Rattus norvegicus

0 known processes

Itch

itchy E3 ubiquitin protein ligase homolog (mouse)

Itch biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
organic acid metabolic process GO:0006082 292 0.075
oxoacid metabolic process GO:0043436 290 0.065
cellular amino acid metabolic process GO:0006520 107 0.056
carboxylic acid metabolic process GO:0019752 289 0.056
carbohydrate derivative metabolic process GO:1901135 346 0.051
organophosphate metabolic process GO:0019637 370 0.043
nucleobase containing small molecule metabolic process GO:0055086 316 0.041
glycosyl compound metabolic process GO:1901657 182 0.040
cellular component assembly GO:0022607 360 0.040
organic substance catabolic process GO:1901575 316 0.038
Rat
lipid metabolic process GO:0006629 283 0.038
ribonucleoside metabolic process GO:0009119 174 0.038
catabolic process GO:0009056 351 0.038
Rat
purine nucleoside metabolic process GO:0042278 169 0.038
purine containing compound metabolic process GO:0072521 253 0.037
regulation of rna biosynthetic process GO:2001141 381 0.034
intracellular signal transduction GO:0035556 314 0.033
nucleoside metabolic process GO:0009116 179 0.033
nucleic acid templated transcription GO:0097659 379 0.032
rna metabolic process GO:0016070 406 0.032
rna biosynthetic process GO:0032774 380 0.032
cellular ketone metabolic process GO:0042180 51 0.031
regulation of cellular amino acid metabolic process GO:0006521 2 0.031
regulation of phosphate metabolic process GO:0019220 349 0.031
secretion GO:0046903 307 0.031
central nervous system development GO:0007417 311 0.031
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.031
nucleotide metabolic process GO:0009117 279 0.030
regulation of nervous system development GO:0051960 264 0.030
Rat
regulation of multicellular organismal development GO:2000026 376 0.030
Rat
regulation of cellular ketone metabolic process GO:0010565 27 0.030
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.030
amine metabolic process GO:0009308 38 0.030
neuron development GO:0048666 286 0.029
Rat
ribonucleotide metabolic process GO:0009259 231 0.029
cellular catabolic process GO:0044248 295 0.029
regulation of rna metabolic process GO:0051252 391 0.029
vesicle mediated transport GO:0016192 181 0.029
Rat Fly
regulation of phosphorus metabolic process GO:0051174 349 0.028
regulation of transcription dna templated GO:0006355 374 0.028
regulation of cellular amine metabolic process GO:0033238 8 0.028
regulation of molecular function GO:0065009 398 0.027
Rat
regulation of nucleic acid templated transcription GO:1903506 380 0.027
cellular amine metabolic process GO:0044106 38 0.027
reproductive process GO:0022414 372 0.027
nucleoside phosphate metabolic process GO:0006753 283 0.027
coenzyme metabolic process GO:0006732 86 0.026
purine nucleotide metabolic process GO:0006163 229 0.026
cellular lipid metabolic process GO:0044255 208 0.026
protein phosphorylation GO:0006468 345 0.025
cellular component biogenesis GO:0044085 368 0.025
regulation of neuron projection development GO:0010975 161 0.025
Rat
regulation of catalytic activity GO:0050790 304 0.025
ribose phosphate metabolic process GO:0019693 235 0.025
single organism catabolic process GO:0044712 283 0.025
positive regulation of biosynthetic process GO:0009891 319 0.024
purine ribonucleotide metabolic process GO:0009150 227 0.024
regulation of phosphorylation GO:0042325 248 0.024
transcription dna templated GO:0006351 377 0.024
response to inorganic substance GO:0010035 377 0.024
regulation of cell projection organization GO:0031344 175 0.024
Rat
multicellular organism reproduction GO:0032504 233 0.024
neuron differentiation GO:0030182 368 0.023
Rat
cell projection organization GO:0030030 302 0.023
Rat
regulation of cellular component organization GO:0051128 368 0.023
Rat
positive regulation of phosphorus metabolic process GO:0010562 262 0.023
