Rattus norvegicus

12 known processes

Smek2

SMEK homolog 2, suppressor of mek1 (Dictyostelium)

(Aliases: RGD1309450)

Smek2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
enzyme linked receptor protein signaling pathway GO:0007167 116 0.235
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.180
neuron differentiation GO:0030182 368 0.144
protein complex biogenesis GO:0070271 263 0.141
rna biosynthetic process GO:0032774 380 0.133
cellular component biogenesis GO:0044085 368 0.131
rna metabolic process GO:0016070 406 0.118
transcription from rna polymerase ii promoter GO:0006366 252 0.106
protein complex assembly GO:0006461 263 0.100
transcription dna templated GO:0006351 377 0.098
nucleic acid templated transcription GO:0097659 379 0.097
regulation of rab protein signal transduction GO:0032483 3 0.073
regulation of nucleic acid templated transcription GO:1903506 380 0.059
regulation of transcription dna templated GO:0006355 374 0.058
immune system development GO:0002520 41 0.058
negative regulation of developmental process GO:0051093 125 0.058
regulation of catabolic process GO:0009894 113 0.057
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.055
immune system process GO:0002376 204 0.053
cellular response to hormone stimulus GO:0032870 247 0.052
axonogenesis GO:0007409 71 0.051
cell projection organization GO:0030030 302 0.050
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.050
brain development GO:0007420 247 0.049
programmed cell death GO:0012501 392 0.049
macromolecular complex assembly GO:0065003 273 0.049
negative regulation of response to stimulus GO:0048585 155 0.048
positive regulation of nucleic acid templated transcription GO:1903508 197 0.048
programmed necrotic cell death GO:0097300 2 0.045
regulation of cellular response to stress GO:0080135 49 0.045
ras protein signal transduction GO:0007265 29 0.042
intracellular signal transduction GO:0035556 314 0.041
negative regulation of tor signaling GO:0032007 2 0.040
response to metal ion GO:0010038 253 0.040
cellular component assembly GO:0022607 360 0.040
cellular catabolic process GO:0044248 295 0.039
regulation of cellular component organization GO:0051128 368 0.037
cognition GO:0050890 92 0.037
learning or memory GO:0007611 90 0.036
cellular homeostasis GO:0019725 252 0.036
cellular component morphogenesis GO:0032989 155 0.035
protein localization to endoplasmic reticulum GO:0070972 1 0.034
carboxylic acid metabolic process GO:0019752 289 0.034
organic acid metabolic process GO:0006082 292 0.034
protein autophosphorylation GO:0046777 66 0.034
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.033
regulation of cell projection organization GO:0031344 175 0.033
apoptotic process GO:0006915 381 0.033
negative regulation of multicellular organismal process GO:0051241 203 0.033
regulation of response to stress GO:0080134 126 0.033
regulation of cellular amino acid metabolic process GO:0006521 2 0.032
regulation of cellular catabolic process GO:0031329 101 0.032
protein transport GO:0015031 132 0.031
negative regulation of cellular response to insulin stimulus GO:1900077 11 0.030
cellular amino acid metabolic process GO:0006520 107 0.030
amine metabolic process GO:0009308 38 0.029
positive regulation of transcription dna templated GO:0045893 197 0.029
regulation of phosphate metabolic process GO:0019220 349 0.029
cell migration GO:0016477 197 0.028
b cell differentiation GO:0030183 2 0.028
cellular amine metabolic process GO:0044106 38 0.027
catabolic process GO:0009056 351 0.026
positive regulation of gene expression GO:0010628 244 0.026
carbohydrate homeostasis GO:0033500 75 0.026
regulation of cellular component movement GO:0051270 150 0.026
regulation of molecular function GO:0065009 398 0.026
positive regulation of catabolic process GO:0009896 78 0.026
regulation of phosphorus metabolic process GO:0051174 349 0.026
regulation of cell differentiation GO:0045595 320 0.025
glycerolipid metabolic process GO:0046486 67 0.025
protein complex subunit organization GO:0071822 302 0.025
organic substance catabolic process GO:1901575 316 0.024
regulation of intracellular signal transduction GO:1902531 218 0.024
tube formation GO:0035148 3 0.023
negative regulation of insulin receptor signaling pathway GO:0046627 10 0.023
positive regulation of phosphorus metabolic process GO:0010562 262 0.023
