Rattus norvegicus

0 known processes

Nmnat2

nicotinamide nucleotide adenylyltransferase 2

Nmnat2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
positive regulation of secretion GO:0051047 140 0.263
regulation of phosphorus metabolic process GO:0051174 349 0.251
secretion GO:0046903 307 0.249
organelle organization GO:0006996 266 0.193
regulation of secretion GO:0051046 224 0.191
regulation of cellular localization GO:0060341 263 0.146
carboxylic acid metabolic process GO:0019752 289 0.146
regulation of protein metabolic process GO:0051246 289 0.146
nucleobase containing small molecule metabolic process GO:0055086 316 0.145
Yeast
regulation of catalytic activity GO:0050790 304 0.143
macromolecular complex assembly GO:0065003 273 0.142
g protein coupled receptor signaling pathway GO:0007186 242 0.140
positive regulation of transport GO:0051050 245 0.136
oxoacid metabolic process GO:0043436 290 0.132
secretion by cell GO:0032940 248 0.130
regulation of cell differentiation GO:0045595 320 0.129
purine ribonucleotide metabolic process GO:0009150 227 0.126
cellular component biogenesis GO:0044085 368 0.124
transmembrane transport GO:0055085 412 0.122
positive regulation of signaling GO:0023056 270 0.121
positive regulation of phosphate metabolic process GO:0045937 262 0.118
protein complex biogenesis GO:0070271 263 0.117
response to nutrient levels GO:0031667 370 0.117
cytosolic calcium ion homeostasis GO:0051480 140 0.113
regulation of cellular component organization GO:0051128 368 0.106
positive regulation of phosphorus metabolic process GO:0010562 262 0.105
protein complex subunit organization GO:0071822 302 0.102
cellular cation homeostasis GO:0030003 180 0.099
cell cell signaling GO:0007267 335 0.098
regulation of phosphorylation GO:0042325 248 0.093
negative regulation of developmental process GO:0051093 125 0.092
regulation of cellular amine metabolic process GO:0033238 8 0.090
intracellular signal transduction GO:0035556 314 0.087
regulation of cell development GO:0060284 263 0.085
positive regulation of secretion by cell GO:1903532 128 0.085
cellular ion homeostasis GO:0006873 184 0.085
positive regulation of developmental process GO:0051094 283 0.083
response to axon injury GO:0048678 59 0.082
regulation of multicellular organismal development GO:2000026 376 0.082
regulation of cellular protein metabolic process GO:0032268 267 0.081
negative regulation of metabolic process GO:0009892 331 0.081
positive regulation of cellular component organization GO:0051130 200 0.080
organic acid metabolic process GO:0006082 292 0.079
neuron projection development GO:0031175 273 0.079
regulation of neurogenesis GO:0050767 247 0.077
regulation of neuron projection development GO:0010975 161 0.077
response to heat GO:0009408 60 0.077
programmed cell death GO:0012501 392 0.076
purine nucleotide metabolic process GO:0006163 229 0.074
ribose phosphate metabolic process GO:0019693 235 0.074
response to inorganic substance GO:0010035 377 0.074
amine metabolic process GO:0009308 38 0.072
purine containing compound metabolic process GO:0072521 253 0.070
organonitrogen compound biosynthetic process GO:1901566 167 0.069
Yeast
protein processing GO:0016485 68 0.067
hormone secretion GO:0046879 115 0.067
regulation of cellular ketone metabolic process GO:0010565 27 0.066
regulation of molecular function GO:0065009 398 0.063
positive regulation of apoptotic process GO:0043065 154 0.063
positive regulation of cell death GO:0010942 184 0.063
macromolecular complex subunit organization GO:0043933 339 0.061
cellular metal ion homeostasis GO:0006875 172 0.060
regulation of secretion by cell GO:1903530 208 0.057
regulation of organelle organization GO:0033043 80 0.056
regulation of protein modification process GO:0031399 194 0.056
anion transport GO:0006820 178 0.055
cell projection organization GO:0030030 302 0.055
regulation of signal transduction GO:0009966 318 0.055
negative regulation of cellular metabolic process GO:0031324 281 0.053
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.053
negative regulation of cell differentiation GO:0045596 99 0.053
response to temperature stimulus GO:0009266 94 0.053
positive regulation of signal transduction GO:0009967 175 0.053
cellular amino acid metabolic process GO:0006520 107 0.052
regulation of programmed cell death GO:0043067 341 0.052
regulation of rna metabolic process GO:0051252 391 0.050
