Rattus norvegicus

133 known processes

Ide

insulin degrading enzyme

(Aliases: INSDEGM)

Ide biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
macromolecule localization GO:0033036 252 0.289
regulation of cellular localization GO:0060341 263 0.250
cellular component biogenesis GO:0044085 368 0.186
macromolecular complex assembly GO:0065003 273 0.171
protein complex subunit organization GO:0071822 302 0.163
protein complex assembly GO:0006461 263 0.145
single organism intracellular transport GO:1902582 166 0.140
regulation of cellular component organization GO:0051128 368 0.137
Human
macromolecular complex subunit organization GO:0043933 339 0.136
cellular component assembly GO:0022607 360 0.124
regulation of cellular protein metabolic process GO:0032268 267 0.122
nucleic acid templated transcription GO:0097659 379 0.112
single organism biosynthetic process GO:0044711 342 0.107
rna metabolic process GO:0016070 406 0.106
cellular response to organonitrogen compound GO:0071417 197 0.105
regulation of secretion GO:0051046 224 0.105
regulation of rna metabolic process GO:0051252 391 0.104
negative regulation of metabolic process GO:0009892 331 0.098
positive regulation of cellular biosynthetic process GO:0031328 295 0.096
intracellular transport GO:0046907 185 0.095
cellular protein localization GO:0034613 122 0.094
regulation of rna biosynthetic process GO:2001141 381 0.089
secretion GO:0046903 307 0.087
transcription dna templated GO:0006351 377 0.086
positive regulation of biosynthetic process GO:0009891 319 0.086
regulation of t cell chemotaxis GO:0010819 1 0.080
establishment of protein localization GO:0045184 141 0.079
regulation of phosphorus metabolic process GO:0051174 349 0.076
vesicle mediated transport GO:0016192 181 0.071
protein complex biogenesis GO:0070271 263 0.069
secretion by cell GO:0032940 248 0.068
cellular response to stress GO:0033554 269 0.068
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.066
response to decreased oxygen levels GO:0036293 237 0.061
oxoacid metabolic process GO:0043436 290 0.060
cellular homeostasis GO:0019725 252 0.059
Human
single organism carbohydrate metabolic process GO:0044723 118 0.058
Fly
cytoplasmic transport GO:0016482 115 0.057
regulation of protein transport GO:0051223 68 0.057
regulation of protein import into nucleus GO:0042306 24 0.057
cellular catabolic process GO:0044248 295 0.056
positive regulation of gene expression GO:0010628 244 0.056
carbohydrate metabolic process GO:0005975 130 0.055
Fly
regulation of transcription dna templated GO:0006355 374 0.055
protein transport GO:0015031 132 0.054
nucleocytoplasmic transport GO:0006913 48 0.052
cellular response to oxygen containing compound GO:1901701 386 0.052
negative regulation of cellular metabolic process GO:0031324 281 0.050
positive regulation of transport GO:0051050 245 0.049
protein phosphorylation GO:0006468 345 0.049
negative regulation of macromolecule metabolic process GO:0010605 260 0.049
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.049
regulation of cellular catabolic process GO:0031329 101 0.049
single organism catabolic process GO:0044712 283 0.048
ribose phosphate metabolic process GO:0019693 235 0.048
protein localization GO:0008104 191 0.048
response to hexose GO:0009746 144 0.048
cellular response to endogenous stimulus GO:0071495 377 0.047
protein modification by small protein conjugation or removal GO:0070647 35 0.047
regulation of establishment of protein localization GO:0070201 69 0.046
negative regulation of cellular protein metabolic process GO:0032269 106 0.046
regulation of protein localization GO:0032880 81 0.045
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.045
protein heterooligomerization GO:0051291 89 0.045
cellular component movement GO:0006928 248 0.045
metal ion transport GO:0030001 289 0.044
cellular response to peptide hormone stimulus GO:0071375 120 0.041
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.039
organic cyclic compound catabolic process GO:1901361 175 0.038
cell differentiation involved in kidney development GO:0061005 4 0.038
nucleoside phosphate metabolic process GO:0006753 283 0.038
