Rattus norvegicus

131 known processes

Hdac4

histone deacetylase 4

Hdac4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of multicellular organismal development GO:2000026 376 0.148
Mouse
nucleic acid templated transcription GO:0097659 379 0.122
Human Mouse Fly
rna metabolic process GO:0016070 406 0.115
Human Mouse Fly
rna biosynthetic process GO:0032774 380 0.109
Human Mouse Fly
anatomical structure morphogenesis GO:0009653 298 0.105
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.094
Human Mouse
regulation of transcription dna templated GO:0006355 374 0.093
Human Mouse Fly
regulation of cellular component organization GO:0051128 368 0.087
positive regulation of rna metabolic process GO:0051254 203 0.082
Human Mouse
regulation of nucleic acid templated transcription GO:1903506 380 0.078
Human Mouse Fly
cell projection organization GO:0030030 302 0.078
behavior GO:0007610 205 0.072
Fly
positive regulation of multicellular organismal process GO:0051240 387 0.071
cell part morphogenesis GO:0032990 123 0.069
positive regulation of biosynthetic process GO:0009891 319 0.067
reproductive process GO:0022414 372 0.064
oxoacid metabolic process GO:0043436 290 0.063
Mouse
regulation of rna biosynthetic process GO:2001141 381 0.063
Human Mouse Fly
cell cell signaling GO:0007267 335 0.063
synaptic growth at neuromuscular junction GO:0051124 1 0.062
positive regulation of rna biosynthetic process GO:1902680 197 0.061
Human Mouse
neuron projection development GO:0031175 273 0.060
regulation of molecular function GO:0065009 398 0.060
Human
positive regulation of nucleic acid templated transcription GO:1903508 197 0.058
Human Mouse
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.058
Human Mouse
regulation of signal transduction GO:0009966 318 0.056
cell morphogenesis GO:0000902 142 0.056
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.055
Human Mouse
neuron development GO:0048666 286 0.054
carboxylic acid metabolic process GO:0019752 289 0.054
Mouse
negative regulation of metabolic process GO:0009892 331 0.053
Human Mouse
neuron differentiation GO:0030182 368 0.051
Rat
locomotion GO:0040011 237 0.051
cell morphogenesis involved in differentiation GO:0000904 119 0.051
positive regulation of developmental process GO:0051094 283 0.051
central nervous system development GO:0007417 311 0.051
organic acid metabolic process GO:0006082 292 0.049
Mouse
positive regulation of cellular biosynthetic process GO:0031328 295 0.049
Human Mouse
cellular ketone metabolic process GO:0042180 51 0.048
neuron projection morphogenesis GO:0048812 122 0.048
single organism reproductive process GO:0044702 297 0.047
regulation of rna metabolic process GO:0051252 391 0.047
Human Mouse Fly
negative regulation of cellular metabolic process GO:0031324 281 0.047
Human Mouse
cellular component morphogenesis GO:0032989 155 0.047
negative regulation of macromolecule metabolic process GO:0010605 260 0.046
Human Mouse
protein complex subunit organization GO:0071822 302 0.045
regulation of cell projection organization GO:0031344 175 0.045
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.045
transcription from rna polymerase ii promoter GO:0006366 252 0.045
Human Mouse
positive regulation of cellular component organization GO:0051130 200 0.045
regulation of system process GO:0044057 208 0.044
Mouse
regulation of nervous system development GO:0051960 264 0.044
regulation of phosphate metabolic process GO:0019220 349 0.043
cell migration GO:0016477 197 0.043
regulation of cell development GO:0060284 263 0.043
Mouse
positive regulation of programmed cell death GO:0043068 157 0.043
regulation of neurogenesis GO:0050767 247 0.042
positive regulation of cell communication GO:0010647 271 0.042
hormone transport GO:0009914 121 0.041
macromolecular complex subunit organization GO:0043933 339 0.041
head development GO:0060322 247 0.041
regulation of cell differentiation GO:0045595 320 0.040
Human Mouse
cellular component movement GO:0006928 248 0.039
dendrite development GO:0016358 72 0.039
regulation of cell morphogenesis GO:0022604 77 0.039
dendrite morphogenesis GO:0048813 43 0.039
regulation of cellular amino acid metabolic process GO:0006521 2 0.039
signal release GO:0023061 145 0.039
positive regulation of gene expression GO:0010628 244 0.039
Human Mouse
