Rattus norvegicus

0 known processes

Smek1

SMEK homolog 1, suppressor of mek1 (Dictyostelium)

(Aliases: RGD1309059)

Smek1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of phosphorus metabolic process GO:0051174 349 0.243
apoptotic process GO:0006915 381 0.132
positive regulation of cell communication GO:0010647 271 0.095
reproductive structure development GO:0048608 128 0.081
cell projection organization GO:0030030 302 0.075
regulation of apoptotic process GO:0042981 335 0.075
positive regulation of programmed cell death GO:0043068 157 0.065
organic acid metabolic process GO:0006082 292 0.062
regulation of catalytic activity GO:0050790 304 0.059
regulation of cell proliferation GO:0042127 359 0.059
regulation of nucleic acid templated transcription GO:1903506 380 0.058
positive regulation of cell death GO:0010942 184 0.058
intracellular signal transduction GO:0035556 314 0.055
multicellular organismal signaling GO:0035637 44 0.055
neuron differentiation GO:0030182 368 0.055
positive regulation of cellular protein metabolic process GO:0032270 167 0.053
protein phosphorylation GO:0006468 345 0.051
positive regulation of phosphorylation GO:0042327 177 0.049
positive regulation of phosphate metabolic process GO:0045937 262 0.049
organelle organization GO:0006996 266 0.046
negative regulation of apoptotic process GO:0043066 181 0.046
single organism reproductive process GO:0044702 297 0.046
negative regulation of programmed cell death GO:0043069 183 0.046
regulation of multicellular organismal development GO:2000026 376 0.045
lipid transport GO:0006869 61 0.043
transmission of nerve impulse GO:0019226 42 0.043
carboxylic acid metabolic process GO:0019752 289 0.043
organophosphate metabolic process GO:0019637 370 0.043
regulation of protein metabolic process GO:0051246 289 0.042
alpha amino acid metabolic process GO:1901605 71 0.041
positive regulation of intracellular signal transduction GO:1902533 138 0.041
regulation of intracellular signal transduction GO:1902531 218 0.040
positive regulation of catalytic activity GO:0043085 184 0.040
oxoacid metabolic process GO:0043436 290 0.040
development of primary sexual characteristics GO:0045137 107 0.039
amine metabolic process GO:0009308 38 0.039
programmed cell death GO:0012501 392 0.039
response to purine containing compound GO:0014074 126 0.039
regulation of protein phosphorylation GO:0001932 183 0.037
neuron development GO:0048666 286 0.036
response to external biotic stimulus GO:0043207 221 0.036
single organism biosynthetic process GO:0044711 342 0.035
nucleobase containing small molecule metabolic process GO:0055086 316 0.035
positive regulation of multicellular organismal process GO:0051240 387 0.035
carbohydrate derivative metabolic process GO:1901135 346 0.035
response to temperature stimulus GO:0009266 94 0.034
regulation of molecular function GO:0065009 398 0.034
negative regulation of cell death GO:0060548 229 0.034
response to nutrient GO:0007584 248 0.033
regulation of transferase activity GO:0051338 123 0.033
response to organophosphorus GO:0046683 102 0.032
positive regulation of protein phosphorylation GO:0001934 135 0.032
ion homeostasis GO:0050801 212 0.032
positive regulation of molecular function GO:0044093 230 0.032
negative regulation of macromolecule metabolic process GO:0010605 260 0.031
positive regulation of phosphorus metabolic process GO:0010562 262 0.031
regulation of programmed cell death GO:0043067 341 0.031
response to oxidative stress GO:0006979 186 0.030
positive regulation of cell differentiation GO:0045597 217 0.030
regulation of cellular protein metabolic process GO:0032268 267 0.030
cellular amino acid metabolic process GO:0006520 107 0.030
response to heat GO:0009408 60 0.030
negative regulation of metabolic process GO:0009892 331 0.030
response to nutrient levels GO:0031667 370 0.028
lipid localization GO:0010876 62 0.028
regulation of neuron differentiation GO:0045664 208 0.028
purine nucleotide metabolic process GO:0006163 229 0.028
peptide secretion GO:0002790 86 0.028
neuron projection development GO:0031175 273 0.028
regulation of cell development GO:0060284 263 0.028
positive regulation of protein modification process GO:0031401 142 0.028
action potential GO:0001508 54 0.027
regulation of system process GO:0044057 208 0.027
carbohydrate metabolic process GO:0005975 130 0.027
negative regulation of biosynthetic process GO:0009890 168 0.027
nucleoside phosphate metabolic process GO:0006753 283 0.026
cellular catabolic process GO:0044248 295 0.026
regulation of signal transduction GO:0009966 318 0.026
response to wounding GO:0009611 254 0.026
regulation of protein kinase activity GO:0045859 105 0.025
response to hydrogen peroxide GO:0042542 89 0.025
positive regulation of cell development GO:0010720 176 0.025
regulation of mapk cascade GO:0043408 116 0.025
regulation of nervous system development GO:0051960 264 0.024
