Rattus norvegicus

0 known processes

Pde6a

phosphodiesterase 6A, cGMP-specific, rod, alpha

Pde6a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
transmembrane transport GO:0055085 412 0.088
response to nutrient GO:0007584 248 0.077
macromolecule localization GO:0033036 252 0.069
Rat
response to nutrient levels GO:0031667 370 0.067
tissue development GO:0009888 252 0.065
Rat
response to inorganic substance GO:0010035 377 0.063
intracellular signal transduction GO:0035556 314 0.060
Rat
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.057
reproductive process GO:0022414 372 0.055
response to decreased oxygen levels GO:0036293 237 0.054
Rat
rna metabolic process GO:0016070 406 0.053
cellular lipid metabolic process GO:0044255 208 0.051
response to oxygen levels GO:0070482 265 0.050
Rat
aging GO:0007568 241 0.049
regulation of rna metabolic process GO:0051252 391 0.048
multicellular organismal reproductive process GO:0048609 233 0.047
homeostatic process GO:0042592 331 0.046
Human
cellular response to oxygen containing compound GO:1901701 386 0.046
ion homeostasis GO:0050801 212 0.046
Human
divalent inorganic cation homeostasis GO:0072507 165 0.045
Human
anatomical structure morphogenesis GO:0009653 298 0.043
positive regulation of molecular function GO:0044093 230 0.043
response to metal ion GO:0010038 253 0.043
regulation of blood circulation GO:1903522 110 0.042
Rat
response to hypoxia GO:0001666 231 0.042
Rat
negative regulation of cellular metabolic process GO:0031324 281 0.041
Rat
regulation of secretion by cell GO:1903530 208 0.040
cellular response to stress GO:0033554 269 0.039
regulation of transcription dna templated GO:0006355 374 0.038
lipid metabolic process GO:0006629 283 0.038
amine metabolic process GO:0009308 38 0.038
organelle organization GO:0006996 266 0.037
Rat
response to extracellular stimulus GO:0009991 380 0.036
cellular metal ion homeostasis GO:0006875 172 0.036
Human
cellular component assembly GO:0022607 360 0.036
sodium ion transport GO:0006814 82 0.036
circulatory system process GO:0003013 183 0.036
Rat
epithelial cell differentiation GO:0030855 71 0.036
Rat
ion transmembrane transport GO:0034220 365 0.035
response to corticosteroid GO:0031960 235 0.035
organophosphate metabolic process GO:0019637 370 0.035
Human Rat
chemical homeostasis GO:0048878 292 0.035
Human
regulation of molecular function GO:0065009 398 0.033
single organism reproductive process GO:0044702 297 0.033
oxoacid metabolic process GO:0043436 290 0.033
cellular ion homeostasis GO:0006873 184 0.033
Human
developmental process involved in reproduction GO:0003006 159 0.032
response to estrogen GO:0043627 232 0.032
multicellular organism reproduction GO:0032504 233 0.032
cellular response to lipid GO:0071396 201 0.032
single organism biosynthetic process GO:0044711 342 0.032
Rat
cellular calcium ion homeostasis GO:0006874 160 0.032
Human
multi organism reproductive process GO:0044703 262 0.031
negative regulation of gene expression GO:0010629 199 0.031
anion transport GO:0006820 178 0.031
metal ion homeostasis GO:0055065 186 0.030
Human
development of primary sexual characteristics GO:0045137 107 0.030
sexual reproduction GO:0019953 148 0.030
regulation of cell proliferation GO:0042127 359 0.030
regulation of signal transduction GO:0009966 318 0.030
cellular component morphogenesis GO:0032989 155 0.029
regulation of nucleic acid templated transcription GO:1903506 380 0.029
transcription dna templated GO:0006351 377 0.029
nucleic acid templated transcription GO:0097659 379 0.029
positive regulation of cellular biosynthetic process GO:0031328 295 0.028
response to glucocorticoid GO:0051384 223 0.028
rna biosynthetic process GO:0032774 380 0.028
reproduction GO:0000003 245 0.028
single organism intracellular transport GO:1902582 166 0.028
Rat
metal ion transport GO:0030001 289 0.028
