|
|
negative regulation of cellular macromolecule biosynthetic process
|
GO:2000113 |
141 |
0.572
|
Mouse |
|
|
rna metabolic process
|
GO:0016070 |
406 |
0.164
|
Mouse |
|
|
negative regulation of metabolic process
|
GO:0009892 |
331 |
0.162
|
Mouse |
|
|
negative regulation of cellular biosynthetic process
|
GO:0031327 |
161 |
0.156
|
Mouse |
|
|
nucleic acid templated transcription
|
GO:0097659 |
379 |
0.142
|
Mouse |
|
|
negative regulation of nitrogen compound metabolic process
|
GO:0051172 |
161 |
0.138
|
Mouse |
|
|
negative regulation of macromolecule biosynthetic process
|
GO:0010558 |
148 |
0.131
|
Mouse |
|
|
single organism reproductive process
|
GO:0044702 |
297 |
0.096
|
|
|
|
rna biosynthetic process
|
GO:0032774 |
380 |
0.094
|
Mouse |
|
|
negative regulation of rna splicing
|
GO:0033119 |
3 |
0.091
|
|
|
|
negative regulation of gene expression
|
GO:0010629 |
199 |
0.090
|
Mouse |
|
|
regulation of transcription dna templated
|
GO:0006355 |
374 |
0.086
|
Mouse |
|
|
negative regulation of macromolecule metabolic process
|
GO:0010605 |
260 |
0.084
|
Mouse |
|
|
regulation of cell proliferation
|
GO:0042127 |
359 |
0.074
|
|
|
|
negative regulation of rna biosynthetic process
|
GO:1902679 |
118 |
0.073
|
Mouse |
|
|
negative regulation of rna metabolic process
|
GO:0051253 |
123 |
0.073
|
Mouse |
|
|
central nervous system development
|
GO:0007417 |
311 |
0.071
|
|
|
|
regulation of cellular protein metabolic process
|
GO:0032268 |
267 |
0.064
|
|
|
|
regulation of nucleic acid templated transcription
|
GO:1903506 |
380 |
0.063
|
Mouse |
|
|
regulation of rna biosynthetic process
|
GO:2001141 |
381 |
0.060
|
Mouse |
|
|
multi organism reproductive process
|
GO:0044703 |
262 |
0.059
|
Fly |
|
|
negative regulation of nucleic acid templated transcription
|
GO:1903507 |
117 |
0.058
|
Mouse |
|
|
developmental process involved in reproduction
|
GO:0003006 |
159 |
0.057
|
|
|
|
head development
|
GO:0060322 |
247 |
0.056
|
|
|
|
reproductive process
|
GO:0022414 |
372 |
0.054
|
Fly |
|
|
negative regulation of transcription dna templated
|
GO:0045892 |
116 |
0.054
|
Mouse |
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
37 |
0.053
|
|
|
|
cell cycle process
|
GO:0022402 |
57 |
0.053
|
|
|
|
brain development
|
GO:0007420 |
247 |
0.052
|
|
|
|
positive regulation of signaling
|
GO:0023056 |
270 |
0.052
|
|
|
|
response to lipopolysaccharide
|
GO:0032496 |
191 |
0.050
|
|
|
|
negative regulation of cellular metabolic process
|
GO:0031324 |
281 |
0.050
|
Mouse |
|
|
dna metabolic process
|
GO:0006259 |
96 |
0.049
|
|
|
|
regulation of transcription from rna polymerase ii promoter
|
GO:0006357 |
234 |
0.049
|
|
|
|
negative regulation of biosynthetic process
|
GO:0009890 |
168 |
0.048
|
Mouse |
|
|
organic acid metabolic process
|
GO:0006082 |
292 |
0.046
|
|
|
|
carboxylic acid metabolic process
|
GO:0019752 |
289 |
0.045
|
|
|
|
apoptotic process
|
GO:0006915 |
381 |
0.045
|
Human |
|
|
rhythmic process
|
GO:0048511 |
156 |
0.045
|
|
|
|
translation
|
GO:0006412 |
35 |
0.044
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
157 |
0.042
|
|
|
|
response to extracellular stimulus
|
GO:0009991 |
380 |
0.042
|
|
|
|
mrna stabilization
|
GO:0048255 |
2 |
0.041
|
|
|
|