positive regulation of rna metabolic process GO:0051254 203 0.038
nucleotide metabolic process GO:0009117 279 0.036
ribonucleotide metabolic process GO:0009259 231 0.036
cation homeostasis GO:0055080 195 0.035
negative regulation of protein phosphorylation GO:0001933 44 0.034
response to peptide hormone GO:0043434 278 0.034
response to extracellular stimulus GO:0009991 380 0.034
Fly
regulation of cell development GO:0060284 263 0.033
negative regulation of protein metabolic process GO:0051248 114 0.033
regulation of molecular function GO:0065009 398 0.033
regulation of multicellular organismal development GO:2000026 376 0.032
organelle localization GO:0051640 55 0.032
intracellular protein transport GO:0006886 79 0.032
cellular macromolecule localization GO:0070727 122 0.031
response to nutrient levels GO:0031667 370 0.031
Fly
protein oligomerization GO:0051259 191 0.030
purine nucleotide metabolic process GO:0006163 229 0.030
peptidyl amino acid modification GO:0018193 126 0.030
organonitrogen compound catabolic process GO:1901565 179 0.030
positive regulation of phosphorus metabolic process GO:0010562 262 0.030
homeostatic process GO:0042592 331 0.030
Human
neurological system process GO:0050877 219 0.030
nuclear transport GO:0051169 49 0.030
organelle organization GO:0006996 266 0.030
carbohydrate derivative metabolic process GO:1901135 346 0.029
organic acid metabolic process GO:0006082 292 0.029
regulation of secretion by cell GO:1903530 208 0.029
nucleoside metabolic process GO:0009116 179 0.029
carbohydrate derivative biosynthetic process GO:1901137 124 0.029
neuron projection development GO:0031175 273 0.028
transcription from rna polymerase ii promoter GO:0006366 252 0.028
single organism organelle organization GO:1902589 180 0.028
purine ribonucleotide metabolic process GO:0009150 227 0.028
development of primary female sexual characteristics GO:0046545 56 0.028
cytoskeleton organization GO:0007010 111 0.028
response to transition metal nanoparticle GO:1990267 122 0.027
negative regulation of phosphate metabolic process GO:0045936 80 0.027
protein deubiquitination GO:0016579 4 0.027
regulation of phosphate metabolic process GO:0019220 349 0.027
multi organism reproductive process GO:0044703 262 0.027
Fly
response to metal ion GO:0010038 253 0.027
regulation of catalytic activity GO:0050790 304 0.027
heart morphogenesis GO:0003007 3 0.026
proteolysis GO:0006508 175 0.026
single organism cellular localization GO:1902580 102 0.026
cellular amino acid metabolic process GO:0006520 107 0.026
memory GO:0007613 54 0.025
immune system process GO:0002376 204 0.025
Fly
positive regulation of nucleotide metabolic process GO:0045981 91 0.025
regulation of protein metabolic process GO:0051246 289 0.025
response to monosaccharide GO:0034284 159 0.025
ribose phosphate biosynthetic process GO:0046390 87 0.025
positive regulation of molecular function GO:0044093 230 0.025
regulation of nucleocytoplasmic transport GO:0046822 28 0.025
cellular ion homeostasis GO:0006873 184 0.025
amine metabolic process GO:0009308 38 0.025
glycoprotein biosynthetic process GO:0009101 19 0.025
organophosphate biosynthetic process GO:0090407 143 0.024
nucleoside phosphate biosynthetic process GO:1901293 102 0.024
protein localization to organelle GO:0033365 57 0.024
regulation of canonical wnt signaling pathway GO:0060828 4 0.024
rna biosynthetic process GO:0032774 380 0.024
spindle organization GO:0007051 2 0.024
neuromuscular synaptic transmission GO:0007274 2 0.024
negative regulation of transport GO:0051051 136 0.024
positive regulation of cell differentiation GO:0045597 217 0.024
response to nutrient GO:0007584 248 0.024
cellular carbohydrate metabolic process GO:0044262 72 0.024
Fly
positive regulation of secretion GO:0051047 140 0.024
protein import into nucleus GO:0006606 35 0.024
organophosphate metabolic process GO:0019637 370 0.023
regulation of cellular ketone metabolic process GO:0010565 27 0.023
small gtpase mediated signal transduction GO:0007264 36 0.023
cellular ketone metabolic process GO:0042180 51 0.023
