Rattus norvegicus

0 known processes

Map4k5

mitogen-activated protein kinase kinase kinase kinase 5

(Aliases: RGD1562028)

Map4k5 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
nucleic acid templated transcription GO:0097659 379 0.185
rna metabolic process GO:0016070 406 0.163
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.136
regulation of rna metabolic process GO:0051252 391 0.135
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.118
rna biosynthetic process GO:0032774 380 0.118
transcription dna templated GO:0006351 377 0.110
apoptotic process GO:0006915 381 0.097
regulation of transcription dna templated GO:0006355 374 0.091
cellular component biogenesis GO:0044085 368 0.079
regulation of nucleic acid templated transcription GO:1903506 380 0.078
regulation of phosphorus metabolic process GO:0051174 349 0.077
positive regulation of nucleic acid templated transcription GO:1903508 197 0.074
transcription from rna polymerase ii promoter GO:0006366 252 0.072
localization of cell GO:0051674 202 0.068
macromolecular complex assembly GO:0065003 273 0.059
regulation of apoptotic process GO:0042981 335 0.059
programmed cell death GO:0012501 392 0.057
neurological system process GO:0050877 219 0.056
positive regulation of biosynthetic process GO:0009891 319 0.055
regulation of rna biosynthetic process GO:2001141 381 0.052
negative regulation of metabolic process GO:0009892 331 0.052
protein phosphorylation GO:0006468 345 0.051
Human
positive regulation of phosphorylation GO:0042327 177 0.050
positive regulation of rna biosynthetic process GO:1902680 197 0.049
cellular protein localization GO:0034613 122 0.049
regulation of molecular function GO:0065009 398 0.048
positive regulation of transcription dna templated GO:0045893 197 0.048
positive regulation of cellular biosynthetic process GO:0031328 295 0.047
activation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 1 0.046
positive regulation of gene expression GO:0010628 244 0.046
locomotion GO:0040011 237 0.045
cellular ketone metabolic process GO:0042180 51 0.043
single organism reproductive process GO:0044702 297 0.043
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.041
developmental process involved in reproduction GO:0003006 159 0.039
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.039
positive regulation of molecular function GO:0044093 230 0.039
negative regulation of cellular biosynthetic process GO:0031327 161 0.038
regulation of cellular ketone metabolic process GO:0010565 27 0.038
protein complex assembly GO:0006461 263 0.037
organophosphate metabolic process GO:0019637 370 0.037
organic acid metabolic process GO:0006082 292 0.037
oxoacid metabolic process GO:0043436 290 0.037
cellular response to peptide GO:1901653 133 0.037
negative regulation of macromolecule metabolic process GO:0010605 260 0.036
negative regulation of apoptotic process GO:0043066 181 0.036
regulation of signal transduction GO:0009966 318 0.036
positive regulation of catalytic activity GO:0043085 184 0.036
regulation of hormone levels GO:0010817 187 0.035
cellular response to endogenous stimulus GO:0071495 377 0.035
macromolecular complex subunit organization GO:0043933 339 0.035
regulation of cellular component organization GO:0051128 368 0.034
tissue development GO:0009888 252 0.034
negative regulation of cellular metabolic process GO:0031324 281 0.034
protein complex biogenesis GO:0070271 263 0.034
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.034
cell motility GO:0048870 202 0.033
positive regulation of protein metabolic process GO:0051247 178 0.033
regulation of nervous system development GO:0051960 264 0.033
positive regulation of rna metabolic process GO:0051254 203 0.033
reproductive system development GO:0061458 128 0.033
positive regulation of phosphorus metabolic process GO:0010562 262 0.032
regulation of cell proliferation GO:0042127 359 0.032
carboxylic acid metabolic process GO:0019752 289 0.031
regulation of catalytic activity GO:0050790 304 0.031
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.031
protein complex subunit organization GO:0071822 302 0.030
positive regulation of cell proliferation GO:0008284 249 0.030
response to decreased oxygen levels GO:0036293 237 0.030
single organism cellular localization GO:1902580 102 0.030
response to extracellular stimulus GO:0009991 380 0.029
response to nutrient levels GO:0031667 370 0.029
embryonic pattern specification GO:0009880 1 0.029
cellular response to oxygen containing compound GO:1901701 386 0.029
positive regulation of signaling GO:0023056 270 0.028
reproductive structure development GO:0048608 128 0.028
positive regulation of cellular protein metabolic process GO:0032270 167 0.028
cellular response to hormone stimulus GO:0032870 247 0.027
catabolic process GO:0009056 351 0.027
chemical homeostasis GO:0048878 292 0.027
regulation of cellular localization GO:0060341 263 0.027
regulation of programmed cell death GO:0043067 341 0.027
negative regulation of cell death GO:0060548 229 0.027
positive regulation of phosphate metabolic process GO:0045937 262 0.026
negative regulation of biosynthetic process GO:0009890 168 0.026
vesicle mediated transport GO:0016192 181 0.026
amine metabolic process GO:0009308 38 0.026
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.026
nucleoside phosphate metabolic process GO:0006753 283 0.026
reproductive process GO:0022414 372 0.025
positive regulation of response to stimulus GO:0048584 285 0.025
intracellular transport GO:0046907 185 0.025
cellular component assembly GO:0022607 360 0.024
proteolysis GO:0006508 175 0.024
