Rattus norvegicus

46 known processes

H2afx

H2A histone family, member X

(Aliases: RGD1566119)

H2afx biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
rna metabolic process GO:0016070 406 0.091
nucleic acid templated transcription GO:0097659 379 0.088
negative regulation of gene expression GO:0010629 199 0.088
negative regulation of metabolic process GO:0009892 331 0.079
negative regulation of macromolecule metabolic process GO:0010605 260 0.078
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.070
negative regulation of cellular metabolic process GO:0031324 281 0.070
negative regulation of cellular biosynthetic process GO:0031327 161 0.063
organelle organization GO:0006996 266 0.060
negative regulation of biosynthetic process GO:0009890 168 0.060
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.053
single organism organelle organization GO:1902589 180 0.051
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.049
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.049
regulation of nucleic acid templated transcription GO:1903506 380 0.048
response to peptide hormone GO:0043434 278 0.048
rna biosynthetic process GO:0032774 380 0.047
macromolecular complex subunit organization GO:0043933 339 0.047
cellular response to stress GO:0033554 269 0.045
regulation of cellular protein metabolic process GO:0032268 267 0.045
positive regulation of biosynthetic process GO:0009891 319 0.044
cell cycle checkpoint GO:0000075 2 0.043
regulation of rna biosynthetic process GO:2001141 381 0.041
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.041
regulation of protein metabolic process GO:0051246 289 0.039
cellular homeostasis GO:0019725 252 0.038
cellular component assembly GO:0022607 360 0.038
response to peptide GO:1901652 292 0.037
chemical homeostasis GO:0048878 292 0.037
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.036
negative regulation of protein metabolic process GO:0051248 114 0.036
response to inorganic substance GO:0010035 377 0.035
regulation of molecular function GO:0065009 398 0.035
negative regulation of rna metabolic process GO:0051253 123 0.035
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.034
intracellular signal transduction GO:0035556 314 0.034
positive regulation of rna biosynthetic process GO:1902680 197 0.033
ion homeostasis GO:0050801 212 0.033
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.032
cellular ion homeostasis GO:0006873 184 0.032
regulation of rna metabolic process GO:0051252 391 0.031
negative regulation of rna biosynthetic process GO:1902679 118 0.031
response to biotic stimulus GO:0009607 226 0.031
negative regulation of cell death GO:0060548 229 0.031
cation homeostasis GO:0055080 195 0.030
dna metabolic process GO:0006259 96 0.030
reproduction GO:0000003 245 0.030
positive regulation of nucleic acid templated transcription GO:1903508 197 0.029
cell projection organization GO:0030030 302 0.029
positive regulation of gene expression GO:0010628 244 0.029
negative regulation of rna splicing GO:0033119 3 0.029
protein complex subunit organization GO:0071822 302 0.029
head development GO:0060322 247 0.028
cellular protein localization GO:0034613 122 0.028
nitrogen compound transport GO:0071705 229 0.028
central nervous system development GO:0007417 311 0.028
tissue development GO:0009888 252 0.027
transcription dna templated GO:0006351 377 0.027
meiotic cell cycle process GO:1903046 3 0.027
translation GO:0006412 35 0.027
macromolecular complex assembly GO:0065003 273 0.026
positive regulation of cellular biosynthetic process GO:0031328 295 0.026
regulation of dna metabolic process GO:0051052 60 0.026
ion transmembrane transport GO:0034220 365 0.025
cell cycle GO:0007049 101 0.025
protein localization to organelle GO:0033365 57 0.025
cellular catabolic process GO:0044248 295 0.025
rhythmic process GO:0048511 156 0.025
positive regulation of rna metabolic process GO:0051254 203 0.024
regulation of cellular localization GO:0060341 263 0.024
cellular chemical homeostasis GO:0055082 247 0.024
reproductive process GO:0022414 372 0.024
multi organism reproductive process GO:0044703 262 0.024
transcription from rna polymerase ii promoter GO:0006366 252 0.024
anatomical structure morphogenesis GO:0009653 298 0.024
cellular amine metabolic process GO:0044106 38 0.023
catabolic process GO:0009056 351 0.023
protein localization GO:0008104 191 0.023
macromolecule localization GO:0033036 252 0.023
response to other organism GO:0051707 220 0.023
transmembrane transport GO:0055085 412 0.022
regulation of cellular component organization GO:0051128 368 0.021
cellular amino acid metabolic process GO:0006520 107 0.021
regulation of transcription dna templated GO:0006355 374 0.021
negative regulation of programmed cell death GO:0043069 183 0.021
regulation of cell cycle GO:0051726 73 0.021