response to growth factor GO:0070848 189 0.023
macroautophagy GO:0016236 4 0.023
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.023
carboxylic acid metabolic process GO:0019752 289 0.023
regulation of ion transport GO:0043269 245 0.023
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.022
regulation of intracellular transport GO:0032386 65 0.022
positive regulation of protein metabolic process GO:0051247 178 0.022
positive regulation of transcription dna templated GO:0045893 197 0.022
g protein coupled receptor signaling pathway GO:0007186 242 0.022
response to purine containing compound GO:0014074 126 0.022
positive regulation of cell development GO:0010720 176 0.022
nucleotide biosynthetic process GO:0009165 98 0.022
nucleobase containing small molecule metabolic process GO:0055086 316 0.021
lipid metabolic process GO:0006629 283 0.021
glycerolipid metabolic process GO:0046486 67 0.021
synaptic growth at neuromuscular junction GO:0051124 1 0.021
negative regulation of cell communication GO:0010648 158 0.021
Fly
catabolic process GO:0009056 351 0.021
response to oxygen levels GO:0070482 265 0.021
response to cadmium ion GO:0046686 35 0.021
female sex differentiation GO:0046660 59 0.021
negative regulation of cell death GO:0060548 229 0.021
negative regulation of nucleic acid templated transcription GO:1903507 117 0.020
positive regulation of rna biosynthetic process GO:1902680 197 0.020
cellular response to nitrogen compound GO:1901699 210 0.020
cellular response to organic cyclic compound GO:0071407 202 0.020
cellular chemical homeostasis GO:0055082 247 0.020
regulation of protein modification process GO:0031399 194 0.020
positive regulation of nucleic acid templated transcription GO:1903508 197 0.020
regulation of nucleotide metabolic process GO:0006140 117 0.020
divalent inorganic cation homeostasis GO:0072507 165 0.020
reproductive system development GO:0061458 128 0.020
signal release GO:0023061 145 0.020
synaptic transmission GO:0007268 235 0.020
cellular protein complex assembly GO:0043623 44 0.020
dna metabolic process GO:0006259 96 0.020
cell cycle GO:0007049 101 0.020
positive regulation of cell proliferation GO:0008284 249 0.020
defense response GO:0006952 194 0.020
Fly
positive regulation of cellular component organization GO:0051130 200 0.020
Human
response to peptide GO:1901652 292 0.020
positive regulation of cellular catabolic process GO:0031331 71 0.019
intracellular signal transduction GO:0035556 314 0.019
Fly
regulation of cell differentiation GO:0045595 320 0.019
cation transport GO:0006812 382 0.019
neuron differentiation GO:0030182 368 0.019
lipid biosynthetic process GO:0008610 128 0.019
regulation of protein kinase activity GO:0045859 105 0.019
purine nucleotide biosynthetic process GO:0006164 83 0.019
negative regulation of cellular component organization GO:0051129 83 0.019
proteolysis involved in cellular protein catabolic process GO:0051603 19 0.019
negative regulation of response to stimulus GO:0048585 155 0.019
Fly
negative regulation of rna biosynthetic process GO:1902679 118 0.018
cell cell signaling GO:0007267 335 0.018
negative regulation of apoptotic process GO:0043066 181 0.018
transmembrane transport GO:0055085 412 0.018
organic substance catabolic process GO:1901575 316 0.018
cellular cation homeostasis GO:0030003 180 0.018
response to inorganic substance GO:0010035 377 0.018
behavior GO:0007610 205 0.018
Fly
cellular response to peptide GO:1901653 133 0.018
chemical homeostasis GO:0048878 292 0.018
response to ethanol GO:0045471 162 0.018
regulation of response to stress GO:0080134 126 0.018
Fly
protein import GO:0017038 37 0.017
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.017
regulation of gtpase activity GO:0043087 57 0.017
ribonucleoside catabolic process GO:0042454 126 0.017
growth GO:0040007 165 0.017
Fly
ribonucleotide biosynthetic process GO:0009260 85 0.017
regulation of catabolic process GO:0009894 113 0.017
cell morphogenesis GO:0000902 142 0.017
organophosphate catabolic process GO:0046434 148 0.017
maintenance of location GO:0051235 17 0.017
purine ribonucleotide catabolic process GO:0009154 136 0.017