macromolecule localization
|
GO:0033036 |
252 |
0.039
|
|
|
|
positive regulation of signal transduction
|
GO:0009967 |
175 |
0.039
|
|
|
|
positive regulation of cellular biosynthetic process
|
GO:0031328 |
295 |
0.039
|
|
|
|
positive regulation of cellular protein metabolic process
|
GO:0032270 |
167 |
0.039
|
|
|
|
positive regulation of response to stimulus
|
GO:0048584 |
285 |
0.038
|
|
|
|
negative regulation of nucleobase containing compound metabolic process
|
GO:0045934 |
153 |
0.038
|
Mouse |
|
|
nitrogen compound transport
|
GO:0071705 |
229 |
0.038
|
|
|
|
positive regulation of protein metabolic process
|
GO:0051247 |
178 |
0.037
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
49 |
0.037
|
|
|
|
positive regulation of biosynthetic process
|
GO:0009891 |
319 |
0.037
|
|
|
|
regulation of protein metabolic process
|
GO:0051246 |
289 |
0.036
|
|
|
|
transcription from rna polymerase ii promoter
|
GO:0006366 |
252 |
0.036
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
184 |
0.035
|
|
|
|
response to molecule of bacterial origin
|
GO:0002237 |
194 |
0.035
|
|
|
|
positive regulation of macromolecule biosynthetic process
|
GO:0010557 |
247 |
0.034
|
|
|
|
intracellular signal transduction
|
GO:0035556 |
314 |
0.034
|
Human |
|
|
positive regulation of cell proliferation
|
GO:0008284 |
249 |
0.034
|
|
|
|
chromatin assembly or disassembly
|
GO:0006333 |
1 |
0.034
|
|
|
|
response to nutrient levels
|
GO:0031667 |
370 |
0.034
|
|
|
|
response to heat
|
GO:0009408 |
60 |
0.033
|
|
|
|
oxoacid metabolic process
|
GO:0043436 |
290 |
0.033
|
|
|
|
protein homooligomerization
|
GO:0051260 |
91 |
0.032
|
|
|
|
positive regulation of multicellular organismal process
|
GO:0051240 |
387 |
0.030
|
|
|
|
programmed cell death
|
GO:0012501 |
392 |
0.030
|
Human |
|
|
positive regulation of cell communication
|
GO:0010647 |
271 |
0.030
|
|
|
|
cell morphogenesis involved in differentiation
|
GO:0000904 |
119 |
0.030
|
|
|
|
positive regulation of gene expression
|
GO:0010628 |
244 |
0.030
|
|
|
|
multicellular organism reproduction
|
GO:0032504 |
233 |
0.029
|
Fly |
|
|
positive regulation of rna metabolic process
|
GO:0051254 |
203 |
0.029
|
|
|
|
regulation of apoptotic process
|
GO:0042981 |
335 |
0.029
|
Human |
|
|
immune system process
|
GO:0002376 |
204 |
0.028
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
320 |
0.028
|
|
|
|
development of primary sexual characteristics
|
GO:0045137 |
107 |
0.027
|
|
|
|
cell cycle
|
GO:0007049 |
101 |
0.027
|
|
|
|
regulation of gene expression epigenetic
|
GO:0040029 |
10 |
0.027
|
|
|
|
reproductive system development
|
GO:0061458 |
128 |
0.026
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
283 |
0.026
|
|
|
|
transcription dna templated
|
GO:0006351 |
377 |
0.026
|
Mouse |
|
|
cellular component assembly
|
GO:0022607 |
360 |
0.026
|
|
|
|
nucleosome organization
|
GO:0034728 |
1 |
0.025
|
|
|
|
circadian rhythm
|
GO:0007623 |
88 |
0.025
|
|
|
|
positive regulation of nitrogen compound metabolic process
|
GO:0051173 |
334 |
0.025
|
|
|
|
chromosome segregation
|
GO:0007059 |
2 |
0.025
|
|
|
|
reproductive structure development
|
GO:0048608 |
128 |
0.025
|
|
|
|
response to other organism
|
GO:0051707 |
220 |
0.025
|
|
|
|
