Rattus norvegicus

0 known processes

Gsdmd

gasdermin D

(Aliases: Gsdmdc1)

Gsdmd biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of cell communication GO:0010647 271 0.095
organic substance catabolic process GO:1901575 316 0.084
intracellular signal transduction GO:0035556 314 0.084
cellular catabolic process GO:0044248 295 0.077
positive regulation of phosphate metabolic process GO:0045937 262 0.075
regulation of signal transduction GO:0009966 318 0.072
negative regulation of metabolic process GO:0009892 331 0.071
catabolic process GO:0009056 351 0.070
nucleobase containing small molecule metabolic process GO:0055086 316 0.067
regulation of cell proliferation GO:0042127 359 0.064
transcription dna templated GO:0006351 377 0.061
positive regulation of response to stimulus GO:0048584 285 0.060
programmed cell death GO:0012501 392 0.055
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.055
regulation of molecular function GO:0065009 398 0.052
regulation of intracellular signal transduction GO:1902531 218 0.051
nucleoside phosphate metabolic process GO:0006753 283 0.050
negative regulation of cellular metabolic process GO:0031324 281 0.050
regulation of phosphate metabolic process GO:0019220 349 0.050
positive regulation of biosynthetic process GO:0009891 319 0.048
response to peptide GO:1901652 292 0.047
defense response GO:0006952 194 0.044
rna biosynthetic process GO:0032774 380 0.044
regulation of programmed cell death GO:0043067 341 0.044
regulation of protein metabolic process GO:0051246 289 0.043
apoptotic process GO:0006915 381 0.043
neuron projection development GO:0031175 273 0.043
transmembrane transport GO:0055085 412 0.042
response to metal ion GO:0010038 253 0.042
aging GO:0007568 241 0.042
mapk cascade GO:0000165 140 0.042
immune system process GO:0002376 204 0.041
protein complex biogenesis GO:0070271 263 0.040
positive regulation of cell proliferation GO:0008284 249 0.040
negative regulation of multicellular organismal process GO:0051241 203 0.039
secretion GO:0046903 307 0.038
glycosyl compound metabolic process GO:1901657 182 0.038
nucleoside metabolic process GO:0009116 179 0.038
regulation of phosphorus metabolic process GO:0051174 349 0.037
regulation of rna biosynthetic process GO:2001141 381 0.037
organophosphate metabolic process GO:0019637 370 0.037
protein complex assembly GO:0006461 263 0.037
regulation of catalytic activity GO:0050790 304 0.036
negative regulation of macromolecule metabolic process GO:0010605 260 0.036
cellular component movement GO:0006928 248 0.036
neuron development GO:0048666 286 0.036
cellular response to stress GO:0033554 269 0.036
ribonucleoside metabolic process GO:0009119 174 0.035
cellular nitrogen compound catabolic process GO:0044270 163 0.035
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.034
regulation of anatomical structure morphogenesis GO:0022603 141 0.034
response to peptide hormone GO:0043434 278 0.033
regulation of apoptotic process GO:0042981 335 0.033
reproductive process GO:0022414 372 0.033
purine nucleoside triphosphate catabolic process GO:0009146 122 0.033
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.033
positive regulation of phosphorus metabolic process GO:0010562 262 0.033
nucleic acid templated transcription GO:0097659 379 0.032
regulation of cellular component organization GO:0051128 368 0.032
positive regulation of catalytic activity GO:0043085 184 0.032
regulation of cellular protein metabolic process GO:0032268 267 0.032
carbohydrate derivative metabolic process GO:1901135 346 0.031
regulation of cell development GO:0060284 263 0.031
ribonucleoside triphosphate metabolic process GO:0009199 141 0.031
response to wounding GO:0009611 254 0.031
chemical homeostasis GO:0048878 292 0.031
carbohydrate derivative catabolic process GO:1901136 147 0.031
positive regulation of multicellular organismal process GO:0051240 387 0.031
