Rattus norvegicus

177 known processes

Cyp1a1

cytochrome P450, family 1, subfamily a, polypeptide 1

(Aliases: P450DX,Cypc45c,P1-450,P-450MC,AHH,AHRR,P450-C,CYP1,CP11,Cyp45c)

Cyp1a1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
linoleic acid metabolic process GO:0043651 4 0.850
exogenous drug catabolic process GO:0042738 1 0.736
carboxylic acid metabolic process GO:0019752 289 0.653
response to peptide GO:1901652 292 0.576
Rat
halogenated hydrocarbon metabolic process GO:0042197 4 0.514
response to xenobiotic stimulus GO:0009410 23 0.485
calcitriol biosynthetic process from calciol GO:0036378 2 0.479
alkaloid metabolic process GO:0009820 3 0.478
drug catabolic process GO:0042737 1 0.473
drug metabolic process GO:0017144 11 0.436
Human
reproductive process GO:0022414 372 0.419
monocarboxylic acid metabolic process GO:0032787 152 0.417
chlorinated hydrocarbon metabolic process GO:0042196 4 0.411
arachidonic acid metabolic process GO:0019369 20 0.407
oxoacid metabolic process GO:0043436 290 0.372
response to corticosteroid GO:0031960 235 0.370
response to peptide hormone GO:0043434 278 0.314
Rat
fatty acid metabolic process GO:0006631 99 0.302
response to estradiol GO:0032355 164 0.302
organic anion transport GO:0015711 132 0.282
coumarin metabolic process GO:0009804 5 0.280
response to biotic stimulus GO:0009607 226 0.265
cellular response to hormone stimulus GO:0032870 247 0.246
Rat
lipid metabolic process GO:0006629 283 0.225
secondary alcohol metabolic process GO:1902652 2 0.213
cellular response to xenobiotic stimulus GO:0071466 19 0.207
multi organism reproductive process GO:0044703 262 0.206
cellular lipid metabolic process GO:0044255 208 0.189
lauric acid metabolic process GO:0048252 4 0.183
cellular response to organonitrogen compound GO:0071417 197 0.171
Rat
response to insulin GO:0032868 133 0.170
organic hydroxy compound metabolic process GO:1901615 115 0.164
Rat
xenobiotic metabolic process GO:0006805 19 0.162
organic acid metabolic process GO:0006082 292 0.161
long chain fatty acid metabolic process GO:0001676 32 0.158
nicotine metabolic process GO:0018933 1 0.151
cellular response to endogenous stimulus GO:0071495 377 0.145
Rat
response to glucocorticoid GO:0051384 223 0.137
isoprenoid metabolic process GO:0006720 45 0.136
cellular hormone metabolic process GO:0034754 49 0.136
response to acid chemical GO:0001101 222 0.128
Rat
steroid metabolic process GO:0008202 73 0.127
Rat
response to organophosphorus GO:0046683 102 0.124
Rat
trichloroethylene metabolic process GO:0018979 1 0.120
cellular amino acid metabolic process GO:0006520 107 0.118
multicellular organism reproduction GO:0032504 233 0.114
single organism reproductive process GO:0044702 297 0.110
response to estrogen GO:0043627 232 0.104
epoxygenase p450 pathway GO:0019373 1 0.102
aging GO:0007568 241 0.101
vitamin d3 metabolic process GO:0070640 2 0.098
acylglycerol metabolic process GO:0006639 21 0.097
response to nutrient GO:0007584 248 0.094
unsaturated fatty acid metabolic process GO:0033559 39 0.089
icosanoid metabolic process GO:0006690 38 0.087
anion transport GO:0006820 178 0.086
naphthalene metabolic process GO:0018931 2 0.084
fat soluble vitamin biosynthetic process GO:0042362 2 0.084
female pregnancy GO:0007565 122 0.082
response to ethanol GO:0045471 162 0.080
response to ddt GO:0046680 1 0.078
response to ketone GO:1901654 182 0.077
cellular catabolic process GO:0044248 295 0.073
amino acid transport GO:0006865 70 0.071
vitamin d metabolic process GO:0042359 4 0.070
regulation of lipid metabolic process GO:0019216 68 0.069
Rat
growth GO:0040007 165 0.069
response to metal ion GO:0010038 253 0.067
biphenyl catabolic process GO:0070980 2 0.066
response to extracellular stimulus GO:0009991 380 0.065
multi multicellular organism process GO:0044706 138 0.065
response to nutrient levels GO:0031667 370 0.064
cellular response to oxygen containing compound GO:1901701 386 0.063
Rat
4 chlorobiphenyl metabolic process GO:0018880 1 0.060
reproductive structure development GO:0048608 128 0.059
Rat
fluorene metabolic process GO:0018917 1 0.057