organophosphate biosynthetic process GO:0090407 143 0.024
positive regulation of protein kinase activity GO:0045860 73 0.024
regulation of cellular amine metabolic process GO:0033238 8 0.024
mapk cascade GO:0000165 140 0.024
positive regulation of signaling GO:0023056 270 0.023
ribonucleotide metabolic process GO:0009259 231 0.023
regulation of neurogenesis GO:0050767 247 0.022
small molecule biosynthetic process GO:0044283 124 0.022
positive regulation of response to stimulus GO:0048584 285 0.022
regulation of cellular component organization GO:0051128 368 0.022
regulation of transcription dna templated GO:0006355 374 0.022
positive regulation of cell proliferation GO:0008284 249 0.022
organic substance catabolic process GO:1901575 316 0.021
vesicle mediated transport GO:0016192 181 0.021
response to extracellular stimulus GO:0009991 380 0.021
response to monosaccharide GO:0034284 159 0.021
regulation of purine nucleotide metabolic process GO:1900542 115 0.021
reproductive process GO:0022414 372 0.021
neuronal action potential GO:0019228 35 0.021
positive regulation of signal transduction GO:0009967 175 0.020
reproductive system development GO:0061458 128 0.020
regulation of cellular amino acid metabolic process GO:0006521 2 0.020
defense response GO:0006952 194 0.020
nucleotide metabolic process GO:0009117 279 0.020
regulation of phosphate metabolic process GO:0019220 349 0.020
nucleic acid templated transcription GO:0097659 379 0.019
catabolic process GO:0009056 351 0.019
macromolecule localization GO:0033036 252 0.019
cellular metal ion homeostasis GO:0006875 172 0.019
positive regulation of cellular amine metabolic process GO:0033240 3 0.019
regulation of protein modification process GO:0031399 194 0.019
regulation of cellular ketone metabolic process GO:0010565 27 0.019
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.019
positive regulation of neuron differentiation GO:0045666 126 0.018
developmental process involved in reproduction GO:0003006 159 0.018
regulation of rna biosynthetic process GO:2001141 381 0.018
positive regulation of nervous system development GO:0051962 178 0.018
response to carbohydrate GO:0009743 183 0.018
positive regulation of mapk cascade GO:0043410 92 0.018
ribonucleoside catabolic process GO:0042454 126 0.018
response to oxygen levels GO:0070482 265 0.018
multicellular organismal reproductive process GO:0048609 233 0.018
chemical homeostasis GO:0048878 292 0.018
neurological system process GO:0050877 219 0.017
response to estradiol GO:0032355 164 0.017
regulation of anatomical structure size GO:0090066 135 0.017
response to alkaloid GO:0043279 132 0.017
defecation GO:0030421 1 0.017
sex differentiation GO:0007548 113 0.017
protein complex subunit organization GO:0071822 302 0.017
retina morphogenesis in camera type eye GO:0060042 1 0.016
regulation of neuron apoptotic process GO:0043523 83 0.016
response to camp GO:0051591 91 0.016
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.016
organonitrogen compound catabolic process GO:1901565 179 0.016
regulation of cell projection organization GO:0031344 175 0.016
negative regulation of signaling GO:0023057 157 0.016
growth GO:0040007 165 0.016
regulation of phosphorylation GO:0042325 248 0.016
neuron death GO:0070997 127 0.016
carboxylic acid catabolic process GO:0046395 49 0.016
single organism catabolic process GO:0044712 283 0.016
response to tumor necrosis factor GO:0034612 56 0.016
positive regulation of apoptotic process GO:0043065 154 0.016
central nervous system development GO:0007417 311 0.016
small gtpase mediated signal transduction GO:0007264 36 0.015
anatomical structure morphogenesis GO:0009653 298 0.015
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.015
regulation of nucleotide metabolic process GO:0006140 117 0.015
inflammatory response GO:0006954 150 0.015
purine containing compound metabolic process GO:0072521 253 0.015
positive regulation of developmental process GO:0051094 283 0.015
regulation of cell differentiation GO:0045595 320 0.015
purine ribonucleotide metabolic process GO:0009150 227 0.015
regulation of hydrolase activity GO:0051336 143 0.015
positive regulation of protein metabolic process GO:0051247 178 0.015
cellular component biogenesis GO:0044085 368 0.014
negative regulation of cellular biosynthetic process GO:0031327 161 0.014
single organism organelle organization GO:1902589 180 0.014
regulation of erk1 and erk2 cascade GO:0070372 41 0.014
negative regulation of phosphorus metabolic process GO:0010563 80 0.014
signal release GO:0023061 145 0.014
ribonucleoside metabolic process GO:0009119 174 0.014
peptide transport GO:0015833 97 0.014
metal ion homeostasis GO:0055065 186 0.014
cellular ion homeostasis GO:0006873 184 0.014
negative regulation of transport GO:0051051 136 0.014
negative regulation of cell communication GO:0010648 158 0.014
