Rattus norvegicus

12 known processes

Eif4a1

eukaryotic translation initiation factor 4A, isoform 1

Eif4a1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein complex biogenesis GO:0070271 263 0.208
nucleoside phosphate metabolic process GO:0006753 283 0.137
Yeast
reproductive process GO:0022414 372 0.134
nucleic acid templated transcription GO:0097659 379 0.133
rna biosynthetic process GO:0032774 380 0.131
anatomical structure morphogenesis GO:0009653 298 0.115
regulation of rna metabolic process GO:0051252 391 0.096
regulation of molecular function GO:0065009 398 0.086
rna metabolic process GO:0016070 406 0.084
regulation of nucleic acid templated transcription GO:1903506 380 0.080
multi organism reproductive process GO:0044703 262 0.080
macromolecular complex subunit organization GO:0043933 339 0.072
organelle organization GO:0006996 266 0.070
positive regulation of nucleic acid templated transcription GO:1903508 197 0.069
nucleotide metabolic process GO:0009117 279 0.068
Yeast
reproduction GO:0000003 245 0.065
transcription from rna polymerase ii promoter GO:0006366 252 0.064
multicellular organismal reproductive process GO:0048609 233 0.064
macromolecular complex assembly GO:0065003 273 0.064
carbohydrate derivative metabolic process GO:1901135 346 0.064
Yeast
transcription dna templated GO:0006351 377 0.064
cell cycle GO:0007049 101 0.061
protein complex assembly GO:0006461 263 0.058
cellular component biogenesis GO:0044085 368 0.055
cellular amino acid metabolic process GO:0006520 107 0.054
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.051
multicellular organism reproduction GO:0032504 233 0.050
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.050
regulation of rna biosynthetic process GO:2001141 381 0.049
positive regulation of gene expression GO:0010628 244 0.049
chromosome organization GO:0051276 36 0.048
purine containing compound metabolic process GO:0072521 253 0.048
Yeast
meiotic cell cycle process GO:1903046 3 0.047
regulation of organelle organization GO:0033043 80 0.047
regulation of transcription dna templated GO:0006355 374 0.046
response to purine containing compound GO:0014074 126 0.046
positive regulation of biosynthetic process GO:0009891 319 0.046
cellular homeostasis GO:0019725 252 0.045
protein complex subunit organization GO:0071822 302 0.045
cellular component assembly GO:0022607 360 0.044
cellular catabolic process GO:0044248 295 0.044
Yeast
tissue development GO:0009888 252 0.042
head development GO:0060322 247 0.042
regulation of cellular component organization GO:0051128 368 0.040
single organism reproductive process GO:0044702 297 0.039
negative regulation of cell death GO:0060548 229 0.039
positive regulation of cellular component organization GO:0051130 200 0.038
negative regulation of cellular metabolic process GO:0031324 281 0.038
anterior posterior pattern specification GO:0009952 1 0.037
single organism biosynthetic process GO:0044711 342 0.036
response to peptide hormone GO:0043434 278 0.035
organophosphate metabolic process GO:0019637 370 0.034
Yeast
axis specification GO:0009798 4 0.034
oxoacid metabolic process GO:0043436 290 0.034
liver development GO:0001889 90 0.034
chemical homeostasis GO:0048878 292 0.034
sexual reproduction GO:0019953 148 0.033
organic substance catabolic process GO:1901575 316 0.033
Yeast
negative regulation of apoptotic process GO:0043066 181 0.033
nucleobase containing small molecule metabolic process GO:0055086 316 0.032
Yeast
positive regulation of cellular biosynthetic process GO:0031328 295 0.031
positive regulation of rna metabolic process GO:0051254 203 0.031
gland development GO:0048732 155 0.031
negative regulation of gene expression GO:0010629 199 0.031
organ regeneration GO:0031100 101 0.031
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.030
regulation of cellular protein metabolic process GO:0032268 267 0.030
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.030
organic acid metabolic process GO:0006082 292 0.029
carboxylic acid metabolic process GO:0019752 289 0.029
response to nutrient levels GO:0031667 370 0.029
positive regulation of rna biosynthetic process GO:1902680 197 0.029
locomotion GO:0040011 237 0.029
neuron projection development GO:0031175 273 0.029
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.029
programmed cell death GO:0012501 392 0.029
cellular amine metabolic process GO:0044106 38 0.029
cellular response to oxidative stress GO:0034599 76 0.028
response to organophosphorus GO:0046683 102 0.028
