Rattus norvegicus

278 known processes

Sirt1

sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)

(Aliases: Sir2)

Sirt1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
organic acid metabolic process GO:0006082 292 0.056
carboxylic acid metabolic process GO:0019752 289 0.052
oxoacid metabolic process GO:0043436 290 0.049
regulation of cellular ketone metabolic process GO:0010565 27 0.047
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.044
rna metabolic process GO:0016070 406 0.044
response to extracellular stimulus GO:0009991 380 0.042
response to nutrient levels GO:0031667 370 0.041
cellular ketone metabolic process GO:0042180 51 0.041
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.040
positive regulation of cellular biosynthetic process GO:0031328 295 0.040
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.040
regulation of transcription dna templated GO:0006355 374 0.039
transcription dna templated GO:0006351 377 0.037
positive regulation of rna biosynthetic process GO:1902680 197 0.037
regulation of rna metabolic process GO:0051252 391 0.037
oxidation reduction process GO:0055114 304 0.036
regulation of nucleic acid templated transcription GO:1903506 380 0.036
nucleic acid templated transcription GO:0097659 379 0.035
cellular amino acid metabolic process GO:0006520 107 0.035
rna biosynthetic process GO:0032774 380 0.035
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.034
cellular response to oxygen containing compound GO:1901701 386 0.034
cellular amine metabolic process GO:0044106 38 0.034
cellular response to endogenous stimulus GO:0071495 377 0.034
regulation of rna biosynthetic process GO:2001141 381 0.033
regulation of phosphate metabolic process GO:0019220 349 0.033
response to inorganic substance GO:0010035 377 0.033
regulation of cellular amino acid metabolic process GO:0006521 2 0.032
single organism biosynthetic process GO:0044711 342 0.032
catabolic process GO:0009056 351 0.031
carbohydrate derivative metabolic process GO:1901135 346 0.030
positive regulation of rna metabolic process GO:0051254 203 0.030
regulation of cellular amine metabolic process GO:0033238 8 0.029
single organism catabolic process GO:0044712 283 0.029
positive regulation of gene expression GO:0010628 244 0.028
transcription from rna polymerase ii promoter GO:0006366 252 0.028
negative regulation of metabolic process GO:0009892 331 0.028
regulation of molecular function GO:0065009 398 0.028
cellular response to nitrogen compound GO:1901699 210 0.028
regulation of programmed cell death GO:0043067 341 0.027
organophosphate metabolic process GO:0019637 370 0.027
regulation of phosphorus metabolic process GO:0051174 349 0.027
nucleobase containing small molecule metabolic process GO:0055086 316 0.027
response to glucocorticoid GO:0051384 223 0.026
response to oxygen levels GO:0070482 265 0.026
response to acid chemical GO:0001101 222 0.026
positive regulation of biosynthetic process GO:0009891 319 0.026
organic substance catabolic process GO:1901575 316 0.026
purine containing compound metabolic process GO:0072521 253 0.026
positive regulation of transcription dna templated GO:0045893 197 0.026
regulation of cellular component organization GO:0051128 368 0.025
regulation of apoptotic process GO:0042981 335 0.025
response to nutrient GO:0007584 248 0.025
transmembrane transport GO:0055085 412 0.025
regulation of cell proliferation GO:0042127 359 0.025
positive regulation of nucleic acid templated transcription GO:1903508 197 0.025
amine metabolic process GO:0009308 38 0.025
lipid metabolic process GO:0006629 283 0.025
response to corticosteroid GO:0031960 235 0.024
positive regulation of molecular function GO:0044093 230 0.024
positive regulation of phosphate metabolic process GO:0045937 262 0.024
regulation of signal transduction GO:0009966 318 0.023
apoptotic process GO:0006915 381 0.023
carbohydrate metabolic process GO:0005975 130 0.023
monocarboxylic acid metabolic process GO:0032787 152 0.023
secretion GO:0046903 307 0.023
cellular response to stress GO:0033554 269 0.023
nucleoside phosphate metabolic process GO:0006753 283 0.023
cellular component assembly GO:0022607 360 0.022
positive regulation of cell proliferation GO:0008284 249 0.022
positive regulation of phosphorus metabolic process GO:0010562 262 0.022
response to decreased oxygen levels GO:0036293 237 0.022
ion transmembrane transport GO:0034220 365 0.022
response to hypoxia GO:0001666 231 0.021
regulation of protein metabolic process GO:0051246 289 0.021
