Rattus norvegicus

20 known processes

Nfkbie

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon

(Aliases: MGC72568,Slc35b2)

Nfkbie biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
macromolecular complex subunit organization GO:0043933 339 0.132
taxis GO:0042330 67 0.128
nucleic acid templated transcription GO:0097659 379 0.109
response to tumor necrosis factor GO:0034612 56 0.107
cellular response to organonitrogen compound GO:0071417 197 0.101
transcription dna templated GO:0006351 377 0.100
response to peptide GO:1901652 292 0.098
regulation of transcription dna templated GO:0006355 374 0.095
cellular response to nitrogen compound GO:1901699 210 0.094
cellular response to cytokine stimulus GO:0071345 127 0.092
regulation of signal transduction GO:0009966 318 0.090
Rat
positive regulation of tumor necrosis factor production GO:0032760 8 0.088
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.086
regulation of cell proliferation GO:0042127 359 0.086
regulation of nucleic acid templated transcription GO:1903506 380 0.083
intracellular signal transduction GO:0035556 314 0.081
Rat
cellular response to peptide GO:1901653 133 0.081
cellular response to oxygen containing compound GO:1901701 386 0.079
enzyme linked receptor protein signaling pathway GO:0007167 116 0.078
response to biotic stimulus GO:0009607 226 0.070
regulation of rna metabolic process GO:0051252 391 0.070
response to other organism GO:0051707 220 0.068
response to peptide hormone GO:0043434 278 0.068
cellular response to peptide hormone stimulus GO:0071375 120 0.066
cation transport GO:0006812 382 0.066
positive regulation of cell proliferation GO:0008284 249 0.062
positive regulation of biosynthetic process GO:0009891 319 0.062
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.061
positive regulation of multicellular organismal process GO:0051240 387 0.060
rna metabolic process GO:0016070 406 0.059
regulation of phosphate metabolic process GO:0019220 349 0.059
rna biosynthetic process GO:0032774 380 0.058
anatomical structure morphogenesis GO:0009653 298 0.055
cell morphogenesis GO:0000902 142 0.054
carbohydrate derivative metabolic process GO:1901135 346 0.053
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.053
positive regulation of rna biosynthetic process GO:1902680 197 0.052
cellular response to endogenous stimulus GO:0071495 377 0.051
response to acid chemical GO:0001101 222 0.050
regulation of protein transport GO:0051223 68 0.050
Rat
response to external biotic stimulus GO:0043207 221 0.049
positive regulation of rna metabolic process GO:0051254 203 0.049
positive regulation of molecular function GO:0044093 230 0.048
reproduction GO:0000003 245 0.047
cellular component morphogenesis GO:0032989 155 0.047
anion transport GO:0006820 178 0.046
neuron projection development GO:0031175 273 0.046
positive regulation of phosphate metabolic process GO:0045937 262 0.046
positive regulation of intracellular signal transduction GO:1902533 138 0.046
positive regulation of cellular biosynthetic process GO:0031328 295 0.044
response to inorganic substance GO:0010035 377 0.044
regulation of ion transport GO:0043269 245 0.043
positive regulation of neurogenesis GO:0050769 165 0.043
cellular component assembly GO:0022607 360 0.042
cellular component biogenesis GO:0044085 368 0.042
brain development GO:0007420 247 0.042
organophosphate metabolic process GO:0019637 370 0.040
positive regulation of nervous system development GO:0051962 178 0.040
cell projection organization GO:0030030 302 0.039
reproductive process GO:0022414 372 0.039
establishment of protein localization GO:0045184 141 0.038
Rat
positive regulation of signaling GO:0023056 270 0.038
response to cytokine GO:0034097 215 0.037
positive regulation of nucleic acid templated transcription GO:1903508 197 0.036
cell morphogenesis involved in differentiation GO:0000904 119 0.036