protein maturation GO:0051604 68 0.050
sex differentiation GO:0007548 113 0.050
regulation of kinase activity GO:0043549 117 0.049
response to peptide hormone GO:0043434 278 0.049
neuron development GO:0048666 286 0.049
cellular amine metabolic process GO:0044106 38 0.048
regeneration GO:0031099 163 0.048
cellular calcium ion homeostasis GO:0006874 160 0.047
muscle contraction GO:0006936 88 0.047
carbohydrate derivative metabolic process GO:1901135 346 0.047
positive regulation of cell development GO:0010720 176 0.047
negative regulation of signaling GO:0023057 157 0.046
nucleoside phosphate metabolic process GO:0006753 283 0.045
Yeast
calcium ion homeostasis GO:0055074 162 0.045
regulation of transcription dna templated GO:0006355 374 0.045
organophosphate metabolic process GO:0019637 370 0.045
Yeast
homeostatic process GO:0042592 331 0.045
positive regulation of response to stimulus GO:0048584 285 0.045
regulation of phosphate metabolic process GO:0019220 349 0.044
cellular component assembly GO:0022607 360 0.044
regulation of cellular amino acid metabolic process GO:0006521 2 0.043
response to organophosphorus GO:0046683 102 0.043
positive regulation of cell proliferation GO:0008284 249 0.043
regulation of rna biosynthetic process GO:2001141 381 0.043
negative regulation of cell communication GO:0010648 158 0.042
regulation of neuron differentiation GO:0045664 208 0.042
response to oxygen levels GO:0070482 265 0.042
nucleotide metabolic process GO:0009117 279 0.042
Yeast
positive regulation of biosynthetic process GO:0009891 319 0.042
positive regulation of cell differentiation GO:0045597 217 0.041
positive regulation of phosphorylation GO:0042327 177 0.041
hormone transport GO:0009914 121 0.040
response to extracellular stimulus GO:0009991 380 0.039
signal transduction by phosphorylation GO:0023014 144 0.038
ribonucleotide metabolic process GO:0009259 231 0.038
cellular chemical homeostasis GO:0055082 247 0.038
negative regulation of macromolecule metabolic process GO:0010605 260 0.038
positive regulation of protein phosphorylation GO:0001934 135 0.037
regulation of apoptotic process GO:0042981 335 0.037
neuron differentiation GO:0030182 368 0.036
metal ion homeostasis GO:0055065 186 0.036
macromolecule localization GO:0033036 252 0.035
cellular ketone metabolic process GO:0042180 51 0.035
cellular response to oxygen containing compound GO:1901701 386 0.035
negative regulation of gene expression GO:0010629 199 0.035
positive regulation of cellular biosynthetic process GO:0031328 295 0.034
establishment of protein localization GO:0045184 141 0.034
regulation of cytoskeleton organization GO:0051493 49 0.034
single organism intracellular transport GO:1902582 166 0.034
positive regulation of molecular function GO:0044093 230 0.034
glutamate secretion GO:0014047 19 0.034
immune system process GO:0002376 204 0.034
protein complex assembly GO:0006461 263 0.033
positive regulation of protein modification process GO:0031401 142 0.033
rna metabolic process GO:0016070 406 0.033
positive regulation of protein metabolic process GO:0051247 178 0.033
positive regulation of programmed cell death GO:0043068 157 0.033
synaptic transmission GO:0007268 235 0.033
response to ethanol GO:0045471 162 0.033
cellular divalent inorganic cation homeostasis GO:0072503 162 0.033
single organism catabolic process GO:0044712 283 0.032
regulation of hormone levels GO:0010817 187 0.032
positive regulation of cellular amine metabolic process GO:0033240 3 0.032
lipid biosynthetic process GO:0008610 128 0.032
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.032
nitrogen compound transport GO:0071705 229 0.032
positive regulation of catalytic activity GO:0043085 184 0.032
reproductive system development GO:0061458 128 0.032
response to metal ion GO:0010038 253 0.032
development of primary sexual characteristics GO:0045137 107 0.032
signal release GO:0023061 145 0.032
reproductive structure development GO:0048608 128 0.032
positive regulation of cell projection organization GO:0031346 111 0.031
regulation of nervous system development GO:0051960 264 0.031
ion homeostasis GO:0050801 212 0.030
growth GO:0040007 165 0.030
reactive oxygen species biosynthetic process GO:1903409 8 0.030
positive regulation of cellular protein metabolic process GO:0032270 167 0.030
gonad development GO:0008406 104 0.030
response to camp GO:0051591 91 0.030
