Rattus norvegicus

0 known processes

Topbp1

topoisomerase (DNA) II binding protein 1

(Aliases: RGD1562949)

Topbp1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
carboxylic acid metabolic process GO:0019752 289 0.064
organic acid metabolic process GO:0006082 292 0.052
cellular response to endogenous stimulus GO:0071495 377 0.052
cellular amino acid metabolic process GO:0006520 107 0.046
carbohydrate derivative metabolic process GO:1901135 346 0.038
response to nutrient levels GO:0031667 370 0.036
oxoacid metabolic process GO:0043436 290 0.035
regulation of nucleic acid templated transcription GO:1903506 380 0.033
transcription dna templated GO:0006351 377 0.032
negative regulation of gene expression GO:0010629 199 0.031
transcription from rna polymerase ii promoter GO:0006366 252 0.030
regulation of programmed cell death GO:0043067 341 0.030
regulation of rna metabolic process GO:0051252 391 0.028
regulation of molecular function GO:0065009 398 0.028
negative regulation of metabolic process GO:0009892 331 0.027
apoptotic process GO:0006915 381 0.027
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.026
regulation of cellular ketone metabolic process GO:0010565 27 0.026
negative regulation of macromolecule metabolic process GO:0010605 260 0.026
organophosphate metabolic process GO:0019637 370 0.026
cellular amine metabolic process GO:0044106 38 0.026
head development GO:0060322 247 0.025
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.025
nucleoside phosphate metabolic process GO:0006753 283 0.025
cellular modified amino acid metabolic process GO:0006575 61 0.025
regulation of cellular amine metabolic process GO:0033238 8 0.025
protein phosphorylation GO:0006468 345 0.024
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.024
brain development GO:0007420 247 0.024
cellular ketone metabolic process GO:0042180 51 0.024
regulation of cellular amino acid metabolic process GO:0006521 2 0.024
regulation of rna biosynthetic process GO:2001141 381 0.024
programmed cell death GO:0012501 392 0.023
response to extracellular stimulus GO:0009991 380 0.023
negative regulation of cellular biosynthetic process GO:0031327 161 0.023
regulation of cell differentiation GO:0045595 320 0.023
rna biosynthetic process GO:0032774 380 0.022
neuron differentiation GO:0030182 368 0.022
regulation of protein metabolic process GO:0051246 289 0.022
cellular response to growth factor stimulus GO:0071363 162 0.021
single organism biosynthetic process GO:0044711 342 0.021
nucleic acid templated transcription GO:0097659 379 0.021
cellular response to stress GO:0033554 269 0.021
nucleotide metabolic process GO:0009117 279 0.021
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.021
central nervous system development GO:0007417 311 0.021
cellular response to oxygen containing compound GO:1901701 386 0.021
purine containing compound metabolic process GO:0072521 253 0.021
positive regulation of transport GO:0051050 245 0.020
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.020
nucleobase containing small molecule metabolic process GO:0055086 316 0.020
regulation of cell development GO:0060284 263 0.020
negative regulation of biosynthetic process GO:0009890 168 0.020
positive regulation of cell death GO:0010942 184 0.020
organic substance catabolic process GO:1901575 316 0.020
negative regulation of cellular metabolic process GO:0031324 281 0.020
ribose phosphate metabolic process GO:0019693 235 0.019
positive regulation of biosynthetic process GO:0009891 319 0.019
response to nutrient GO:0007584 248 0.019
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.019
single organism reproductive process GO:0044702 297 0.019
response to estradiol GO:0032355 164 0.019
macromolecular complex subunit organization GO:0043933 339 0.019
protein oligomerization GO:0051259 191 0.018
homeostatic process GO:0042592 331 0.018
catabolic process GO:0009056 351 0.018
cellular response to lipid GO:0071396 201 0.018
purine nucleoside metabolic process GO:0042278 169 0.018
amine metabolic process GO:0009308 38 0.018
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.018
cellular response to nitrogen compound GO:1901699 210 0.017
regulation of neurogenesis GO:0050767 247 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.017