carboxylic acid transport GO:0046942 115 0.057
negative regulation of innate immune response GO:0045824 4 0.057
response to bacterium GO:0009617 200 0.056
vitamin d biosynthetic process GO:0042368 2 0.056
response to purine containing compound GO:0014074 126 0.055
Rat
response to inorganic substance GO:0010035 377 0.053
cellular alcohol biosynthetic process GO:0044108 2 0.053
tube development GO:0035295 89 0.053
single organism biosynthetic process GO:0044711 342 0.052
carboxylic acid biosynthetic process GO:0046394 83 0.052
lipid localization GO:0010876 62 0.050
organ growth GO:0035265 24 0.048
developmental process involved in reproduction GO:0003006 159 0.048
Rat
xenobiotic catabolic process GO:0042178 7 0.048
lipid biosynthetic process GO:0008610 128 0.047
regulation of growth GO:0040008 105 0.046
reproduction GO:0000003 245 0.046
terpenoid metabolic process GO:0006721 37 0.044
small molecule biosynthetic process GO:0044283 124 0.044
response to cesium ion GO:0010164 2 0.044
diterpenoid metabolic process GO:0016101 33 0.044
monocarboxylic acid transport GO:0015718 52 0.043
multicellular organismal reproductive process GO:0048609 233 0.043
sexual reproduction GO:0019953 148 0.043
Rat
development of primary sexual characteristics GO:0045137 107 0.043
Rat
organic acid transport GO:0015849 116 0.042
naphthalene containing compound metabolic process GO:0090420 2 0.041
muscle structure development GO:0061061 87 0.041
gland development GO:0048732 155 0.041
response to sulfur dioxide GO:0010477 3 0.040
cation transmembrane transport GO:0098655 263 0.040
organic hydroxy compound biosynthetic process GO:1901617 51 0.040
anatomical structure morphogenesis GO:0009653 298 0.040
regulation of multicellular organismal development GO:2000026 376 0.040
catabolic process GO:0009056 351 0.040
phenol containing compound metabolic process GO:0018958 30 0.038
Rat
cellular response to stress GO:0033554 269 0.037
vitamin biosynthetic process GO:0009110 3 0.037
neuron projection development GO:0031175 273 0.036
brain development GO:0007420 247 0.036
Rat
response to lipopolysaccharide GO:0032496 191 0.035
intracellular signal transduction GO:0035556 314 0.034
response to fungicide GO:0060992 20 0.034
Rat
positive regulation of signaling GO:0023056 270 0.034
fatty acid derivative metabolic process GO:1901568 38 0.034
regulation of hormone levels GO:0010817 187 0.034
circulatory system process GO:0003013 183 0.034
positive regulation of biosynthetic process GO:0009891 319 0.033
Rat
regulation of intracellular signal transduction GO:1902531 218 0.033
regulation of cellular amino acid metabolic process GO:0006521 2 0.033
reproductive system development GO:0061458 128 0.032
Rat
glycerolipid metabolic process GO:0046486 67 0.032
negative regulation of macromolecule metabolic process GO:0010605 260 0.032
positive regulation of cell communication GO:0010647 271 0.032
response to oxidative stress GO:0006979 186 0.032
response to nicotine GO:0035094 51 0.032
enzyme linked receptor protein signaling pathway GO:0007167 116 0.032
single organism behavior GO:0044708 130 0.031
regulation of molecular function GO:0065009 398 0.031
response to other organism GO:0051707 220 0.031
response to reactive oxygen species GO:0000302 120 0.031
response to camp GO:0051591 91 0.030
Rat
tetrahydrofolate metabolic process GO:0046653 9 0.030
oxidation reduction process GO:0055114 304 0.029
organic acid biosynthetic process GO:0016053 83 0.029
developmental induction GO:0031128 2 0.029
positive regulation of molecular function GO:0044093 230 0.028
negative regulation of protein metabolic process GO:0051248 114 0.028
lipid transport GO:0006869 61 0.028
folic acid containing compound metabolic process GO:0006760 10 0.028
regulation of cellular catabolic process GO:0031329 101 0.028
toxin catabolic process GO:0009407 1 0.027
regulation of cell growth GO:0001558 85 0.027
rna biosynthetic process GO:0032774 380 0.027
regulation of rna biosynthetic process GO:2001141 381 0.027
developmental growth GO:0048589 100 0.026
alcohol metabolic process GO:0006066 77 0.026
cell growth GO:0016049 104 0.026