regulation of phosphorus metabolic process GO:0051174 349 0.039
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.038
Human Mouse
tissue development GO:0009888 252 0.038
Mouse
cellular component biogenesis GO:0044085 368 0.038
protein complex biogenesis GO:0070271 263 0.038
protein complex assembly GO:0006461 263 0.037
cellular amino acid metabolic process GO:0006520 107 0.037
cell projection morphogenesis GO:0048858 123 0.037
regulation of anatomical structure morphogenesis GO:0022603 141 0.037
cellular response to endogenous stimulus GO:0071495 377 0.036
regulation of secretion by cell GO:1903530 208 0.036
positive regulation of signaling GO:0023056 270 0.036
macromolecular complex assembly GO:0065003 273 0.035
negative regulation of gene expression GO:0010629 199 0.035
Human Mouse
regulation of cellular ketone metabolic process GO:0010565 27 0.035
secretion by cell GO:0032940 248 0.034
regulation of cellular amine metabolic process GO:0033238 8 0.034
secretion GO:0046903 307 0.033
response to other organism GO:0051707 220 0.033
Rat
positive regulation of molecular function GO:0044093 230 0.033
Human
cellular amine metabolic process GO:0044106 38 0.033
developmental process involved in reproduction GO:0003006 159 0.032
regulation of neuron differentiation GO:0045664 208 0.032
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.032
cellular response to oxygen containing compound GO:1901701 386 0.031
Rat
cellular component assembly GO:0022607 360 0.031
negative regulation of multicellular organismal process GO:0051241 203 0.031
Mouse
transcription dna templated GO:0006351 377 0.031
Human Mouse Fly
intracellular signal transduction GO:0035556 314 0.031
Mouse
positive regulation of transcription dna templated GO:0045893 197 0.030
Human Mouse
amine metabolic process GO:0009308 38 0.030
carbohydrate derivative metabolic process GO:1901135 346 0.030
regulation of intracellular signal transduction GO:1902531 218 0.030
organic substance catabolic process GO:1901575 316 0.029
Mouse
regulation of cellular localization GO:0060341 263 0.029
regulation of hormone levels GO:0010817 187 0.028
positive regulation of response to stimulus GO:0048584 285 0.028
localization of cell GO:0051674 202 0.028
negative regulation of cellular component organization GO:0051129 83 0.028
ribonucleoside triphosphate catabolic process GO:0009203 122 0.028
cell motility GO:0048870 202 0.027
positive regulation of cell development GO:0010720 176 0.027
gonad development GO:0008406 104 0.026
response to extracellular stimulus GO:0009991 380 0.026
multicellular organismal reproductive process GO:0048609 233 0.026
positive regulation of catalytic activity GO:0043085 184 0.026
organic cyclic compound catabolic process GO:1901361 175 0.026
nucleoside phosphate metabolic process GO:0006753 283 0.026
regulation of neuron projection development GO:0010975 161 0.026
positive regulation of phosphorus metabolic process GO:0010562 262 0.026
regulation of apoptotic process GO:0042981 335 0.026
positive regulation of signal transduction GO:0009967 175 0.025
programmed cell death GO:0012501 392 0.025
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.025
small gtpase mediated signal transduction GO:0007264 36 0.025
nucleobase containing small molecule metabolic process GO:0055086 316 0.025
multicellular organism reproduction GO:0032504 233 0.025
regulation of protein metabolic process GO:0051246 289 0.024
Human
reproductive structure development GO:0048608 128 0.024
response to nutrient levels GO:0031667 370 0.024
muscle system process GO:0003012 115 0.024
Mouse
response to wounding GO:0009611 254 0.024
purine nucleotide metabolic process GO:0006163 229 0.024
positive regulation of apoptotic process GO:0043065 154 0.024
regulation of catalytic activity GO:0050790 304 0.024
brain development GO:0007420 247 0.024
cellular response to hormone stimulus GO:0032870 247 0.024
positive regulation of phosphate metabolic process GO:0045937 262 0.024
ras protein signal transduction GO:0007265 29 0.024
vesicle mediated transport GO:0016192 181 0.023
positive regulation of neurogenesis GO:0050769 165 0.023
cellular response to stress GO:0033554 269 0.023
single organism catabolic process GO:0044712 283 0.023
Mouse
regulation of cellular protein metabolic process GO:0032268 267 0.023
Human