macromolecular complex subunit organization GO:0043933 339 0.023
regulation of apoptotic process GO:0042981 335 0.023
cation transport GO:0006812 382 0.022
Rat
negative regulation of metabolic process GO:0009892 331 0.022
regulation of cell differentiation GO:0045595 320 0.022
Rat
sulfur compound metabolic process GO:0006790 70 0.021
homeostatic process GO:0042592 331 0.021
regulation of signal transduction GO:0009966 318 0.021
Fly
single organism biosynthetic process GO:0044711 342 0.021
apoptotic process GO:0006915 381 0.021
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.021
reproduction GO:0000003 245 0.021
regulation of protein metabolic process GO:0051246 289 0.021
Rat
multi organism reproductive process GO:0044703 262 0.021
organic cyclic compound catabolic process GO:1901361 175 0.020
cellular response to endogenous stimulus GO:0071495 377 0.020
positive regulation of cellular biosynthetic process GO:0031328 295 0.020
single organism reproductive process GO:0044702 297 0.020
brain development GO:0007420 247 0.020
regulation of neurogenesis GO:0050767 247 0.020
Rat
multicellular organismal reproductive process GO:0048609 233 0.020
positive regulation of cellular amine metabolic process GO:0033240 3 0.020
response to nutrient levels GO:0031667 370 0.020
purine ribonucleoside metabolic process GO:0046128 168 0.020
response to extracellular stimulus GO:0009991 380 0.019
regulation of programmed cell death GO:0043067 341 0.019
positive regulation of multicellular organismal process GO:0051240 387 0.019
regulation of protein modification process GO:0031399 194 0.019
positive regulation of gene expression GO:0010628 244 0.019
regulation of cell development GO:0060284 263 0.019
Rat
response to growth factor GO:0070848 189 0.019
heterocycle catabolic process GO:0046700 167 0.019
cellular response to oxygen containing compound GO:1901701 386 0.019
regulation of system process GO:0044057 208 0.019
Rat
positive regulation of phosphate metabolic process GO:0045937 262 0.019
cofactor metabolic process GO:0051186 95 0.019
nucleobase containing compound catabolic process GO:0034655 152 0.019
programmed cell death GO:0012501 392 0.019
protein complex assembly GO:0006461 263 0.018
regulation of catabolic process GO:0009894 113 0.018
Rat
organophosphate catabolic process GO:0046434 148 0.018
positive regulation of molecular function GO:0044093 230 0.018
positive regulation of protein phosphorylation GO:0001934 135 0.018
positive regulation of developmental process GO:0051094 283 0.018
locomotion GO:0040011 237 0.018
neuron projection development GO:0031175 273 0.018
Rat
head development GO:0060322 247 0.018
regulation of neuron differentiation GO:0045664 208 0.018
Rat
response to nutrient GO:0007584 248 0.018
ras protein signal transduction GO:0007265 29 0.018
positive regulation of neurogenesis GO:0050769 165 0.018
chemical homeostasis GO:0048878 292 0.018
cellular homeostasis GO:0019725 252 0.018
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.018
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.018
positive regulation of cell differentiation GO:0045597 217 0.018
response to peptide hormone GO:0043434 278 0.018
positive regulation of cell development GO:0010720 176 0.018
cellular response to organic cyclic compound GO:0071407 202 0.018
nucleotide catabolic process GO:0009166 139 0.018
organelle organization GO:0006996 266 0.018
cellular response to hormone stimulus GO:0032870 247 0.018
secretion by cell GO:0032940 248 0.018
cellular nitrogen compound catabolic process GO:0044270 163 0.017
ion transmembrane transport GO:0034220 365 0.017
Rat
response to peptide GO:1901652 292 0.017
transcription from rna polymerase ii promoter GO:0006366 252 0.017
negative regulation of cellular metabolic process GO:0031324 281 0.017
positive regulation of nervous system development GO:0051962 178 0.017
response to acid chemical GO:0001101 222 0.017
