Rattus norvegicus

32 known processes

Pdk1

pyruvate dehydrogenase kinase, isozyme 1

(Aliases: MGC108625)

Pdk1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
single organism biosynthetic process GO:0044711 342 0.104
Mouse
organic acid metabolic process GO:0006082 292 0.097
Mouse
oxoacid metabolic process GO:0043436 290 0.097
Mouse
response to oxygen levels GO:0070482 265 0.096
Human
response to nutrient levels GO:0031667 370 0.095
catabolic process GO:0009056 351 0.088
oxidation reduction process GO:0055114 304 0.081
carbohydrate catabolic process GO:0016052 40 0.079
response to hypoxia GO:0001666 231 0.078
Human
carboxylic acid metabolic process GO:0019752 289 0.070
Mouse
carbohydrate metabolic process GO:0005975 130 0.067
Human
single organism catabolic process GO:0044712 283 0.066
single organism carbohydrate metabolic process GO:0044723 118 0.061
Human
coenzyme metabolic process GO:0006732 86 0.061
Mouse
organophosphate metabolic process GO:0019637 370 0.060
response to nutrient GO:0007584 248 0.058
response to decreased oxygen levels GO:0036293 237 0.056
Human
regulation of cellular component organization GO:0051128 368 0.055
programmed cell death GO:0012501 392 0.054
Human
regulation of apoptotic process GO:0042981 335 0.052
organelle organization GO:0006996 266 0.050
response to ketone GO:1901654 182 0.050
reproductive process GO:0022414 372 0.049
regulation of programmed cell death GO:0043067 341 0.048
central nervous system development GO:0007417 311 0.046
single organism carbohydrate catabolic process GO:0044724 40 0.046
lipid metabolic process GO:0006629 283 0.046
Mouse
negative regulation of metabolic process GO:0009892 331 0.044
cellular catabolic process GO:0044248 295 0.044
cellular response to stress GO:0033554 269 0.043
Human
reproduction GO:0000003 245 0.042
positive regulation of cellular component organization GO:0051130 200 0.041
negative regulation of cellular metabolic process GO:0031324 281 0.041
regulation of multicellular organismal development GO:2000026 376 0.040
neuron development GO:0048666 286 0.040
single organism reproductive process GO:0044702 297 0.039
response to glucocorticoid GO:0051384 223 0.039
response to extracellular stimulus GO:0009991 380 0.039
intracellular transport GO:0046907 185 0.037
cellular amino acid metabolic process GO:0006520 107 0.036
multicellular organism reproduction GO:0032504 233 0.034
organophosphate biosynthetic process GO:0090407 143 0.034
cellular response to oxygen containing compound GO:1901701 386 0.033
single organism organelle organization GO:1902589 180 0.033
secretion GO:0046903 307 0.033
positive regulation of biosynthetic process GO:0009891 319 0.032
apoptotic process GO:0006915 381 0.032
Human
brain development GO:0007420 247 0.032
positive regulation of multicellular organismal process GO:0051240 387 0.032
cellular ketone metabolic process GO:0042180 51 0.032
Mouse
response to corticosteroid GO:0031960 235 0.031
multi organism reproductive process GO:0044703 262 0.031
response to acid chemical GO:0001101 222 0.030
carbohydrate derivative metabolic process GO:1901135 346 0.029
response to lipopolysaccharide GO:0032496 191 0.029
multicellular organismal reproductive process GO:0048609 233 0.029
regulation of cellular localization GO:0060341 263 0.028
response to other organism GO:0051707 220 0.028
head development GO:0060322 247 0.028
regulation of cell differentiation GO:0045595 320 0.028
neuron differentiation GO:0030182 368 0.027
neuron death GO:0070997 127 0.027
cellular response to external stimulus GO:0071496 118 0.027
regulation of cell proliferation GO:0042127 359 0.026
positive regulation of developmental process GO:0051094 283 0.026
cellular response to oxidative stress GO:0034599 76 0.026
Human
cell type specific apoptotic process GO:0097285 134 0.026
nucleobase containing small molecule metabolic process GO:0055086 316 0.026
macromolecule localization GO:0033036 252 0.026
cell cell signaling GO:0007267 335 0.026
response to carbohydrate GO:0009743 183 0.026
negative regulation of macromolecule metabolic process GO:0010605 260 0.025
tissue development GO:0009888 252 0.025
response to biotic stimulus GO:0009607 226 0.025