cellular response to hormone stimulus GO:0032870 247 0.021
ribose phosphate metabolic process GO:0019693 235 0.021
regulation of nervous system development GO:0051960 264 0.021
cellular response to lipid GO:0071396 201 0.021
purine nucleotide metabolic process GO:0006163 229 0.021
cellular component biogenesis GO:0044085 368 0.021
regulation of homeostatic process GO:0032844 101 0.021
single organism carbohydrate metabolic process GO:0044723 118 0.020
intracellular signal transduction GO:0035556 314 0.020
ribonucleotide metabolic process GO:0009259 231 0.020
single organism reproductive process GO:0044702 297 0.020
purine ribonucleotide metabolic process GO:0009150 227 0.020
regulation of secretion GO:0051046 224 0.019
purine nucleoside metabolic process GO:0042278 169 0.019
positive regulation of developmental process GO:0051094 283 0.019
homeostatic process GO:0042592 331 0.019
neuron differentiation GO:0030182 368 0.019
regulation of neurogenesis GO:0050767 247 0.019
ribonucleoside metabolic process GO:0009119 174 0.019
protein phosphorylation GO:0006468 345 0.019
negative regulation of cell death GO:0060548 229 0.019
response to oxidative stress GO:0006979 186 0.019
cell projection organization GO:0030030 302 0.019
negative regulation of cellular metabolic process GO:0031324 281 0.019
purine ribonucleoside metabolic process GO:0046128 168 0.019
cellular carbohydrate metabolic process GO:0044262 72 0.018
cellular catabolic process GO:0044248 295 0.018
regulation of ion transport GO:0043269 245 0.018
positive regulation of cellular amine metabolic process GO:0033240 3 0.018
regulation of secretion by cell GO:1903530 208 0.018
response to cytokine GO:0034097 215 0.018
negative regulation of macromolecule metabolic process GO:0010605 260 0.018
ion homeostasis GO:0050801 212 0.018
glycosyl compound metabolic process GO:1901657 182 0.018
programmed cell death GO:0012501 392 0.018
chemical homeostasis GO:0048878 292 0.018
cellular homeostasis GO:0019725 252 0.017
macromolecular complex assembly GO:0065003 273 0.017
multi organism reproductive process GO:0044703 262 0.017
positive regulation of cellular component organization GO:0051130 200 0.017
cell cell signaling GO:0007267 335 0.017
regulation of cell development GO:0060284 263 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.017
nucleoside metabolic process GO:0009116 179 0.017
regulation of hormone levels GO:0010817 187 0.017
response to peptide hormone GO:0043434 278 0.017
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.017
response to vitamin GO:0033273 131 0.017
regulation of cell differentiation GO:0045595 320 0.017
positive regulation of signaling GO:0023056 270 0.017
nucleotide metabolic process GO:0009117 279 0.017
cellular chemical homeostasis GO:0055082 247 0.017
regulation of membrane potential GO:0042391 110 0.017
rhythmic process GO:0048511 156 0.017
positive regulation of cell communication GO:0010647 271 0.017
protein complex biogenesis GO:0070271 263 0.017
response to carbohydrate GO:0009743 183 0.016
regulation of cellular localization GO:0060341 263 0.016
positive regulation of cellular protein metabolic process GO:0032270 167 0.016
neuron projection development GO:0031175 273 0.016
response to hexose GO:0009746 144 0.016
response to ethanol GO:0045471 162 0.016
regulation of catalytic activity GO:0050790 304 0.016
organelle organization GO:0006996 266 0.016
positive regulation of multicellular organismal process GO:0051240 387 0.016
protein complex subunit organization GO:0071822 302 0.016
response to monosaccharide GO:0034284 159 0.016
negative regulation of transport GO:0051051 136 0.016
neurological system process GO:0050877 219 0.016
defense response GO:0006952 194 0.016
cation transport GO:0006812 382 0.016
regulation of neuron death GO:1901214 115 0.016
regulation of multicellular organismal development GO:2000026 376 0.015
positive regulation of catalytic activity GO:0043085 184 0.015
regulation of neuron projection development GO:0010975 161 0.015
organophosphate biosynthetic process GO:0090407 143 0.015
tissue development GO:0009888 252 0.015
protein complex assembly GO:0006461 263 0.015
negative regulation of programmed cell death GO:0043069 183 0.015
central nervous system development GO:0007417 311 0.015
establishment of tissue polarity GO:0007164 2 0.015
localization of cell GO:0051674 202 0.015
nitrogen compound transport GO:0071705 229 0.015
reproductive process GO:0022414 372 0.015