small gtpase mediated signal transduction GO:0007264 36 0.017
positive regulation of phosphorylation GO:0042327 177 0.017
oxidation reduction process GO:0055114 304 0.017
negative regulation of macromolecule metabolic process GO:0010605 260 0.017
response to metal ion GO:0010038 253 0.017
purine containing compound catabolic process GO:0072523 138 0.017
macromolecular complex assembly GO:0065003 273 0.017
metal ion transport GO:0030001 289 0.017
Rat
regulation of intracellular signal transduction GO:1902531 218 0.017
positive regulation of signal transduction GO:0009967 175 0.017
immune system process GO:0002376 204 0.017
Rat
aromatic compound catabolic process GO:0019439 168 0.017
cellular chemical homeostasis GO:0055082 247 0.017
single organism intracellular transport GO:1902582 166 0.017
ribonucleoside triphosphate metabolic process GO:0009199 141 0.017
anterior posterior pattern specification GO:0009952 1 0.017
anatomical structure morphogenesis GO:0009653 298 0.017
Rat Fly
purine ribonucleotide catabolic process GO:0009154 136 0.017
carbohydrate derivative catabolic process GO:1901136 147 0.017
neurological system process GO:0050877 219 0.017
purine ribonucleoside catabolic process GO:0046130 124 0.017
alpha amino acid metabolic process GO:1901605 71 0.017
synaptic transmission GO:0007268 235 0.016
response to corticosteroid GO:0031960 235 0.016
ribonucleotide catabolic process GO:0009261 136 0.016
single organism organelle organization GO:1902589 180 0.016
response to wounding GO:0009611 254 0.016
nucleoside phosphate catabolic process GO:1901292 140 0.016
cellular response to stress GO:0033554 269 0.016
positive regulation of rna metabolic process GO:0051254 203 0.016
positive regulation of cellular component organization GO:0051130 200 0.016
Rat
chromosome segregation GO:0007059 2 0.016
response to oxidative stress GO:0006979 186 0.016
ribonucleoside catabolic process GO:0042454 126 0.016
cell migration GO:0016477 197 0.016
purine nucleoside triphosphate metabolic process GO:0009144 141 0.016
regulation of cell proliferation GO:0042127 359 0.016
positive regulation of response to stimulus GO:0048584 285 0.016
protein complex subunit organization GO:0071822 302 0.016
positive regulation of transcription dna templated GO:0045893 197 0.016
positive regulation of protein metabolic process GO:0051247 178 0.016
Rat
regulation of protein phosphorylation GO:0001932 183 0.015
regulation of cellular protein metabolic process GO:0032268 267 0.015
negative regulation of transport GO:0051051 136 0.015
Rat
nucleoside triphosphate metabolic process GO:0009141 144 0.015
cellular component movement GO:0006928 248 0.015
regulation of membrane potential GO:0042391 110 0.015
Rat
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.015
protein complex biogenesis GO:0070271 263 0.015
negative regulation of cellular biosynthetic process GO:0031327 161 0.015
organonitrogen compound catabolic process GO:1901565 179 0.015
positive regulation of cellular protein metabolic process GO:0032270 167 0.015
heart morphogenesis GO:0003007 3 0.015
positive regulation of cell proliferation GO:0008284 249 0.015
transmembrane transport GO:0055085 412 0.015
Rat
cellular response to growth factor stimulus GO:0071363 162 0.015
cellular response to lipid GO:0071396 201 0.015
negative regulation of cell death GO:0060548 229 0.015
cell morphogenesis GO:0000902 142 0.015
Rat
regulation of neuron apoptotic process GO:0043523 83 0.014
positive regulation of neuron projection development GO:0010976 99 0.014
negative regulation of gene expression GO:0010629 199 0.014
response to hypoxia GO:0001666 231 0.014
growth GO:0040007 165 0.014
protein oligomerization GO:0051259 191 0.014
muscle system process GO:0003012 115 0.014
tissue development GO:0009888 252 0.014
response to carbohydrate GO:0009743 183 0.014
positive regulation of cell projection organization GO:0031346 111 0.014