positive regulation of cell differentiation GO:0045597 217 0.017
positive regulation of neurogenesis GO:0050769 165 0.017
regulation of transcription dna templated GO:0006355 374 0.017
regulation of cellular component organization GO:0051128 368 0.017
regulation of catalytic activity GO:0050790 304 0.017
response to inorganic substance GO:0010035 377 0.016
positive regulation of nucleic acid templated transcription GO:1903508 197 0.016
cellular response to organonitrogen compound GO:0071417 197 0.016
regeneration GO:0031099 163 0.016
positive regulation of cellular biosynthetic process GO:0031328 295 0.016
regulation of cellular protein metabolic process GO:0032268 267 0.016
response to ethanol GO:0045471 162 0.015
response to estrogen GO:0043627 232 0.015
regulation of cellular localization GO:0060341 263 0.015
positive regulation of cell development GO:0010720 176 0.015
negative regulation of transcription dna templated GO:0045892 116 0.015
organonitrogen compound biosynthetic process GO:1901566 167 0.015
cellular response to hormone stimulus GO:0032870 247 0.015
positive regulation of multicellular organismal process GO:0051240 387 0.015
positive regulation of rna biosynthetic process GO:1902680 197 0.015
negative regulation of programmed cell death GO:0043069 183 0.015
positive regulation of molecular function GO:0044093 230 0.015
negative regulation of rna biosynthetic process GO:1902679 118 0.015
positive regulation of transcription dna templated GO:0045893 197 0.015
regulation of cell projection organization GO:0031344 175 0.015
response to growth factor GO:0070848 189 0.015
macromolecular complex assembly GO:0065003 273 0.015
negative regulation of nucleic acid templated transcription GO:1903507 117 0.015
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.015
ras protein signal transduction GO:0007265 29 0.015
positive regulation of nervous system development GO:0051962 178 0.015
regulation of cell proliferation GO:0042127 359 0.014
regulation of apoptotic process GO:0042981 335 0.014
positive regulation of apoptotic process GO:0043065 154 0.014
regulation of phosphate metabolic process GO:0019220 349 0.014
aging GO:0007568 241 0.014
neuron death GO:0070997 127 0.014
lipid metabolic process GO:0006629 283 0.014
cell cell signaling GO:0007267 335 0.014
transmembrane transport GO:0055085 412 0.014
nucleoside metabolic process GO:0009116 179 0.014
neuron projection development GO:0031175 273 0.014
response to wounding GO:0009611 254 0.014
cell projection organization GO:0030030 302 0.014
chemical homeostasis GO:0048878 292 0.014
forebrain development GO:0030900 98 0.014
single organism catabolic process GO:0044712 283 0.014
ribonucleoside metabolic process GO:0009119 174 0.014
signal release GO:0023061 145 0.013
cellular response to organic cyclic compound GO:0071407 202 0.013
glycosyl compound metabolic process GO:1901657 182 0.013
cellular chemical homeostasis GO:0055082 247 0.013
response to ketone GO:1901654 182 0.013
ribonucleotide metabolic process GO:0009259 231 0.013
cation transport GO:0006812 382 0.013
reproduction GO:0000003 245 0.013
negative regulation of multicellular organismal process GO:0051241 203 0.013
cellular component biogenesis GO:0044085 368 0.013
regulation of neuron differentiation GO:0045664 208 0.013
positive regulation of neuron projection development GO:0010976 99 0.013
regulation of nervous system development GO:0051960 264 0.013
neuron development GO:0048666 286 0.013
positive regulation of cell proliferation GO:0008284 249 0.013
regulation of signal transduction GO:0009966 318 0.013
negative regulation of protein metabolic process GO:0051248 114 0.013
ion transmembrane transport GO:0034220 365 0.013
dna metabolic process GO:0006259 96 0.013
negative regulation of cell death GO:0060548 229 0.012
axis specification GO:0009798 4 0.012
regulation of phosphorus metabolic process GO:0051174 349 0.012
purine nucleotide metabolic process GO:0006163 229 0.012
anterior posterior pattern specification GO:0009952 1 0.012
cofactor metabolic process GO:0051186 95 0.012
macromolecule localization GO:0033036 252 0.012
response to vitamin GO:0033273 131 0.012
positive regulation of gene expression GO:0010628 244 0.012