fatty acid metabolic process
|
GO:0006631 |
99 |
0.024
|
|
|
|
amine metabolic process
|
GO:0009308 |
38 |
0.024
|
|
|
|
gamete generation
|
GO:0007276 |
124 |
0.024
|
|
|
|
lipid metabolic process
|
GO:0006629 |
283 |
0.024
|
|
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
377 |
0.023
|
|
|
|
carbohydrate metabolic process
|
GO:0005975 |
130 |
0.022
|
|
|
|
intracellular transport
|
GO:0046907 |
185 |
0.022
|
|
|
|
neuron projection development
|
GO:0031175 |
273 |
0.022
|
|
|
|
positive regulation of cell differentiation
|
GO:0045597 |
217 |
0.022
|
|
|
|
cellular response to stress
|
GO:0033554 |
269 |
0.022
|
Human |
|
|
protein complex biogenesis
|
GO:0070271 |
263 |
0.022
|
|
|
|
regulation of signal transduction
|
GO:0009966 |
318 |
0.022
|
Human |
|
|
positive regulation of apoptotic process
|
GO:0043065 |
154 |
0.022
|
|
|
|
positive regulation of cell development
|
GO:0010720 |
176 |
0.021
|
|
|
|
multicellular organismal reproductive process
|
GO:0048609 |
233 |
0.021
|
Fly |
|
|
positive regulation of transcription dna templated
|
GO:0045893 |
197 |
0.021
|
|
|
|
macromolecular complex assembly
|
GO:0065003 |
273 |
0.020
|
|
|
|
regulation of rna metabolic process
|
GO:0051252 |
391 |
0.020
|
Mouse |
|
|
positive regulation of transcription from rna polymerase ii promoter
|
GO:0045944 |
148 |
0.019
|
|
|
|
positive regulation of rna biosynthetic process
|
GO:1902680 |
197 |
0.019
|
|
|
|
regulation of molecular function
|
GO:0065009 |
398 |
0.019
|
|
|
|
regulation of alternative mrna splicing via spliceosome
|
GO:0000381 |
2 |
0.019
|
|
|
|
regulation of hormone levels
|
GO:0010817 |
187 |
0.019
|
|
|
|
regulation of programmed cell death
|
GO:0043067 |
341 |
0.019
|
Human |
|
|
hair follicle development
|
GO:0001942 |
2 |
0.019
|
|
|
|
positive regulation of intracellular signal transduction
|
GO:1902533 |
138 |
0.018
|
|
|
|
regulation of neurogenesis
|
GO:0050767 |
247 |
0.018
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
27 |
0.018
|
|
|
|
protein complex assembly
|
GO:0006461 |
263 |
0.018
|
|
|
|
cellular response to organic cyclic compound
|
GO:0071407 |
202 |
0.018
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
51 |
0.018
|
|
|
|
sexual reproduction
|
GO:0019953 |
148 |
0.018
|
Fly |
|
|
gonad development
|
GO:0008406 |
104 |
0.017
|
|
|
|
male sex differentiation
|
GO:0046661 |
64 |
0.017
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
38 |
0.017
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
8 |
0.017
|
|
|
|
positive regulation of nucleic acid templated transcription
|
GO:1903508 |
197 |
0.017
|
|
|
|
sex differentiation
|
GO:0007548 |
113 |
0.017
|
|
|
|
nucleobase containing small molecule metabolic process
|
GO:0055086 |
316 |
0.017
|
|
|
|
organelle organization
|
GO:0006996 |
266 |
0.016
|
|
|
|
hormone secretion
|
GO:0046879 |
115 |
0.016
|
|
|
|
chromatin remodeling
|
GO:0006338 |
3 |
0.016
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
3 |
0.016
|
|
|
|
response to peptide
|
GO:1901652 |
292 |
0.016
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
107 |
0.016
|
|
|
|
forebrain development
|
GO:0030900 |
98 |
0.016
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
2 |
0.015
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