positive regulation of rna biosynthetic process GO:1902680 197 0.014
negative regulation of apoptotic process GO:0043066 181 0.014
cell cell signaling GO:0007267 335 0.014
regulation of kinase activity GO:0043549 117 0.014
positive regulation of cell communication GO:0010647 271 0.014
cellular cation homeostasis GO:0030003 180 0.014
negative regulation of programmed cell death GO:0043069 183 0.014
purine nucleoside catabolic process GO:0006152 124 0.014
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.014
purine nucleoside triphosphate catabolic process GO:0009146 122 0.014
regulation of cellular catabolic process GO:0031329 101 0.014
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.014
metal ion homeostasis GO:0055065 186 0.014
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.014
response to bacterium GO:0009617 200 0.014
axis specification GO:0009798 4 0.014
embryonic pattern specification GO:0009880 1 0.014
response to hexose GO:0009746 144 0.014
regulation of transferase activity GO:0051338 123 0.014
purine nucleotide catabolic process GO:0006195 136 0.014
regulation of purine nucleotide metabolic process GO:1900542 115 0.014
response to external biotic stimulus GO:0043207 221 0.014
cellular response to external stimulus GO:0071496 118 0.013
nucleoside triphosphate catabolic process GO:0009143 123 0.013
leukocyte activation GO:0045321 76 0.013
positive regulation of nucleic acid templated transcription GO:1903508 197 0.013
ion homeostasis GO:0050801 212 0.013
glycosyl compound catabolic process GO:1901658 126 0.013
negative regulation of response to stimulus GO:0048585 155 0.013
Fly
positive regulation of neuron differentiation GO:0045666 126 0.013
positive regulation of signaling GO:0023056 270 0.013
organophosphate biosynthetic process GO:0090407 143 0.013
mapk cascade GO:0000165 140 0.013
protein localization GO:0008104 191 0.013
Fly
defense response GO:0006952 194 0.013
ribonucleoside triphosphate catabolic process GO:0009203 122 0.013
carbohydrate derivative biosynthetic process GO:1901137 124 0.013
organonitrogen compound biosynthetic process GO:1901566 167 0.013
response to glucocorticoid GO:0051384 223 0.013
macromolecule localization GO:0033036 252 0.013
Fly
cellular response to nitrogen compound GO:1901699 210 0.013
maintenance of location GO:0051235 17 0.013
Fly
regulation of hormone levels GO:0010817 187 0.013
lipid storage GO:0019915 1 0.013
Fly
regulation of cellular localization GO:0060341 263 0.013
g protein coupled receptor signaling pathway GO:0007186 242 0.013
nucleoside catabolic process GO:0009164 126 0.013
response to biotic stimulus GO:0009607 226 0.013
intracellular transport GO:0046907 185 0.013
spindle organization GO:0007051 2 0.012
regulation of secretion by cell GO:1903530 208 0.012
reactive nitrogen species metabolic process GO:2001057 1 0.012
sex differentiation GO:0007548 113 0.012
response to ketone GO:1901654 182 0.012
localization of cell GO:0051674 202 0.012
negative regulation of cell communication GO:0010648 158 0.012
Fly
regulation of nucleotide metabolic process GO:0006140 117 0.012
carbohydrate metabolic process GO:0005975 130 0.012
anion transport GO:0006820 178 0.012
response to cytokine GO:0034097 215 0.012
circulatory system process GO:0003013 183 0.012
negative regulation of biosynthetic process GO:0009890 168 0.012
sexual reproduction GO:0019953 148 0.012
response to decreased oxygen levels GO:0036293 237 0.012
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.012
cytoplasmic transport GO:0016482 115 0.012
negative regulation of cellular protein metabolic process GO:0032269 106 0.012
regulation of neuron death GO:1901214 115 0.012
cellular response to organonitrogen compound GO:0071417 197 0.012
response to monosaccharide GO:0034284 159 0.012
positive regulation of transport GO:0051050 245 0.012
Rat
single organism carbohydrate metabolic process GO:0044723 118 0.012
