Rattus norvegicus

0 known processes

Rab12

RAB12, member RAS oncogene family

Rab12 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of protein phosphorylation GO:0001932 183 0.107
transcription dna templated GO:0006351 377 0.104
rna biosynthetic process GO:0032774 380 0.096
protein phosphorylation GO:0006468 345 0.087
programmed cell death GO:0012501 392 0.077
nucleic acid templated transcription GO:0097659 379 0.073
heart morphogenesis GO:0003007 3 0.068
positive regulation of biosynthetic process GO:0009891 319 0.067
regulation of rna metabolic process GO:0051252 391 0.066
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.063
response to growth factor GO:0070848 189 0.062
regulation of rna biosynthetic process GO:2001141 381 0.062
cellular response to oxygen containing compound GO:1901701 386 0.060
regulation of nucleic acid templated transcription GO:1903506 380 0.059
response to extracellular stimulus GO:0009991 380 0.059
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.058
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.055
positive regulation of transcription dna templated GO:0045893 197 0.053
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.053
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.053
cellular response to organonitrogen compound GO:0071417 197 0.052
intracellular signal transduction GO:0035556 314 0.051
positive regulation of protein metabolic process GO:0051247 178 0.049
regulation of cell differentiation GO:0045595 320 0.047
regulation of catalytic activity GO:0050790 304 0.045
positive regulation of multicellular organismal process GO:0051240 387 0.045
protein complex assembly GO:0006461 263 0.044
negative regulation of biosynthetic process GO:0009890 168 0.043
regulation of protein modification process GO:0031399 194 0.042
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.042
reproductive process GO:0022414 372 0.042
regulation of phosphate metabolic process GO:0019220 349 0.041
cation transport GO:0006812 382 0.041
regulation of phosphorus metabolic process GO:0051174 349 0.041
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.040
central nervous system development GO:0007417 311 0.040
regulation of transcription dna templated GO:0006355 374 0.040
cellular component assembly GO:0022607 360 0.039
multicellular organism reproduction GO:0032504 233 0.039
response to glucocorticoid GO:0051384 223 0.039
cellular ketone metabolic process GO:0042180 51 0.039
cellular homeostasis GO:0019725 252 0.039
macromolecular complex assembly GO:0065003 273 0.039
transcription from rna polymerase ii promoter GO:0006366 252 0.039
negative regulation of rna metabolic process GO:0051253 123 0.039
positive regulation of molecular function GO:0044093 230 0.039
regulation of phosphorylation GO:0042325 248 0.038
rna metabolic process GO:0016070 406 0.038
response to nutrient levels GO:0031667 370 0.038
multi organism reproductive process GO:0044703 262 0.037
cellular response to stress GO:0033554 269 0.037
cardiac chamber development GO:0003205 1 0.037
regulation of cellular amino acid metabolic process GO:0006521 2 0.036
response to other organism GO:0051707 220 0.036
regulation of neurogenesis GO:0050767 247 0.035
anatomical structure morphogenesis GO:0009653 298 0.035
regulation of protein kinase activity GO:0045859 105 0.035
negative regulation of multicellular organismal process GO:0051241 203 0.034
positive regulation of nucleic acid templated transcription GO:1903508 197 0.034
regulation of apoptotic process GO:0042981 335 0.034
positive regulation of catalytic activity GO:0043085 184 0.034
cellular component biogenesis GO:0044085 368 0.034
regulation of protein metabolic process GO:0051246 289 0.034
regulation of cellular protein metabolic process GO:0032268 267 0.034
negative regulation of nucleic acid templated transcription GO:1903507 117 0.034
brain development GO:0007420 247 0.034
oxoacid metabolic process GO:0043436 290 0.034
regulation of cell development GO:0060284 263 0.034
response to radiation GO:0009314 137 0.033
negative regulation of transcription dna templated GO:0045892 116 0.033
cellular response to hormone stimulus GO:0032870 247 0.033
positive regulation of gene expression GO:0010628 244 0.032
regulation of cellular amine metabolic process GO:0033238 8 0.032
negative regulation of metabolic process GO:0009892 331 0.032
calcium ion transport GO:0006816 131 0.032
response to insulin GO:0032868 133 0.032
heart development GO:0007507 72 0.032