homeostatic process GO:0042592 331 0.030
organelle organization GO:0006996 266 0.030
cellular component assembly GO:0022607 360 0.030
protein oligomerization GO:0051259 191 0.030
macromolecule localization GO:0033036 252 0.030
regulation of hydrolase activity GO:0051336 143 0.030
anion transport GO:0006820 178 0.030
response to other organism GO:0051707 220 0.030
positive regulation of signaling GO:0023056 270 0.030
regulation of rna metabolic process GO:0051252 391 0.030
positive regulation of molecular function GO:0044093 230 0.029
ribose phosphate metabolic process GO:0019693 235 0.029
response to nutrient levels GO:0031667 370 0.029
regulation of response to stress GO:0080134 126 0.029
organonitrogen compound catabolic process GO:1901565 179 0.029
single organism catabolic process GO:0044712 283 0.029
positive regulation of cellular component organization GO:0051130 200 0.028
purine nucleotide metabolic process GO:0006163 229 0.028
immunoglobulin mediated immune response GO:0016064 4 0.028
macromolecular complex assembly GO:0065003 273 0.028
tissue development GO:0009888 252 0.028
purine containing compound catabolic process GO:0072523 138 0.028
purine nucleoside catabolic process GO:0006152 124 0.028
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.027
purine containing compound metabolic process GO:0072521 253 0.027
cellular component biogenesis GO:0044085 368 0.027
response to molecule of bacterial origin GO:0002237 194 0.027
regulation of cell differentiation GO:0045595 320 0.027
ribonucleotide metabolic process GO:0009259 231 0.027
proteolysis GO:0006508 175 0.027
aromatic compound catabolic process GO:0019439 168 0.027
positive regulation of transport GO:0051050 245 0.027
blood circulation GO:0008015 183 0.026
rna metabolic process GO:0016070 406 0.026
positive regulation of developmental process GO:0051094 283 0.026
purine ribonucleoside metabolic process GO:0046128 168 0.026
rhythmic process GO:0048511 156 0.026
regulation of phosphorylation GO:0042325 248 0.026
response to hypoxia GO:0001666 231 0.026
ribonucleotide catabolic process GO:0009261 136 0.026
single organism reproductive process GO:0044702 297 0.026
nucleotide catabolic process GO:0009166 139 0.026
organophosphate catabolic process GO:0046434 148 0.026
wound healing GO:0042060 122 0.026
ion transmembrane transport GO:0034220 365 0.026
positive regulation of intracellular signal transduction GO:1902533 138 0.025
regulation of protein phosphorylation GO:0001932 183 0.025
signal transduction by phosphorylation GO:0023014 144 0.025
nucleobase containing compound catabolic process GO:0034655 152 0.025
positive regulation of signal transduction GO:0009967 175 0.025
nucleoside triphosphate metabolic process GO:0009141 144 0.025
regulation of multicellular organismal development GO:2000026 376 0.025
nucleotide metabolic process GO:0009117 279 0.025
transcription from rna polymerase ii promoter GO:0006366 252 0.025
regulation of nucleic acid templated transcription GO:1903506 380 0.025
response to inorganic substance GO:0010035 377 0.024
cell motility GO:0048870 202 0.024
positive regulation of hydrolase activity GO:0051345 86 0.024
response to external biotic stimulus GO:0043207 221 0.024
response to bacterium GO:0009617 200 0.024
nucleoside catabolic process GO:0009164 126 0.024
organic cyclic compound catabolic process GO:1901361 175 0.024
heterocycle catabolic process GO:0046700 167 0.024
macromolecular complex subunit organization GO:0043933 339 0.024
protein complex subunit organization GO:0071822 302 0.024
nucleoside triphosphate catabolic process GO:0009143 123 0.023
regulation of transcription dna templated GO:0006355 374 0.023
response to biotic stimulus GO:0009607 226 0.023
cell projection organization GO:0030030 302 0.023
ras protein signal transduction GO:0007265 29 0.023
purine nucleoside triphosphate metabolic process GO:0009144 141 0.023