regulation of phosphorylation GO:0042325 248 0.026
ovulation cycle GO:0042698 67 0.026
cellular response to organic cyclic compound GO:0071407 202 0.026
Human Zebrafish
cellular response to peptide GO:1901653 133 0.026
Rat
regulation of developmental growth GO:0048638 45 0.026
regulation of cellular ketone metabolic process GO:0010565 27 0.026
negative regulation of collagen biosynthetic process GO:0032966 4 0.025
hepaticobiliary system development GO:0061008 90 0.025
rhythmic process GO:0048511 156 0.025
phenylpropanoid catabolic process GO:0046271 3 0.025
membrane organization GO:0061024 94 0.025
regulation of fat cell proliferation GO:0070344 1 0.025
sex differentiation GO:0007548 113 0.024
Rat
regulation of phosphate metabolic process GO:0019220 349 0.024
response to radiation GO:0009314 137 0.023
Rat
regulation of blood circulation GO:1903522 110 0.023
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.023
blood circulation GO:0008015 183 0.022
neutral lipid metabolic process GO:0006638 21 0.022
regulation of cellular protein metabolic process GO:0032268 267 0.022
triglyceride metabolic process GO:0006641 21 0.022
organic hydroxy compound transport GO:0015850 77 0.022
transmembrane transport GO:0055085 412 0.022
regulation of neuron death GO:1901214 115 0.022
development of primary female sexual characteristics GO:0046545 56 0.022
regulation of cellular component organization GO:0051128 368 0.022
organophosphate metabolic process GO:0019637 370 0.022
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.022
organonitrogen compound biosynthetic process GO:1901566 167 0.022
phenylpropanoid metabolic process GO:0009698 5 0.022
positive regulation of multicellular organismal process GO:0051240 387 0.022
4 nitrophenol metabolic process GO:0018960 1 0.021
fat cell proliferation GO:0070341 2 0.021
coumarin catabolic process GO:0046226 3 0.021
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.021
cellular response to glucocorticoid stimulus GO:0071385 68 0.021
cellular modified amino acid metabolic process GO:0006575 61 0.021
cellular response to growth factor stimulus GO:0071363 162 0.021
female gonad development GO:0008585 53 0.020
positive regulation of catalytic activity GO:0043085 184 0.020
epithelium development GO:0060429 96 0.020
response to amino acid GO:0043200 75 0.020
response to growth factor GO:0070848 189 0.020
bile acid and bile salt transport GO:0015721 12 0.020
response to toxic substance GO:0009636 133 0.020
response to transition metal nanoparticle GO:1990267 122 0.019
skeletal muscle cell differentiation GO:0035914 2 0.019
regulation of sodium ion transmembrane transporter activity GO:2000649 4 0.019
negative regulation of organ growth GO:0046621 3 0.019
regulation of neurogenesis GO:0050767 247 0.019
response to external biotic stimulus GO:0043207 221 0.019
regulation of cell proliferation GO:0042127 359 0.019
multicellular organism growth GO:0035264 1 0.019
cell projection organization GO:0030030 302 0.019
response to alkaloid GO:0043279 132 0.019
response to wounding GO:0009611 254 0.019
response to fibroblast growth factor GO:0071774 29 0.019
regulation of system process GO:0044057 208 0.019
small gtpase mediated signal transduction GO:0007264 36 0.019
cellular ketone metabolic process GO:0042180 51 0.018
Rat
negative regulation of cardiac muscle tissue development GO:0055026 3 0.018
positive regulation of behavioral fear response GO:2000987 3 0.018
positive regulation of phosphorus metabolic process GO:0010562 262 0.018
female sex differentiation GO:0046660 59 0.018
cellular amine metabolic process GO:0044106 38 0.018
cell communication by chemical coupling GO:0010643 2 0.018
response to gonadotropin GO:0034698 34 0.018
Rat
regulation of signal transduction GO:0009966 318 0.018
organ induction GO:0001759 1 0.018
neuron development GO:0048666 286 0.018
response to vitamin GO:0033273 131 0.018
cellular response to steroid hormone stimulus GO:0071383 93 0.018
single organism catabolic process GO:0044712 283 0.017
negative regulation of metabolic process GO:0009892 331 0.017
insecticide metabolic process GO:0017143 4 0.017