regulation of molecular function GO:0065009 398 0.032
protein complex biogenesis GO:0070271 263 0.032
regulation of nervous system development GO:0051960 264 0.032
metal ion transport GO:0030001 289 0.032
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.032
response to peptide GO:1901652 292 0.032
apoptotic process GO:0006915 381 0.031
negative regulation of nervous system development GO:0051961 79 0.031
negative regulation of developmental process GO:0051093 125 0.031
protein dephosphorylation GO:0006470 38 0.031
regulation of kinase activity GO:0043549 117 0.031
positive regulation of rna biosynthetic process GO:1902680 197 0.031
calcium ion homeostasis GO:0055074 162 0.031
regeneration GO:0031099 163 0.031
positive regulation of cellular component organization GO:0051130 200 0.030
regulation of cell proliferation GO:0042127 359 0.030
cellular amine metabolic process GO:0044106 38 0.030
carboxylic acid metabolic process GO:0019752 289 0.030
response to inorganic substance GO:0010035 377 0.030
homeostatic process GO:0042592 331 0.030
cellular response to lipid GO:0071396 201 0.030
positive regulation of cell proliferation GO:0008284 249 0.029
blood circulation GO:0008015 183 0.029
single organism reproductive process GO:0044702 297 0.029
positive regulation of phosphorylation GO:0042327 177 0.028
cation transmembrane transport GO:0098655 263 0.028
ion transmembrane transport GO:0034220 365 0.028
regulation of neuron differentiation GO:0045664 208 0.028
small gtpase mediated signal transduction GO:0007264 36 0.028
cellular divalent inorganic cation homeostasis GO:0072503 162 0.028
cell type specific apoptotic process GO:0097285 134 0.028
negative regulation of cellular biosynthetic process GO:0031327 161 0.028
regulation of cellular ketone metabolic process GO:0010565 27 0.027
response to peptide hormone GO:0043434 278 0.027
cellular chemical homeostasis GO:0055082 247 0.027
negative regulation of cell differentiation GO:0045596 99 0.027
protein complex subunit organization GO:0071822 302 0.027
regulation of metal ion transport GO:0010959 118 0.027
regulation of signal transduction GO:0009966 318 0.027
cellular response to nitrogen compound GO:1901699 210 0.027
single organism carbohydrate metabolic process GO:0044723 118 0.027
positive regulation of cellular biosynthetic process GO:0031328 295 0.026
cardiac ventricle development GO:0003231 1 0.026
cellular amino acid metabolic process GO:0006520 107 0.026
transmembrane transport GO:0055085 412 0.026
actin filament based process GO:0030029 86 0.026
response to carbohydrate GO:0009743 183 0.026
cellular response to growth factor stimulus GO:0071363 162 0.026
cell projection organization GO:0030030 302 0.026
spindle organization GO:0007051 2 0.026
positive regulation of developmental process GO:0051094 283 0.026
olfactory learning GO:0008355 1 0.025
multicellular organismal reproductive process GO:0048609 233 0.025
negative regulation of cellular metabolic process GO:0031324 281 0.025
regulation of transferase activity GO:0051338 123 0.024
amine metabolic process GO:0009308 38 0.024
response to decreased oxygen levels GO:0036293 237 0.024
cellular response to peptide hormone stimulus GO:0071375 120 0.024
positive regulation of cell differentiation GO:0045597 217 0.024
regulation of intracellular signal transduction GO:1902531 218 0.024
cellular response to endogenous stimulus GO:0071495 377 0.024
positive regulation of intracellular signal transduction GO:1902533 138 0.024
negative regulation of response to stimulus GO:0048585 155 0.024
response to hexose GO:0009746 144 0.024
response to glucose GO:0009749 136 0.024
cellular response to peptide GO:1901653 133 0.023
positive regulation of protein modification process GO:0031401 142 0.023
regulation of multicellular organismal development GO:2000026 376 0.023
protein heterooligomerization GO:0051291 89 0.023
response to corticosteroid GO:0031960 235 0.023
mitotic spindle organization GO:0007052 2 0.023
cell fate determination GO:0001709 2 0.023
single organism biosynthetic process GO:0044711 342 0.022
regulation of cellular component biogenesis GO:0044087 86 0.022
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.022
regulation of vesicle mediated transport GO:0060627 81 0.022
growth GO:0040007 165 0.022
neuron differentiation GO:0030182 368 0.022
response to nutrient GO:0007584 248 0.022
regulation of system process GO:0044057 208 0.022
catabolic process GO:0009056 351 0.022