carboxylic acid metabolic process GO:0019752 289 0.028
programmed cell death GO:0012501 392 0.027
Rat
inorganic ion transmembrane transport GO:0098660 229 0.027
cellular divalent inorganic cation homeostasis GO:0072503 162 0.027
Human
cellular chemical homeostasis GO:0055082 247 0.027
Human
organic acid metabolic process GO:0006082 292 0.027
macromolecular complex subunit organization GO:0043933 339 0.027
negative regulation of metabolic process GO:0009892 331 0.026
Rat
response to radiation GO:0009314 137 0.026
negative regulation of biosynthetic process GO:0009890 168 0.026
Rat
response to peptide GO:1901652 292 0.026
cellular amino acid metabolic process GO:0006520 107 0.026
regulation of cellular localization GO:0060341 263 0.026
reproductive structure development GO:0048608 128 0.026
regulation of protein metabolic process GO:0051246 289 0.026
blood circulation GO:0008015 183 0.026
Rat
cellular amine metabolic process GO:0044106 38 0.025
calcium ion homeostasis GO:0055074 162 0.025
Human
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.025
Rat
positive regulation of biosynthetic process GO:0009891 319 0.025
protein phosphorylation GO:0006468 345 0.025
apoptotic process GO:0006915 381 0.025
Rat
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.025
intracellular transport GO:0046907 185 0.025
Rat
gonad development GO:0008406 104 0.024
regulation of protein phosphorylation GO:0001932 183 0.024
positive regulation of response to stimulus GO:0048584 285 0.024
Rat
regulation of programmed cell death GO:0043067 341 0.024
Rat
cation homeostasis GO:0055080 195 0.024
Human
negative regulation of macromolecule metabolic process GO:0010605 260 0.024
negative regulation of programmed cell death GO:0043069 183 0.024
response to wounding GO:0009611 254 0.024
Rat
epithelium development GO:0060429 96 0.024
Rat
reproductive system development GO:0061458 128 0.024
response to toxic substance GO:0009636 133 0.023
carbohydrate derivative metabolic process GO:1901135 346 0.023
Human Rat
regulation of secretion GO:0051046 224 0.023
regulation of cell differentiation GO:0045595 320 0.023
positive regulation of gene expression GO:0010628 244 0.023
positive regulation of signaling GO:0023056 270 0.023
response to biotic stimulus GO:0009607 226 0.023
Rat
response to vitamin GO:0033273 131 0.023
regulation of cellular protein metabolic process GO:0032268 267 0.022
cellular component biogenesis GO:0044085 368 0.022
negative regulation of cell death GO:0060548 229 0.022
response to cytokine GO:0034097 215 0.022
cellular response to organic cyclic compound GO:0071407 202 0.022
positive regulation of cell communication GO:0010647 271 0.022
cellular homeostasis GO:0019725 252 0.022
Human
protein transport GO:0015031 132 0.021
Rat
regulation of apoptotic process GO:0042981 335 0.021
Rat
regulation of catalytic activity GO:0050790 304 0.021
regulation of system process GO:0044057 208 0.021
Rat
positive regulation of phosphorus metabolic process GO:0010562 262 0.021
cellular cation homeostasis GO:0030003 180 0.021
Human
protein localization GO:0008104 191 0.021
Rat
macromolecular complex assembly GO:0065003 273 0.021
regulation of cellular component movement GO:0051270 150 0.021
regulation of blood vessel size GO:0050880 89 0.020
Rat
regulation of phosphorus metabolic process GO:0051174 349 0.020
Rat
heart morphogenesis GO:0003007 3 0.020
cellular component movement GO:0006928 248 0.020
gamete generation GO:0007276 124 0.020
positive regulation of cellular protein metabolic process GO:0032270 167 0.020
transcription from rna polymerase ii promoter GO:0006366 252 0.020
purine ribonucleotide metabolic process GO:0009150 227 0.020
Human Rat
central nervous system development GO:0007417 311 0.020
regulation of cellular ketone metabolic process GO:0010565 27 0.020
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.020
secretion GO:0046903 307 0.020