small gtpase mediated signal transduction GO:0007264 36 0.023
purine ribonucleoside catabolic process GO:0046130 124 0.022
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.022
anatomical structure morphogenesis GO:0009653 298 0.022
negative regulation of cell communication GO:0010648 158 0.022
purine nucleotide catabolic process GO:0006195 136 0.022
response to decreased oxygen levels GO:0036293 237 0.021
purine ribonucleotide catabolic process GO:0009154 136 0.021
positive regulation of mapk cascade GO:0043410 92 0.021
cell cell signaling GO:0007267 335 0.021
cellular chemical homeostasis GO:0055082 247 0.021
purine ribonucleotide metabolic process GO:0009150 227 0.021
organic acid metabolic process GO:0006082 292 0.021
regulation of mapk cascade GO:0043408 116 0.020
multicellular organism reproduction GO:0032504 233 0.020
positive regulation of nucleic acid templated transcription GO:1903508 197 0.020
glycosyl compound catabolic process GO:1901658 126 0.020
ribonucleoside catabolic process GO:0042454 126 0.020
cell migration GO:0016477 197 0.020
negative regulation of response to stimulus GO:0048585 155 0.020
regulation of kinase activity GO:0043549 117 0.020
circulatory system process GO:0003013 183 0.019
lipid metabolic process GO:0006629 283 0.019
regulation of neuron differentiation GO:0045664 208 0.019
central nervous system development GO:0007417 311 0.019
cellular amine metabolic process GO:0044106 38 0.019
positive regulation of phosphorylation GO:0042327 177 0.019
positive regulation of programmed cell death GO:0043068 157 0.019
positive regulation of protein metabolic process GO:0051247 178 0.019
regulation of secretion GO:0051046 224 0.019
reproduction GO:0000003 245 0.019
cytokine production GO:0001816 61 0.019
purine nucleoside metabolic process GO:0042278 169 0.019
reproductive system development GO:0061458 128 0.018
negative regulation of molecular function GO:0044092 133 0.018
regulation of neurogenesis GO:0050767 247 0.018
immune response GO:0006955 104 0.018
positive regulation of cell differentiation GO:0045597 217 0.018
single organism biosynthetic process GO:0044711 342 0.018
cellular response to nitrogen compound GO:1901699 210 0.018
inflammatory response GO:0006954 150 0.018
nucleoside phosphate catabolic process GO:1901292 140 0.017
positive regulation of cellular biosynthetic process GO:0031328 295 0.017
localization of cell GO:0051674 202 0.017
ovulation cycle GO:0042698 67 0.017
multi organism reproductive process GO:0044703 262 0.017
locomotion GO:0040011 237 0.017
neuron differentiation GO:0030182 368 0.017
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.017
cytoskeleton organization GO:0007010 111 0.017
cellular response to hormone stimulus GO:0032870 247 0.017
cellular metal ion homeostasis GO:0006875 172 0.017
regulation of secretion by cell GO:1903530 208 0.017
negative regulation of biosynthetic process GO:0009890 168 0.017
response to lipopolysaccharide GO:0032496 191 0.017
regulation of ion transport GO:0043269 245 0.017
cellular response to oxygen containing compound GO:1901701 386 0.016
regulation of cell projection organization GO:0031344 175 0.016
dna metabolic process GO:0006259 96 0.016
regulation of cellular localization GO:0060341 263 0.016
nitrogen compound transport GO:0071705 229 0.016
regulation of neuron death GO:1901214 115 0.016
positive regulation of cell development GO:0010720 176 0.016
regulation of neuron projection development GO:0010975 161 0.016
brain development GO:0007420 247 0.016
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.016
positive regulation of apoptotic process GO:0043065 154 0.016
guanosine containing compound metabolic process GO:1901068 74 0.016
protein localization GO:0008104 191 0.016
response to ethanol GO:0045471 162 0.016
response to extracellular stimulus GO:0009991 380 0.016