response to monosaccharide GO:0034284 159 0.022
negative regulation of rna biosynthetic process GO:1902679 118 0.022
positive regulation of map kinase activity GO:0043406 46 0.022
reproduction GO:0000003 245 0.022
behavior GO:0007610 205 0.022
positive regulation of cellular amine metabolic process GO:0033240 3 0.022
cellular calcium ion homeostasis GO:0006874 160 0.021
cell adhesion GO:0007155 110 0.021
single organism organelle organization GO:1902589 180 0.021
nitrogen compound transport GO:0071705 229 0.021
cellular response to alcohol GO:0097306 87 0.021
cellular component morphogenesis GO:0032989 155 0.021
positive regulation of nervous system development GO:0051962 178 0.021
biological adhesion GO:0022610 110 0.021
intracellular transport GO:0046907 185 0.021
response to external biotic stimulus GO:0043207 221 0.020
protein oligomerization GO:0051259 191 0.020
positive regulation of rna metabolic process GO:0051254 203 0.020
positive regulation of signal transduction GO:0009967 175 0.020
cellular catabolic process GO:0044248 295 0.020
ion homeostasis GO:0050801 212 0.020
positive regulation of kinase activity GO:0033674 77 0.020
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.020
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.020
divalent metal ion transport GO:0070838 132 0.020
negative regulation of macromolecule metabolic process GO:0010605 260 0.019
regulation of cellular component organization GO:0051128 368 0.019
head development GO:0060322 247 0.019
metal ion homeostasis GO:0055065 186 0.019
heart contraction GO:0060047 57 0.019
negative regulation of cell cycle phase transition GO:1901988 4 0.019
regulation of cell projection organization GO:0031344 175 0.019
response to metal ion GO:0010038 253 0.019
regulation of organelle organization GO:0033043 80 0.019
cell cycle checkpoint GO:0000075 2 0.019
action potential GO:0001508 54 0.019
response to molecule of bacterial origin GO:0002237 194 0.019
positive regulation of cellular protein metabolic process GO:0032270 167 0.019
vesicle mediated transport GO:0016192 181 0.019
sexual reproduction GO:0019953 148 0.019
response to lipopolysaccharide GO:0032496 191 0.018
ribonucleotide metabolic process GO:0009259 231 0.018
positive regulation of transferase activity GO:0051347 81 0.018
regulation of ion transmembrane transport GO:0034765 121 0.018
positive regulation of protein kinase activity GO:0045860 73 0.018
regulation of programmed cell death GO:0043067 341 0.018
negative regulation of gene expression GO:0010629 199 0.018
divalent inorganic cation homeostasis GO:0072507 165 0.018
circulatory system development GO:0072359 134 0.018
positive regulation of neurogenesis GO:0050769 165 0.018
monosaccharide metabolic process GO:0005996 61 0.018
response to oxygen levels GO:0070482 265 0.018
g protein coupled receptor signaling pathway GO:0007186 242 0.018
organic acid metabolic process GO:0006082 292 0.018
negative regulation of molecular function GO:0044092 133 0.018
protein localization GO:0008104 191 0.018
chemical homeostasis GO:0048878 292 0.018
inorganic ion transmembrane transport GO:0098660 229 0.018
cellular response to insulin stimulus GO:0032869 81 0.017
potassium ion transmembrane transport GO:0071805 71 0.017
positive regulation of protein phosphorylation GO:0001934 135 0.017
macromolecule localization GO:0033036 252 0.017
organelle organization GO:0006996 266 0.017
establishment of protein localization GO:0045184 141 0.017
chemosensory behavior GO:0007635 2 0.017
regulation of transmembrane transport GO:0034762 122 0.017
circulatory system process GO:0003013 183 0.017
embryonic pattern specification GO:0009880 1 0.017
positive regulation of signaling GO:0023056 270 0.017
regulation of ion transport GO:0043269 245 0.017
regulation of neuron projection development GO:0010975 161 0.016
developmental process involved in reproduction GO:0003006 159 0.016
lysosomal transport GO:0007041 8 0.016
antigen receptor mediated signaling pathway GO:0050851 1 0.016
peptide transport GO:0015833 97 0.016
regulation of cellular component movement GO:0051270 150 0.016
epithelial cell proliferation GO:0050673 54 0.016
positive regulation of phosphate metabolic process GO:0045937 262 0.016
cardiovascular system development GO:0072358 134 0.016
regulation of transporter activity GO:0032409 50 0.016
negative regulation of apoptotic process GO:0043066 181 0.016
spermatogenesis GO:0007283 99 0.016