positive regulation of cellular biosynthetic process GO:0031328 295 0.025
rna biosynthetic process GO:0032774 380 0.024
response to bacterium GO:0009617 200 0.024
organic substance catabolic process GO:1901575 316 0.024
cellular amine metabolic process GO:0044106 38 0.024
anatomical structure morphogenesis GO:0009653 298 0.024
transcription dna templated GO:0006351 377 0.024
neuron apoptotic process GO:0051402 88 0.024
regulation of nervous system development GO:0051960 264 0.024
secretion by cell GO:0032940 248 0.024
response to insulin GO:0032868 133 0.024
chemical homeostasis GO:0048878 292 0.024
monocarboxylic acid metabolic process GO:0032787 152 0.024
Mouse
protein phosphorylation GO:0006468 345 0.023
regeneration GO:0031099 163 0.023
cellular chemical homeostasis GO:0055082 247 0.023
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.023
response to peptide hormone GO:0043434 278 0.022
regulation of neuron differentiation GO:0045664 208 0.022
negative regulation of cell death GO:0060548 229 0.022
positive regulation of neuron projection development GO:0010976 99 0.022
synaptic transmission GO:0007268 235 0.022
nucleic acid templated transcription GO:0097659 379 0.022
cytoplasmic transport GO:0016482 115 0.022
positive regulation of neuron differentiation GO:0045666 126 0.022
response to wounding GO:0009611 254 0.022
amine metabolic process GO:0009308 38 0.022
regulation of response to stress GO:0080134 126 0.022
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.022
positive regulation of transport GO:0051050 245 0.022
negative regulation of programmed cell death GO:0043069 183 0.022
lipid biosynthetic process GO:0008610 128 0.021
positive regulation of cell death GO:0010942 184 0.021
response to inorganic substance GO:0010035 377 0.021
positive regulation of cell projection organization GO:0031346 111 0.021
regulation of system process GO:0044057 208 0.021
single organism intracellular transport GO:1902582 166 0.021
neuron projection development GO:0031175 273 0.021
positive regulation of nervous system development GO:0051962 178 0.021
response to ethanol GO:0045471 162 0.021
single organism cellular localization GO:1902580 102 0.021
cellular carbohydrate metabolic process GO:0044262 72 0.020
Human
regulation of neurogenesis GO:0050767 247 0.020
cytosolic calcium ion homeostasis GO:0051480 140 0.020
regulation of nucleic acid templated transcription GO:1903506 380 0.020
negative regulation of signaling GO:0023057 157 0.020
regulation of secretion GO:0051046 224 0.020
regulation of transcription dna templated GO:0006355 374 0.020
gamete generation GO:0007276 124 0.020
negative regulation of response to stimulus GO:0048585 155 0.020
positive regulation of cell proliferation GO:0008284 249 0.020
developmental process involved in reproduction GO:0003006 159 0.020
rna metabolic process GO:0016070 406 0.019
regulation of rna biosynthetic process GO:2001141 381 0.019
behavior GO:0007610 205 0.019
sexual reproduction GO:0019953 148 0.019
ion homeostasis GO:0050801 212 0.019
cellular component assembly GO:0022607 360 0.019
nucleoside phosphate metabolic process GO:0006753 283 0.019
phospholipid metabolic process GO:0006644 61 0.019
regulation of cell development GO:0060284 263 0.019
response to estrogen GO:0043627 232 0.019
homeostatic process GO:0042592 331 0.019
ribose phosphate metabolic process GO:0019693 235 0.019
regulation of rna metabolic process GO:0051252 391 0.019
cellular cation homeostasis GO:0030003 180 0.019
aging GO:0007568 241 0.018
regulation of cell projection organization GO:0031344 175 0.018
positive regulation of neurogenesis GO:0050769 165 0.018
maintenance of location GO:0051235 17 0.018
response to molecule of bacterial origin GO:0002237 194 0.018
response to mechanical stimulus GO:0009612 134 0.018
regulation of neuron projection development GO:0010975 161 0.018
regulation of molecular function GO:0065009 398 0.018
neurological system process GO:0050877 219 0.018
regulation of catabolic process GO:0009894 113 0.018
small molecule catabolic process GO:0044282 59 0.018
cellular component biogenesis GO:0044085 368 0.018
intracellular signal transduction GO:0035556 314 0.018
Human
regulation of metal ion transport GO:0010959 118 0.018
calcium ion homeostasis GO:0055074 162 0.018