reproductive process GO:0022414 372 0.029
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.029
amide transport GO:0042886 105 0.029
negative regulation of neurogenesis GO:0050768 78 0.029
reproduction GO:0000003 245 0.029
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.029
protein oligomerization GO:0051259 191 0.028
positive regulation of multicellular organismal process GO:0051240 387 0.028
cation transport GO:0006812 382 0.028
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.028
locomotion GO:0040011 237 0.028
cell cycle GO:0007049 101 0.028
hormone mediated signaling pathway GO:0009755 23 0.028
positive regulation of cytoskeleton organization GO:0051495 26 0.028
regulation of cell projection organization GO:0031344 175 0.028
single organism organelle organization GO:1902589 180 0.027
purine nucleoside metabolic process GO:0042278 169 0.027
response to purine containing compound GO:0014074 126 0.027
nucleotide biosynthetic process GO:0009165 98 0.027
Yeast
intracellular transport GO:0046907 185 0.027
regulation of intracellular signal transduction GO:1902531 218 0.026
negative regulation of multicellular organismal process GO:0051241 203 0.026
cellular response to stress GO:0033554 269 0.026
cell motility GO:0048870 202 0.025
negative regulation of nucleic acid templated transcription GO:1903507 117 0.025
proteolysis GO:0006508 175 0.025
peptide secretion GO:0002790 86 0.025
positive regulation of cell communication GO:0010647 271 0.025
ion transmembrane transport GO:0034220 365 0.025
organophosphate biosynthetic process GO:0090407 143 0.025
Yeast
nucleoside triphosphate catabolic process GO:0009143 123 0.025
negative regulation of programmed cell death GO:0043069 183 0.024
regulation of hydrolase activity GO:0051336 143 0.024
positive regulation of homeostatic process GO:0032846 49 0.024
nucleic acid templated transcription GO:0097659 379 0.024
regulation of cellular component biogenesis GO:0044087 86 0.024
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.024
regulation of hormone secretion GO:0046883 106 0.024
central nervous system development GO:0007417 311 0.024
positive regulation of neurogenesis GO:0050769 165 0.024
positive regulation of neuron projection development GO:0010976 99 0.023
chemical homeostasis GO:0048878 292 0.023
positive regulation of organelle organization GO:0010638 48 0.023
regulation of protein phosphorylation GO:0001932 183 0.023
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.023
response to nutrient GO:0007584 248 0.023
response to wounding GO:0009611 254 0.023
response to acid chemical GO:0001101 222 0.022
carboxylic acid transport GO:0046942 115 0.022
vesicle mediated transport GO:0016192 181 0.022
peptide hormone secretion GO:0030072 84 0.022
purine nucleotide catabolic process GO:0006195 136 0.022
protein phosphorylation GO:0006468 345 0.022
response to decreased oxygen levels GO:0036293 237 0.022
response to vitamin GO:0033273 131 0.022
cell morphogenesis involved in differentiation GO:0000904 119 0.022
neuropeptide signaling pathway GO:0007218 29 0.022
peptide transport GO:0015833 97 0.022
divalent inorganic cation homeostasis GO:0072507 165 0.022
response to transition metal nanoparticle GO:1990267 122 0.022
negative regulation of protein metabolic process GO:0051248 114 0.022
motor neuron axon guidance GO:0008045 1 0.021
acid secretion GO:0046717 48 0.021
angiotensin mediated drinking behavior GO:0003051 2 0.021
apoptotic process GO:0006915 381 0.021
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.021
regulation of cell cycle GO:0051726 73 0.021
cellular homeostasis GO:0019725 252 0.021
positive regulation of protein kinase activity GO:0045860 73 0.021
glycosyl compound metabolic process GO:1901657 182 0.021
regulation of interleukin 1 beta secretion GO:0050706 3 0.021
chemosensory behavior GO:0007635 2 0.021
negative regulation of cell development GO:0010721 82 0.020
cyclic nucleotide metabolic process GO:0009187 80 0.020
positive regulation of mapk cascade GO:0043410 92 0.020
positive regulation of nucleic acid templated transcription GO:1903508 197 0.020
negative regulation of cellular protein metabolic process GO:0032269 106 0.020
neurological system process GO:0050877 219 0.020
head development GO:0060322 247 0.020
ribonucleoside metabolic process GO:0009119 174 0.019
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.019
organic anion transport GO:0015711 132 0.019