nucleoside metabolic process GO:0009116 179 0.028
Yeast
homeostatic process GO:0042592 331 0.028
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.028
response to extracellular stimulus GO:0009991 380 0.028
negative regulation of metabolic process GO:0009892 331 0.027
protein localization GO:0008104 191 0.027
cellular response to oxygen containing compound GO:1901701 386 0.027
gamete generation GO:0007276 124 0.027
cellular response to stress GO:0033554 269 0.027
single organism organelle organization GO:1902589 180 0.026
aromatic compound catabolic process GO:0019439 168 0.026
Yeast
response to oxidative stress GO:0006979 186 0.026
regulation of phosphate metabolic process GO:0019220 349 0.026
oxidation reduction process GO:0055114 304 0.025
protein transport GO:0015031 132 0.025
response to cytokine GO:0034097 215 0.025
purine nucleotide metabolic process GO:0006163 229 0.025
Yeast
ribose phosphate metabolic process GO:0019693 235 0.025
Yeast
positive regulation of cellular protein metabolic process GO:0032270 167 0.025
regulation of catalytic activity GO:0050790 304 0.024
hepaticobiliary system development GO:0061008 90 0.024
negative regulation of macromolecule metabolic process GO:0010605 260 0.024
intracellular transport GO:0046907 185 0.024
brain development GO:0007420 247 0.024
regulation of phosphorus metabolic process GO:0051174 349 0.024
negative regulation of cell communication GO:0010648 158 0.023
cellular response to endogenous stimulus GO:0071495 377 0.023
regulation of meiotic cell cycle GO:0051445 3 0.023
regulation of secretion GO:0051046 224 0.023
positive regulation of protein metabolic process GO:0051247 178 0.022
catabolic process GO:0009056 351 0.022
Yeast
negative regulation of cellular biosynthetic process GO:0031327 161 0.022
cell projection organization GO:0030030 302 0.022
carbohydrate derivative biosynthetic process GO:1901137 124 0.022
positive regulation of phosphate metabolic process GO:0045937 262 0.022
dna metabolic process GO:0006259 96 0.022
regulation of neuron differentiation GO:0045664 208 0.021
neuron differentiation GO:0030182 368 0.021
regulation of cellular catabolic process GO:0031329 101 0.021
central nervous system development GO:0007417 311 0.021
cellular response to peptide hormone stimulus GO:0071375 120 0.021
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.021
growth GO:0040007 165 0.021
secretion by cell GO:0032940 248 0.021
regulation of multicellular organismal development GO:2000026 376 0.021
response to peptide GO:1901652 292 0.021
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.021
negative regulation of rna metabolic process GO:0051253 123 0.021
cellular response to nitrogen compound GO:1901699 210 0.021
positive regulation of phosphorus metabolic process GO:0010562 262 0.020
glycosyl compound metabolic process GO:1901657 182 0.020
Yeast
single organism catabolic process GO:0044712 283 0.020
Yeast
cell cell signaling GO:0007267 335 0.020
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.020
positive regulation of molecular function GO:0044093 230 0.020
embryonic pattern specification GO:0009880 1 0.020
translation GO:0006412 35 0.020
Yeast
nucleocytoplasmic transport GO:0006913 48 0.019
spermatogenesis GO:0007283 99 0.019
apoptotic process GO:0006915 381 0.019
purine ribonucleoside metabolic process GO:0046128 168 0.019
Yeast
regulation of cell development GO:0060284 263 0.019
response to inorganic substance GO:0010035 377 0.019
cellular macromolecule localization GO:0070727 122 0.019
nucleoside phosphate catabolic process GO:1901292 140 0.019
Yeast
positive regulation of transport GO:0051050 245 0.019
positive regulation of response to stimulus GO:0048584 285 0.019
metal ion homeostasis GO:0055065 186 0.019
embryonic axis specification GO:0000578 1 0.019
ribonucleotide metabolic process GO:0009259 231 0.019
Yeast
regulation of cellular amino acid metabolic process GO:0006521 2 0.019
defense response GO:0006952 194 0.018
organonitrogen compound biosynthetic process GO:1901566 167 0.018
response to nutrient GO:0007584 248 0.018
protein phosphorylation GO:0006468 345 0.018
positive regulation of catalytic activity GO:0043085 184 0.018
negative regulation of biosynthetic process GO:0009890 168 0.018
chromosome segregation GO:0007059 2 0.018
negative regulation of rna biosynthetic process GO:1902679 118 0.018
regulation of immune system process GO:0002682 123 0.018
response to glucocorticoid GO:0051384 223 0.018
regulation of anatomical structure size GO:0090066 135 0.018