positive regulation of secretion by cell GO:1903532 128 0.016
positive regulation of secretion GO:0051047 140 0.016
protein heterooligomerization GO:0051291 89 0.016
negative regulation of gene expression GO:0010629 199 0.016
gtp catabolic process GO:0006184 71 0.016
oxoacid metabolic process GO:0043436 290 0.016
negative regulation of programmed cell death GO:0043069 183 0.015
multicellular organismal reproductive process GO:0048609 233 0.015
cellular response to organic cyclic compound GO:0071407 202 0.015
cellular response to abiotic stimulus GO:0071214 85 0.015
regulation of cell activation GO:0050865 50 0.015
ribonucleoside triphosphate catabolic process GO:0009203 122 0.015
regulation of cellular ketone metabolic process GO:0010565 27 0.015
positive regulation of protein modification process GO:0031401 142 0.015
cation homeostasis GO:0055080 195 0.015
response to reactive oxygen species GO:0000302 120 0.015
positive regulation of cell projection organization GO:0031346 111 0.015
sex differentiation GO:0007548 113 0.015
ion homeostasis GO:0050801 212 0.015
secretion by cell GO:0032940 248 0.015
regulation of protein modification process GO:0031399 194 0.015
regulation of cellular catabolic process GO:0031329 101 0.015
negative regulation of transport GO:0051051 136 0.014
developmental process involved in reproduction GO:0003006 159 0.014
calcium ion transport GO:0006816 131 0.014
negative regulation of catalytic activity GO:0043086 103 0.014
response to oxidative stress GO:0006979 186 0.014
cellular ketone metabolic process GO:0042180 51 0.014
positive regulation of cell death GO:0010942 184 0.014
regulation of transferase activity GO:0051338 123 0.014
cellular homeostasis GO:0019725 252 0.014
head development GO:0060322 247 0.014
response to acid chemical GO:0001101 222 0.014
metal ion transport GO:0030001 289 0.014
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.014
cellular component morphogenesis GO:0032989 155 0.014
amine metabolic process GO:0009308 38 0.014
cellular response to endogenous stimulus GO:0071495 377 0.014
positive regulation of cellular protein metabolic process GO:0032270 167 0.014
carboxylic acid metabolic process GO:0019752 289 0.014
embryonic pattern specification GO:0009880 1 0.014
protein phosphorylation GO:0006468 345 0.014
mitotic sister chromatid segregation GO:0000070 1 0.013
positive regulation of rna metabolic process GO:0051254 203 0.013
negative regulation of cellular biosynthetic process GO:0031327 161 0.013
regulation of blood pressure GO:0008217 83 0.013
response to estrogen GO:0043627 232 0.013
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.013
chromosome segregation GO:0007059 2 0.013
regulation of defense response GO:0031347 68 0.013
cellular cation homeostasis GO:0030003 180 0.013
positive regulation of cellular amine metabolic process GO:0033240 3 0.013
neuron death GO:0070997 127 0.013
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.013
single organism organelle organization GO:1902589 180 0.013
g protein coupled receptor signaling pathway GO:0007186 242 0.013
response to radiation GO:0009314 137 0.013
regulation of cellular amine metabolic process GO:0033238 8 0.013
negative regulation of signaling GO:0023057 157 0.012
negative regulation of innate immune response GO:0045824 4 0.012
organonitrogen compound biosynthetic process GO:1901566 167 0.012
positive regulation of nucleotide metabolic process GO:0045981 91 0.012
response to transition metal nanoparticle GO:1990267 122 0.012
positive regulation of neurogenesis GO:0050769 165 0.012
cellular response to organonitrogen compound GO:0071417 197 0.012
regulation of nervous system development GO:0051960 264 0.012
vesicle mediated transport GO:0016192 181 0.012
reactive oxygen species biosynthetic process GO:1903409 8 0.012
axis specification GO:0009798 4 0.012
inorganic ion transmembrane transport GO:0098660 229 0.012