cardiovascular system development GO:0072358 134 0.023
macromolecule localization GO:0033036 252 0.023
protein phosphorylation GO:0006468 345 0.022
regulation of hydrolase activity GO:0051336 143 0.022
neurological system process GO:0050877 219 0.022
Fly
apoptotic process GO:0006915 381 0.022
cellular nitrogen compound catabolic process GO:0044270 163 0.022
reproduction GO:0000003 245 0.022
nucleotide metabolic process GO:0009117 279 0.022
regulation of secretion GO:0051046 224 0.022
negative regulation of cell communication GO:0010648 158 0.022
positive regulation of nervous system development GO:0051962 178 0.022
purine containing compound metabolic process GO:0072521 253 0.022
cation transport GO:0006812 382 0.022
negative regulation of rna metabolic process GO:0051253 123 0.022
Human Mouse
glycosyl compound metabolic process GO:1901657 182 0.022
regulation of anatomical structure size GO:0090066 135 0.021
positive regulation of cellular amine metabolic process GO:0033240 3 0.021
synaptic transmission GO:0007268 235 0.021
multi organism reproductive process GO:0044703 262 0.021
cellular response to growth factor stimulus GO:0071363 162 0.021
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.021
Human Mouse
purine ribonucleotide metabolic process GO:0009150 227 0.021
ribonucleotide metabolic process GO:0009259 231 0.021
purine containing compound catabolic process GO:0072523 138 0.021
peptidyl amino acid modification GO:0018193 126 0.021
Human
purine ribonucleoside metabolic process GO:0046128 168 0.021
ribose phosphate metabolic process GO:0019693 235 0.020
forebrain development GO:0030900 98 0.020
positive regulation of phosphorylation GO:0042327 177 0.020
regulation of cell motility GO:2000145 131 0.020
axonogenesis GO:0007409 71 0.020
purine nucleoside triphosphate metabolic process GO:0009144 141 0.020
response to peptide GO:1901652 292 0.020
regulation of synaptic plasticity GO:0048167 70 0.020
nucleoside triphosphate metabolic process GO:0009141 144 0.020
development of primary sexual characteristics GO:0045137 107 0.020
purine nucleoside catabolic process GO:0006152 124 0.020
organonitrogen compound catabolic process GO:1901565 179 0.020
transmembrane transport GO:0055085 412 0.020
negative regulation of nucleic acid templated transcription GO:1903507 117 0.019
Human Mouse
homeostatic process GO:0042592 331 0.019
regulation of protein modification process GO:0031399 194 0.019
Human
metal ion transport GO:0030001 289 0.019
sex differentiation GO:0007548 113 0.019
negative regulation of response to stimulus GO:0048585 155 0.019
negative regulation of rna biosynthetic process GO:1902679 118 0.019
Human Mouse
regulation of locomotion GO:0040012 148 0.019
hormone secretion GO:0046879 115 0.019
response to growth factor GO:0070848 189 0.019
cellular catabolic process GO:0044248 295 0.019
Mouse
enzyme linked receptor protein signaling pathway GO:0007167 116 0.018
negative regulation of transport GO:0051051 136 0.018
circulatory system development GO:0072359 134 0.018
cell adhesion GO:0007155 110 0.018
response to oxygen levels GO:0070482 265 0.018
cellular response to organonitrogen compound GO:0071417 197 0.018
regulation of cellular component movement GO:0051270 150 0.018
protein oligomerization GO:0051259 191 0.018
negative regulation of transcription dna templated GO:0045892 116 0.018
Human Mouse
biological adhesion GO:0022610 110 0.018
regulation of proteasomal protein catabolic process GO:0061136 4 0.018
epithelium development GO:0060429 96 0.018
positive regulation of cell death GO:0010942 184 0.018
protein autophosphorylation GO:0046777 66 0.017
growth GO:0040007 165 0.017
cellular response to nitrogen compound GO:1901699 210 0.017
response to lipopolysaccharide GO:0032496 191 0.017
Rat
nucleoside phosphate catabolic process GO:1901292 140 0.017
regulation of dendrite development GO:0050773 59 0.017
protein localization GO:0008104 191 0.017
divalent inorganic cation transport GO:0072511 134 0.017
positive regulation of neuron differentiation GO:0045666 126 0.017
response to metal ion GO:0010038 253 0.017
regulation of transferase activity GO:0051338 123 0.017
positive regulation of cell differentiation GO:0045597 217 0.017
positive regulation of protein metabolic process GO:0051247 178 0.017
Human
