Rattus norvegicus

24 known processes

Penk

proenkephalin

(Aliases: Penk-rs,Penk2,Enk,Penk1,MGC93514)

Penk biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of rna metabolic process GO:0051252 391 0.132
regulation of transcription dna templated GO:0006355 374 0.113
oxoacid metabolic process GO:0043436 290 0.108
organic acid metabolic process GO:0006082 292 0.105
cellular component movement GO:0006928 248 0.100
single organism biosynthetic process GO:0044711 342 0.089
cellular calcium ion homeostasis GO:0006874 160 0.088
rna metabolic process GO:0016070 406 0.082
cellular metal ion homeostasis GO:0006875 172 0.080
carboxylic acid metabolic process GO:0019752 289 0.069
chemical homeostasis GO:0048878 292 0.068
cation transport GO:0006812 382 0.066
regulation of programmed cell death GO:0043067 341 0.063
protein complex subunit organization GO:0071822 302 0.062
nucleic acid templated transcription GO:0097659 379 0.059
positive regulation of cell proliferation GO:0008284 249 0.058
rna biosynthetic process GO:0032774 380 0.057
central nervous system development GO:0007417 311 0.057
cellular ion homeostasis GO:0006873 184 0.056
cellular amino acid metabolic process GO:0006520 107 0.056
learning or memory GO:0007611 90 0.055
reproductive process GO:0022414 372 0.054
response to mechanical stimulus GO:0009612 134 0.054
positive regulation of signal transduction GO:0009967 175 0.054
homeostatic process GO:0042592 331 0.053
divalent inorganic cation homeostasis GO:0072507 165 0.053
regulation of cell differentiation GO:0045595 320 0.053
cell migration GO:0016477 197 0.053
regulation of signal transduction GO:0009966 318 0.053
ion homeostasis GO:0050801 212 0.052
cellular chemical homeostasis GO:0055082 247 0.051
transcription dna templated GO:0006351 377 0.050
regulation of synaptic transmission GO:0050804 141 0.050
reproduction GO:0000003 245 0.050
cellular component morphogenesis GO:0032989 155 0.049
positive regulation of cell communication GO:0010647 271 0.048
rhythmic process GO:0048511 156 0.048
protein complex assembly GO:0006461 263 0.048
metal ion transport GO:0030001 289 0.046
brain development GO:0007420 247 0.045
g protein coupled receptor signaling pathway GO:0007186 242 0.045
cellular homeostasis GO:0019725 252 0.045
cellular component biogenesis GO:0044085 368 0.045
response to decreased oxygen levels GO:0036293 237 0.045
amine metabolic process GO:0009308 38 0.044
cytosolic calcium ion homeostasis GO:0051480 140 0.044
metal ion homeostasis GO:0055065 186 0.044
positive regulation of signaling GO:0023056 270 0.043
anatomical structure morphogenesis GO:0009653 298 0.043
monocarboxylic acid metabolic process GO:0032787 152 0.042
regulation of molecular function GO:0065009 398 0.041
small molecule biosynthetic process GO:0044283 124 0.041
macromolecular complex subunit organization GO:0043933 339 0.040
cation homeostasis GO:0055080 195 0.040
negative regulation of metabolic process GO:0009892 331 0.039
transcription from rna polymerase ii promoter GO:0006366 252 0.039
cellular cation homeostasis GO:0030003 180 0.039
locomotion GO:0040011 237 0.038
calcium ion homeostasis GO:0055074 162 0.038
response to nutrient levels GO:0031667 370 0.038
purine containing compound metabolic process GO:0072521 253 0.038
cellular divalent inorganic cation homeostasis GO:0072503 162 0.037
regulation of behavior GO:0050795 61 0.037
cellular amine metabolic process GO:0044106 38 0.037
single organism reproductive process GO:0044702 297 0.036
response to peptide hormone GO:0043434 278 0.036
multi organism reproductive process GO:0044703 262 0.036
regulation of cellular component organization GO:0051128 368 0.036
regulation of cell proliferation GO:0042127 359 0.036
regulation of rna biosynthetic process GO:2001141 381 0.036
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.036
protein localization GO:0008104 191 0.035
organelle organization GO:0006996 266 0.035
lipid metabolic process GO:0006629 283 0.034
regulation of cell development GO:0060284 263 0.034
cellular component assembly GO:0022607 360 0.034
regulation of phosphate metabolic process GO:0019220 349 0.034
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.033
apoptotic process GO:0006915 381 0.033
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.033
negative regulation of multicellular organismal process GO:0051241 203 0.032