benzene containing compound metabolic process GO:0042537 22 0.017
Rat
cellular response to vitamin e GO:0071306 3 0.017
hormone catabolic process GO:0042447 2 0.017
secondary metabolite catabolic process GO:0090487 1 0.017
sterol homeostasis GO:0055092 3 0.017
regulation of transcription dna templated GO:0006355 374 0.017
male gonad development GO:0008584 59 0.017
Rat
regulation of catabolic process GO:0009894 113 0.017
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.017
response to ionizing radiation GO:0010212 59 0.017
Rat
acid secretion GO:0046717 48 0.017
regulation of transferase activity GO:0051338 123 0.017
regulation of cellular amine metabolic process GO:0033238 8 0.017
cellular component movement GO:0006928 248 0.017
ion transmembrane transport GO:0034220 365 0.017
pyridine containing compound metabolic process GO:0072524 32 0.017
inorganic cation transmembrane transport GO:0098662 202 0.016
positive regulation of growth GO:0045927 55 0.016
response to corticosterone GO:0051412 40 0.016
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.016
rna metabolic process GO:0016070 406 0.016
drug transmembrane transport GO:0006855 13 0.016
response to carbohydrate GO:0009743 183 0.016
regulation of protein metabolic process GO:0051246 289 0.016
coronary vasculature morphogenesis GO:0060977 3 0.016
regulation of body fluid levels GO:0050878 90 0.016
cholesterol homeostasis GO:0042632 3 0.016
central nervous system development GO:0007417 311 0.015
Rat
amide transport GO:0042886 105 0.015
neuron death GO:0070997 127 0.015
nucleic acid templated transcription GO:0097659 379 0.015
positive regulation of response to stimulus GO:0048584 285 0.015
alcohol biosynthetic process GO:0046165 38 0.015
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.015
gonad development GO:0008406 104 0.015
Rat
cellular response to alcohol GO:0097306 87 0.015
regulation of blood pressure GO:0008217 83 0.015
amine metabolic process GO:0009308 38 0.015
Mouse
response to transforming growth factor beta GO:0071559 46 0.015
negative regulation of cell communication GO:0010648 158 0.015
negative regulation of molecular function GO:0044092 133 0.015
regulation of cell development GO:0060284 263 0.015
positive regulation of phosphate metabolic process GO:0045937 262 0.014
neuromuscular process GO:0050905 2 0.014
cellular response to corticosteroid stimulus GO:0071384 69 0.014
cellular response to oxidative stress GO:0034599 76 0.014
nucleobase containing small molecule metabolic process GO:0055086 316 0.014
negative regulation of cellular biosynthetic process GO:0031327 161 0.014
neuron differentiation GO:0030182 368 0.014
gamete generation GO:0007276 124 0.014
Rat
c21 steroid hormone metabolic process GO:0008207 14 0.014
Rat
regulation of rna metabolic process GO:0051252 391 0.014
regulation of cell differentiation GO:0045595 320 0.014
peptide biosynthetic process GO:0043043 3 0.014
negative regulation of catalytic activity GO:0043086 103 0.014
positive regulation of cell proliferation GO:0008284 249 0.014
cellular response to peptide hormone stimulus GO:0071375 120 0.014
Rat
regulation of cell projection organization GO:0031344 175 0.014
regulation of cytokine biosynthetic process GO:0042035 3 0.014
secretion GO:0046903 307 0.014
lipid storage GO:0019915 1 0.014
regulation of nervous system development GO:0051960 264 0.014
negative regulation of cell proliferation GO:0008285 119 0.014
positive regulation of secretion by cell GO:1903532 128 0.014
neurological system process GO:0050877 219 0.014
positive regulation of fat cell proliferation GO:0070346 1 0.014
positive regulation of developmental process GO:0051094 283 0.013
response to retinoic acid GO:0032526 63 0.013
Rat
transcription from rna polymerase ii promoter GO:0006366 252 0.013
sulfation GO:0051923 2 0.013
negative regulation of biosynthetic process GO:0009890 168 0.013
digestive tract development GO:0048565 39 0.013
grooming behavior GO:0007625 4 0.013
regulation of neuron differentiation GO:0045664 208 0.013
regulation of vascular smooth muscle contraction GO:0003056 3 0.013