protein autophosphorylation GO:0046777 66 0.016
regulation of catabolic process GO:0009894 113 0.016
vascular process in circulatory system GO:0003018 96 0.016
gamete generation GO:0007276 124 0.016
positive regulation of phosphorus metabolic process GO:0010562 262 0.016
positive regulation of cellular component biogenesis GO:0044089 55 0.016
regulation of immune system process GO:0002682 123 0.016
axis specification GO:0009798 4 0.016
response to hypoxia GO:0001666 231 0.016
purine ribonucleotide metabolic process GO:0009150 227 0.016
taxis GO:0042330 67 0.016
gastrulation GO:0007369 2 0.016
carbohydrate derivative metabolic process GO:1901135 346 0.016
negative regulation of cardiac muscle tissue development GO:0055026 3 0.015
neurological system process GO:0050877 219 0.015
divalent inorganic cation transport GO:0072511 134 0.015
muscle system process GO:0003012 115 0.015
negative regulation of transport GO:0051051 136 0.015
ras protein signal transduction GO:0007265 29 0.015
regulation of hydrolase activity GO:0051336 143 0.015
negative regulation of phosphate metabolic process GO:0045936 80 0.015
regulation of growth GO:0040008 105 0.015
negative regulation of cell communication GO:0010648 158 0.015
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.015
cell growth GO:0016049 104 0.015
camp metabolic process GO:0046058 63 0.015
immune system process GO:0002376 204 0.015
negative regulation of heart growth GO:0061117 3 0.015
inorganic cation transmembrane transport GO:0098662 202 0.015
wound healing GO:0042060 122 0.015
cellular cation homeostasis GO:0030003 180 0.015
negative regulation of programmed cell death GO:0043069 183 0.014
tissue development GO:0009888 252 0.014
regulation of purine nucleotide metabolic process GO:1900542 115 0.014
amide transport GO:0042886 105 0.014
regulation of homeostatic process GO:0032844 101 0.014
erbb signaling pathway GO:0038127 23 0.014
muscle contraction GO:0006936 88 0.014
mapk cascade GO:0000165 140 0.014
regulation of response to external stimulus GO:0032101 106 0.014
heterocycle catabolic process GO:0046700 167 0.014
enzyme linked receptor protein signaling pathway GO:0007167 116 0.014
chromosome segregation GO:0007059 2 0.014
response to biotic stimulus GO:0009607 226 0.014
learning or memory GO:0007611 90 0.014
positive regulation of cell projection organization GO:0031346 111 0.014
response to ketone GO:1901654 182 0.014
actin cytoskeleton organization GO:0030036 73 0.014
regulation of cell cycle GO:0051726 73 0.014
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.013
single organism catabolic process GO:0044712 283 0.013
negative regulation of cell development GO:0010721 82 0.013
ribonucleoside metabolic process GO:0009119 174 0.013
potassium ion transport GO:0006813 97 0.013
sequestering of metal ion GO:0051238 9 0.013
organ regeneration GO:0031100 101 0.013
carbohydrate metabolic process GO:0005975 130 0.013
negative regulation of cell proliferation GO:0008285 119 0.013
regulation of stem cell differentiation GO:2000736 2 0.013
negative regulation of neurogenesis GO:0050768 78 0.013
negative regulation of protein metabolic process GO:0051248 114 0.013
gtp catabolic process GO:0006184 71 0.013
heart process GO:0003015 57 0.013
carbohydrate derivative catabolic process GO:1901136 147 0.013
organic substance catabolic process GO:1901575 316 0.013
anion transport GO:0006820 178 0.013
response to wounding GO:0009611 254 0.013
neuron projection development GO:0031175 273 0.013
regulation of calcium ion transport GO:0051924 77 0.013
ribose phosphate metabolic process GO:0019693 235 0.013
response to acid chemical GO:0001101 222 0.013
positive regulation of cell development GO:0010720 176 0.013
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.013
nucleoside phosphate metabolic process GO:0006753 283 0.013
positive regulation of neuron differentiation GO:0045666 126 0.013
peptidyl amino acid modification GO:0018193 126 0.013
response to ethanol GO:0045471 162 0.013
t cell receptor signaling pathway GO:0050852 1 0.013
cyclic nucleotide metabolic process GO:0009187 80 0.013
positive regulation of cell communication GO:0010647 271 0.013
regulation of endocytosis GO:0030100 42 0.013
glucose homeostasis GO:0042593 75 0.013
synaptic growth at neuromuscular junction GO:0051124 1 0.013
cognition GO:0050890 92 0.012
regulation of mapk cascade GO:0043408 116 0.012
regulation of cytoskeleton organization GO:0051493 49 0.012
response to calcium ion GO:0051592 59 0.012