regulation of intracellular protein transport GO:0033157 34 0.016
protein targeting GO:0006605 61 0.016
regulation of cellular carbohydrate metabolic process GO:0010675 39 0.016
Fly
protein modification by small protein conjugation GO:0032446 31 0.016
negative regulation of phosphorus metabolic process GO:0010563 80 0.016
regulation of nucleic acid templated transcription GO:1903506 380 0.016
protein o linked glycosylation GO:0006493 2 0.016
positive regulation of triglyceride metabolic process GO:0090208 4 0.016
positive regulation of multicellular organismal process GO:0051240 387 0.016
positive regulation of phosphorylation GO:0042327 177 0.015
tissue development GO:0009888 252 0.015
cell projection organization GO:0030030 302 0.015
positive regulation of catabolic process GO:0009896 78 0.015
sex differentiation GO:0007548 113 0.015
positive regulation of signaling GO:0023056 270 0.015
glycosyl compound metabolic process GO:1901657 182 0.015
glycoprotein metabolic process GO:0009100 24 0.015
lipid transport GO:0006869 61 0.015
protein ubiquitination GO:0016567 28 0.015
ribonucleoside metabolic process GO:0009119 174 0.015
response to hypoxia GO:0001666 231 0.015
regulation of nervous system development GO:0051960 264 0.015
nucleoside triphosphate catabolic process GO:0009143 123 0.015
chromosome segregation GO:0007059 2 0.015
development of primary sexual characteristics GO:0045137 107 0.015
synaptic vesicle localization GO:0097479 24 0.015
hormone metabolic process GO:0042445 69 0.015
regulation of protein phosphorylation GO:0001932 183 0.015
cellular response to lipid GO:0071396 201 0.015
cellular response to growth factor stimulus GO:0071363 162 0.015
cognition GO:0050890 92 0.014
regulation of body fluid levels GO:0050878 90 0.014
single organism membrane organization GO:0044802 74 0.014
negative regulation of protein transport GO:0051224 17 0.014
ion homeostasis GO:0050801 212 0.014
lymphocyte chemotaxis GO:0048247 3 0.014
positive regulation of protein modification process GO:0031401 142 0.014
regulation of cell motility GO:2000145 131 0.014
regulation of rab protein signal transduction GO:0032483 3 0.014
neuron development GO:0048666 286 0.014
hormone biosynthetic process GO:0042446 25 0.014
regulation of cellular amino acid metabolic process GO:0006521 2 0.014
negative regulation of signaling GO:0023057 157 0.014
Fly
cellular response to hormone stimulus GO:0032870 247 0.014
negative regulation of multicellular organismal process GO:0051241 203 0.014
regulation of membrane potential GO:0042391 110 0.014
lipid localization GO:0010876 62 0.014
cellular amine metabolic process GO:0044106 38 0.013
enzyme linked receptor protein signaling pathway GO:0007167 116 0.013
regulation of hormone levels GO:0010817 187 0.013
regulation of hydrolase activity GO:0051336 143 0.013
regulation of purine nucleotide metabolic process GO:1900542 115 0.013
negative regulation of rna metabolic process GO:0051253 123 0.013
eye morphogenesis GO:0048592 4 0.013
negative regulation of protein modification process GO:0031400 52 0.013
regulation of gtp catabolic process GO:0033124 58 0.013
transmission of nerve impulse GO:0019226 42 0.013
regulation of apoptotic process GO:0042981 335 0.013
secretion by tissue GO:0032941 37 0.013
cellular nitrogen compound catabolic process GO:0044270 163 0.013
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.013
organ morphogenesis GO:0009887 75 0.013
cellular lipid metabolic process GO:0044255 208 0.013
single organism nuclear import GO:1902593 35 0.013
cellular response to molecule of bacterial origin GO:0071219 56 0.013
female gonad development GO:0008585 53 0.013
protein glycosylation GO:0006486 14 0.013
cellular response to oxygen levels GO:0071453 60 0.013
positive regulation of phosphate metabolic process GO:0045937 262 0.013
actin filament based process GO:0030029 86 0.012
reproductive structure development GO:0048608 128 0.012
alpha amino acid metabolic process GO:1901605 71 0.012
mitotic cell cycle GO:0000278 49 0.012
generation of precursor metabolites and energy GO:0006091 62 0.012