regulation of intracellular signal transduction GO:1902531 218 0.036
Rat
cellular response to stress GO:0033554 269 0.036
cellular response to tumor necrosis factor GO:0071356 46 0.036
single organism organelle organization GO:1902589 180 0.036
aging GO:0007568 241 0.036
regulation of cellular component organization GO:0051128 368 0.035
cytoskeleton organization GO:0007010 111 0.035
nucleobase containing small molecule metabolic process GO:0055086 316 0.035
cellular catabolic process GO:0044248 295 0.035
regulation of phosphorus metabolic process GO:0051174 349 0.035
amine metabolic process GO:0009308 38 0.035
regulation of cellular protein metabolic process GO:0032268 267 0.035
purine containing compound metabolic process GO:0072521 253 0.035
regulation of cellular localization GO:0060341 263 0.035
Rat
regulation of protein metabolic process GO:0051246 289 0.034
regulation of immune system process GO:0002682 123 0.034
positive regulation of signal transduction GO:0009967 175 0.034
organic cyclic compound catabolic process GO:1901361 175 0.034
multicellular organism reproduction GO:0032504 233 0.033
regulation of phosphorylation GO:0042325 248 0.033
regulation of cellular amino acid metabolic process GO:0006521 2 0.033
cellular ketone metabolic process GO:0042180 51 0.033
cellular response to insulin stimulus GO:0032869 81 0.032
neuron differentiation GO:0030182 368 0.032
nucleotide metabolic process GO:0009117 279 0.032
regulation of neuron apoptotic process GO:0043523 83 0.032
organic acid metabolic process GO:0006082 292 0.031
cellular amine metabolic process GO:0044106 38 0.031
regulation of cellular amine metabolic process GO:0033238 8 0.031
response to molecule of bacterial origin GO:0002237 194 0.031
ribonucleotide metabolic process GO:0009259 231 0.031
carboxylic acid transport GO:0046942 115 0.031
positive regulation of protein metabolic process GO:0051247 178 0.031
intracellular transport GO:0046907 185 0.030
Rat
metal ion transport GO:0030001 289 0.030
regulation of cellular ketone metabolic process GO:0010565 27 0.030
nitrogen compound transport GO:0071705 229 0.030
positive regulation of phosphorus metabolic process GO:0010562 262 0.030
protein transport GO:0015031 132 0.030
Rat
positive regulation of phosphorylation GO:0042327 177 0.030
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.029
single organism reproductive process GO:0044702 297 0.029
regulation of rna biosynthetic process GO:2001141 381 0.029
chemical homeostasis GO:0048878 292 0.029
cellular response to hormone stimulus GO:0032870 247 0.029
regulation of purine nucleotide metabolic process GO:1900542 115 0.029
response to extracellular stimulus GO:0009991 380 0.029
nucleoside phosphate metabolic process GO:0006753 283 0.029
single organism catabolic process GO:0044712 283 0.029
regulation of nervous system development GO:0051960 264 0.029
central nervous system development GO:0007417 311 0.029
positive regulation of cell development GO:0010720 176 0.028
cytokine mediated signaling pathway GO:0019221 43 0.028
negative regulation of macromolecule metabolic process GO:0010605 260 0.028
macromolecule localization GO:0033036 252 0.028
Rat
regulation of neuron death GO:1901214 115 0.028
small gtpase mediated signal transduction GO:0007264 36 0.028
aromatic compound catabolic process GO:0019439 168 0.028
organic anion transport GO:0015711 132 0.027
regulation of apoptotic process GO:0042981 335 0.027
regulation of multicellular organismal development GO:2000026 376 0.027
purine ribonucleotide catabolic process GO:0009154 136 0.027
regulation of cellular extravasation GO:0002691 2 0.027
positive regulation of response to stimulus GO:0048584 285 0.027
negative regulation of signal transduction GO:0009968 83 0.027
Rat
regulation of protein modification process GO:0031399 194 0.027
positive regulation of cell differentiation GO:0045597 217 0.027