cation transport GO:0006812 382 0.019
positive regulation of protein metabolic process GO:0051247 178 0.019
nitrogen compound transport GO:0071705 229 0.019
positive regulation of rna biosynthetic process GO:1902680 197 0.019
regulation of cellular amino acid metabolic process GO:0006521 2 0.019
axis specification GO:0009798 4 0.019
response to growth factor GO:0070848 189 0.019
single organism organelle organization GO:1902589 180 0.019
negative regulation of apoptotic process GO:0043066 181 0.019
protein complex assembly GO:0006461 263 0.019
positive regulation of synaptic transmission GO:0050806 62 0.019
inorganic cation transmembrane transport GO:0098662 202 0.019
regulation of cellular component organization GO:0051128 368 0.019
response to reactive oxygen species GO:0000302 120 0.019
response to peptide hormone GO:0043434 278 0.019
response to transition metal nanoparticle GO:1990267 122 0.018
positive regulation of catalytic activity GO:0043085 184 0.018
response to other organism GO:0051707 220 0.018
Rat
regulation of phosphate metabolic process GO:0019220 349 0.018
Rat
positive regulation of protein modification process GO:0031401 142 0.018
cellular protein localization GO:0034613 122 0.018
Rat
neuron differentiation GO:0030182 368 0.018
positive regulation of multicellular organismal process GO:0051240 387 0.018
Rat
brain development GO:0007420 247 0.018
regulation of nucleotide metabolic process GO:0006140 117 0.018
Rat
cellular response to oxidative stress GO:0034599 76 0.018
regulation of rna biosynthetic process GO:2001141 381 0.018
positive regulation of rna metabolic process GO:0051254 203 0.017
cellular response to nitrogen compound GO:1901699 210 0.017
negative regulation of rna biosynthetic process GO:1902679 118 0.017
regulation of cellular amine metabolic process GO:0033238 8 0.017
monovalent inorganic cation transport GO:0015672 172 0.017
ribose phosphate metabolic process GO:0019693 235 0.017
Human Rat
protein complex biogenesis GO:0070271 263 0.017
cellular response to abiotic stimulus GO:0071214 85 0.017
cellular response to external stimulus GO:0071496 118 0.017
g protein coupled receptor signaling pathway GO:0007186 242 0.017
positive regulation of cellular component organization GO:0051130 200 0.017
positive regulation of secretion by cell GO:1903532 128 0.017
regulation of multicellular organismal development GO:2000026 376 0.017
protein oligomerization GO:0051259 191 0.017
lipid transport GO:0006869 61 0.017
neurological system process GO:0050877 219 0.017
Rat
sodium ion transmembrane transport GO:0035725 67 0.016
transmission of nerve impulse GO:0019226 42 0.016
regulation of hormone levels GO:0010817 187 0.016
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.016
Rat
vesicle mediated transport GO:0016192 181 0.016
regulation of protein modification process GO:0031399 194 0.016
response to oxidative stress GO:0006979 186 0.016
male sex differentiation GO:0046661 64 0.016
synaptic transmission GO:0007268 235 0.016
sex differentiation GO:0007548 113 0.016
neuron projection development GO:0031175 273 0.016
cellular response to endogenous stimulus GO:0071495 377 0.016
positive regulation of transport GO:0051050 245 0.016
positive regulation of cell death GO:0010942 184 0.015
Rat
eye morphogenesis GO:0048592 4 0.015
cellular response to growth factor stimulus GO:0071363 162 0.015
dephosphorylation GO:0016311 98 0.015
regulation of cell migration GO:0030334 128 0.015
purine containing compound biosynthetic process GO:0072522 85 0.015
Rat
cation transmembrane transport GO:0098655 263 0.015
response to ketone GO:1901654 182 0.015
Rat
response to ethanol GO:0045471 162 0.015
muscle cell proliferation GO:0033002 84 0.015
secretion by cell GO:0032940 248 0.015
neuronal action potential GO:0019228 35 0.015
positive regulation of cell proliferation GO:0008284 249 0.015