cellular component movement GO:0006928 248 0.015
macromolecule localization GO:0033036 252 0.015
purine nucleotide biosynthetic process GO:0006164 83 0.015
organonitrogen compound biosynthetic process GO:1901566 167 0.015
circulatory system process GO:0003013 183 0.015
macromolecular complex subunit organization GO:0043933 339 0.015
positive regulation of phosphorylation GO:0042327 177 0.015
gastrulation GO:0007369 2 0.014
carbohydrate derivative biosynthetic process GO:1901137 124 0.014
nucleoside phosphate biosynthetic process GO:1901293 102 0.014
response to glucose GO:0009749 136 0.014
negative regulation of gene expression GO:0010629 199 0.014
small gtpase mediated signal transduction GO:0007264 36 0.014
regulation of protein modification process GO:0031399 194 0.014
regeneration GO:0031099 163 0.014
nucleoside triphosphate metabolic process GO:0009141 144 0.014
positive regulation of protein metabolic process GO:0051247 178 0.014
cell migration GO:0016477 197 0.014
regulation of cell projection organization GO:0031344 175 0.014
cell motility GO:0048870 202 0.014
transmission of nerve impulse GO:0019226 42 0.014
reproduction GO:0000003 245 0.014
positive regulation of homeostatic process GO:0032846 49 0.014
positive regulation of response to stimulus GO:0048584 285 0.014
regulation of cellular protein metabolic process GO:0032268 267 0.014
regulation of cell motility GO:2000145 131 0.014
intracellular transport GO:0046907 185 0.014
purine nucleoside triphosphate metabolic process GO:0009144 141 0.014
multicellular organismal reproductive process GO:0048609 233 0.014
response to peptide GO:1901652 292 0.014
regulation of phosphorylation GO:0042325 248 0.014
ras protein signal transduction GO:0007265 29 0.014
positive regulation of apoptotic process GO:0043065 154 0.014
negative regulation of molecular function GO:0044092 133 0.014
negative regulation of apoptotic process GO:0043066 181 0.014
anterior posterior pattern specification GO:0009952 1 0.014
head development GO:0060322 247 0.014
positive regulation of cell death GO:0010942 184 0.014
regulation of nucleotide metabolic process GO:0006140 117 0.014
g protein coupled receptor signaling pathway GO:0007186 242 0.014
response to growth factor GO:0070848 189 0.013
anatomical structure morphogenesis GO:0009653 298 0.013
blood circulation GO:0008015 183 0.013
lipid storage GO:0019915 1 0.013
positive regulation of transport GO:0051050 245 0.013
response to estrogen GO:0043627 232 0.013
regulation of protein phosphorylation GO:0001932 183 0.013
monosaccharide metabolic process GO:0005996 61 0.013
cellular divalent inorganic cation homeostasis GO:0072503 162 0.013
inflammatory response GO:0006954 150 0.013
nucleoside monophosphate metabolic process GO:0009123 93 0.013
nucleotide biosynthetic process GO:0009165 98 0.013
neuron development GO:0048666 286 0.013
brain development GO:0007420 247 0.013
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.013
cellular lipid metabolic process GO:0044255 208 0.013
calcium ion homeostasis GO:0055074 162 0.013
response to purine containing compound GO:0014074 126 0.013
metal ion homeostasis GO:0055065 186 0.013
negative regulation of multicellular organismal process GO:0051241 203 0.013
coenzyme metabolic process GO:0006732 86 0.013
axis specification GO:0009798 4 0.013
positive regulation of programmed cell death GO:0043068 157 0.013
response to estradiol GO:0032355 164 0.013
ribonucleoside triphosphate metabolic process GO:0009199 141 0.013
divalent inorganic cation homeostasis GO:0072507 165 0.013
cellular response to organic cyclic compound GO:0071407 202 0.013
cell type specific apoptotic process GO:0097285 134 0.013
response to metal ion GO:0010038 253 0.013
purine containing compound biosynthetic process GO:0072522 85 0.013
cation homeostasis GO:0055080 195 0.013
cellular hormone metabolic process GO:0034754 49 0.013
response to wounding GO:0009611 254 0.013
cellular cation homeostasis GO:0030003 180 0.012
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.012
response to insulin GO:0032868 133 0.012
maintenance of location GO:0051235 17 0.012
secretion by cell GO:0032940 248 0.012
regulation of intracellular signal transduction GO:1902531 218 0.012
positive regulation of nervous system development GO:0051962 178 0.012
cellular ion homeostasis GO:0006873 184 0.012
protein localization GO:0008104 191 0.012
regulation of purine nucleotide metabolic process GO:1900542 115 0.012
protein oligomerization GO:0051259 191 0.012