positive regulation of cell communication GO:0010647 271 0.027
cellular macromolecule localization GO:0070727 122 0.026
Rat
single organism intracellular transport GO:1902582 166 0.026
Rat
positive regulation of gene expression GO:0010628 244 0.026
response to vitamin GO:0033273 131 0.026
multicellular organismal reproductive process GO:0048609 233 0.025
response to nutrient GO:0007584 248 0.025
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.025
response to lipopolysaccharide GO:0032496 191 0.025
purine nucleoside triphosphate metabolic process GO:0009144 141 0.025
regulation of cell activation GO:0050865 50 0.025
protein complex assembly GO:0006461 263 0.025
cell adhesion GO:0007155 110 0.024
single organism nuclear import GO:1902593 35 0.024
Rat
multi organism reproductive process GO:0044703 262 0.024
macromolecular complex assembly GO:0065003 273 0.024
ion homeostasis GO:0050801 212 0.024
regulation of anatomical structure morphogenesis GO:0022603 141 0.024
regulation of cellular catabolic process GO:0031329 101 0.024
regulation of anatomical structure size GO:0090066 135 0.024
nucleobase containing compound catabolic process GO:0034655 152 0.024
cellular response to acid chemical GO:0071229 75 0.024
protein autophosphorylation GO:0046777 66 0.024
interleukin 12 production GO:0032615 3 0.024
metal ion homeostasis GO:0055065 186 0.024
negative regulation of transport GO:0051051 136 0.024
Rat
immune response GO:0006955 104 0.023
purine ribonucleoside metabolic process GO:0046128 168 0.023
ras protein signal transduction GO:0007265 29 0.023
heterocycle catabolic process GO:0046700 167 0.023
regulation of molecular function GO:0065009 398 0.023
response to hypoxia GO:0001666 231 0.022
glycosyl compound metabolic process GO:1901657 182 0.022
positive regulation of transcription dna templated GO:0045893 197 0.022
gastrulation GO:0007369 2 0.022
negative regulation of cellular response to insulin stimulus GO:1900077 11 0.022
positive regulation of cellular component organization GO:0051130 200 0.022
transcription from rna polymerase ii promoter GO:0006366 252 0.022
neuron apoptotic process GO:0051402 88 0.022
response to decreased oxygen levels GO:0036293 237 0.022
regulation of cell morphogenesis GO:0022604 77 0.022
regulation of neuron differentiation GO:0045664 208 0.022
response to amino acid GO:0043200 75 0.022
organic substance catabolic process GO:1901575 316 0.022
cellular component movement GO:0006928 248 0.022
head development GO:0060322 247 0.022
cellular protein localization GO:0034613 122 0.022
Rat
apoptotic process GO:0006915 381 0.022
positive regulation of cellular amine metabolic process GO:0033240 3 0.021
purine containing compound catabolic process GO:0072523 138 0.021
neuron death GO:0070997 127 0.021
nuclear transport GO:0051169 49 0.021
Rat
ion transmembrane transport GO:0034220 365 0.021
cellular response to biotic stimulus GO:0071216 59 0.021
protein heterooligomerization GO:0051291 89 0.021
positive regulation of neuron projection development GO:0010976 99 0.021
negative regulation of cellular metabolic process GO:0031324 281 0.021
ribose phosphate metabolic process GO:0019693 235 0.021
cellular chemical homeostasis GO:0055082 247 0.021
sexual reproduction GO:0019953 148 0.020
jnk cascade GO:0007254 28 0.020
purine nucleotide catabolic process GO:0006195 136 0.020
organelle organization GO:0006996 266 0.020
peptidyl amino acid modification GO:0018193 126 0.020
organic acid transport GO:0015849 116 0.020
regulation of programmed cell death GO:0043067 341 0.020
blood circulation GO:0008015 183 0.020
regulation of metal ion transport GO:0010959 118 0.020
divalent inorganic cation homeostasis GO:0072507 165 0.020
cellular response to lipid GO:0071396 201 0.020
cellular nitrogen compound catabolic process GO:0044270 163 0.020
cellular amino acid metabolic process GO:0006520 107 0.020