regulation of cell development GO:0060284 263 0.015
spermatogenesis GO:0007283 99 0.015
positive regulation of cellular amine metabolic process GO:0033240 3 0.015
regulation of anatomical structure size GO:0090066 135 0.015
Rat
cyclic nucleotide metabolic process GO:0009187 80 0.015
Rat
response to amino acid GO:0043200 75 0.015
cellular response to organonitrogen compound GO:0071417 197 0.015
urogenital system development GO:0001655 78 0.014
positive regulation of developmental process GO:0051094 283 0.014
regulation of body fluid levels GO:0050878 90 0.014
hormone transport GO:0009914 121 0.014
hormone secretion GO:0046879 115 0.014
male gamete generation GO:0048232 99 0.014
cell projection organization GO:0030030 302 0.014
negative regulation of cell communication GO:0010648 158 0.014
membrane organization GO:0061024 94 0.014
positive regulation of cell migration GO:0030335 96 0.014
sensory organ development GO:0007423 74 0.014
reactive oxygen species metabolic process GO:0072593 37 0.013
cell morphogenesis GO:0000902 142 0.013
multicellular organismal signaling GO:0035637 44 0.013
gland development GO:0048732 155 0.013
monocarboxylic acid transport GO:0015718 52 0.013
positive regulation of transcription dna templated GO:0045893 197 0.013
cellular response to steroid hormone stimulus GO:0071383 93 0.013
negative regulation of response to stimulus GO:0048585 155 0.013
male gonad development GO:0008584 59 0.013
nucleotide biosynthetic process GO:0009165 98 0.013
Rat
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.013
neuron development GO:0048666 286 0.013
negative regulation of organ growth GO:0046621 3 0.013
camp biosynthetic process GO:0006171 47 0.013
Rat
action potential GO:0001508 54 0.013
negative regulation of secretion GO:0051048 82 0.013
organic acid biosynthetic process GO:0016053 83 0.013
signal release GO:0023061 145 0.013
regulation of peptide transport GO:0090087 87 0.013
regulation of response to stress GO:0080134 126 0.013
Rat
camera type eye morphogenesis GO:0048593 2 0.013
negative regulation of cellular protein metabolic process GO:0032269 106 0.013
cellular catabolic process GO:0044248 295 0.013
Rat
divalent inorganic cation transport GO:0072511 134 0.013
positive regulation of secretion GO:0051047 140 0.013
olfactory behavior GO:0042048 2 0.013
single organism membrane organization GO:0044802 74 0.013
regulation of establishment of protein localization GO:0070201 69 0.012
signal transduction by phosphorylation GO:0023014 144 0.012
organic anion transport GO:0015711 132 0.012
carbohydrate derivative biosynthetic process GO:1901137 124 0.012
Rat
response to acid chemical GO:0001101 222 0.012
gliogenesis GO:0042063 93 0.012
circulatory system development GO:0072359 134 0.012
actin filament based process GO:0030029 86 0.012
protein homooligomerization GO:0051260 91 0.012
nucleotide metabolic process GO:0009117 279 0.012
Human Rat
organ regeneration GO:0031100 101 0.012
establishment of protein localization GO:0045184 141 0.012
Rat
cellular ketone metabolic process GO:0042180 51 0.012
response to lipopolysaccharide GO:0032496 191 0.012
Rat
cellular response to cytokine stimulus GO:0071345 127 0.012
cardiovascular system development GO:0072358 134 0.012
response to interleukin 1 GO:0070555 55 0.012
positive regulation of cellular component movement GO:0051272 102 0.012
purine nucleotide metabolic process GO:0006163 229 0.012
Human Rat
organic hydroxy compound metabolic process GO:1901615 115 0.012
positive regulation of phosphate metabolic process GO:0045937 262 0.012
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.012
purine nucleotide biosynthetic process GO:0006164 83 0.012
Rat
negative regulation of catalytic activity GO:0043086 103 0.012
cell cell signaling GO:0007267 335 0.012
nucleobase containing small molecule metabolic process GO:0055086 316 0.012
Human Rat
