Rattus norvegicus

103 known processes

Brca2

breast cancer 2

Brca2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of molecular function GO:0065009 398 0.108
negative regulation of metabolic process GO:0009892 331 0.106
reproductive structure development GO:0048608 128 0.078
oxoacid metabolic process GO:0043436 290 0.070
multicellular organism reproduction GO:0032504 233 0.068
single organism reproductive process GO:0044702 297 0.066
gonad development GO:0008406 104 0.058
multi organism reproductive process GO:0044703 262 0.057
regulation of nucleic acid templated transcription GO:1903506 380 0.052
catabolic process GO:0009056 351 0.051
regulation of transcription dna templated GO:0006355 374 0.050
protein complex assembly GO:0006461 263 0.049
organelle organization GO:0006996 266 0.049
negative regulation of developmental process GO:0051093 125 0.048
cellular ketone metabolic process GO:0042180 51 0.048
rna metabolic process GO:0016070 406 0.047
cellular response to stress GO:0033554 269 0.045
organic substance catabolic process GO:1901575 316 0.045
protein complex biogenesis GO:0070271 263 0.044
regulation of cellular component organization GO:0051128 368 0.044
negative regulation of biosynthetic process GO:0009890 168 0.044
response to extracellular stimulus GO:0009991 380 0.044
cellular component biogenesis GO:0044085 368 0.044
programmed cell death GO:0012501 392 0.043
cellular amino acid metabolic process GO:0006520 107 0.042
neuron differentiation GO:0030182 368 0.042
metaphase anaphase transition of cell cycle GO:0044784 1 0.041
cellular catabolic process GO:0044248 295 0.041
regulation of rna metabolic process GO:0051252 391 0.041
carboxylic acid metabolic process GO:0019752 289 0.040
regulation of programmed cell death GO:0043067 341 0.040
regulation of protein metabolic process GO:0051246 289 0.039
single organism catabolic process GO:0044712 283 0.039
organic acid metabolic process GO:0006082 292 0.039
single organism organelle organization GO:1902589 180 0.039
macromolecule localization GO:0033036 252 0.038
cellular component movement GO:0006928 248 0.038
reproductive process GO:0022414 372 0.038
regulation of apoptotic process GO:0042981 335 0.038
apoptotic process GO:0006915 381 0.036
regulation of proteasomal protein catabolic process GO:0061136 4 0.036
development of primary sexual characteristics GO:0045137 107 0.036
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.035
response to nutrient levels GO:0031667 370 0.035
macromolecular complex assembly GO:0065003 273 0.034
cellular response to endogenous stimulus GO:0071495 377 0.034
negative regulation of gene expression GO:0010629 199 0.033
cardiac chamber development GO:0003205 1 0.033
multicellular organismal reproductive process GO:0048609 233 0.032
proteolysis GO:0006508 175 0.032
regulation of organelle organization GO:0033043 80 0.032
regulation of cell cycle GO:0051726 73 0.031
mitotic sister chromatid separation GO:0051306 1 0.031
transcription dna templated GO:0006351 377 0.031
regulation of catalytic activity GO:0050790 304 0.031
regulation of cellular amino acid metabolic process GO:0006521 2 0.031
negative regulation of macromolecule metabolic process GO:0010605 260 0.031
regulation of cellular ketone metabolic process GO:0010565 27 0.031
developmental process involved in reproduction GO:0003006 159 0.030
macromolecular complex subunit organization GO:0043933 339 0.030
biological adhesion GO:0022610 110 0.030
neuron projection development GO:0031175 273 0.030
rna biosynthetic process GO:0032774 380 0.030
transcription from rna polymerase ii promoter GO:0006366 252 0.030
sex differentiation GO:0007548 113 0.028
regulation of cellular amine metabolic process GO:0033238 8 0.028
regulation of multicellular organismal development GO:2000026 376 0.028
protein phosphorylation GO:0006468 345 0.028
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.028
cell projection organization GO:0030030 302 0.028
cell cycle GO:0007049 101 0.027
gamete generation GO:0007276 124 0.027
regulation of rna biosynthetic process GO:2001141 381 0.026
sister chromatid segregation GO:0000819 1 0.026
small gtpase mediated signal transduction GO:0007264 36 0.026
head development GO:0060322 247 0.026
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.025
positive regulation of cellular biosynthetic process GO:0031328 295 0.025
negative regulation of response to stimulus GO:0048585 155 0.025