divalent inorganic cation transport GO:0072511 134 0.012
centrosome organization GO:0051297 1 0.012
regulation of proteolysis GO:0030162 66 0.012
purine nucleoside triphosphate catabolic process GO:0009146 122 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.012
multicellular organismal reproductive process GO:0048609 233 0.012
Fly
regulation of nucleoside metabolic process GO:0009118 66 0.012
negative regulation of developmental process GO:0051093 125 0.012
lipid storage GO:0019915 1 0.012
neuronal action potential GO:0019228 35 0.012
positive regulation of cellular protein metabolic process GO:0032270 167 0.012
regulation of lymphocyte chemotaxis GO:1901623 1 0.012
anatomical structure morphogenesis GO:0009653 298 0.012
response to tumor necrosis factor GO:0034612 56 0.012
cellular response to abiotic stimulus GO:0071214 85 0.012
cellular response to extracellular stimulus GO:0031668 73 0.012
negative regulation of catalytic activity GO:0043086 103 0.012
metal ion homeostasis GO:0055065 186 0.012
action potential GO:0001508 54 0.012
negative regulation of canonical wnt signaling pathway GO:0090090 4 0.012
circadian regulation of gene expression GO:0032922 3 0.012
reproductive process GO:0022414 372 0.012
Fly
cellular metal ion homeostasis GO:0006875 172 0.012
synapse organization GO:0050808 46 0.012
wnt signaling pathway GO:0016055 17 0.012
vesicle localization GO:0051648 33 0.011
protein autophosphorylation GO:0046777 66 0.011
mitotic spindle organization GO:0007052 2 0.011
response to estrogen GO:0043627 232 0.011
negative regulation of molecular function GO:0044092 133 0.011
positive regulation of signal transduction GO:0009967 175 0.011
positive regulation of immune system process GO:0002684 90 0.011
Fly
regulation of nucleotide catabolic process GO:0030811 65 0.011
positive regulation of retinal cell programmed cell death GO:0046670 1 0.011
protein localization to nucleus GO:0034504 39 0.011
male gamete generation GO:0048232 99 0.011
negative regulation of programmed cell death GO:0043069 183 0.011
positive regulation of cytoplasmic transport GO:1903651 32 0.011
positive regulation of catalytic activity GO:0043085 184 0.011
rna localization GO:0006403 4 0.011
response to cytokine GO:0034097 215 0.011
coenzyme metabolic process GO:0006732 86 0.011
cell activation GO:0001775 97 0.011
establishment of protein localization to organelle GO:0072594 44 0.011
negative regulation of intracellular signal transduction GO:1902532 38 0.011
Fly
positive regulation of homeostatic process GO:0032846 49 0.011
purine ribonucleotide biosynthetic process GO:0009152 81 0.011
negative regulation of signal transduction GO:0009968 83 0.011
Fly
learning or memory GO:0007611 90 0.011
acylglycerol metabolic process GO:0006639 21 0.011
purine containing compound biosynthetic process GO:0072522 85 0.011
protein maturation GO:0051604 68 0.011
sex determination GO:0007530 2 0.010
negative regulation of secretion GO:0051048 82 0.010
regulation of cytoplasmic transport GO:1903649 54 0.010
heterocycle catabolic process GO:0046700 167 0.010
regulation of neurogenesis GO:0050767 247 0.010
pyruvate metabolic process GO:0006090 27 0.010
negative regulation of actin filament polymerization GO:0030837 4 0.010
regulation of alternative mrna splicing via spliceosome GO:0000381 2 0.010
sequestering of metal ion GO:0051238 9 0.010
positive regulation of transcription factor import into nucleus GO:0042993 4 0.010
response to activity GO:0014823 73 0.010
female pregnancy GO:0007565 122 0.010
nuclear import GO:0051170 35 0.010
regulation of programmed cell death GO:0043067 341 0.010
nucleotide catabolic process GO:0009166 139 0.010

Ide disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.027
disease of cellular proliferation DOID:14566 0 0.027
disease of anatomical entity DOID:7 0 0.024
nervous system disease DOID:863 0 0.024
organ system cancer DOID:0050686 0 0.015
myopathy DOID:423 0 0.014
muscular disease DOID:0080000 0 0.014
musculoskeletal system disease DOID:17 0 0.014
muscle tissue disease DOID:66 0 0.014
disease of metabolism DOID:0014667 0 0.012
central nervous system disease DOID:331 0 0.011