homeostatic process GO:0042592 331 0.021
regulation of signal transduction GO:0009966 318 0.021
cellular component biogenesis GO:0044085 368 0.020
regulation of cell differentiation GO:0045595 320 0.020
dna integrity checkpoint GO:0031570 2 0.020
response to purine containing compound GO:0014074 126 0.020
cellular response to cytokine stimulus GO:0071345 127 0.020
posttranscriptional regulation of gene expression GO:0010608 37 0.019
negative regulation of apoptotic process GO:0043066 181 0.019
cellular metal ion homeostasis GO:0006875 172 0.019
chromatin modification GO:0016568 33 0.019
neuron development GO:0048666 286 0.019
programmed cell death GO:0012501 392 0.019
positive regulation of molecular function GO:0044093 230 0.018
protein complex assembly GO:0006461 263 0.018
cell migration GO:0016477 197 0.018
negative regulation of cellular protein metabolic process GO:0032269 106 0.018
cell cycle process GO:0022402 57 0.018
regulation of apoptotic process GO:0042981 335 0.018
neuron differentiation GO:0030182 368 0.018
cellular cation homeostasis GO:0030003 180 0.018
nucleobase containing small molecule metabolic process GO:0055086 316 0.018
double strand break repair GO:0006302 1 0.018
regulation of proteasomal protein catabolic process GO:0061136 4 0.017
anterior posterior pattern specification GO:0009952 1 0.017
regulation of translation GO:0006417 27 0.017
protein phosphorylation GO:0006468 345 0.017
response to external biotic stimulus GO:0043207 221 0.017
chromosome segregation GO:0007059 2 0.017
positive regulation of transcription dna templated GO:0045893 197 0.017
single organism biosynthetic process GO:0044711 342 0.017
positive regulation of cell development GO:0010720 176 0.017
multicellular organism reproduction GO:0032504 233 0.017
metal ion homeostasis GO:0055065 186 0.017
multicellular organismal reproductive process GO:0048609 233 0.016
regulation of organelle organization GO:0033043 80 0.016
response to transition metal nanoparticle GO:1990267 122 0.016
chromosome organization GO:0051276 36 0.016
response to oxidative stress GO:0006979 186 0.016
cellular response to oxygen containing compound GO:1901701 386 0.016
nucleobase containing compound catabolic process GO:0034655 152 0.016
aging GO:0007568 241 0.016
regulation of phosphorus metabolic process GO:0051174 349 0.016
protein complex biogenesis GO:0070271 263 0.016
histone h3 acetylation GO:0043966 2 0.016
positive regulation of cellular component organization GO:0051130 200 0.016
divalent inorganic cation homeostasis GO:0072507 165 0.016
axis specification GO:0009798 4 0.016
negative regulation of nucleic acid templated transcription GO:1903507 117 0.016
carboxylic acid transport GO:0046942 115 0.016
organic cyclic compound catabolic process GO:1901361 175 0.016
regulation of homeostatic process GO:0032844 101 0.016
regulation of cell proliferation GO:0042127 359 0.015
response to cytokine GO:0034097 215 0.015
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.015
negative regulation of cell cycle phase transition GO:1901988 4 0.015
regulation of cellular amino acid metabolic process GO:0006521 2 0.015
brain development GO:0007420 247 0.015
response to decreased oxygen levels GO:0036293 237 0.015
single organism reproductive process GO:0044702 297 0.015
covalent chromatin modification GO:0016569 30 0.015
neuron projection development GO:0031175 273 0.014
regulation of catalytic activity GO:0050790 304 0.014
heterocycle catabolic process GO:0046700 167 0.014
amine metabolic process GO:0009308 38 0.014
mrna metabolic process GO:0016071 20 0.014
negative regulation of signaling GO:0023057 157 0.014
regulation of mrna splicing via spliceosome GO:0048024 3 0.014
regulation of protein modification process GO:0031399 194 0.014
single organism intracellular transport GO:1902582 166 0.014
positive regulation of signal transduction GO:0009967 175 0.014
organic substance catabolic process GO:1901575 316 0.014
gland development GO:0048732 155 0.014
regulation of programmed cell death GO:0043067 341 0.014
cellular response to endogenous stimulus GO:0071495 377 0.014
organonitrogen compound biosynthetic process GO:1901566 167 0.014
response to oxygen levels GO:0070482 265 0.014
peptidyl amino acid modification GO:0018193 126 0.014
circadian rhythm GO:0007623 88 0.014
negative regulation of cell communication GO:0010648 158 0.013
gastrulation GO:0007369 2 0.013
mrna processing GO:0006397 14 0.013
response to metal ion GO:0010038 253 0.013
intracellular transport GO:0046907 185 0.013
response to glucose GO:0009749 136 0.013
cellular macromolecule localization GO:0070727 122 0.013
positive regulation of protein modification process GO:0031401 142 0.013
organic anion transport GO:0015711 132 0.013
positive regulation of catalytic activity GO:0043085 184 0.013
positive regulation of nervous system development GO:0051962 178 0.013