eye morphogenesis GO:0048592 4 0.025
anatomical structure morphogenesis GO:0009653 298 0.025
amine metabolic process GO:0009308 38 0.025
positive regulation of biosynthetic process GO:0009891 319 0.025
organonitrogen compound catabolic process GO:1901565 179 0.024
positive regulation of multicellular organismal process GO:0051240 387 0.024
nucleic acid templated transcription GO:0097659 379 0.024
negative regulation of cell cycle phase transition GO:1901988 4 0.024
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.024
cellular amine metabolic process GO:0044106 38 0.024
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.024
cell fate determination GO:0001709 2 0.024
neuron development GO:0048666 286 0.024
regulation of mitotic sister chromatid separation GO:0010965 1 0.024
cellular response to organic cyclic compound GO:0071407 202 0.023
female sex differentiation GO:0046660 59 0.023
heart morphogenesis GO:0003007 3 0.023
brain development GO:0007420 247 0.023
regulation of cell differentiation GO:0045595 320 0.023
negative regulation of programmed cell death GO:0043069 183 0.023
central nervous system development GO:0007417 311 0.023
cardiac ventricle development GO:0003231 1 0.022
organophosphate metabolic process GO:0019637 370 0.022
gland development GO:0048732 155 0.022
sexual reproduction GO:0019953 148 0.022
cell motility GO:0048870 202 0.022
response to estradiol GO:0032355 164 0.022
positive regulation of cell death GO:0010942 184 0.022
cellular component assembly GO:0022607 360 0.022
regulation of cellular protein metabolic process GO:0032268 267 0.022
cellular response to oxygen containing compound GO:1901701 386 0.021
neuron fate commitment GO:0048663 4 0.021
reproductive system development GO:0061458 128 0.021
regulation of neurogenesis GO:0050767 247 0.021
regulation of cell development GO:0060284 263 0.021
response to vitamin GO:0033273 131 0.021
regulation of phosphorylation GO:0042325 248 0.021
cellular modified amino acid metabolic process GO:0006575 61 0.021
regulation of phosphorus metabolic process GO:0051174 349 0.021
negative regulation of cellular biosynthetic process GO:0031327 161 0.021
negative regulation of cell communication GO:0010648 158 0.021
reproduction GO:0000003 245 0.021
regulation of catabolic process GO:0009894 113 0.020
defense response GO:0006952 194 0.020
positive regulation of cellular amine metabolic process GO:0033240 3 0.020
response to temperature stimulus GO:0009266 94 0.020
negative regulation of cellular metabolic process GO:0031324 281 0.020
regulation of chromosome segregation GO:0051983 1 0.020
cellular protein localization GO:0034613 122 0.020
negative regulation of cell death GO:0060548 229 0.020
response to oxygen levels GO:0070482 265 0.020
response to wounding GO:0009611 254 0.020
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.020
oxidation reduction process GO:0055114 304 0.019
protein oligomerization GO:0051259 191 0.019
protein complex subunit organization GO:0071822 302 0.019
negative regulation of cellular protein metabolic process GO:0032269 106 0.019
peptidyl amino acid modification GO:0018193 126 0.019
regulation of phosphate metabolic process GO:0019220 349 0.019
cell cycle process GO:0022402 57 0.019
positive regulation of cell differentiation GO:0045597 217 0.019
response to growth factor GO:0070848 189 0.019
amide transport GO:0042886 105 0.019
negative regulation of signaling GO:0023057 157 0.019
cellular response to nitrogen compound GO:1901699 210 0.019
mitotic cell cycle GO:0000278 49 0.019
b cell differentiation GO:0030183 2 0.019
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.019
chromosome segregation GO:0007059 2 0.019
regulation of neuron differentiation GO:0045664 208 0.019
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 1 0.018
positive regulation of protein metabolic process GO:0051247 178 0.018
rhythmic process GO:0048511 156 0.018
positive regulation of molecular function GO:0044093 230 0.018
negative regulation of cell development GO:0010721 82 0.018
regulation of protein phosphorylation GO:0001932 183 0.018
response to oxidative stress GO:0006979 186 0.017
negative regulation of protein metabolic process GO:0051248 114 0.017
microtubule organizing center organization GO:0031023 1 0.017
tetrahydrofolate metabolic process GO:0046653 9 0.017
positive regulation of nucleic acid templated transcription GO:1903508 197 0.017
circulatory system development GO:0072359 134 0.017