purine ribonucleotide biosynthetic process GO:0009152 81 0.012
Rat
adult locomotory behavior GO:0008344 4 0.012
organic hydroxy compound transport GO:0015850 77 0.012
cellular hormone metabolic process GO:0034754 49 0.012
response to hydrogen peroxide GO:0042542 89 0.012
regulation of membrane potential GO:0042391 110 0.012
multi multicellular organism process GO:0044706 138 0.011
regulation of phosphorylation GO:0042325 248 0.011
cyclic purine nucleotide metabolic process GO:0052652 62 0.011
Rat
negative regulation of protein metabolic process GO:0051248 114 0.011
peptide transport GO:0015833 97 0.011
female pregnancy GO:0007565 122 0.011
heart contraction GO:0060047 57 0.011
Rat
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.011
localization of cell GO:0051674 202 0.011
response to zinc ion GO:0010043 39 0.011
regulation of smooth muscle cell proliferation GO:0048660 75 0.011
camera type eye development GO:0043010 48 0.011
proteolysis GO:0006508 175 0.011
phototransduction visible light GO:0007603 2 0.011
regulation of ion transport GO:0043269 245 0.011
regulation of intracellular signal transduction GO:1902531 218 0.011
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.011
cellular response to peptide GO:1901653 133 0.011
chemosensory behavior GO:0007635 2 0.011
cell type specific apoptotic process GO:0097285 134 0.011
response to alkaloid GO:0043279 132 0.011
nucleoside phosphate metabolic process GO:0006753 283 0.011
Human Rat
response to external biotic stimulus GO:0043207 221 0.011
Rat
monocarboxylic acid metabolic process GO:0032787 152 0.011
negative regulation of nucleic acid templated transcription GO:1903507 117 0.011
positive regulation of phosphorylation GO:0042327 177 0.011
cellular response to alcohol GO:0097306 87 0.011
positive regulation of nucleic acid templated transcription GO:1903508 197 0.011
response to glucose GO:0009749 136 0.011
regulation of protein kinase activity GO:0045859 105 0.011
single organism behavior GO:0044708 130 0.011
Rat
meiotic cell cycle process GO:1903046 3 0.011
organophosphate biosynthetic process GO:0090407 143 0.011
Rat
response to fatty acid GO:0070542 65 0.011
organ morphogenesis GO:0009887 75 0.011
peptide secretion GO:0002790 86 0.011
small gtpase mediated signal transduction GO:0007264 36 0.011
response to carbohydrate GO:0009743 183 0.011
retina morphogenesis in camera type eye GO:0060042 1 0.011
positive regulation of signal transduction GO:0009967 175 0.011
lipid localization GO:0010876 62 0.011
response to mechanical stimulus GO:0009612 134 0.010
detection of visible light GO:0009584 3 0.010
regulation of peptide secretion GO:0002791 82 0.010
positive regulation of cell differentiation GO:0045597 217 0.010
bmp signaling pathway GO:0030509 4 0.010
regulation of cell motility GO:2000145 131 0.010
purine containing compound metabolic process GO:0072521 253 0.010
Human Rat
sequestering of metal ion GO:0051238 9 0.010
lipid biosynthetic process GO:0008610 128 0.010
response to monosaccharide GO:0034284 159 0.010
anterior posterior pattern specification GO:0009952 1 0.010
glial cell differentiation GO:0010001 65 0.010
regulation of metal ion transport GO:0010959 118 0.010
regulation of protein localization GO:0032880 81 0.010
alcohol metabolic process GO:0006066 77 0.010
negative regulation of signaling GO:0023057 157 0.010
chromosome segregation GO:0007059 2 0.010
regulation of mrna splicing via spliceosome GO:0048024 3 0.010

Pde6a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 0 0.074
Human
disease of anatomical entity DOID:7 0 0.074
Human
eye and adnexa disease DOID:1492 0 0.074
Human
nervous system disease DOID:863 0 0.074
Human
eye disease DOID:5614 0 0.035
Human
retinal disease DOID:5679 0 0.028
Human
retinal degeneration DOID:8466 0 0.026
Human
retinitis pigmentosa DOID:10584 0 0.026
Human
musculoskeletal system disease DOID:17 0 0.018