positive regulation of phosphate metabolic process GO:0045937 262 0.032
cellular lipid metabolic process GO:0044255 208 0.032
head development GO:0060322 247 0.032
taxis GO:0042330 67 0.032
response to carbohydrate GO:0009743 183 0.031
intracellular signal transduction GO:0035556 314 0.031
negative regulation of developmental process GO:0051093 125 0.031
cellular ketone metabolic process GO:0042180 51 0.031
regulation of nervous system development GO:0051960 264 0.031
carbohydrate derivative metabolic process GO:1901135 346 0.031
response to temperature stimulus GO:0009266 94 0.031
blood circulation GO:0008015 183 0.031
nucleobase containing small molecule metabolic process GO:0055086 316 0.030
cognition GO:0050890 92 0.030
positive regulation of developmental process GO:0051094 283 0.030
lipid biosynthetic process GO:0008610 128 0.030
regulation of intracellular signal transduction GO:1902531 218 0.030
single organism catabolic process GO:0044712 283 0.030
multicellular organismal reproductive process GO:0048609 233 0.030
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.029
regulation of hydrolase activity GO:0051336 143 0.028
purine ribonucleoside metabolic process GO:0046128 168 0.028
cellular response to endogenous stimulus GO:0071495 377 0.028
positive regulation of cell differentiation GO:0045597 217 0.028
neurological system process GO:0050877 219 0.028
regulation of phosphorus metabolic process GO:0051174 349 0.028
muscle system process GO:0003012 115 0.028
positive regulation of phosphorus metabolic process GO:0010562 262 0.027
regulation of metal ion transport GO:0010959 118 0.027
positive regulation of nervous system development GO:0051962 178 0.027
protein complex biogenesis GO:0070271 263 0.027
positive regulation of gene expression GO:0010628 244 0.027
macromolecular complex assembly GO:0065003 273 0.026
ras protein signal transduction GO:0007265 29 0.026
positive regulation of cellular biosynthetic process GO:0031328 295 0.026
neuron projection development GO:0031175 273 0.026
cell motility GO:0048870 202 0.026
neuron differentiation GO:0030182 368 0.026
circulatory system process GO:0003013 183 0.025
gliogenesis GO:0042063 93 0.025
small gtpase mediated signal transduction GO:0007264 36 0.025
positive regulation of multicellular organismal process GO:0051240 387 0.025
purine nucleotide metabolic process GO:0006163 229 0.025
behavior GO:0007610 205 0.025
multicellular organism reproduction GO:0032504 233 0.025
regulation of ion transport GO:0043269 245 0.025
regulation of cellular ketone metabolic process GO:0010565 27 0.025
programmed cell death GO:0012501 392 0.025
response to peptide GO:1901652 292 0.025
regulation of cellular amine metabolic process GO:0033238 8 0.025
organic hydroxy compound metabolic process GO:1901615 115 0.025
response to oxygen levels GO:0070482 265 0.025
cellular catabolic process GO:0044248 295 0.025
positive regulation of cell development GO:0010720 176 0.024
cellular response to organonitrogen compound GO:0071417 197 0.024
sexual reproduction GO:0019953 148 0.024
organic acid biosynthetic process GO:0016053 83 0.024
negative regulation of gene expression GO:0010629 199 0.024
secretion GO:0046903 307 0.024
negative regulation of cellular metabolic process GO:0031324 281 0.024
regulation of locomotion GO:0040012 148 0.023
kidney development GO:0001822 67 0.023
response to hypoxia GO:0001666 231 0.023
organonitrogen compound biosynthetic process GO:1901566 167 0.023
regulation of cellular amino acid metabolic process GO:0006521 2 0.023
neuron development GO:0048666 286 0.023
positive regulation of cell death GO:0010942 184 0.023
secretion by cell GO:0032940 248 0.023
monovalent inorganic cation transport GO:0015672 172 0.023
positive regulation of rna metabolic process GO:0051254 203 0.023
response to inorganic substance GO:0010035 377 0.022
regulation of nucleic acid templated transcription GO:1903506 380 0.022
response to alkaloid GO:0043279 132 0.022
cell projection organization GO:0030030 302 0.022
positive regulation of biosynthetic process GO:0009891 319 0.022
protein phosphorylation GO:0006468 345 0.022
regulation of purine nucleotide metabolic process GO:1900542 115 0.022
organophosphate catabolic process GO:0046434 148 0.022
response to growth factor GO:0070848 189 0.022
organic substance catabolic process GO:1901575 316 0.022