cellular homeostasis GO:0019725 252 0.019
nucleoside catabolic process GO:0009164 126 0.019
catabolic process GO:0009056 351 0.019
mesoderm development GO:0007498 2 0.019
oxoacid metabolic process GO:0043436 290 0.019
negative regulation of apoptotic process GO:0043066 181 0.019
purine ribonucleotide metabolic process GO:0009150 227 0.019
neuron projection morphogenesis GO:0048812 122 0.019
multicellular organism growth GO:0035264 1 0.019
glycosyl compound catabolic process GO:1901658 126 0.019
defense response GO:0006952 194 0.019
purine nucleotide metabolic process GO:0006163 229 0.019
secretion by cell GO:0032940 248 0.019
response to estrogen GO:0043627 232 0.019
positive regulation of protein phosphorylation GO:0001934 135 0.019
carboxylic acid metabolic process GO:0019752 289 0.018
negative regulation of response to stimulus GO:0048585 155 0.018
Rat
female sex differentiation GO:0046660 59 0.018
regulation of neurogenesis GO:0050767 247 0.018
cytokine production GO:0001816 61 0.018
response to amphetamine GO:0001975 25 0.018
insulin receptor signaling pathway GO:0008286 24 0.018
negative regulation of phosphate metabolic process GO:0045936 80 0.018
regulation of stress activated protein kinase signaling cascade GO:0070302 23 0.018
developmental process involved in reproduction GO:0003006 159 0.018
jak stat cascade GO:0007259 26 0.018
regulation of proteasomal protein catabolic process GO:0061136 4 0.018
organonitrogen compound biosynthetic process GO:1901566 167 0.018
cell projection morphogenesis GO:0048858 123 0.018
protein complex subunit organization GO:0071822 302 0.018
oxidation reduction process GO:0055114 304 0.018
secretion GO:0046903 307 0.017
nucleoside triphosphate catabolic process GO:0009143 123 0.017
regulation of cell differentiation GO:0045595 320 0.017
response to alkaloid GO:0043279 132 0.017
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.017
actin cytoskeleton organization GO:0030036 73 0.017
negative regulation of cell communication GO:0010648 158 0.017
Rat
protein complex biogenesis GO:0070271 263 0.017
biological adhesion GO:0022610 110 0.017
positive regulation of cellular catabolic process GO:0031331 71 0.017
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.017
purine nucleoside metabolic process GO:0042278 169 0.017
purine nucleoside triphosphate catabolic process GO:0009146 122 0.017
cytokine biosynthetic process GO:0042089 3 0.017
regulation of protein phosphorylation GO:0001932 183 0.017
protein localization GO:0008104 191 0.017
Rat
response to ethanol GO:0045471 162 0.016
ribonucleotide catabolic process GO:0009261 136 0.016
actin filament organization GO:0007015 42 0.016
regulation of catabolic process GO:0009894 113 0.016
regulation of intracellular transport GO:0032386 65 0.016
Rat
protein oligomerization GO:0051259 191 0.016
defense response to other organism GO:0098542 17 0.016
organic hydroxy compound metabolic process GO:1901615 115 0.016
salivary gland development GO:0007431 3 0.016
response to nutrient levels GO:0031667 370 0.016
cytoplasmic transport GO:0016482 115 0.016
Rat
protein phosphorylation GO:0006468 345 0.016
regulation of catalytic activity GO:0050790 304 0.016
ribonucleoside metabolic process GO:0009119 174 0.016
response to bacterium GO:0009617 200 0.016
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.016
regulation of vesicle mediated transport GO:0060627 81 0.016
nucleoside triphosphate metabolic process GO:0009141 144 0.016
synaptic growth at neuromuscular junction GO:0051124 1 0.016
positive regulation of protein modification process GO:0031401 142 0.016
regulation of neuron projection development GO:0010975 161 0.016
regulation of nucleoside metabolic process GO:0009118 66 0.015
reactive oxygen species biosynthetic process GO:1903409 8 0.015
protein import into nucleus GO:0006606 35 0.015
Rat
regulation of protein complex assembly GO:0043254 33 0.015