single organism intracellular transport GO:1902582 166 0.012
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.012
hormone secretion GO:0046879 115 0.012
sex differentiation GO:0007548 113 0.012
cellular metal ion homeostasis GO:0006875 172 0.012
metal ion transport GO:0030001 289 0.012
negative regulation of biosynthetic process GO:0009890 168 0.012
proteolysis GO:0006508 175 0.012
circadian rhythm GO:0007623 88 0.012
response to ketone GO:1901654 182 0.012
heart morphogenesis GO:0003007 3 0.012
negative regulation of signaling GO:0023057 157 0.012
chromosome segregation GO:0007059 2 0.012
cellular calcium ion homeostasis GO:0006874 160 0.012
organic cyclic compound catabolic process GO:1901361 175 0.012
ribonucleoside monophosphate metabolic process GO:0009161 88 0.012
peptidyl amino acid modification GO:0018193 126 0.012
cellular response to growth factor stimulus GO:0071363 162 0.012
amide transport GO:0042886 105 0.012
negative regulation of innate immune response GO:0045824 4 0.011
lipid modification GO:0030258 52 0.011
cellular response to cytokine stimulus GO:0071345 127 0.011
regulation of catabolic process GO:0009894 113 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.011
multicellular organismal signaling GO:0035637 44 0.011
aging GO:0007568 241 0.011
dna metabolic process GO:0006259 96 0.011
locomotion GO:0040011 237 0.011
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.011
neuronal action potential GO:0019228 35 0.011
regulation of transferase activity GO:0051338 123 0.011
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.011
peptide transport GO:0015833 97 0.011
cytoplasmic transport GO:0016482 115 0.011
gland development GO:0048732 155 0.011
response to other organism GO:0051707 220 0.011
regulation of peptide secretion GO:0002791 82 0.011
multicellular organism reproduction GO:0032504 233 0.011
cytosolic calcium ion homeostasis GO:0051480 140 0.011
fatty acid metabolic process GO:0006631 99 0.011
ribose phosphate biosynthetic process GO:0046390 87 0.011
peptide secretion GO:0002790 86 0.011
regulation of cell migration GO:0030334 128 0.011
organonitrogen compound catabolic process GO:1901565 179 0.011
regulation of carbohydrate metabolic process GO:0006109 41 0.011
reproductive system development GO:0061458 128 0.011
negative regulation of cell communication GO:0010648 158 0.011
negative regulation of protein metabolic process GO:0051248 114 0.011
cellular response to oxidative stress GO:0034599 76 0.011
eye morphogenesis GO:0048592 4 0.011
cation transmembrane transport GO:0098655 263 0.011
negative regulation of rna metabolic process GO:0051253 123 0.011
response to external biotic stimulus GO:0043207 221 0.011
establishment of protein localization GO:0045184 141 0.011
regulation of body fluid levels GO:0050878 90 0.011
negative regulation of cell development GO:0010721 82 0.010
response to amino acid GO:0043200 75 0.010
negative regulation of developmental process GO:0051093 125 0.010
cholesterol homeostasis GO:0042632 3 0.010
response to activity GO:0014823 73 0.010
positive regulation of cell differentiation GO:0045597 217 0.010
cellular response to peptide GO:1901653 133 0.010
nucleobase containing compound catabolic process GO:0034655 152 0.010
synaptic transmission GO:0007268 235 0.010
regulation of neuron differentiation GO:0045664 208 0.010
positive regulation of neuron differentiation GO:0045666 126 0.010
purine ribonucleotide biosynthetic process GO:0009152 81 0.010
regulation of ion transmembrane transport GO:0034765 121 0.010
peptide hormone secretion GO:0030072 84 0.010
purine nucleoside monophosphate metabolic process GO:0009126 84 0.010
ribonucleotide biosynthetic process GO:0009260 85 0.010
regulation of kinase activity GO:0043549 117 0.010
hormone transport GO:0009914 121 0.010
regulation of cellular catabolic process GO:0031329 101 0.010
response to fatty acid GO:0070542 65 0.010
embryonic pattern specification GO:0009880 1 0.010
negative regulation of response to stimulus GO:0048585 155 0.010
cellular nitrogen compound catabolic process GO:0044270 163 0.010
alpha amino acid metabolic process GO:1901605 71 0.010
small molecule biosynthetic process GO:0044283 124 0.010

Sirt1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.022
nervous system disease DOID:863 0 0.022
disease of metabolism DOID:0014667 0 0.016
sensory system disease DOID:0050155 0 0.013
musculoskeletal system disease DOID:17 0 0.011
central nervous system disease DOID:331 0 0.010