cellular response to growth factor stimulus GO:0071363 162 0.021
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.021
carboxylic acid biosynthetic process GO:0046394 83 0.021
regulation of secretion by cell GO:1903530 208 0.021
neuron projection morphogenesis GO:0048812 122 0.021
fatty acid metabolic process GO:0006631 99 0.021
negative regulation of macromolecule metabolic process GO:0010605 260 0.021
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.021
positive regulation of cell migration GO:0030335 96 0.021
catabolic process GO:0009056 351 0.020
regulation of cellular component movement GO:0051270 150 0.020
organophosphate biosynthetic process GO:0090407 143 0.020
positive regulation of cellular component organization GO:0051130 200 0.020
ribonucleoside metabolic process GO:0009119 174 0.020
nucleotide metabolic process GO:0009117 279 0.020
response to monosaccharide GO:0034284 159 0.020
intracellular transport GO:0046907 185 0.020
divalent inorganic cation transport GO:0072511 134 0.020
positive regulation of transport GO:0051050 245 0.020
negative regulation of cell differentiation GO:0045596 99 0.020
ribose phosphate metabolic process GO:0019693 235 0.020
regulation of multicellular organismal development GO:2000026 376 0.019
synaptic transmission GO:0007268 235 0.019
response to ethanol GO:0045471 162 0.019
glial cell differentiation GO:0010001 65 0.019
purine ribonucleotide metabolic process GO:0009150 227 0.019
organophosphate metabolic process GO:0019637 370 0.019
regulation of cellular protein metabolic process GO:0032268 267 0.019
positive regulation of nucleic acid templated transcription GO:1903508 197 0.019
response to other organism GO:0051707 220 0.019
cell growth GO:0016049 104 0.019
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.019
positive regulation of response to stimulus GO:0048584 285 0.019
regulation of phosphorylation GO:0042325 248 0.019
heart process GO:0003015 57 0.019
nucleoside metabolic process GO:0009116 179 0.018
axis specification GO:0009798 4 0.018
response to amine GO:0014075 46 0.018
regulation of response to external stimulus GO:0032101 106 0.018
macromolecule localization GO:0033036 252 0.018
regulation of neurogenesis GO:0050767 247 0.018
positive regulation of rna biosynthetic process GO:1902680 197 0.018
regulation of hormone levels GO:0010817 187 0.018
positive regulation of synaptic transmission GO:0050806 62 0.018
regulation of cell migration GO:0030334 128 0.018
transmembrane transport GO:0055085 412 0.018
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.018
positive regulation of programmed cell death GO:0043068 157 0.017
regulation of secretion GO:0051046 224 0.017
positive regulation of transcription dna templated GO:0045893 197 0.017
cell chemotaxis GO:0060326 31 0.017
renal system development GO:0072001 67 0.017
nucleoside phosphate metabolic process GO:0006753 283 0.017
regulation of protein metabolic process GO:0051246 289 0.017
negative regulation of rna metabolic process GO:0051253 123 0.017
regulation of cell projection organization GO:0031344 175 0.017
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.017
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.017
positive regulation of ion transport GO:0043270 94 0.017
regulation of catalytic activity GO:0050790 304 0.017
negative regulation of rna biosynthetic process GO:1902679 118 0.017
positive regulation of neurogenesis GO:0050769 165 0.017
regulation of apoptotic process GO:0042981 335 0.017
regulation of cell motility GO:2000145 131 0.017
negative regulation of transcription dna templated GO:0045892 116 0.017
nucleobase containing compound catabolic process GO:0034655 152 0.016
gamete generation GO:0007276 124 0.016
response to vitamin GO:0033273 131 0.016
sequestering of calcium ion GO:0051208 8 0.016
response to molecule of bacterial origin GO:0002237 194 0.016
regulation of blood pressure GO:0008217 83 0.016
negative regulation of biosynthetic process GO:0009890 168 0.016
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.016
response to biotic stimulus GO:0009607 226 0.016
circadian rhythm GO:0007623 88 0.016
negative regulation of signaling GO:0023057 157 0.016
protein transport GO:0015031 132 0.016
response to nutrient GO:0007584 248 0.016
aging GO:0007568 241 0.016
heart contraction GO:0060047 57 0.016
positive regulation of cellular component movement GO:0051272 102 0.016