signal transduction by phosphorylation GO:0023014 144 0.014
response to axon injury GO:0048678 59 0.014
steroid metabolic process GO:0008202 73 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.014
regulation of neuron death GO:1901214 115 0.014
mechanoreceptor differentiation GO:0042490 2 0.014
cellular ketone metabolic process GO:0042180 51 0.014
regulation of neuron projection development GO:0010975 161 0.014
positive regulation of transferase activity GO:0051347 81 0.014
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.014
regulation of dna metabolic process GO:0051052 60 0.014
metal ion transport GO:0030001 289 0.013
cellular amine metabolic process GO:0044106 38 0.013
regulation of kinase activity GO:0043549 117 0.013
response to corticosteroid GO:0031960 235 0.013
cellular cation homeostasis GO:0030003 180 0.013
ribose phosphate metabolic process GO:0019693 235 0.013
positive regulation of neurogenesis GO:0050769 165 0.013
positive regulation of neuron projection development GO:0010976 99 0.013
salivary gland development GO:0007431 3 0.013
response to biotic stimulus GO:0009607 226 0.013
endocytosis GO:0006897 84 0.013
negative regulation of neuron death GO:1901215 69 0.013
cellular component maintenance GO:0043954 4 0.013
cellular response to stress GO:0033554 269 0.013
rna metabolic process GO:0016070 406 0.013
cellular response to oxygen containing compound GO:1901701 386 0.013
response to glucose GO:0009749 136 0.013
cellular homeostasis GO:0019725 252 0.012
regulation of protein serine threonine kinase activity GO:0071900 64 0.012
circulatory system process GO:0003013 183 0.012
multi organism reproductive process GO:0044703 262 0.012
macromolecular complex subunit organization GO:0043933 339 0.012
reactive oxygen species metabolic process GO:0072593 37 0.012
fatty acid transport GO:0015908 25 0.012
regulation of peptide secretion GO:0002791 82 0.012
regulation of peptide transport GO:0090087 87 0.012
regulation of peptide hormone secretion GO:0090276 80 0.012
cellular response to cytokine stimulus GO:0071345 127 0.012
regulation of dendrite development GO:0050773 59 0.012
negative regulation of innate immune response GO:0045824 4 0.012
regeneration GO:0031099 163 0.012
response to cytokine GO:0034097 215 0.012
cellular response to endogenous stimulus GO:0071495 377 0.012
cellular response to external stimulus GO:0071496 118 0.011
aging GO:0007568 241 0.011
positive regulation of kinase activity GO:0033674 77 0.011
regulation of response to stress GO:0080134 126 0.011
aromatic compound catabolic process GO:0019439 168 0.011
cyclic purine nucleotide metabolic process GO:0052652 62 0.011
gamete generation GO:0007276 124 0.011
leukocyte cell cell adhesion GO:0007159 4 0.011
response to estrogen GO:0043627 232 0.011
protein complex assembly GO:0006461 263 0.011
leukocyte activation GO:0045321 76 0.011
nucleoside phosphate biosynthetic process GO:1901293 102 0.011
defense response to gram negative bacterium GO:0050829 3 0.011
negative regulation of natural killer cell mediated immunity GO:0002716 4 0.011
response to molecule of bacterial origin GO:0002237 194 0.011
cytosolic calcium ion homeostasis GO:0051480 140 0.011
reproduction GO:0000003 245 0.011
ribonucleoside triphosphate catabolic process GO:0009203 122 0.011
positive regulation of cellular catabolic process GO:0031331 71 0.011
tissue development GO:0009888 252 0.011
regulation of cellular catabolic process GO:0031329 101 0.011
response to decreased oxygen levels GO:0036293 237 0.011
regulation of natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002858 1 0.011
sulfur amino acid metabolic process GO:0000096 9 0.011
pigment biosynthetic process GO:0046148 4 0.011
nucleoside metabolic process GO:0009116 179 0.011
negative regulation of molecular function GO:0044092 133 0.011
positive regulation of cell projection organization GO:0031346 111 0.011
female pregnancy GO:0007565 122 0.011
regulation of vesicle mediated transport GO:0060627 81 0.011
dna metabolic process GO:0006259 96 0.011
glycosyl compound metabolic process GO:1901657 182 0.011
regulation of map kinase activity GO:0043405 53 0.010
positive regulation of catabolic process GO:0009896 78 0.010
nucleotide catabolic process GO:0009166 139 0.010
rhythmic process GO:0048511 156 0.010
sexual reproduction GO:0019953 148 0.010
multicellular organism reproduction GO:0032504 233 0.010
response to hexose GO:0009746 144 0.010
monocarboxylic acid transport GO:0015718 52 0.010
amide transport GO:0042886 105 0.010
spermatogenesis GO:0007283 99 0.010

Smek1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.017
disease of cellular proliferation DOID:14566 0 0.017
organ system cancer DOID:0050686 0 0.017
disease of anatomical entity DOID:7 0 0.011
nervous system disease DOID:863 0 0.011
musculoskeletal system disease DOID:17 0 0.010
disease of metabolism DOID:0014667 0 0.010