single organism cellular localization GO:1902580 102 0.019
transcription dna templated GO:0006351 377 0.019
cellular response to growth factor stimulus GO:0071363 162 0.019
gland development GO:0048732 155 0.019
negative regulation of transport GO:0051051 136 0.019
regulation of anatomical structure morphogenesis GO:0022603 141 0.019
cellular response to organonitrogen compound GO:0071417 197 0.019
response to growth factor GO:0070848 189 0.018
neuron death GO:0070997 127 0.018
regulation of cell cycle process GO:0010564 31 0.018
single organism biosynthetic process GO:0044711 342 0.018
Yeast
regulation of peptidase activity GO:0052547 55 0.018
negative regulation of response to stimulus GO:0048585 155 0.018
cation homeostasis GO:0055080 195 0.018
cellular response to endogenous stimulus GO:0071495 377 0.018
metal ion transport GO:0030001 289 0.018
locomotory exploration behavior GO:0035641 1 0.018
regulation of nucleic acid templated transcription GO:1903506 380 0.017
protein transport GO:0015031 132 0.017
regulation of synaptic transmission GO:0050804 141 0.017
regulation of nucleotide metabolic process GO:0006140 117 0.017
mapk cascade GO:0000165 140 0.017
negative regulation of signal transduction GO:0009968 83 0.017
erk1 and erk2 cascade GO:0070371 48 0.017
purine ribonucleoside metabolic process GO:0046128 168 0.017
negative regulation of protein maturation GO:1903318 47 0.016
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.016
purine nucleoside catabolic process GO:0006152 124 0.016
brain development GO:0007420 247 0.016
purine nucleoside triphosphate metabolic process GO:0009144 141 0.016
response to hypoxia GO:0001666 231 0.016
multicellular organism reproduction GO:0032504 233 0.016
protein localization GO:0008104 191 0.016
neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 3 0.016
rna biosynthetic process GO:0032774 380 0.016
negative regulation of molecular function GO:0044092 133 0.016
peptidyl amino acid modification GO:0018193 126 0.015
regulation of ion transport GO:0043269 245 0.015
developmental growth GO:0048589 100 0.015
glycosyl compound catabolic process GO:1901658 126 0.015
male sex differentiation GO:0046661 64 0.015
endocrine hormone secretion GO:0060986 21 0.015
positive regulation of nucleotide metabolic process GO:0045981 91 0.015
response to vitamin a GO:0033189 36 0.015
positive regulation of transferase activity GO:0051347 81 0.015
peptidyl tyrosine modification GO:0018212 72 0.014
calcium ion transport GO:0006816 131 0.014
regulation of protein kinase activity GO:0045859 105 0.014
single organism reproductive process GO:0044702 297 0.014
regulation of calcium ion transport GO:0051924 77 0.014
regulation of proteolysis GO:0030162 66 0.014
amine transport GO:0015837 57 0.014
cell migration GO:0016477 197 0.014
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.014
male gamete generation GO:0048232 99 0.014
negative regulation of cellular component organization GO:0051129 83 0.014
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.014
positive regulation of rna biosynthetic process GO:1902680 197 0.014
protein polymerization GO:0051258 22 0.014
cofactor metabolic process GO:0051186 95 0.014
Yeast
nucleoside triphosphate metabolic process GO:0009141 144 0.014
behavioral response to nicotine GO:0035095 2 0.013
positive regulation of neuron differentiation GO:0045666 126 0.013
response to chromate GO:0046687 3 0.013
negative regulation of protein processing GO:0010955 47 0.013
purine nucleoside triphosphate catabolic process GO:0009146 122 0.013
organonitrogen compound catabolic process GO:1901565 179 0.013
regulation of defecation GO:2000292 1 0.013
cellular response to nitrogen compound GO:1901699 210 0.013
positive regulation of kinase activity GO:0033674 77 0.013
renal system development GO:0072001 67 0.013
negative regulation of intracellular signal transduction GO:1902532 38 0.013
cell growth GO:0016049 104 0.013
regulation of mapk cascade GO:0043408 116 0.013
regulation of lyase activity GO:0051339 22 0.013
positive regulation of gene expression GO:0010628 244 0.013
nucleoside phosphate catabolic process GO:1901292 140 0.013
axon development GO:0061564 96 0.013
dna metabolic process GO:0006259 96 0.013
organic acid transport GO:0015849 116 0.013
response to reactive oxygen species GO:0000302 120 0.013
nucleoside catabolic process GO:0009164 126 0.012