progesterone biosynthetic process GO:0006701 3 0.013
positive regulation of cellular amine metabolic process GO:0033240 3 0.013
transcription dna templated GO:0006351 377 0.013
tissue development GO:0009888 252 0.012
regulation of phosphorus metabolic process GO:0051174 349 0.012
macromolecular complex assembly GO:0065003 273 0.012
ras protein signal transduction GO:0007265 29 0.012
programmed cell death GO:0012501 392 0.012
negative regulation of cell development GO:0010721 82 0.012
positive regulation of cellular biosynthetic process GO:0031328 295 0.012
Rat
regeneration GO:0031099 163 0.012
response to vitamin a GO:0033189 36 0.012
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.012
negative regulation of cellular metabolic process GO:0031324 281 0.012
negative regulation of cardiac muscle tissue growth GO:0055022 3 0.012
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.012
regulation of brown fat cell proliferation GO:0070347 1 0.012
positive regulation of brown fat cell proliferation GO:0070349 1 0.012
behavioral response to ethanol GO:0048149 1 0.012
regulation of tube size GO:0035150 89 0.012
cellular modified amino acid biosynthetic process GO:0042398 18 0.012
negative regulation of intracellular signal transduction GO:1902532 38 0.012
cardiac muscle tissue growth GO:0055017 20 0.012
organophosphate biosynthetic process GO:0090407 143 0.012
defense response to gram negative bacterium GO:0050829 3 0.012
regulation of organ formation GO:0003156 2 0.012
dephosphorylation GO:0016311 98 0.012
vascular process in circulatory system GO:0003018 96 0.012
response to monosaccharide GO:0034284 159 0.011
regulation of catalytic activity GO:0050790 304 0.011
cytokine biosynthetic process GO:0042089 3 0.011
response to lithium ion GO:0010226 28 0.011
secondary metabolic process GO:0019748 15 0.011
negative regulation of multicellular organismal process GO:0051241 203 0.011
striated muscle tissue development GO:0014706 58 0.011
alpha amino acid metabolic process GO:1901605 71 0.011
positive regulation of phagocytosis engulfment GO:0060100 4 0.011
cellular response to camp GO:0071320 26 0.011
positive regulation of cell differentiation GO:0045597 217 0.011
specification of organ identity GO:0010092 2 0.011
response to cytokine GO:0034097 215 0.011
Rat
proteolysis GO:0006508 175 0.011
regulation of cellular extravasation GO:0002691 2 0.011
organ formation GO:0048645 3 0.011
brown fat cell proliferation GO:0070342 2 0.011
embryo development GO:0009790 49 0.011
cellular amino acid biosynthetic process GO:0008652 32 0.011
cardiac muscle tissue development GO:0048738 26 0.011
sodium ion transmembrane transport GO:0035725 67 0.011
negative regulation of cell cycle phase transition GO:1901988 4 0.011
toxin metabolic process GO:0009404 9 0.011
cellular response to nitrogen compound GO:1901699 210 0.011
Rat
cellular response to extracellular stimulus GO:0031668 73 0.011
cell cell signaling involved in cell fate commitment GO:0045168 2 0.010
response to cadmium ion GO:0046686 35 0.010
heart development GO:0007507 72 0.010
regulation of fat cell differentiation GO:0045598 3 0.010
carbohydrate catabolic process GO:0016052 40 0.010
positive regulation of renin secretion into blood stream GO:1900135 1 0.010
cellular homeostasis GO:0019725 252 0.010
response to hexose GO:0009746 144 0.010
cellular response to nutrient levels GO:0031669 60 0.010
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.010
positive regulation of lipid metabolic process GO:0045834 33 0.010
Rat

Cyp1a1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
hypertension DOID:10763 0 0.078
artery disease DOID:0050828 0 0.078
disease of anatomical entity DOID:7 0 0.078
vascular disease DOID:178 0 0.078
essential hypertension DOID:10825 0 0.078
cardiovascular system disease DOID:1287 0 0.078
nervous system disease DOID:863 0 0.013
disease of metabolism DOID:0014667 0 0.013
congenital adrenal hyperplasia DOID:0050811 0 0.013
lipid metabolism disorder DOID:3146 0 0.013
inherited metabolic disorder DOID:655 0 0.013
steroid inherited metabolic disorder DOID:1701 0 0.013