proteolysis GO:0006508 175 0.012
gtp metabolic process GO:0046039 72 0.012
signal transduction by phosphorylation GO:0023014 144 0.012
male gamete generation GO:0048232 99 0.012
inorganic ion transmembrane transport GO:0098660 229 0.012
Rat
cellular ion homeostasis GO:0006873 184 0.012
peptidyl amino acid modification GO:0018193 126 0.012
positive regulation of protein modification process GO:0031401 142 0.012
response to vitamin GO:0033273 131 0.011
negative regulation of innate immune response GO:0045824 4 0.011
response to glucose GO:0009749 136 0.011
aging GO:0007568 241 0.011
cellular calcium ion homeostasis GO:0006874 160 0.011
guanosine containing compound metabolic process GO:1901068 74 0.011
phospholipid metabolic process GO:0006644 61 0.011
response to lipopolysaccharide GO:0032496 191 0.011
response to oxygen levels GO:0070482 265 0.011
protein autophosphorylation GO:0046777 66 0.011
cardiovascular system development GO:0072358 134 0.011
rhythmic process GO:0048511 156 0.011
salivary gland development GO:0007431 3 0.011
response to molecule of bacterial origin GO:0002237 194 0.011
cell morphogenesis involved in differentiation GO:0000904 119 0.011
Rat
cell motility GO:0048870 202 0.011
circulatory system development GO:0072359 134 0.011
negative regulation of molecular function GO:0044092 133 0.011
Rat
gtp catabolic process GO:0006184 71 0.011
glycerolipid metabolic process GO:0046486 67 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.011
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.011
reproductive system development GO:0061458 128 0.011
gamete generation GO:0007276 124 0.011
response to radiation GO:0009314 137 0.011
cell growth GO:0016049 104 0.011
forebrain development GO:0030900 98 0.011
organic hydroxy compound metabolic process GO:1901615 115 0.011
eye morphogenesis GO:0048592 4 0.011
nucleotide biosynthetic process GO:0009165 98 0.011
regeneration GO:0031099 163 0.011
positive regulation of intracellular signal transduction GO:1902533 138 0.011
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.011
divalent metal ion transport GO:0070838 132 0.011
salivary gland morphogenesis GO:0007435 1 0.011
gliogenesis GO:0042063 93 0.011
negative regulation of cell cycle phase transition GO:1901988 4 0.011
hormone secretion GO:0046879 115 0.010
dephosphorylation GO:0016311 98 0.010
sequestering of calcium ion GO:0051208 8 0.010
gonad development GO:0008406 104 0.010
developmental growth GO:0048589 100 0.010
regulation of hydrolase activity GO:0051336 143 0.010
regulation of mapk cascade GO:0043408 116 0.010
reproductive structure development GO:0048608 128 0.010
regulation of cell migration GO:0030334 128 0.010
chemosensory behavior GO:0007635 2 0.010
defense response to gram negative bacterium GO:0050829 3 0.010
cell cycle checkpoint GO:0000075 2 0.010
spermatogenesis GO:0007283 99 0.010
negative regulation of signaling GO:0023057 157 0.010
Fly
regulation of anatomical structure size GO:0090066 135 0.010
female pregnancy GO:0007565 122 0.010
positive regulation of transferase activity GO:0051347 81 0.010
positive regulation of catalytic activity GO:0043085 184 0.010
multicellular organism growth GO:0035264 1 0.010
cellular macromolecule localization GO:0070727 122 0.010
calcium ion homeostasis GO:0055074 162 0.010
monocarboxylic acid metabolic process GO:0032787 152 0.010
dna metabolic process GO:0006259 96 0.010

Itch disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
nervous system disease DOID:863 0 0.026
disease of anatomical entity DOID:7 0 0.026
central nervous system disease DOID:331 0 0.016
musculoskeletal system disease DOID:17 0 0.016
disease of metabolism DOID:0014667 0 0.014
inherited metabolic disorder DOID:655 0 0.012
sensory system disease DOID:0050155 0 0.011
disease of cellular proliferation DOID:14566 0 0.010
organ system cancer DOID:0050686 0 0.010
cancer DOID:162 0 0.010