response to molecule of bacterial origin GO:0002237 194 0.017
Rat
regulation of protein kinase activity GO:0045859 105 0.017
oxidation reduction process GO:0055114 304 0.017
negative regulation of signaling GO:0023057 157 0.017
response to external biotic stimulus GO:0043207 221 0.017
Rat
cellular homeostasis GO:0019725 252 0.017
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.017
Human Mouse
regulation of hormone secretion GO:0046883 106 0.017
negative regulation of phosphate metabolic process GO:0045936 80 0.016
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.016
Human Mouse
regulation of cell proliferation GO:0042127 359 0.016
organophosphate metabolic process GO:0019637 370 0.016
heterocycle catabolic process GO:0046700 167 0.016
developmental growth GO:0048589 100 0.016
embryonic pattern specification GO:0009880 1 0.016
response to biotic stimulus GO:0009607 226 0.016
Rat
regulation of programmed cell death GO:0043067 341 0.016
chemical homeostasis GO:0048878 292 0.016
positive regulation of cellular protein metabolic process GO:0032270 167 0.016
Human
regulation of cellular component biogenesis GO:0044087 86 0.016
glycosyl compound catabolic process GO:1901658 126 0.016
nucleotide catabolic process GO:0009166 139 0.016
gastrulation GO:0007369 2 0.016
bmp signaling pathway GO:0030509 4 0.016
response to glucose GO:0009749 136 0.016
chromosome segregation GO:0007059 2 0.015
response to hexose GO:0009746 144 0.015
taxis GO:0042330 67 0.015
negative regulation of nervous system development GO:0051961 79 0.015
aromatic compound catabolic process GO:0019439 168 0.015
negative regulation of biosynthetic process GO:0009890 168 0.015
Human Mouse
ribonucleoside metabolic process GO:0009119 174 0.015
nucleoside triphosphate catabolic process GO:0009143 123 0.015
appendage morphogenesis GO:0035107 4 0.015
nucleoside catabolic process GO:0009164 126 0.015
nucleobase containing compound catabolic process GO:0034655 152 0.015
gamete generation GO:0007276 124 0.015
negative regulation of molecular function GO:0044092 133 0.015
Human
positive regulation of transport GO:0051050 245 0.015
sexual reproduction GO:0019953 148 0.015
positive regulation of neuron projection development GO:0010976 99 0.015
reproductive system development GO:0061458 128 0.015
catabolic process GO:0009056 351 0.015
Mouse
purine nucleoside metabolic process GO:0042278 169 0.015
nitrogen compound transport GO:0071705 229 0.014
nucleoside metabolic process GO:0009116 179 0.014
proteolysis GO:0006508 175 0.014
single organism biosynthetic process GO:0044711 342 0.014
regulation of catabolic process GO:0009894 113 0.014
Mouse
actin filament based process GO:0030029 86 0.014
organelle organization GO:0006996 266 0.014
response to decreased oxygen levels GO:0036293 237 0.014
urogenital system development GO:0001655 78 0.014
mapk cascade GO:0000165 140 0.014
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.014
positive regulation of mapk cascade GO:0043410 92 0.014
cellular chemical homeostasis GO:0055082 247 0.014
positive regulation of cell projection organization GO:0031346 111 0.014
response to glucocorticoid GO:0051384 223 0.014
axon development GO:0061564 96 0.014
motor neuron axon guidance GO:0008045 1 0.014
negative regulation of cell proliferation GO:0008285 119 0.014
Mouse
ribonucleoside triphosphate metabolic process GO:0009199 141 0.014
response to acid chemical GO:0001101 222 0.014
response to hypoxia GO:0001666 231 0.014
response to inorganic substance GO:0010035 377 0.014
cell growth GO:0016049 104 0.014
anterior posterior pattern specification GO:0009952 1 0.014
positive regulation of protein modification process GO:0031401 142 0.014
Human
response to carbohydrate GO:0009743 183 0.013
response to ethanol GO:0045471 162 0.013
limb morphogenesis GO:0035108 4 0.013
single organism behavior GO:0044708 130 0.013
Fly
cellular ion homeostasis GO:0006873 184 0.013
embryonic appendage morphogenesis GO:0035113 4 0.013
regulation of protein phosphorylation GO:0001932 183 0.013
mesoderm development GO:0007498 2 0.013
regulation of growth GO:0040008 105 0.013
axis specification GO:0009798 4 0.013
positive regulation of catabolic process GO:0009896 78 0.013
positive regulation of protein phosphorylation GO:0001934 135 0.013
response to monosaccharide GO:0034284 159 0.013
