secondary metabolite catabolic process GO:0090487 1 0.019
regulation of neuron differentiation GO:0045664 208 0.019
developmental process involved in reproduction GO:0003006 159 0.019
linoleic acid metabolic process GO:0043651 4 0.018
neuron apoptotic process GO:0051402 88 0.018
vascular process in circulatory system GO:0003018 96 0.018
glial cell differentiation GO:0010001 65 0.018
regulation of cellular localization GO:0060341 263 0.018
cation transmembrane transport GO:0098655 263 0.018
gastrulation GO:0007369 2 0.018
neuron projection development GO:0031175 273 0.018
cell cycle GO:0007049 101 0.018
reproductive process GO:0022414 372 0.018
purine nucleotide metabolic process GO:0006163 229 0.018
cognition GO:0050890 92 0.018
positive regulation of cell communication GO:0010647 271 0.018
positive regulation of cellular amine metabolic process GO:0033240 3 0.018
response to glucose GO:0009749 136 0.018
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.018
embryonic pattern specification GO:0009880 1 0.018
amide transport GO:0042886 105 0.018
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.018
cellular response to growth factor stimulus GO:0071363 162 0.018
chemical homeostasis GO:0048878 292 0.018
establishment or maintenance of transmembrane electrochemical gradient GO:0010248 1 0.018
lipid localization GO:0010876 62 0.017
defense response GO:0006952 194 0.017
metal ion transport GO:0030001 289 0.017
coenzyme metabolic process GO:0006732 86 0.017
response to l ascorbic acid GO:0033591 15 0.017
cellular response to xenobiotic stimulus GO:0071466 19 0.017
heterocycle catabolic process GO:0046700 167 0.017
cellular response to epidermal growth factor stimulus GO:0071364 12 0.017
cellular response to alcohol GO:0097306 87 0.017
monocarboxylic acid transport GO:0015718 52 0.017
action potential GO:0001508 54 0.017
serine family amino acid catabolic process GO:0009071 3 0.017
positive regulation of signaling GO:0023056 270 0.017
learning or memory GO:0007611 90 0.017
muscle system process GO:0003012 115 0.017
growth GO:0040007 165 0.017
localization of cell GO:0051674 202 0.017
regulation of secretion GO:0051046 224 0.017
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.017
purine containing compound metabolic process GO:0072521 253 0.016
learning GO:0007612 33 0.016
response to ionizing radiation GO:0010212 59 0.016
organic cyclic compound catabolic process GO:1901361 175 0.016
mesoderm development GO:0007498 2 0.016
cellular amino acid biosynthetic process GO:0008652 32 0.016
negative regulation of cell communication GO:0010648 158 0.016
regulation of phosphorus metabolic process GO:0051174 349 0.016
nucleic acid templated transcription GO:0097659 379 0.016
single organism intracellular transport GO:1902582 166 0.016
cellular response to cytokine stimulus GO:0071345 127 0.016
regulation of ion transport GO:0043269 245 0.016
negative regulation of multicellular organismal process GO:0051241 203 0.016
reproductive system development GO:0061458 128 0.016
regulation of inflammatory response GO:0050727 48 0.016
nucleobase containing small molecule metabolic process GO:0055086 316 0.016
cellular protein localization GO:0034613 122 0.016
heart morphogenesis GO:0003007 3 0.016
positive regulation of response to stimulus GO:0048584 285 0.016
regulation of organelle organization GO:0033043 80 0.016
antibiotic transport GO:0042891 2 0.016
immune system process GO:0002376 204 0.016
endocytosis GO:0006897 84 0.015
unsaturated fatty acid metabolic process GO:0033559 39 0.015
regulation of nervous system development GO:0051960 264 0.015
regulation of cell cycle GO:0051726 73 0.015
regulation of cellular ketone metabolic process GO:0010565 27 0.015
epithelial cell differentiation GO:0030855 71 0.015
transmission of nerve impulse GO:0019226 42 0.015
cellular response to testosterone stimulus GO:0071394 5 0.015
regulation of vesicle mediated transport GO:0060627 81 0.015