regulation of cellular localization GO:0060341 263 0.018
cellular macromolecular complex assembly GO:0034622 58 0.018
cellular response to insulin stimulus GO:0032869 81 0.018
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.018
Yeast
forebrain development GO:0030900 98 0.017
cellular response to cytokine stimulus GO:0071345 127 0.017
negative regulation of nucleic acid templated transcription GO:1903507 117 0.017
purine containing compound biosynthetic process GO:0072522 85 0.017
cellular component movement GO:0006928 248 0.017
regulation of cell differentiation GO:0045595 320 0.017
nucleoside monophosphate metabolic process GO:0009123 93 0.017
Yeast
nucleotide catabolic process GO:0009166 139 0.017
Yeast
ncrna processing GO:0034470 3 0.017
negative regulation of innate immune response GO:0045824 4 0.017
cellular response to external stimulus GO:0071496 118 0.017
response to growth factor GO:0070848 189 0.016
male gamete generation GO:0048232 99 0.016
cellular nitrogen compound catabolic process GO:0044270 163 0.016
Yeast
response to estrogen GO:0043627 232 0.016
regulation of programmed cell death GO:0043067 341 0.016
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.016
regulation of dna metabolic process GO:0051052 60 0.016
cellular response to organonitrogen compound GO:0071417 197 0.016
sensory organ development GO:0007423 74 0.016
cytoplasmic transport GO:0016482 115 0.016
positive regulation of cell differentiation GO:0045597 217 0.016
purine nucleoside metabolic process GO:0042278 169 0.016
Yeast
ras protein signal transduction GO:0007265 29 0.016
gastrulation GO:0007369 2 0.016
regulation of cell motility GO:2000145 131 0.016
nucleobase containing compound catabolic process GO:0034655 152 0.016
Yeast
response to corticosteroid GO:0031960 235 0.016
heterocycle catabolic process GO:0046700 167 0.016
Yeast
circulatory system development GO:0072359 134 0.016
positive regulation of transcription dna templated GO:0045893 197 0.015
regulation of protein metabolic process GO:0051246 289 0.015
cellular response to hormone stimulus GO:0032870 247 0.015
purine nucleotide catabolic process GO:0006195 136 0.015
Yeast
cellular ketone metabolic process GO:0042180 51 0.015
positive regulation of phosphorylation GO:0042327 177 0.015
regulation of cellular amine metabolic process GO:0033238 8 0.015
proteolysis GO:0006508 175 0.015
regulation of cell proliferation GO:0042127 359 0.015
response to temperature stimulus GO:0009266 94 0.015
multi multicellular organism process GO:0044706 138 0.015
regeneration GO:0031099 163 0.015
neuron development GO:0048666 286 0.015
negative regulation of signaling GO:0023057 157 0.015
cellular protein complex assembly GO:0043623 44 0.015
ribonucleoside metabolic process GO:0009119 174 0.014
Yeast
aging GO:0007568 241 0.014
single organism carbohydrate metabolic process GO:0044723 118 0.014
positive regulation of nucleotide catabolic process GO:0030813 53 0.014
carbohydrate metabolic process GO:0005975 130 0.014
positive regulation of nucleoside metabolic process GO:0045979 55 0.014
ribonucleoside triphosphate metabolic process GO:0009199 141 0.014
Yeast
regulation of nucleotide metabolic process GO:0006140 117 0.014
negative regulation of natural killer cell mediated immunity GO:0002716 4 0.014
negative regulation of response to stimulus GO:0048585 155 0.014
cardiovascular system development GO:0072358 134 0.014
regulation of catabolic process GO:0009894 113 0.014
response to metal ion GO:0010038 253 0.014
tolerance induction dependent upon immune response GO:0002461 2 0.014
positive regulation of nervous system development GO:0051962 178 0.014
purine ribonucleotide metabolic process GO:0009150 227 0.014
Yeast
response to radiation GO:0009314 137 0.014
multicellular organism growth GO:0035264 1 0.013
cellular chemical homeostasis GO:0055082 247 0.013
enzyme linked receptor protein signaling pathway GO:0007167 116 0.013
muscle organ morphogenesis GO:0048644 1 0.013
intracellular signal transduction GO:0035556 314 0.013
hematopoietic progenitor cell differentiation GO:0002244 2 0.013
regulation of secretion by cell GO:1903530 208 0.013
behavior GO:0007610 205 0.013
cytoskeleton dependent cytokinesis GO:0061640 2 0.013
positive regulation of protein modification process GO:0031401 142 0.013
positive regulation of nucleotide metabolic process GO:0045981 91 0.013
positive regulation of developmental process GO:0051094 283 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.013