olfactory behavior GO:0042048 2 0.012
negative regulation of signaling GO:0023057 157 0.012
positive regulation of erk1 and erk2 cascade GO:0070374 29 0.012
negative regulation of catalytic activity GO:0043086 103 0.012
cellular metal ion homeostasis GO:0006875 172 0.012
cell activation GO:0001775 97 0.012
anatomical structure formation involved in morphogenesis GO:0048646 83 0.012
cellular response to organic cyclic compound GO:0071407 202 0.012
positive regulation of ion transport GO:0043270 94 0.012
response to mechanical stimulus GO:0009612 134 0.012
multicellular organism growth GO:0035264 1 0.012
regulation of secretion by cell GO:1903530 208 0.012
positive regulation of secretion by cell GO:1903532 128 0.012
regulation of dna metabolic process GO:0051052 60 0.012
cellular ion homeostasis GO:0006873 184 0.012
cellular carbohydrate metabolic process GO:0044262 72 0.012
negative regulation of protein phosphorylation GO:0001933 44 0.012
organic anion transport GO:0015711 132 0.012
regulation of protein serine threonine kinase activity GO:0071900 64 0.012
macromolecular complex subunit organization GO:0043933 339 0.012
macromolecule catabolic process GO:0009057 58 0.012
regulation of protein transport GO:0051223 68 0.012
cytosolic calcium ion homeostasis GO:0051480 140 0.012
cell morphogenesis GO:0000902 142 0.012
cellular response to abiotic stimulus GO:0071214 85 0.012
single organism intracellular transport GO:1902582 166 0.012
carbohydrate homeostasis GO:0033500 75 0.012
sequestering of calcium ion GO:0051208 8 0.012
locomotion GO:0040011 237 0.011
negative regulation of signal transduction GO:0009968 83 0.011
male gamete generation GO:0048232 99 0.011
monovalent inorganic cation transport GO:0015672 172 0.011
cellular process involved in reproduction in multicellular organism GO:0022412 35 0.011
response to vitamin GO:0033273 131 0.011
cytoplasmic transport GO:0016482 115 0.011
negative regulation of cell death GO:0060548 229 0.011
erythrocyte differentiation GO:0030218 1 0.011
regulation of anatomical structure size GO:0090066 135 0.011
negative regulation of phosphorus metabolic process GO:0010563 80 0.011
cation homeostasis GO:0055080 195 0.011
secretion by cell GO:0032940 248 0.011
regulation of secretion GO:0051046 224 0.011
cell morphogenesis involved in differentiation GO:0000904 119 0.011
nucleotide metabolic process GO:0009117 279 0.011
synaptic transmission GO:0007268 235 0.011
signal transduction by phosphorylation GO:0023014 144 0.011
microtubule organizing center organization GO:0031023 1 0.011
anterior posterior pattern specification GO:0009952 1 0.011
cellular response to carbohydrate stimulus GO:0071322 72 0.011
regulation of blood circulation GO:1903522 110 0.011
epithelial cell differentiation GO:0030855 71 0.011
localization of cell GO:0051674 202 0.011
regulation of peptide transport GO:0090087 87 0.011
response to light stimulus GO:0009416 52 0.011
dendrite development GO:0016358 72 0.011
negative regulation of homeostatic process GO:0032845 47 0.011
carbohydrate derivative biosynthetic process GO:1901137 124 0.011
response to estrogen GO:0043627 232 0.011
regulation of transmembrane transporter activity GO:0022898 49 0.011
regulation of protein localization GO:0032880 81 0.011
regulation of hormone levels GO:0010817 187 0.011
epidermal growth factor receptor signaling pathway GO:0007173 23 0.011
regulation of necroptotic process GO:0060544 2 0.011
nucleobase containing small molecule metabolic process GO:0055086 316 0.011
lipid metabolic process GO:0006629 283 0.011
negative regulation of cellular protein metabolic process GO:0032269 106 0.010
regulation of proteasomal protein catabolic process GO:0061136 4 0.010
regulation of fat cell differentiation GO:0045598 3 0.010
positive regulation of response to stimulus GO:0048584 285 0.010
proteolysis GO:0006508 175 0.010
regulation of membrane potential GO:0042391 110 0.010
positive regulation of cyclic nucleotide biosynthetic process GO:0030804 34 0.010
hormone secretion GO:0046879 115 0.010
erk1 and erk2 cascade GO:0070371 48 0.010
positive regulation of endothelial cell migration GO:0010595 4 0.010

Rab12 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.022
disease of anatomical entity DOID:7 0 0.014
nervous system disease DOID:863 0 0.014
musculoskeletal system disease DOID:17 0 0.014
urinary system disease DOID:18 0 0.011
central nervous system disease DOID:331 0 0.011
kidney disease DOID:557 0 0.011