cellular response to hormone stimulus GO:0032870 247 0.016
nucleoside phosphate catabolic process GO:1901292 140 0.016
oxidation reduction process GO:0055114 304 0.016
peptidyl amino acid modification GO:0018193 126 0.016
negative regulation of cell communication GO:0010648 158 0.016
positive regulation of molecular function GO:0044093 230 0.016
localization of cell GO:0051674 202 0.016
single organism intracellular transport GO:1902582 166 0.016
divalent metal ion transport GO:0070838 132 0.016
positive regulation of neuron projection development GO:0010976 99 0.016
response to cytokine GO:0034097 215 0.015
defense response GO:0006952 194 0.015
regulation of blood vessel size GO:0050880 89 0.015
response to extracellular stimulus GO:0009991 380 0.015
regulation of nucleotide metabolic process GO:0006140 117 0.015
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.015
ribonucleoside catabolic process GO:0042454 126 0.015
regulation of anatomical structure morphogenesis GO:0022603 141 0.015
positive regulation of cellular amine metabolic process GO:0033240 3 0.015
muscle contraction GO:0006936 88 0.015
response to purine containing compound GO:0014074 126 0.015
cytoplasmic transport GO:0016482 115 0.015
memory GO:0007613 54 0.015
negative regulation of transport GO:0051051 136 0.015
response to glucose GO:0009749 136 0.015
protein oligomerization GO:0051259 191 0.014
nucleotide catabolic process GO:0009166 139 0.014
purine ribonucleoside catabolic process GO:0046130 124 0.014
cell cell signaling GO:0007267 335 0.014
response to lipopolysaccharide GO:0032496 191 0.014
circulatory system development GO:0072359 134 0.014
organonitrogen compound catabolic process GO:1901565 179 0.014
purine nucleoside triphosphate metabolic process GO:0009144 141 0.014
cell morphogenesis involved in differentiation GO:0000904 119 0.014
ribonucleotide metabolic process GO:0009259 231 0.014
regulation of canonical wnt signaling pathway GO:0060828 4 0.014
regulation of cellular localization GO:0060341 263 0.014
alcohol metabolic process GO:0006066 77 0.014
cell morphogenesis GO:0000902 142 0.014
response to hexose GO:0009746 144 0.014
calcium ion transport GO:0006816 131 0.014
regulation of neuron projection development GO:0010975 161 0.014
organic hydroxy compound biosynthetic process GO:1901617 51 0.014
positive regulation of mapk cascade GO:0043410 92 0.014
carbohydrate derivative catabolic process GO:1901136 147 0.014
smooth muscle contraction GO:0006939 37 0.014
regulation of cell morphogenesis GO:0022604 77 0.014
positive regulation of protein modification process GO:0031401 142 0.014
actin filament based process GO:0030029 86 0.014
cellular response to nitrogen compound GO:1901699 210 0.014
regulation of cell growth GO:0001558 85 0.014
positive regulation of phosphorylation GO:0042327 177 0.014
positive regulation of intracellular signal transduction GO:1902533 138 0.014
salivary gland morphogenesis GO:0007435 1 0.013
regulation of fat cell differentiation GO:0045598 3 0.013
response to acid chemical GO:0001101 222 0.013
cell projection morphogenesis GO:0048858 123 0.013
regulation of body fluid levels GO:0050878 90 0.013
cell part morphogenesis GO:0032990 123 0.013
positive regulation of cell motility GO:2000147 97 0.013
cellular response to organic cyclic compound GO:0071407 202 0.013
cellular response to stress GO:0033554 269 0.013
chemotaxis GO:0006935 66 0.013
positive regulation of cell projection organization GO:0031346 111 0.013
positive regulation of apoptotic process GO:0043065 154 0.013
regulation of blood circulation GO:1903522 110 0.013
positive regulation of protein metabolic process GO:0051247 178 0.013
actin cytoskeleton organization GO:0030036 73 0.013
positive regulation of nucleotide metabolic process GO:0045981 91 0.013
regulation of dendrite development GO:0050773 59 0.013
renal system process GO:0003014 40 0.013
proteolysis GO:0006508 175 0.013
chemosensory behavior GO:0007635 2 0.013
vesicle mediated transport GO:0016192 181 0.013
heart morphogenesis GO:0003007 3 0.013
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.012
regulation of respiratory gaseous exchange GO:0043576 2 0.012
enzyme linked receptor protein signaling pathway GO:0007167 116 0.012
response to wounding GO:0009611 254 0.012
regulation of neuron differentiation GO:0045664 208 0.012