1 |
0.015
|
|
|
|
cofactor metabolic process
|
GO:0051186 |
95 |
0.015
|
|
|
|
ion transmembrane transport
|
GO:0034220 |
365 |
0.015
|
|
|
|
cellular response to hormone stimulus
|
GO:0032870 |
247 |
0.015
|
|
|
|
regulation of canonical wnt signaling pathway
|
GO:0060828 |
4 |
0.015
|
|
|
|
positive regulation of protein modification process
|
GO:0031401 |
142 |
0.015
|
|
|
|
response to bacterium
|
GO:0009617 |
200 |
0.015
|
|
|
|
positive regulation of nucleobase containing compound metabolic process
|
GO:0045935 |
319 |
0.015
|
|
|
|
cellular homeostasis
|
GO:0019725 |
252 |
0.015
|
|
|
|
cell morphogenesis
|
GO:0000902 |
142 |
0.015
|
|
|
|
glycosyl compound metabolic process
|
GO:1901657 |
182 |
0.015
|
|
|
|
positive regulation of nervous system development
|
GO:0051962 |
178 |
0.014
|
|
|
|
single organism organelle organization
|
GO:1902589 |
180 |
0.014
|
|
|
|
reproduction
|
GO:0000003 |
245 |
0.014
|
Worm Fly |
|
|
regulation of protein modification process
|
GO:0031399 |
194 |
0.014
|
|
|
|
cell projection organization
|
GO:0030030 |
302 |
0.014
|
|
|
|
multicellular organism growth
|
GO:0035264 |
1 |
0.014
|
|
|
|
positive regulation of cellular component organization
|
GO:0051130 |
200 |
0.014
|
|
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
197 |
0.014
|
|
|
|
positive regulation of neuron differentiation
|
GO:0045666 |
126 |
0.014
|
|
|
|
peptide transport
|
GO:0015833 |
97 |
0.014
|
|
|
|
regulation of secretion
|
GO:0051046 |
224 |
0.014
|
|
|
|
carbohydrate derivative metabolic process
|
GO:1901135 |
346 |
0.014
|
|
|
|
cellular response to nitrogen compound
|
GO:1901699 |
210 |
0.014
|
|
|
|
cell cycle checkpoint
|
GO:0000075 |
2 |
0.014
|
|
|
|
regulation of cellular component organization
|
GO:0051128 |
368 |
0.014
|
|
|
|
rna processing
|
GO:0006396 |
22 |
0.014
|
|
|
|
regulation of jak stat cascade
|
GO:0046425 |
21 |
0.014
|
|
|
|
rna localization
|
GO:0006403 |
4 |
0.014
|
|
|
|
spermatogenesis
|
GO:0007283 |
99 |
0.014
|
|
|
|
immune response
|
GO:0006955 |
104 |
0.013
|
|
|
|
cellular calcium ion homeostasis
|
GO:0006874 |
160 |
0.013
|
|
|
|
positive regulation of cell projection organization
|
GO:0031346 |
111 |
0.013
|
|
|
|
secretion
|
GO:0046903 |
307 |
0.013
|
|
|
|
development of primary female sexual characteristics
|
GO:0046545 |
56 |
0.013
|
|
|
|
axis specification
|
GO:0009798 |
4 |
0.013
|
|
|
|
protein oligomerization
|
GO:0051259 |
191 |
0.013
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
162 |
0.013
|
|
|
|
male gonad development
|
GO:0008584 |
59 |
0.013
|
|
|
|
response to inorganic substance
|
GO:0010035 |
377 |
0.013
|
|
|
|
regulation of response to stress
|
GO:0080134 |
126 |
0.013
|
Human |
|
|
male gamete generation
|
GO:0048232 |
99 |
0.013
|
|
|
|
organ regeneration
|
GO:0031100 |
101 |
0.013
|
|
|
|
signal release
|
GO:0023061 |
145 |
0.013
|
|
|
|
response to estrogen
|
GO:0043627 |
232 |
0.012
|
|
|
|
regulation of cell projection organization
|
GO:0031344 |
175 |
0.012
|
|
|
|
alternative mrna splicing via spliceosome
|
GO:0000380 |
4 |
0.012
|
|
|
|
embryonic pattern specification
|
GO:0009880 |
1 |
0.012
|
|
|
|
regulation of cellular localization
|
GO:0060341 |
263 |
0.012
|
|
|
|