response to decreased oxygen levels GO:0036293 237 0.023
positive regulation of cellular component organization GO:0051130 200 0.023
hematopoietic or lymphoid organ development GO:0048534 36 0.023
oxoacid metabolic process GO:0043436 290 0.023
carbohydrate metabolic process GO:0005975 130 0.022
behavior GO:0007610 205 0.022
small gtpase mediated signal transduction GO:0007264 36 0.022
axon cargo transport GO:0008088 1 0.022
cellular response to nitrite GO:0071250 2 0.022
regulation of multicellular organismal development GO:2000026 376 0.022
regulation of locomotion GO:0040012 148 0.021
positive regulation of catalytic activity GO:0043085 184 0.021
regulation of cellular protein metabolic process GO:0032268 267 0.021
axon development GO:0061564 96 0.021
regulation of cellular localization GO:0060341 263 0.021
regulation of apoptotic process GO:0042981 335 0.021
positive regulation of rna metabolic process GO:0051254 203 0.021
neuron apoptotic process GO:0051402 88 0.021
macromolecular complex subunit organization GO:0043933 339 0.020
positive regulation of cell proliferation GO:0008284 249 0.020
negative regulation of macromolecule metabolic process GO:0010605 260 0.020
response to acid chemical GO:0001101 222 0.020
regulation of cellular component biogenesis GO:0044087 86 0.020
cellular response to peptide hormone stimulus GO:0071375 120 0.019
head development GO:0060322 247 0.019
cell activation GO:0001775 97 0.019
central nervous system development GO:0007417 311 0.019
single organism catabolic process GO:0044712 283 0.019
protein homooligomerization GO:0051260 91 0.019
positive regulation of rna biosynthetic process GO:1902680 197 0.019
cellular response to stress GO:0033554 269 0.019
multi organism reproductive process GO:0044703 262 0.019
regulation of neuron projection development GO:0010975 161 0.019
regulation of neuron differentiation GO:0045664 208 0.019
ribose phosphate metabolic process GO:0019693 235 0.019
negative regulation of programmed cell death GO:0043069 183 0.019
regulation of cellular amine metabolic process GO:0033238 8 0.019
memory GO:0007613 54 0.018
locomotion GO:0040011 237 0.018
cellular ketone metabolic process GO:0042180 51 0.018
hemopoiesis GO:0030097 34 0.018
positive regulation of molecular function GO:0044093 230 0.018
positive regulation of apoptotic process GO:0043065 154 0.018
positive regulation of rab gtpase activity GO:0032851 3 0.018
cellular response to growth factor stimulus GO:0071363 162 0.017
positive regulation of cellular biosynthetic process GO:0031328 295 0.017
cellular response to oxygen containing compound GO:1901701 386 0.017
chemical homeostasis GO:0048878 292 0.017
purine ribonucleotide metabolic process GO:0009150 227 0.017
cellular component movement GO:0006928 248 0.017
positive regulation of nucleotide catabolic process GO:0030813 53 0.017
cellular chemical homeostasis GO:0055082 247 0.017
neurological system process GO:0050877 219 0.017
negative regulation of cellular metabolic process GO:0031324 281 0.017
positive regulation of response to stimulus GO:0048584 285 0.017
ion homeostasis GO:0050801 212 0.016
regulation of behavior GO:0050795 61 0.016
actin filament based process GO:0030029 86 0.016
regulation of cellular ketone metabolic process GO:0010565 27 0.016
regulation of nervous system development GO:0051960 264 0.016
protein phosphorylation GO:0006468 345 0.016
negative regulation of signal transduction GO:0009968 83 0.015
glucose homeostasis GO:0042593 75 0.015
secretion GO:0046903 307 0.015
regulation of neurogenesis GO:0050767 247 0.015
positive regulation of ras gtpase activity GO:0032320 28 0.015
regulation of rna metabolic process GO:0051252 391 0.015
response to oxygen levels GO:0070482 265 0.015
negative regulation of cell proliferation GO:0008285 119 0.015
response to transition metal nanoparticle GO:1990267 122 0.015
response to cytokine GO:0034097 215 0.014
negative regulation of transport GO:0051051 136 0.014
homeostatic process GO:0042592 331 0.014
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.014
regulation of cell migration GO:0030334 128 0.014
response to glucose GO:0009749 136 0.014
negative regulation of cell cycle phase transition GO:1901988 4 0.014
homeostasis of number of cells GO:0048872 10 0.014
response to estrogen GO:0043627 232 0.014