positive regulation of neuron differentiation GO:0045666 126 0.013
positive regulation of catabolic process GO:0009896 78 0.013
positive regulation of transferase activity GO:0051347 81 0.013
positive regulation of purine nucleotide catabolic process GO:0033123 53 0.013
cellular response to nutrient levels GO:0031669 60 0.013
response to estradiol GO:0032355 164 0.013
ncrna metabolic process GO:0034660 8 0.013
secretion GO:0046903 307 0.013
tongue morphogenesis GO:0043587 3 0.013
regulation of purine nucleotide metabolic process GO:1900542 115 0.013
mitotic spindle organization GO:0007052 2 0.013
response to hexose GO:0009746 144 0.012
positive regulation of growth GO:0045927 55 0.012
cellular response to extracellular stimulus GO:0031668 73 0.012
cation transport GO:0006812 382 0.012
cellular response to peptide GO:1901653 133 0.012
regulation of neurogenesis GO:0050767 247 0.012
positive regulation of multicellular organismal process GO:0051240 387 0.012
synaptic transmission GO:0007268 235 0.012
amine metabolic process GO:0009308 38 0.012
eye morphogenesis GO:0048592 4 0.012
protein oligomerization GO:0051259 191 0.012
regulation of hydrolase activity GO:0051336 143 0.012
regulation of response to stress GO:0080134 126 0.012
alpha amino acid metabolic process GO:1901605 71 0.012
dephosphorylation GO:0016311 98 0.012
lipid storage GO:0019915 1 0.012
macromolecule localization GO:0033036 252 0.012
regulation of apoptotic process GO:0042981 335 0.012
positive regulation of organelle organization GO:0010638 48 0.011
positive regulation of secretion by cell GO:1903532 128 0.011
developmental process involved in reproduction GO:0003006 159 0.011
cell motility GO:0048870 202 0.011
cellular metal ion homeostasis GO:0006875 172 0.011
regulation of protein phosphorylation GO:0001932 183 0.011
regulation of transferase activity GO:0051338 123 0.011
cell cycle process GO:0022402 57 0.011
ion homeostasis GO:0050801 212 0.011
fertilization GO:0009566 3 0.011
response to wounding GO:0009611 254 0.011
cell morphogenesis GO:0000902 142 0.011
regulation of canonical wnt signaling pathway GO:0060828 4 0.011
actin nucleation GO:0045010 2 0.011
positive regulation of dna metabolic process GO:0051054 39 0.011
organonitrogen compound catabolic process GO:1901565 179 0.011
Yeast
cell part morphogenesis GO:0032990 123 0.011
sulfur compound metabolic process GO:0006790 70 0.011
regulation of protein modification process GO:0031399 194 0.011
small gtpase mediated signal transduction GO:0007264 36 0.011
mesenchymal cell proliferation GO:0010463 4 0.011
purine nucleoside triphosphate metabolic process GO:0009144 141 0.011
Yeast
regulation of protein complex assembly GO:0043254 33 0.011
response to glucose GO:0009749 136 0.011
positive regulation of cell proliferation GO:0008284 249 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.011
biological adhesion GO:0022610 110 0.011
protein polymerization GO:0051258 22 0.011
nucleoside triphosphate metabolic process GO:0009141 144 0.011
Yeast
mitotic cell cycle GO:0000278 49 0.011
neuron death GO:0070997 127 0.011
immune system process GO:0002376 204 0.011
circadian rhythm GO:0007623 88 0.011
cell morphogenesis involved in differentiation GO:0000904 119 0.011
g protein coupled receptor signaling pathway GO:0007186 242 0.011
circulatory system process GO:0003013 183 0.011
posttranscriptional regulation of gene expression GO:0010608 37 0.011
ribonucleoside monophosphate metabolic process GO:0009161 88 0.010
Yeast
cellular protein localization GO:0034613 122 0.010
regulation of nucleotide catabolic process GO:0030811 65 0.010
carbohydrate derivative catabolic process GO:1901136 147 0.010
Yeast
heart morphogenesis GO:0003007 3 0.010
regulation of signal transduction GO:0009966 318 0.010
cellular modified amino acid metabolic process GO:0006575 61 0.010
response to interleukin 1 GO:0070555 55 0.010
positive regulation of cellular catabolic process GO:0031331 71 0.010
localization of cell GO:0051674 202 0.010
negative regulation of transcription dna templated GO:0045892 116 0.010
cell cell signaling involved in cell fate commitment GO:0045168 2 0.010
regulation of cellular component biogenesis GO:0044087 86 0.010
regulation of cell projection organization GO:0031344 175 0.010
lipid metabolic process GO:0006629 283 0.010

Eif4a1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011
disease of anatomical entity DOID:7 0 0.011
nervous system disease DOID:863 0 0.011
organ system cancer DOID:0050686 0 0.010