response to extracellular stimulus GO:0009991 380 0.013
response to hypoxia GO:0001666 231 0.013
cytoplasmic transport GO:0016482 115 0.013
cell motility GO:0048870 202 0.013
cation transport GO:0006812 382 0.013
proteolysis GO:0006508 175 0.013
positive regulation of apoptotic process GO:0043065 154 0.013
cellular response to nitrogen compound GO:1901699 210 0.013
cell cell signaling GO:0007267 335 0.012
cellular component movement GO:0006928 248 0.012
regulation of neurogenesis GO:0050767 247 0.012
organic acid metabolic process GO:0006082 292 0.012
response to reactive oxygen species GO:0000302 120 0.012
cellular response to insulin stimulus GO:0032869 81 0.012
cellular divalent inorganic cation homeostasis GO:0072503 162 0.012
response to ethanol GO:0045471 162 0.012
microtubule organizing center organization GO:0031023 1 0.012
negative regulation of transcription dna templated GO:0045892 116 0.012
vesicle mediated transport GO:0016192 181 0.012
positive regulation of programmed cell death GO:0043068 157 0.012
regulation of intracellular signal transduction GO:1902531 218 0.012
regulation of multicellular organismal development GO:2000026 376 0.012
embryonic pattern specification GO:0009880 1 0.012
nucleotide metabolic process GO:0009117 279 0.012
regulation of ion transport GO:0043269 245 0.012
negative regulation of signal transduction GO:0009968 83 0.012
centrosome organization GO:0051297 1 0.012
positive regulation of cell proliferation GO:0008284 249 0.012
negative regulation of response to stimulus GO:0048585 155 0.012
spermatogenesis GO:0007283 99 0.012
regulation of neuron differentiation GO:0045664 208 0.012
small gtpase mediated signal transduction GO:0007264 36 0.012
protein oligomerization GO:0051259 191 0.012
positive regulation of cellular protein metabolic process GO:0032270 167 0.012
response to estradiol GO:0032355 164 0.011
regulation of cellular amine metabolic process GO:0033238 8 0.011
protein homooligomerization GO:0051260 91 0.011
organophosphate biosynthetic process GO:0090407 143 0.011
epithelium development GO:0060429 96 0.011
positive regulation of phosphorus metabolic process GO:0010562 262 0.011
cell morphogenesis GO:0000902 142 0.011
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.011
regulation of cell development GO:0060284 263 0.011
positive regulation of developmental process GO:0051094 283 0.011
regulation of neuron projection development GO:0010975 161 0.011
cellular response to interleukin 1 GO:0071347 37 0.011
mitotic cell cycle GO:0000278 49 0.011
cellular response to organonitrogen compound GO:0071417 197 0.011
response to organophosphorus GO:0046683 102 0.011
regulation of alternative mrna splicing via spliceosome GO:0000381 2 0.011
positive regulation of neuron differentiation GO:0045666 126 0.011
cytosolic calcium ion homeostasis GO:0051480 140 0.011
single organism cellular localization GO:1902580 102 0.011
response to acid chemical GO:0001101 222 0.011
spindle organization GO:0007051 2 0.011
positive regulation of catabolic process GO:0009896 78 0.011
regulation of cell projection organization GO:0031344 175 0.011
protein targeting GO:0006605 61 0.011
regulation of cellular ketone metabolic process GO:0010565 27 0.011
g protein coupled receptor signaling pathway GO:0007186 242 0.011
organophosphate metabolic process GO:0019637 370 0.011
chromatin organization GO:0006325 34 0.011
response to nutrient levels GO:0031667 370 0.011
response to wounding GO:0009611 254 0.011
response to hexose GO:0009746 144 0.011
growth GO:0040007 165 0.011
positive regulation of protein metabolic process GO:0051247 178 0.011
regulation of nervous system development GO:0051960 264 0.010
positive regulation of response to stimulus GO:0048584 285 0.010
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.010
epithelial cell differentiation GO:0030855 71 0.010
gamete generation GO:0007276 124 0.010
positive regulation of phosphate metabolic process GO:0045937 262 0.010
mrna stabilization GO:0048255 2 0.010
response to toxic substance GO:0009636 133 0.010
dna damage checkpoint GO:0000077 2 0.010
carboxylic acid metabolic process GO:0019752 289 0.010
cytoskeleton dependent cytokinesis GO:0061640 2 0.010
regulation of phosphorylation GO:0042325 248 0.010
cellular response to organic cyclic compound GO:0071407 202 0.010
negative regulation of cellular component organization GO:0051129 83 0.010

H2afx disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.012
nervous system disease DOID:863 0 0.012
large intestine cancer DOID:5672 0 0.012
colon cancer DOID:219 0 0.012
gastrointestinal system cancer DOID:3119 0 0.012
intestinal cancer DOID:10155 0 0.012
cancer DOID:162 0 0.012
disease of cellular proliferation DOID:14566 0 0.012
organ system cancer DOID:0050686 0 0.012
colorectal cancer DOID:9256 0 0.012