response to alkaloid GO:0043279 132 0.014
multicellular organismal movement GO:0050879 17 0.014
positive regulation of gtpase activity GO:0043547 47 0.014
neuron projection development GO:0031175 273 0.014
neuron development GO:0048666 286 0.014
cell cycle checkpoint GO:0000075 2 0.013
positive regulation of cell communication GO:0010647 271 0.013
cation homeostasis GO:0055080 195 0.013
positive regulation of secretion GO:0051047 140 0.013
metal ion homeostasis GO:0055065 186 0.013
cation transport GO:0006812 382 0.013
extrinsic apoptotic signaling pathway GO:0097191 10 0.013
neural crest cell development GO:0014032 2 0.013
regulation of mapk cascade GO:0043408 116 0.013
regulation of gluconeogenesis GO:0006111 4 0.013
multicellular organismal reproductive process GO:0048609 233 0.013
response to molecule of bacterial origin GO:0002237 194 0.013
chromosome organization GO:0051276 36 0.013
response to inorganic substance GO:0010035 377 0.013
positive regulation of biosynthetic process GO:0009891 319 0.013
epithelial tube formation GO:0072175 3 0.013
negative regulation of signaling GO:0023057 157 0.013
negative regulation of cell communication GO:0010648 158 0.013
response to carbohydrate GO:0009743 183 0.013
regulation of immunoglobulin mediated immune response GO:0002889 2 0.013
macromolecule localization GO:0033036 252 0.012
cellular response to hypoxia GO:0071456 51 0.012
mammary gland epithelium development GO:0061180 1 0.012
regulation of vesicle mediated transport GO:0060627 81 0.012
purine nucleoside metabolic process GO:0042278 169 0.012
anatomical structure morphogenesis GO:0009653 298 0.012
regulation of phosphorylation GO:0042325 248 0.012
organophosphate metabolic process GO:0019637 370 0.012
positive regulation of cell projection organization GO:0031346 111 0.012
negative regulation of leukocyte apoptotic process GO:2000107 4 0.012
positive regulation of cell death GO:0010942 184 0.012
single organism reproductive process GO:0044702 297 0.012
neural tube formation GO:0001841 1 0.012
positive regulation of transport GO:0051050 245 0.012
regulation of anatomical structure morphogenesis GO:0022603 141 0.012
purine nucleoside triphosphate metabolic process GO:0009144 141 0.012
secretion by cell GO:0032940 248 0.012
protein oligomerization GO:0051259 191 0.012
cellular response to organic cyclic compound GO:0071407 202 0.012
regulation of cellular component size GO:0032535 51 0.011
negative regulation of cell differentiation GO:0045596 99 0.011
positive regulation of organelle organization GO:0010638 48 0.011
cell morphogenesis involved in differentiation GO:0000904 119 0.011
negative regulation of neuron differentiation GO:0045665 62 0.011
alcohol metabolic process GO:0006066 77 0.011
cellular response to external stimulus GO:0071496 118 0.011
regulation of cell development GO:0060284 263 0.011
morphogenesis of an epithelium GO:0002009 20 0.011
peptidyl cysteine modification GO:0018198 2 0.011
cellular macromolecular complex assembly GO:0034622 58 0.011
biological adhesion GO:0022610 110 0.011
cytoskeleton organization GO:0007010 111 0.011
exocrine system development GO:0035272 5 0.011
multicellular organism reproduction GO:0032504 233 0.011
negative regulation of metabolic process GO:0009892 331 0.011
negative regulation of cellular component organization GO:0051129 83 0.011
peptide biosynthetic process GO:0043043 3 0.011
protein localization GO:0008104 191 0.011
metal ion transport GO:0030001 289 0.011
t cell chemotaxis GO:0010818 2 0.011
regulation of isotype switching GO:0045191 1 0.010
cellular cation homeostasis GO:0030003 180 0.010
purine ribonucleoside catabolic process GO:0046130 124 0.010
response to electrical stimulus GO:0051602 56 0.010
positive regulation of phosphate metabolic process GO:0045937 262 0.010
nucleotide metabolic process GO:0009117 279 0.010
response to ethanol GO:0045471 162 0.010
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.010
positive regulation of nucleotide metabolic process GO:0045981 91 0.010
somatic diversification of immunoglobulins involved in immune response GO:0002208 1 0.010
ion transmembrane transport GO:0034220 365 0.010
positive regulation of smooth muscle cell proliferation GO:0048661 51 0.010
lymphocyte activation GO:0046649 43 0.010

Smek2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org