ribonucleoside catabolic process GO:0042454 126 0.013
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.013
Human Mouse
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.013
synapse assembly GO:0007416 29 0.013
regulation of phosphorylation GO:0042325 248 0.013
regulation of organelle organization GO:0033043 80 0.013
aging GO:0007568 241 0.013
dephosphorylation GO:0016311 98 0.013
rhythmic process GO:0048511 156 0.013
lipid metabolic process GO:0006629 283 0.013
regulation of axonogenesis GO:0050770 37 0.013
circulatory system process GO:0003013 183 0.013
Mouse
response to nutrient GO:0007584 248 0.013
ribonucleotide catabolic process GO:0009261 136 0.013
salivary gland morphogenesis GO:0007435 1 0.012
negative regulation of neurogenesis GO:0050768 78 0.012
cognition GO:0050890 92 0.012
Fly
olfactory behavior GO:0042048 2 0.012
purine ribonucleotide catabolic process GO:0009154 136 0.012
regulation of cell growth GO:0001558 85 0.012
salivary gland development GO:0007431 3 0.012
multicellular organism growth GO:0035264 1 0.012
ion transmembrane transport GO:0034220 365 0.012
rho protein signal transduction GO:0007266 11 0.012
regulation of synaptic transmission GO:0050804 141 0.012
cellular protein localization GO:0034613 122 0.012
positive regulation of cell morphogenesis involved in differentiation GO:0010770 41 0.012
negative regulation of cell death GO:0060548 229 0.012
organonitrogen compound biosynthetic process GO:1901566 167 0.012
regulation of purine nucleotide metabolic process GO:1900542 115 0.012
cytoskeleton organization GO:0007010 111 0.012
regulation of response to stress GO:0080134 126 0.012
regulation of cell migration GO:0030334 128 0.012
purine nucleotide catabolic process GO:0006195 136 0.012
mitotic spindle organization GO:0007052 2 0.012
response to cytokine GO:0034097 215 0.012
regulation of vesicle mediated transport GO:0060627 81 0.012
b cell differentiation GO:0030183 2 0.012
cell type specific apoptotic process GO:0097285 134 0.012
ion homeostasis GO:0050801 212 0.011
membrane organization GO:0061024 94 0.011
multi multicellular organism process GO:0044706 138 0.011
carboxylic acid transport GO:0046942 115 0.011
positive regulation of hydrolase activity GO:0051345 86 0.011
carbohydrate derivative catabolic process GO:1901136 147 0.011
amide transport GO:0042886 105 0.011
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.011
Human Mouse
cellular response to organic cyclic compound GO:0071407 202 0.011
cellular response to peptide GO:1901653 133 0.011
regulation of mapk cascade GO:0043408 116 0.011
embryo development GO:0009790 49 0.011
negative regulation of secretion GO:0051048 82 0.011
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.011
ribonucleoside monophosphate metabolic process GO:0009161 88 0.011
regulation of cellular catabolic process GO:0031329 101 0.011
Mouse
male sex differentiation GO:0046661 64 0.011
organophosphate catabolic process GO:0046434 148 0.011
regulation of kinase activity GO:0043549 117 0.011
regulation of nucleotide metabolic process GO:0006140 117 0.011
non canonical wnt signaling pathway GO:0035567 3 0.010
spindle organization GO:0007051 2 0.010
negative regulation of programmed cell death GO:0043069 183 0.010
regulation of nucleoside metabolic process GO:0009118 66 0.010
negative regulation of catalytic activity GO:0043086 103 0.010
regulation of membrane potential GO:0042391 110 0.010
regulation of cell adhesion GO:0030155 52 0.010
actin cytoskeleton organization GO:0030036 73 0.010
heart development GO:0007507 72 0.010
male mating behavior GO:0060179 3 0.010
cellular calcium ion homeostasis GO:0006874 160 0.010
regulation of purine nucleotide catabolic process GO:0033121 65 0.010
signal transduction by phosphorylation GO:0023014 144 0.010
response to estradiol GO:0032355 164 0.010
positive regulation of cell proliferation GO:0008284 249 0.010
purine ribonucleoside catabolic process GO:0046130 124 0.010
blood circulation GO:0008015 183 0.010
Mouse
synapse organization GO:0050808 46 0.010
regulation of ion transport GO:0043269 245 0.010

Hdac4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.019
musculoskeletal system disease DOID:17 0 0.019
bone disease DOID:0080001 0 0.017
connective tissue disease DOID:65 0 0.017
nervous system disease DOID:863 0 0.014