neuronal action potential GO:0019228 35 0.015
monovalent inorganic cation transport GO:0015672 172 0.015
purine nucleoside catabolic process GO:0006152 124 0.015
response to radiation GO:0009314 137 0.015
peptidyl tyrosine phosphorylation GO:0018108 72 0.015
regulation of cell projection organization GO:0031344 175 0.015
motor neuron axon guidance GO:0008045 1 0.015
cellular response to molecule of bacterial origin GO:0071219 56 0.015
negative regulation of nervous system development GO:0051961 79 0.015
nucleotide catabolic process GO:0009166 139 0.015
ribonucleoside triphosphate metabolic process GO:0009199 141 0.015
gtp metabolic process GO:0046039 72 0.015
leukocyte chemotaxis GO:0030595 22 0.015
nucleoside metabolic process GO:0009116 179 0.015
neuron development GO:0048666 286 0.015
calcium ion homeostasis GO:0055074 162 0.015
regulation of mapk cascade GO:0043408 116 0.015
divalent metal ion transport GO:0070838 132 0.015
positive regulation of developmental process GO:0051094 283 0.014
positive regulation of mapk cascade GO:0043410 92 0.014
neurological system process GO:0050877 219 0.014
homeostatic process GO:0042592 331 0.014
vascular process in circulatory system GO:0003018 96 0.014
stress activated protein kinase signaling cascade GO:0031098 37 0.014
regulation of nucleotide metabolic process GO:0006140 117 0.014
axon development GO:0061564 96 0.014
ribonucleoside triphosphate catabolic process GO:0009203 122 0.014
response to peptidoglycan GO:0032494 1 0.014
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.014
circulatory system process GO:0003013 183 0.014
positive regulation of jnk cascade GO:0046330 13 0.014
positive regulation of cellular protein metabolic process GO:0032270 167 0.014
response to mechanical stimulus GO:0009612 134 0.014
negative regulation of multicellular organismal process GO:0051241 203 0.014
sequestering of calcium ion GO:0051208 8 0.014
intracellular protein transport GO:0006886 79 0.014
Rat
regulation of cell development GO:0060284 263 0.014
behavior GO:0007610 205 0.014
stress activated mapk cascade GO:0051403 35 0.014
gliogenesis GO:0042063 93 0.014
regulation of system process GO:0044057 208 0.014
sequestering of metal ion GO:0051238 9 0.014
axis specification GO:0009798 4 0.014
response to metal ion GO:0010038 253 0.014
cellular response to interleukin 1 GO:0071347 37 0.014
single organism biosynthetic process GO:0044711 342 0.014
negative regulation of signaling GO:0023057 157 0.014
Rat
regulation of stress activated mapk cascade GO:0032872 23 0.014
immune system process GO:0002376 204 0.013
regulation of vasoconstriction GO:0019229 44 0.013
reactive nitrogen species metabolic process GO:2001057 1 0.013
ribonucleoside catabolic process GO:0042454 126 0.013
nucleoside phosphate catabolic process GO:1901292 140 0.013
regulation of organelle organization GO:0033043 80 0.013
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.013
cellular ion homeostasis GO:0006873 184 0.013
response to oxygen levels GO:0070482 265 0.013
regulation of sequence specific dna binding transcription factor activity GO:0051090 35 0.013
response to insulin GO:0032868 133 0.013
response to ketone GO:1901654 182 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.013
locomotion GO:0040011 237 0.013
erk1 and erk2 cascade GO:0070371 48 0.013
reactive oxygen species metabolic process GO:0072593 37 0.012
regulation of growth GO:0040008 105 0.012
rho protein signal transduction GO:0007266 11 0.012
regulation of cellular component biogenesis GO:0044087 86 0.012
positive regulation of hydrolase activity GO:0051345 86 0.012
negative regulation of programmed cell death GO:0043069 183 0.012
chromosome segregation GO:0007059 2 0.012
single organism cellular localization GO:1902580 102 0.012
Rat
positive regulation of secretion GO:0051047 140 0.012
response to corticosteroid GO:0031960 235 0.012