cellular response to vitamin e GO:0071306 3 0.015
peptide biosynthetic process GO:0043043 3 0.015
multicellular organism reproduction GO:0032504 233 0.015
regulation of system process GO:0044057 208 0.015
negative regulation of biosynthetic process GO:0009890 168 0.015
dopamine metabolic process GO:0042417 12 0.015
reproduction GO:0000003 245 0.015
actin filament based process GO:0030029 86 0.015
carbohydrate derivative metabolic process GO:1901135 346 0.015
chemosensory behavior GO:0007635 2 0.015
blood circulation GO:0008015 183 0.015
synaptic transmission GO:0007268 235 0.015
protein homooligomerization GO:0051260 91 0.015
signal release GO:0023061 145 0.015
regulation of response to stress GO:0080134 126 0.015
naphthalene containing compound metabolic process GO:0090420 2 0.015
multi multicellular organism process GO:0044706 138 0.015
brain development GO:0007420 247 0.015
multicellular organism growth GO:0035264 1 0.014
cellular ion homeostasis GO:0006873 184 0.014
regulation of catabolic process GO:0009894 113 0.014
regulation of neurogenesis GO:0050767 247 0.014
phenol containing compound metabolic process GO:0018958 30 0.014
response to hydrogen peroxide GO:0042542 89 0.014
carboxylic acid catabolic process GO:0046395 49 0.014
urogenital system development GO:0001655 78 0.014
regulation of cell development GO:0060284 263 0.014
nonribosomal peptide biosynthetic process GO:0019184 3 0.014
toxin catabolic process GO:0009407 1 0.014
locomotion GO:0040011 237 0.014
positive regulation of rna metabolic process GO:0051254 203 0.014
positive regulation of cellular protein metabolic process GO:0032270 167 0.014
positive regulation of biosynthetic process GO:0009891 319 0.014
negative regulation of signaling GO:0023057 157 0.014
cellular response to extracellular stimulus GO:0031668 73 0.014
cellular response to metal ion GO:0071248 55 0.013
naphthalene metabolic process GO:0018931 2 0.013
icosanoid metabolic process GO:0006690 38 0.013
modified amino acid transport GO:0072337 12 0.013
sexual reproduction GO:0019953 148 0.013
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.013
cellular component movement GO:0006928 248 0.013
cofactor biosynthetic process GO:0051188 28 0.013
ribonucleotide metabolic process GO:0009259 231 0.013
organophosphate catabolic process GO:0046434 148 0.013
cofactor metabolic process GO:0051186 95 0.013
cellular homeostasis GO:0019725 252 0.013
organic acid catabolic process GO:0016054 49 0.013
cellular macromolecule localization GO:0070727 122 0.013
cell cycle checkpoint GO:0000075 2 0.013
regulation of phosphorylation GO:0042325 248 0.013
response to lithium ion GO:0010226 28 0.013
retinoid metabolic process GO:0001523 24 0.013
intracellular transport GO:0046907 185 0.013
positive regulation of rna biosynthetic process GO:1902680 197 0.013
positive regulation of secretion GO:0051047 140 0.013
cell migration GO:0016477 197 0.012
small gtpase mediated signal transduction GO:0007264 36 0.012
membrane organization GO:0061024 94 0.012
response to zinc ion GO:0010043 39 0.012
cellular macromolecular complex assembly GO:0034622 58 0.012
positive regulation of mitochondrion organization GO:0010822 4 0.012
negative regulation of secretion by cell GO:1903531 72 0.012
positive regulation of cell motility GO:2000147 97 0.012
anterior posterior pattern specification GO:0009952 1 0.012
positive regulation of cellular component organization GO:0051130 200 0.012
response to lead ion GO:0010288 33 0.012
lipid storage GO:0019915 1 0.012
gamete generation GO:0007276 124 0.012
regulation of synaptic transmission GO:0050804 141 0.012
cytoskeleton organization GO:0007010 111 0.012
negative regulation of rna biosynthetic process GO:1902679 118 0.012
regulation of response to wounding GO:1903034 69 0.012
ras protein signal transduction GO:0007265 29 0.012
purine ribonucleotide metabolic process GO:0009150 227 0.012
regulation of cell migration GO:0030334 128 0.012