regulation of endopeptidase activity GO:0052548 51 0.012
response to carbohydrate GO:0009743 183 0.012
negative regulation of amine transport GO:0051953 24 0.012
regulation of transferase activity GO:0051338 123 0.012
response to peptide GO:1901652 292 0.012
response to interleukin 1 GO:0070555 55 0.012
organic acid biosynthetic process GO:0016053 83 0.012
rhythmic process GO:0048511 156 0.012
cytoplasmic transport GO:0016482 115 0.012
regulation of neuron death GO:1901214 115 0.012
carboxylic acid biosynthetic process GO:0046394 83 0.012
maintenance of location GO:0051235 17 0.012
negative regulation of phosphorus metabolic process GO:0010563 80 0.012
negative regulation of cellular biosynthetic process GO:0031327 161 0.012
positive regulation of nervous system development GO:0051962 178 0.012
axis specification GO:0009798 4 0.012
muscle structure development GO:0061061 87 0.012
positive regulation of interleukin 1 beta secretion GO:0050718 3 0.012
regulation of cell proliferation GO:0042127 359 0.012
positive regulation of rna metabolic process GO:0051254 203 0.012
cellular component movement GO:0006928 248 0.012
nucleoside metabolic process GO:0009116 179 0.012
response to corticosterone GO:0051412 40 0.011
unsaturated fatty acid metabolic process GO:0033559 39 0.011
negative regulation of phosphate metabolic process GO:0045936 80 0.011
luteinizing hormone secretion GO:0032275 6 0.011
regulation of map kinase activity GO:0043405 53 0.011
gamete generation GO:0007276 124 0.011
regulation of exit from mitosis GO:0007096 1 0.011
multi organism reproductive process GO:0044703 262 0.011
nucleotide catabolic process GO:0009166 139 0.011
negative regulation of peptidase activity GO:0010466 38 0.011
negative regulation of protein phosphorylation GO:0001933 44 0.011
reactive nitrogen species metabolic process GO:2001057 1 0.011
cellular response to peptide GO:1901653 133 0.011
negative regulation of neuron projection development GO:0010977 46 0.011
purine containing compound catabolic process GO:0072523 138 0.011
purine nucleotide biosynthetic process GO:0006164 83 0.011
localization of cell GO:0051674 202 0.011
fatty acid biosynthetic process GO:0006633 33 0.011
activation of protein kinase activity GO:0032147 47 0.011
cellular response to hormone stimulus GO:0032870 247 0.011
gonadotropin secretion GO:0032274 8 0.011
regulation of protein localization GO:0032880 81 0.011
regulation of peptide transport GO:0090087 87 0.011
development of primary male sexual characteristics GO:0046546 59 0.011
regulation of intracellular transport GO:0032386 65 0.011
mitochondrion organization GO:0007005 35 0.011
positive regulation of locomotion GO:0040017 102 0.011
sequestering of calcium ion GO:0051208 8 0.011
non canonical wnt signaling pathway GO:0035567 3 0.011
cognition GO:0050890 92 0.011
regulation of cell growth GO:0001558 85 0.011
organophosphate catabolic process GO:0046434 148 0.011
micturition GO:0060073 4 0.011
response to glucose GO:0009749 136 0.011
positive regulation of intracellular signal transduction GO:1902533 138 0.011
circulatory system process GO:0003013 183 0.011
sequestering of metal ion GO:0051238 9 0.011
ribose phosphate biosynthetic process GO:0046390 87 0.011
regulation of system process GO:0044057 208 0.011
regulation of protein processing GO:0070613 50 0.011
ribonucleoside triphosphate catabolic process GO:0009203 122 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.010
regulation of protein maturation GO:1903317 50 0.010
negative regulation of catalytic activity GO:0043086 103 0.010
multicellular organismal reproductive process GO:0048609 233 0.010
spermatogenesis GO:0007283 99 0.010
cellular response to molecule of bacterial origin GO:0071219 56 0.010
regulation of glutamate secretion GO:0014048 17 0.010
positive regulation of ion transport GO:0043270 94 0.010
negative regulation of apoptotic process GO:0043066 181 0.010
positive regulation of camp mediated signaling GO:0043950 2 0.010
regulation of homeostatic process GO:0032844 101 0.010
positive regulation of peptide hormone secretion GO:0090277 50 0.010
carbohydrate derivative biosynthetic process GO:1901137 124 0.010
insulin receptor signaling pathway GO:0008286 24 0.010

Nmnat2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.023
nervous system disease DOID:863 0 0.023
sensory system disease DOID:0050155 0 0.016
usher syndrome DOID:0050439 0 0.011