regulation of multicellular organismal development GO:2000026 376 0.012
chromosome segregation GO:0007059 2 0.012
regulation of secretion by cell GO:1903530 208 0.012
regulation of establishment of protein localization GO:0070201 69 0.012
cellular component assembly GO:0022607 360 0.012
organophosphate biosynthetic process GO:0090407 143 0.012
eye morphogenesis GO:0048592 4 0.012
rna metabolic process GO:0016070 406 0.012
multi organism reproductive process GO:0044703 262 0.012
organonitrogen compound catabolic process GO:1901565 179 0.012
nucleoside triphosphate metabolic process GO:0009141 144 0.012
positive regulation of rna metabolic process GO:0051254 203 0.012
purine ribonucleotide metabolic process GO:0009150 227 0.012
intracellular transport GO:0046907 185 0.012
positive regulation of programmed cell death GO:0043068 157 0.012
negative regulation of rna metabolic process GO:0051253 123 0.012
positive regulation of cell projection organization GO:0031346 111 0.012
small gtpase mediated signal transduction GO:0007264 36 0.012
negative regulation of innate immune response GO:0045824 4 0.012
cation transmembrane transport GO:0098655 263 0.012
cellular nitrogen compound catabolic process GO:0044270 163 0.012
positive regulation of cellular amine metabolic process GO:0033240 3 0.012
inorganic ion transmembrane transport GO:0098660 229 0.011
response to acid chemical GO:0001101 222 0.011
regulation of protein modification process GO:0031399 194 0.011
purine nucleoside triphosphate metabolic process GO:0009144 141 0.011
negative regulation of catalytic activity GO:0043086 103 0.011
cellular homeostasis GO:0019725 252 0.011
response to peptide GO:1901652 292 0.011
secretion GO:0046903 307 0.011
coenzyme metabolic process GO:0006732 86 0.011
reproductive process GO:0022414 372 0.011
positive regulation of developmental process GO:0051094 283 0.011
response to radiation GO:0009314 137 0.011
positive regulation of neuron differentiation GO:0045666 126 0.011
regulation of response to stress GO:0080134 126 0.011
intracellular signal transduction GO:0035556 314 0.011
negative regulation of apoptotic process GO:0043066 181 0.011
oxidation reduction process GO:0055114 304 0.011
protein complex subunit organization GO:0071822 302 0.011
response to alkaloid GO:0043279 132 0.011
motor neuron axon guidance GO:0008045 1 0.011
carbohydrate derivative biosynthetic process GO:1901137 124 0.011
cell adhesion GO:0007155 110 0.011
nucleobase containing compound catabolic process GO:0034655 152 0.011
purine ribonucleoside metabolic process GO:0046128 168 0.011
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.011
liver development GO:0001889 90 0.011
negative regulation of molecular function GO:0044092 133 0.011
localization of cell GO:0051674 202 0.011
positive regulation of catalytic activity GO:0043085 184 0.011
cell type specific apoptotic process GO:0097285 134 0.011
alpha amino acid metabolic process GO:1901605 71 0.011
response to metal ion GO:0010038 253 0.011
negative regulation of cellular protein metabolic process GO:0032269 106 0.011
positive regulation of protein modification process GO:0031401 142 0.011
organic cyclic compound catabolic process GO:1901361 175 0.010
rho protein signal transduction GO:0007266 11 0.010
multicellular organism growth GO:0035264 1 0.010
cellular protein localization GO:0034613 122 0.010
regulation of hormone levels GO:0010817 187 0.010
cellular response to alcohol GO:0097306 87 0.010
response to purine containing compound GO:0014074 126 0.010
positive regulation of protein metabolic process GO:0051247 178 0.010
response to external biotic stimulus GO:0043207 221 0.010
positive regulation of response to stimulus GO:0048584 285 0.010
secretion by cell GO:0032940 248 0.010
single organism intracellular transport GO:1902582 166 0.010
multicellular organismal reproductive process GO:0048609 233 0.010
multicellular organism reproduction GO:0032504 233 0.010
regulation of protein phosphorylation GO:0001932 183 0.010
positive regulation of cell communication GO:0010647 271 0.010

Topbp1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.025
nervous system disease DOID:863 0 0.025
central nervous system disease DOID:331 0 0.012