negative regulation of response to stimulus GO:0048585 155 0.012
cellular response to acid chemical GO:0071229 75 0.012
development of primary sexual characteristics GO:0045137 107 0.012
response to molecule of fungal origin GO:0002238 3 0.012
regulation of purine nucleotide metabolic process GO:1900542 115 0.012
glutathione biosynthetic process GO:0006750 3 0.012
negative regulation of cell differentiation GO:0045596 99 0.012
response to camp GO:0051591 91 0.012
enzyme linked receptor protein signaling pathway GO:0007167 116 0.012
cell morphogenesis involved in differentiation GO:0000904 119 0.011
regulation of multicellular organismal development GO:2000026 376 0.011
positive regulation of protein phosphorylation GO:0001934 135 0.011
regulation of blood pressure GO:0008217 83 0.011
ribose phosphate metabolic process GO:0019693 235 0.011
positive regulation of ion transport GO:0043270 94 0.011
inorganic ion transmembrane transport GO:0098660 229 0.011
lipid biosynthetic process GO:0008610 128 0.011
response to axon injury GO:0048678 59 0.011
positive regulation of catalytic activity GO:0043085 184 0.011
negative regulation of transcription regulatory region dna binding GO:2000678 2 0.011
positive regulation of programmed cell death GO:0043068 157 0.011
regulation of cell projection organization GO:0031344 175 0.011
regulation of blood circulation GO:1903522 110 0.011
transmembrane transport GO:0055085 412 0.011
regulation of secretion by cell GO:1903530 208 0.011
positive regulation of molecular function GO:0044093 230 0.011
positive regulation of cell projection organization GO:0031346 111 0.011
neurotrophin production GO:0032898 2 0.011
fatty acid derivative metabolic process GO:1901568 38 0.011
regulation of cell motility GO:2000145 131 0.011
regulation of neuron apoptotic process GO:0043523 83 0.011
positive regulation of phosphate metabolic process GO:0045937 262 0.011
monovalent inorganic cation transport GO:0015672 172 0.011
positive regulation of developmental process GO:0051094 283 0.011
hormone secretion GO:0046879 115 0.011
nucleoside triphosphate metabolic process GO:0009141 144 0.011
inflammatory response GO:0006954 150 0.011
porphyrin containing compound metabolic process GO:0006778 8 0.011
regulation of protein modification process GO:0031399 194 0.011
eye morphogenesis GO:0048592 4 0.011
response to starvation GO:0042594 59 0.011
negative regulation of transport GO:0051051 136 0.011
positive regulation of cell differentiation GO:0045597 217 0.010
defense response to gram negative bacterium GO:0050829 3 0.010
cellular response to oxidative stress GO:0034599 76 0.010
ion homeostasis GO:0050801 212 0.010
positive regulation of response to wounding GO:1903036 34 0.010
long chain fatty acid metabolic process GO:0001676 32 0.010
regulation of cellular catabolic process GO:0031329 101 0.010
catecholamine metabolic process GO:0006584 19 0.010
positive regulation of nucleic acid templated transcription GO:1903508 197 0.010
positive regulation of neuron apoptotic process GO:0043525 33 0.010
toxin metabolic process GO:0009404 9 0.010
cellular response to dexamethasone stimulus GO:0071549 36 0.010
cell cell signaling GO:0007267 335 0.010
organophosphate biosynthetic process GO:0090407 143 0.010
regulation of anatomical structure morphogenesis GO:0022603 141 0.010
organic hydroxy compound transport GO:0015850 77 0.010
organic cation transport GO:0015695 11 0.010
tetrapyrrole metabolic process GO:0033013 11 0.010

Akr7a3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
hypertension DOID:10763 0 0.023
artery disease DOID:0050828 0 0.023
disease of anatomical entity DOID:7 0 0.023
vascular disease DOID:178 0 0.023
essential hypertension DOID:10825 0 0.023
cardiovascular system disease DOID:1287 0 0.023
nervous system disease DOID:863 0 0.019
musculoskeletal system disease DOID:17 0 0.011
disease of metabolism DOID:0014667 0 0.011
inherited metabolic disorder DOID:655 0 0.011