single organism behavior GO:0044708 130 0.012
axonogenesis GO:0007409 71 0.012
neuron death GO:0070997 127 0.012
anion transport GO:0006820 178 0.012
response to metal ion GO:0010038 253 0.012
spermatogenesis GO:0007283 99 0.012
positive regulation of secretion GO:0051047 140 0.012
positive regulation of response to external stimulus GO:0032103 51 0.012
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.012
negative regulation of cell death GO:0060548 229 0.012
lipid catabolic process GO:0016042 46 0.012
nucleoside triphosphate metabolic process GO:0009141 144 0.012
organic cyclic compound catabolic process GO:1901361 175 0.012
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.012
ribonucleoside triphosphate metabolic process GO:0009199 141 0.012
regulation of hormone secretion GO:0046883 106 0.012
aromatic compound catabolic process GO:0019439 168 0.012
relaxation of muscle GO:0090075 4 0.012
adult locomotory behavior GO:0008344 4 0.012
ribonucleoside triphosphate catabolic process GO:0009203 122 0.012
cellular response to external stimulus GO:0071496 118 0.012
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.012
negative regulation of response to stimulus GO:0048585 155 0.012
regulation of synaptic plasticity GO:0048167 70 0.012
membrane organization GO:0061024 94 0.012
cellular response to peptide GO:1901653 133 0.011
nucleoside phosphate biosynthetic process GO:1901293 102 0.011
ion transmembrane transport GO:0034220 365 0.011
gtp catabolic process GO:0006184 71 0.011
purine containing compound biosynthetic process GO:0072522 85 0.011
rho protein signal transduction GO:0007266 11 0.011
positive regulation of neuron differentiation GO:0045666 126 0.011
feeding behavior GO:0007631 53 0.011
negative regulation of neurogenesis GO:0050768 78 0.011
positive regulation of immune system process GO:0002684 90 0.011
purine containing compound catabolic process GO:0072523 138 0.011
epithelium development GO:0060429 96 0.011
carbohydrate metabolic process GO:0005975 130 0.011
ribose phosphate biosynthetic process GO:0046390 87 0.011
single organism organelle organization GO:1902589 180 0.011
cellular response to oxygen containing compound GO:1901701 386 0.011
male gamete generation GO:0048232 99 0.011
cellular carbohydrate metabolic process GO:0044262 72 0.011
neuronal action potential GO:0019228 35 0.011
smooth muscle cell migration GO:0014909 36 0.011
regulation of calcium ion transport GO:0051924 77 0.011
purine nucleoside catabolic process GO:0006152 124 0.011
vascular process in circulatory system GO:0003018 96 0.011
inflammatory response GO:0006954 150 0.011
neural crest cell development GO:0014032 2 0.011
axon development GO:0061564 96 0.011
negative regulation of protein metabolic process GO:0051248 114 0.011
response to amphetamine GO:0001975 25 0.011
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.011
biological adhesion GO:0022610 110 0.011
cytoskeleton organization GO:0007010 111 0.011
regulation of mapk cascade GO:0043408 116 0.011
negative regulation of programmed cell death GO:0043069 183 0.011
neuron neuron synaptic transmission GO:0007270 60 0.011
developmental process involved in reproduction GO:0003006 159 0.011
positive regulation of blood circulation GO:1903524 65 0.011
regulation of ion homeostasis GO:2000021 63 0.010
positive regulation of secretion by cell GO:1903532 128 0.010
purine nucleoside triphosphate catabolic process GO:0009146 122 0.010
glycosyl compound metabolic process GO:1901657 182 0.010
purine nucleoside metabolic process GO:0042278 169 0.010
cardiovascular system development GO:0072358 134 0.010
cellular response to molecule of bacterial origin GO:0071219 56 0.010
glycosyl compound catabolic process GO:1901658 126 0.010
anterior posterior pattern specification GO:0009952 1 0.010
negative regulation of nucleic acid templated transcription GO:1903507 117 0.010
regulation of neurological system process GO:0031644 43 0.010
embryonic pattern specification GO:0009880 1 0.010
action potential GO:0001508 54 0.010
steroid metabolic process GO:0008202 73 0.010
regulation of system process GO:0044057 208 0.010
alcohol biosynthetic process GO:0046165 38 0.010
response to external biotic stimulus GO:0043207 221 0.010

Penk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.016
nervous system disease DOID:863 0 0.016
musculoskeletal system disease DOID:17 0 0.010