response to cytokine GO:0034097 215 0.017
chromosome separation GO:0051304 1 0.017
aging GO:0007568 241 0.017
regulation of cell proliferation GO:0042127 359 0.017
development of primary female sexual characteristics GO:0046545 56 0.017
protein transport GO:0015031 132 0.017
negative regulation of apoptotic process GO:0043066 181 0.017
intracellular signal transduction GO:0035556 314 0.017
response to decreased oxygen levels GO:0036293 237 0.017
carbohydrate derivative metabolic process GO:1901135 346 0.017
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.016
response to monosaccharide GO:0034284 159 0.016
regulation of neuron projection development GO:0010975 161 0.016
regulation of sister chromatid segregation GO:0033045 1 0.016
embryonic pattern specification GO:0009880 1 0.016
response to ketone GO:1901654 182 0.016
secretion GO:0046903 307 0.016
cell cycle checkpoint GO:0000075 2 0.016
localization of cell GO:0051674 202 0.016
intracellular transport GO:0046907 185 0.016
locomotion GO:0040011 237 0.016
positive regulation of cell development GO:0010720 176 0.016
regulation of cell morphogenesis GO:0022604 77 0.016
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.016
anterior posterior pattern specification GO:0009952 1 0.016
ras protein signal transduction GO:0007265 29 0.016
response to peptide GO:1901652 292 0.015
dna metabolic process GO:0006259 96 0.015
metaphase anaphase transition of mitotic cell cycle GO:0007091 1 0.015
positive regulation of cell proliferation GO:0008284 249 0.015
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.015
purine containing compound metabolic process GO:0072521 253 0.015
transformation of host cell by virus GO:0019087 4 0.015
liver development GO:0001889 90 0.015
response to hypoxia GO:0001666 231 0.015
regulation of nervous system development GO:0051960 264 0.015
regulation of mitotic sister chromatid segregation GO:0033047 1 0.015
organophosphate catabolic process GO:0046434 148 0.015
negative regulation of cell division GO:0051782 1 0.015
positive regulation of transcription dna templated GO:0045893 197 0.015
positive regulation of rna biosynthetic process GO:1902680 197 0.015
response to glucose GO:0009749 136 0.015
cellular response to cytokine stimulus GO:0071345 127 0.014
cardiovascular system development GO:0072358 134 0.014
response to hexose GO:0009746 144 0.014
regulation of protein modification process GO:0031399 194 0.014
mitotic sister chromatid segregation GO:0000070 1 0.014
single organism biosynthetic process GO:0044711 342 0.014
cellular response to organonitrogen compound GO:0071417 197 0.014
neural crest cell development GO:0014032 2 0.014
cell adhesion GO:0007155 110 0.014
positive regulation of transport GO:0051050 245 0.014
positive regulation of rna metabolic process GO:0051254 203 0.014
cell morphogenesis GO:0000902 142 0.014
mitotic cell cycle process GO:1903047 35 0.014
positive regulation of cellular component organization GO:0051130 200 0.014
centrosome organization GO:0051297 1 0.014
ribonucleotide metabolic process GO:0009259 231 0.014
antral ovarian follicle growth GO:0001547 3 0.014
cellular homeostasis GO:0019725 252 0.014
response to acid chemical GO:0001101 222 0.014
response to nutrient GO:0007584 248 0.014
cytoskeleton dependent cytokinesis GO:0061640 2 0.013
positive regulation of neuron migration GO:2001224 2 0.013
carbohydrate derivative catabolic process GO:1901136 147 0.013
organonitrogen compound biosynthetic process GO:1901566 167 0.013
chromosome organization GO:0051276 36 0.013
response to carbohydrate GO:0009743 183 0.013
axon development GO:0061564 96 0.013
multicellular organism growth GO:0035264 1 0.013
response to other organism GO:0051707 220 0.013
purine nucleotide metabolic process GO:0006163 229 0.013
response to estrogen GO:0043627 232 0.013
aromatic compound catabolic process GO:0019439 168 0.013
negative regulation of nuclear division GO:0051784 1 0.013
regulation of kinase activity GO:0043549 117 0.013
cardiac muscle tissue morphogenesis GO:0055008 1 0.013
negative regulation of rna metabolic process GO:0051253 123 0.013
protein localization GO:0008104 191 0.013
negative regulation of molecular function GO:0044092 133 0.012
organ regeneration GO:0031100 101 0.012
gastrulation GO:0007369 2 0.012
positive regulation of developmental process GO:0051094 283 0.012
ribonucleoside triphosphate metabolic process GO:0009199 141 0.012