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.012
b cell differentiation GO:0030183 2 0.012
regulation of protein localization GO:0032880 81 0.012
Rat
axonogenesis GO:0007409 71 0.012
response to growth factor GO:0070848 189 0.012
tissue development GO:0009888 252 0.012
regulation of blood circulation GO:1903522 110 0.012
positive regulation of protein transport GO:0051222 41 0.012
positive regulation of neuron differentiation GO:0045666 126 0.012
regulation of arp2 3 complex mediated actin nucleation GO:0034315 2 0.012
negative regulation of protein metabolic process GO:0051248 114 0.012
response to organophosphorus GO:0046683 102 0.012
lipid storage GO:0019915 1 0.012
regulation of jnk cascade GO:0046328 19 0.012
localization of cell GO:0051674 202 0.012
inflammatory response GO:0006954 150 0.011
regulation of nucleocytoplasmic transport GO:0046822 28 0.011
Rat
positive regulation of cellular component biogenesis GO:0044089 55 0.011
organophosphate catabolic process GO:0046434 148 0.011
dephosphorylation GO:0016311 98 0.011
transmembrane transport GO:0055085 412 0.011
regulation of odontogenesis of dentin containing tooth GO:0042487 2 0.011
positive regulation of cytokine production GO:0001819 42 0.011
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.011
negative regulation of neuron apoptotic process GO:0043524 45 0.011
cell cycle GO:0007049 101 0.011
positive regulation of cell death GO:0010942 184 0.011
positive regulation of nucleotide metabolic process GO:0045981 91 0.011
response to ammonium ion GO:0060359 71 0.011
regulation of anion transport GO:0044070 43 0.011
developmental growth GO:0048589 100 0.011
negative regulation of cell death GO:0060548 229 0.011
negative regulation of molecular function GO:0044092 133 0.011
anterior posterior pattern specification GO:0009952 1 0.011
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.011
response to interleukin 1 GO:0070555 55 0.011
cellular cation homeostasis GO:0030003 180 0.011
regulation of protein serine threonine kinase activity GO:0071900 64 0.011
actin filament based process GO:0030029 86 0.011
single organism carbohydrate metabolic process GO:0044723 118 0.010
regulation of sister chromatid segregation GO:0033045 1 0.010
positive regulation of cell projection organization GO:0031346 111 0.010
vasoconstriction GO:0042310 54 0.010
carbohydrate derivative biosynthetic process GO:1901137 124 0.010
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 1 0.010
regulation of cellular component size GO:0032535 51 0.010
positive regulation of gtp catabolic process GO:0033126 48 0.010
positive regulation of catalytic activity GO:0043085 184 0.010
response to amine GO:0014075 46 0.010
glycosaminoglycan biosynthetic process GO:0006024 4 0.010
positive regulation of intracellular transport GO:0032388 39 0.010
regulation of hormone levels GO:0010817 187 0.010
protein localization to organelle GO:0033365 57 0.010
Rat
cell migration GO:0016477 197 0.010
cell part morphogenesis GO:0032990 123 0.010
negative regulation of insulin receptor signaling pathway GO:0046627 10 0.010
purine ribonucleoside catabolic process GO:0046130 124 0.010
maintenance of location GO:0051235 17 0.010
Rat
negative regulation of cellular component organization GO:0051129 83 0.010
regulation of hydrolase activity GO:0051336 143 0.010
negative regulation of phosphorus metabolic process GO:0010563 80 0.010
potassium ion transport GO:0006813 97 0.010
female gonad development GO:0008585 53 0.010
regulation of cytoskeleton organization GO:0051493 49 0.010
positive regulation of programmed cell death GO:0043068 157 0.010
negative regulation of neuron death GO:1901215 69 0.010

Nfkbie disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.018
cancer DOID:162 0 0.015
organ system cancer DOID:0050686 0 0.015
disease of anatomical entity DOID:7 0 0.013
musculoskeletal system disease DOID:17 0 0.013