regulation of neuron differentiation
|
GO:0045664 |
208 |
0.012
|
|
|
|
response to ethanol
|
GO:0045471 |
162 |
0.012
|
|
|
|
cellular metal ion homeostasis
|
GO:0006875 |
172 |
0.012
|
|
|
|
response to growth factor
|
GO:0070848 |
189 |
0.012
|
|
|
|
protein localization
|
GO:0008104 |
191 |
0.012
|
|
|
|
response to alkaloid
|
GO:0043279 |
132 |
0.012
|
|
|
|
rna stabilization
|
GO:0043489 |
2 |
0.012
|
|
|
|
regulation of cell development
|
GO:0060284 |
263 |
0.012
|
|
|
|
hormone transport
|
GO:0009914 |
121 |
0.012
|
|
|
|
cellular chemical homeostasis
|
GO:0055082 |
247 |
0.012
|
|
|
|
cell morphogenesis involved in neuron differentiation
|
GO:0048667 |
106 |
0.012
|
|
|
|
negative regulation of transport
|
GO:0051051 |
136 |
0.012
|
|
|
|
aromatic compound catabolic process
|
GO:0019439 |
168 |
0.011
|
|
|
|
activation of cysteine type endopeptidase activity
|
GO:0097202 |
4 |
0.011
|
|
|
|
response to nutrient
|
GO:0007584 |
248 |
0.011
|
|
|
|
tongue morphogenesis
|
GO:0043587 |
3 |
0.011
|
|
|
|
regulation of response to external stimulus
|
GO:0032101 |
106 |
0.011
|
|
|
|
cellular component biogenesis
|
GO:0044085 |
368 |
0.011
|
|
|
|
positive regulation of neuron projection development
|
GO:0010976 |
99 |
0.011
|
|
|
|
peptide hormone secretion
|
GO:0030072 |
84 |
0.011
|
|
|
|
protein complex subunit organization
|
GO:0071822 |
302 |
0.011
|
|
|
|
response to decreased oxygen levels
|
GO:0036293 |
237 |
0.011
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
73 |
0.011
|
|
|
|
response to ionizing radiation
|
GO:0010212 |
59 |
0.011
|
|
|
|
negative regulation of cell communication
|
GO:0010648 |
158 |
0.011
|
Human |
|
|
alpha amino acid metabolic process
|
GO:1901605 |
71 |
0.011
|
|
|
|
response to peptide hormone
|
GO:0043434 |
278 |
0.011
|
|
|
|
response to radiation
|
GO:0009314 |
137 |
0.011
|
|
|
|
response to biotic stimulus
|
GO:0009607 |
226 |
0.011
|
|
|
|
response to external biotic stimulus
|
GO:0043207 |
221 |
0.011
|
|
|
|
female sex differentiation
|
GO:0046660 |
59 |
0.011
|
|
|
|
response to oxygen levels
|
GO:0070482 |
265 |
0.011
|
|
|
|
regulation of growth
|
GO:0040008 |
105 |
0.011
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
127 |
0.011
|
|
|
|
positive regulation of neurogenesis
|
GO:0050769 |
165 |
0.011
|
|
|
|
cellular macromolecule localization
|
GO:0070727 |
122 |
0.011
|
|
|
|
response to metal ion
|
GO:0010038 |
253 |
0.011
|
|
|
|
organonitrogen compound biosynthetic process
|
GO:1901566 |
167 |
0.011
|
|
|
|
growth
|
GO:0040007 |
165 |
0.010
|
Worm |
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
114 |
0.010
|
|
|
|
regulation of intracellular signal transduction
|
GO:1902531 |
218 |
0.010
|
Human |
|
|
response to temperature stimulus
|
GO:0009266 |
94 |
0.010
|
|
|
|
neuron differentiation
|
GO:0030182 |
368 |
0.010
|
|
|
|
regulation of mrna stability
|
GO:0043488 |
3 |
0.010
|
|
|
|
response to cytokine
|
GO:0034097 |
215 |
0.010
|
|
|
|
bmp signaling pathway
|
GO:0030509 |
4 |
0.010
|
|
|
|
cellular process involved in reproduction in multicellular organism
|
GO:0022412 |
35 |
0.010
|
|
|
|
organic acid biosynthetic process
|
GO:0016053 |
83 |
0.010
|
|
|
|
appendage morphogenesis
|
GO:0035107 |
4 |
0.010
|
|