positive regulation of gene expression GO:0010628 244 0.012
nucleotide metabolic process GO:0009117 279 0.012
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.012
cell part morphogenesis GO:0032990 123 0.012
regeneration GO:0031099 163 0.012
regulation of membrane potential GO:0042391 110 0.012
chemical homeostasis GO:0048878 292 0.012
embryo development GO:0009790 49 0.012
monocarboxylic acid transport GO:0015718 52 0.012
neural crest cell differentiation GO:0014033 2 0.012
regulation of cellular localization GO:0060341 263 0.012
negative regulation of multicellular organismal process GO:0051241 203 0.012
cellular response to lipid GO:0071396 201 0.012
male gamete generation GO:0048232 99 0.012
purine ribonucleoside metabolic process GO:0046128 168 0.012
response to ethanol GO:0045471 162 0.012
dendrite development GO:0016358 72 0.012
cell migration GO:0016477 197 0.012
meiotic cell cycle process GO:1903046 3 0.012
positive regulation of catalytic activity GO:0043085 184 0.012
purine ribonucleotide metabolic process GO:0009150 227 0.012
purine nucleoside triphosphate catabolic process GO:0009146 122 0.012
axis specification GO:0009798 4 0.012
alpha amino acid metabolic process GO:1901605 71 0.012
response to corticosteroid GO:0031960 235 0.012
positive regulation of phosphorylation GO:0042327 177 0.012
organ morphogenesis GO:0009887 75 0.012
regulation of cell cycle process GO:0010564 31 0.012
response to purine containing compound GO:0014074 126 0.012
cell cycle phase transition GO:0044770 21 0.012
nucleobase containing compound catabolic process GO:0034655 152 0.012
regulation of anatomical structure morphogenesis GO:0022603 141 0.011
ribonucleoside metabolic process GO:0009119 174 0.011
positive regulation of neurogenesis GO:0050769 165 0.011
negative regulation of catalytic activity GO:0043086 103 0.011
protein catabolic process GO:0030163 30 0.011
regulation of signal transduction GO:0009966 318 0.011
spindle organization GO:0007051 2 0.011
single organism intracellular transport GO:1902582 166 0.011
folic acid containing compound metabolic process GO:0006760 10 0.011
intracellular protein transport GO:0006886 79 0.011
regulation of intracellular signal transduction GO:1902531 218 0.011
reactive oxygen species metabolic process GO:0072593 37 0.011
nucleobase containing small molecule metabolic process GO:0055086 316 0.011
mitotic cell cycle phase transition GO:0044772 20 0.011
hepaticobiliary system development GO:0061008 90 0.011
purine nucleoside metabolic process GO:0042278 169 0.011
regulation of reactive oxygen species metabolic process GO:2000377 26 0.011
hexose metabolic process GO:0019318 58 0.011
regulation of ubiquitin protein transferase activity GO:0051438 1 0.011
dna integrity checkpoint GO:0031570 2 0.011
bmp signaling pathway GO:0030509 4 0.011
neuronal action potential GO:0019228 35 0.011
nucleotide catabolic process GO:0009166 139 0.011
cellular response to hormone stimulus GO:0032870 247 0.011
regulation of cytokine biosynthetic process GO:0042035 3 0.011
regulation of mrna splicing via spliceosome GO:0048024 3 0.011
motor neuron axon guidance GO:0008045 1 0.011
response to external biotic stimulus GO:0043207 221 0.011
organic cyclic compound catabolic process GO:1901361 175 0.011
enzyme linked receptor protein signaling pathway GO:0007167 116 0.010
positive regulation of neuron differentiation GO:0045666 126 0.010
response to inorganic substance GO:0010035 377 0.010
nitrogen compound transport GO:0071705 229 0.010
double strand break repair GO:0006302 1 0.010
response to biotic stimulus GO:0009607 226 0.010
nucleoside metabolic process GO:0009116 179 0.010
response to glucocorticoid GO:0051384 223 0.010
action potential GO:0001508 54 0.010
epithelium development GO:0060429 96 0.010
rho protein signal transduction GO:0007266 11 0.010
negative regulation of nervous system development GO:0051961 79 0.010
nucleoside triphosphate metabolic process GO:0009141 144 0.010
negative regulation of neurogenesis GO:0050768 78 0.010
tube development GO:0035295 89 0.010
positive regulation of cellular protein metabolic process GO:0032270 167 0.010
positive regulation of protein phosphorylation GO:0001934 135 0.010
spermatogenesis GO:0007283 99 0.010
purine ribonucleoside catabolic process GO:0046130 124 0.010
peptide transport GO:0015833 97 0.010

Brca2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.014
nervous system disease DOID:863 0 0.014