cell projection organization GO:0030030 302 0.018
regulation of cellular ketone metabolic process GO:0010565 27 0.017
Mouse
positive regulation of cell differentiation GO:0045597 217 0.017
cellular response to hypoxia GO:0071456 51 0.017
Human
response to metal ion GO:0010038 253 0.017
cellular homeostasis GO:0019725 252 0.017
cellular divalent inorganic cation homeostasis GO:0072503 162 0.017
cellular ion homeostasis GO:0006873 184 0.017
positive regulation of cellular amine metabolic process GO:0033240 3 0.017
positive regulation of cell development GO:0010720 176 0.017
single organism behavior GO:0044708 130 0.017
purine ribonucleotide metabolic process GO:0009150 227 0.017
response to estradiol GO:0032355 164 0.017
negative regulation of apoptotic process GO:0043066 181 0.017
regulation of cell motility GO:2000145 131 0.017
circulatory system process GO:0003013 183 0.016
response to hexose GO:0009746 144 0.016
cellular calcium ion homeostasis GO:0006874 160 0.016
protein complex assembly GO:0006461 263 0.016
positive regulation of ion transport GO:0043270 94 0.016
generation of precursor metabolites and energy GO:0006091 62 0.016
molting cycle process GO:0022404 2 0.016
hexose metabolic process GO:0019318 58 0.016
Human
metal ion homeostasis GO:0055065 186 0.016
macromolecular complex assembly GO:0065003 273 0.016
protein localization to organelle GO:0033365 57 0.016
cellular response to hormone stimulus GO:0032870 247 0.016
vesicle mediated transport GO:0016192 181 0.016
blood circulation GO:0008015 183 0.016
protein complex subunit organization GO:0071822 302 0.016
protein transport GO:0015031 132 0.016
negative regulation of gene expression GO:0010629 199 0.016
negative regulation of transport GO:0051051 136 0.016
establishment of protein localization GO:0045184 141 0.015
response to glucose GO:0009749 136 0.015
cellular response to oxygen levels GO:0071453 60 0.015
Human
protein complex biogenesis GO:0070271 263 0.015
regulation of cellular catabolic process GO:0031329 101 0.015
cation transport GO:0006812 382 0.015
localization of cell GO:0051674 202 0.015
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.015
membrane organization GO:0061024 94 0.015
monosaccharide metabolic process GO:0005996 61 0.015
Human
negative regulation of multicellular organismal process GO:0051241 203 0.015
cellular metal ion homeostasis GO:0006875 172 0.015
cellular component movement GO:0006928 248 0.015
ribose phosphate biosynthetic process GO:0046390 87 0.015
heart morphogenesis GO:0003007 3 0.015
negative regulation of rna metabolic process GO:0051253 123 0.015
negative regulation of cell proliferation GO:0008285 119 0.015
cellular protein localization GO:0034613 122 0.014
response to peptide GO:1901652 292 0.014
sequestering of calcium ion GO:0051208 8 0.014
divalent inorganic cation homeostasis GO:0072507 165 0.014
response to oxidative stress GO:0006979 186 0.014
Human
regulation of cellular amino acid metabolic process GO:0006521 2 0.014
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.014
response to external biotic stimulus GO:0043207 221 0.014
regulation of growth GO:0040008 105 0.014
cation homeostasis GO:0055080 195 0.014
regulation of immune system process GO:0002682 123 0.014
cellular response to lipid GO:0071396 201 0.014
transcription from rna polymerase ii promoter GO:0006366 252 0.014
negative regulation of cellular biosynthetic process GO:0031327 161 0.014
regulation of phosphorus metabolic process GO:0051174 349 0.014
Mouse
cellular macromolecule localization GO:0070727 122 0.014
nucleotide metabolic process GO:0009117 279 0.014
carbohydrate derivative biosynthetic process GO:1901137 124 0.013
positive regulation of rna metabolic process GO:0051254 203 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.013
negative regulation of molecular function GO:0044092 133 0.013
purine nucleotide metabolic process GO:0006163 229 0.013
cellular response to organonitrogen compound GO:0071417 197 0.013
ion transmembrane transport GO:0034220 365 0.013
smooth muscle cell migration GO:0014909 36 0.013
regulation of catalytic activity GO:0050790 304 0.013
protein processing GO:0016485 68 0.013
male gamete generation GO:0048232 99 0.013