regulation of membrane potential GO:0042391 110 0.012
response to mechanical stimulus GO:0009612 134 0.012
cell activation GO:0001775 97 0.012
regulation of cellular amino acid metabolic process GO:0006521 2 0.012
response to vitamin GO:0033273 131 0.012
enzyme linked receptor protein signaling pathway GO:0007167 116 0.012
neuron apoptotic process GO:0051402 88 0.012
reproductive structure development GO:0048608 128 0.012
regulation of small gtpase mediated signal transduction GO:0051056 48 0.012
regulation of immune system process GO:0002682 123 0.012
cation transport GO:0006812 382 0.012
positive regulation of gene expression GO:0010628 244 0.011
actin cytoskeleton organization GO:0030036 73 0.011
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.011
renal system development GO:0072001 67 0.011
regulation of purine nucleotide metabolic process GO:1900542 115 0.011
regulation of nucleoside metabolic process GO:0009118 66 0.011
muscle structure development GO:0061061 87 0.011
negative regulation of apoptotic process GO:0043066 181 0.011
response to glucocorticoid GO:0051384 223 0.011
negative regulation of phosphorus metabolic process GO:0010563 80 0.011
reactive oxygen species metabolic process GO:0072593 37 0.011
lipid transport GO:0006869 61 0.011
negative regulation of developmental process GO:0051093 125 0.011
negative regulation of transcription dna templated GO:0045892 116 0.011
negative regulation of cellular protein metabolic process GO:0032269 106 0.011
positive regulation of nucleotide catabolic process GO:0030813 53 0.011
regulation of body fluid levels GO:0050878 90 0.011
gonad development GO:0008406 104 0.011
guanosine containing compound catabolic process GO:1901069 71 0.011
establishment of protein localization GO:0045184 141 0.011
sister chromatid segregation GO:0000819 1 0.011
rho protein signal transduction GO:0007266 11 0.011
regulation of cytokine production GO:0001817 56 0.011
response to insulin GO:0032868 133 0.011
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.011
positive regulation of defense response GO:0031349 37 0.011
development of primary sexual characteristics GO:0045137 107 0.011
regulation of cellular component biogenesis GO:0044087 86 0.011
gtp metabolic process GO:0046039 72 0.011
response to amino acid GO:0043200 75 0.011
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.010
negative regulation of protein metabolic process GO:0051248 114 0.010
protein transport GO:0015031 132 0.010
cellular ion homeostasis GO:0006873 184 0.010
response to alkaloid GO:0043279 132 0.010
positive regulation of protein phosphorylation GO:0001934 135 0.010
regulation of protein kinase activity GO:0045859 105 0.010
purine containing compound biosynthetic process GO:0072522 85 0.010
response to nutrient GO:0007584 248 0.010
gliogenesis GO:0042063 93 0.010
regulation of proteolysis GO:0030162 66 0.010
positive regulation of neuron apoptotic process GO:0043525 33 0.010
cell cycle checkpoint GO:0000075 2 0.010
regulation of cell morphogenesis GO:0022604 77 0.010
response to cytokine GO:0034097 215 0.010
gland development GO:0048732 155 0.010
ribonucleoside monophosphate metabolic process GO:0009161 88 0.010
regulation of nucleotide metabolic process GO:0006140 117 0.010
smooth muscle cell proliferation GO:0048659 77 0.010
anion transmembrane transport GO:0098656 77 0.010

Gsdmd disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.025
disease of cellular proliferation DOID:14566 0 0.025
disease of anatomical entity DOID:7 0 0.022
musculoskeletal system disease DOID:17 0 0.022
organ system cancer DOID:0050686 0 0.018
nervous system disease DOID:863 0 0.014
disease of metabolism DOID:0014667 0 0.013
central nervous system disease DOID:331 0 0.012
connective tissue disease DOID:65 0 0.011
inherited metabolic disorder DOID:655 0 0.010
sensory system disease DOID:0050155 0 0.010