sequestering of metal ion GO:0051238 9 0.013
glycosyl compound metabolic process GO:1901657 182 0.013
organ regeneration GO:0031100 101 0.013
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.013
chromosome segregation GO:0007059 2 0.013
alpha amino acid metabolic process GO:1901605 71 0.013
response to camp GO:0051591 91 0.013
growth GO:0040007 165 0.013
small gtpase mediated signal transduction GO:0007264 36 0.012
alcohol metabolic process GO:0006066 77 0.012
fatty acid metabolic process GO:0006631 99 0.012
Mouse
regulation of secretion by cell GO:1903530 208 0.012
carbohydrate biosynthetic process GO:0016051 42 0.012
cellular response to nitrogen compound GO:1901699 210 0.012
response to vitamin GO:0033273 131 0.012
response to toxic substance GO:0009636 133 0.012
positive regulation of cell communication GO:0010647 271 0.012
response to transition metal nanoparticle GO:1990267 122 0.012
regulation of synaptic transmission GO:0050804 141 0.012
regulation of neuron death GO:1901214 115 0.012
intracellular protein transport GO:0006886 79 0.012
response to purine containing compound GO:0014074 126 0.012
negative regulation of transcription dna templated GO:0045892 116 0.012
carbohydrate derivative catabolic process GO:1901136 147 0.012
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.012
positive regulation of phosphorylation GO:0042327 177 0.012
protein localization GO:0008104 191 0.012
regulation of phosphate metabolic process GO:0019220 349 0.012
response to temperature stimulus GO:0009266 94 0.012
ras protein signal transduction GO:0007265 29 0.011
macromolecular complex subunit organization GO:0043933 339 0.011
positive regulation of phosphorus metabolic process GO:0010562 262 0.011
regulation of cellular amine metabolic process GO:0033238 8 0.011
cellular response to endogenous stimulus GO:0071495 377 0.011
cell motility GO:0048870 202 0.011
regulation of organelle organization GO:0033043 80 0.011
regulation of cell migration GO:0030334 128 0.011
cellular response to growth factor stimulus GO:0071363 162 0.011
regulation of lipid metabolic process GO:0019216 68 0.011
Mouse
fatty acid beta oxidation GO:0006635 22 0.011
potassium ion transport GO:0006813 97 0.011
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.011
response to cytokine GO:0034097 215 0.011
regulation of muscle system process GO:0090257 79 0.011
negative regulation of cell communication GO:0010648 158 0.011
positive regulation of rna biosynthetic process GO:1902680 197 0.011
regulation of protein metabolic process GO:0051246 289 0.011
regulation of signal transduction GO:0009966 318 0.011
purine nucleoside metabolic process GO:0042278 169 0.011
nitrogen compound transport GO:0071705 229 0.011
regulation of ion transport GO:0043269 245 0.011
protein oligomerization GO:0051259 191 0.011
response to hydrogen peroxide GO:0042542 89 0.011
immune system process GO:0002376 204 0.011
response to reactive oxygen species GO:0000302 120 0.011
carboxylic acid biosynthetic process GO:0046394 83 0.011
positive regulation of gene expression GO:0010628 244 0.011
regulation of cell growth GO:0001558 85 0.011
peptidyl amino acid modification GO:0018193 126 0.011
transmembrane transport GO:0055085 412 0.010
cellular modified amino acid metabolic process GO:0006575 61 0.010
learning or memory GO:0007611 90 0.010
response to organophosphorus GO:0046683 102 0.010
purine containing compound metabolic process GO:0072521 253 0.010
purine nucleoside monophosphate metabolic process GO:0009126 84 0.010
positive regulation of signaling GO:0023056 270 0.010
g protein coupled receptor signaling pathway GO:0007186 242 0.010
glycerolipid metabolic process GO:0046486 67 0.010
regulation of anatomical structure size GO:0090066 135 0.010
regulation of intracellular signal transduction GO:1902531 218 0.010
positive regulation of apoptotic process GO:0043065 154 0.010
positive regulation of protein metabolic process GO:0051247 178 0.010
nucleobase containing compound catabolic process GO:0034655 152 0.010
actin filament based process GO:0030029 86 0.010

Pdk1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.014
disease of anatomical entity DOID:7 0 0.013
nervous system disease DOID:863 0 0.013