sexual reproduction GO:0019953 148 0.024
cell projection organization GO:0030030 302 0.024
g protein coupled receptor signaling pathway GO:0007186 242 0.024
cellular macromolecule localization GO:0070727 122 0.024
response to radiation GO:0009314 137 0.024
cell migration GO:0016477 197 0.024
response to oxygen levels GO:0070482 265 0.023
lipid metabolic process GO:0006629 283 0.023
regulation of secretion GO:0051046 224 0.023
negative regulation of rna biosynthetic process GO:1902679 118 0.023
cell cell signaling GO:0007267 335 0.023
carbohydrate derivative catabolic process GO:1901136 147 0.023
behavior GO:0007610 205 0.023
multicellular organismal reproductive process GO:0048609 233 0.023
neuron differentiation GO:0030182 368 0.023
secretion by cell GO:0032940 248 0.023
transmembrane transport GO:0055085 412 0.023
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.023
secretion GO:0046903 307 0.023
cellular response to luteinizing hormone stimulus GO:0071373 5 0.022
dna metabolic process GO:0006259 96 0.022
anatomical structure morphogenesis GO:0009653 298 0.022
regulation of hydrolase activity GO:0051336 143 0.022
response to ionizing radiation GO:0010212 59 0.022
homeostatic process GO:0042592 331 0.022
sex differentiation GO:0007548 113 0.022
multicellular organism reproduction GO:0032504 233 0.021
cell morphogenesis involved in differentiation GO:0000904 119 0.021
regulation of cell development GO:0060284 263 0.021
protein oligomerization GO:0051259 191 0.021
regulation of membrane potential GO:0042391 110 0.021
mesoderm development GO:0007498 2 0.021
cellular amino acid metabolic process GO:0006520 107 0.021
positive regulation of protein phosphorylation GO:0001934 135 0.021
regulation of cell differentiation GO:0045595 320 0.021
regulation of cellular amino acid metabolic process GO:0006521 2 0.021
negative regulation of response to stimulus GO:0048585 155 0.021
cellular amine metabolic process GO:0044106 38 0.021
cation transport GO:0006812 382 0.021
axis specification GO:0009798 4 0.021
cellular component movement GO:0006928 248 0.021
single organism intracellular transport GO:1902582 166 0.020
purine ribonucleotide metabolic process GO:0009150 227 0.020
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.020
non canonical wnt signaling pathway GO:0035567 3 0.020
positive regulation of protein modification process GO:0031401 142 0.020
response to growth factor GO:0070848 189 0.020
response to temperature stimulus GO:0009266 94 0.020
muscle structure development GO:0061061 87 0.020
regulation of cellular protein metabolic process GO:0032268 267 0.020
ribonucleotide biosynthetic process GO:0009260 85 0.020
negative regulation of transcription dna templated GO:0045892 116 0.019
intracellular signal transduction GO:0035556 314 0.019
Human
reproduction GO:0000003 245 0.019
regulation of neuron differentiation GO:0045664 208 0.019
purine containing compound metabolic process GO:0072521 253 0.019
cellular calcium ion homeostasis GO:0006874 160 0.019
regulation of protein metabolic process GO:0051246 289 0.019
growth GO:0040007 165 0.019
organic substance catabolic process GO:1901575 316 0.019
cell projection morphogenesis GO:0048858 123 0.019
macromolecule localization GO:0033036 252 0.019
regulation of cellular amine metabolic process GO:0033238 8 0.019
central nervous system development GO:0007417 311 0.019
enzyme linked receptor protein signaling pathway GO:0007167 116 0.019
organophosphate biosynthetic process GO:0090407 143 0.018
positive regulation of cell development GO:0010720 176 0.018
organelle organization GO:0006996 266 0.018
negative regulation of multicellular organismal process GO:0051241 203 0.018
protein localization GO:0008104 191 0.018
negative regulation of programmed cell death GO:0043069 183 0.018
response to peptide hormone GO:0043434 278 0.018
nucleobase containing small molecule metabolic process GO:0055086 316 0.018
regulation of phosphate metabolic process GO:0019220 349 0.018
cell cycle GO:0007049 101 0.018
regulation of multicellular organismal development GO:2000026 376 0.018
response to camp GO:0051591 91 0.018
multi organism reproductive process GO:0044703 262 0.018
muscle cell proliferation GO:0033002 84 0.018
cellular component morphogenesis GO:0032989 155 0.018
positive regulation of developmental process GO:0051094 283 0.017
protein heterooligomerization GO:0051291 89 0.017
positive regulation of cell death GO:0010942 184 0.017
positive regulation of immune system process GO:0002684 90 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.017
camp biosynthetic process GO:0006171 47 0.017
positive regulation of cell differentiation GO:0045597 217 0.017
purine nucleotide metabolic process GO:0006163 229 0.017
negative regulation of nucleic acid templated transcription GO:1903507 117 0.017
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.017
cytokine production GO:0001816 61 0.017
neuron projection development GO:0031175 273 0.017
organ regeneration GO:0031100 101 0.017
positive regulation of cellular amine metabolic process GO:0033240 3 0.016
response to peptide GO:1901652 292 0.016
cellular homeostasis GO:0019725 252 0.016
single organism biosynthetic process GO:0044711 342 0.016
regeneration GO:0031099 163 0.016
cell activation GO:0001775 97 0.016
nucleotide metabolic process GO:0009117 279 0.016
carbohydrate derivative metabolic process GO:1901135 346 0.016
gamete generation GO:0007276 124 0.016
ribose phosphate metabolic process GO:0019693 235 0.016
cell morphogenesis GO:0000902 142 0.016
cytoskeleton organization GO:0007010 111 0.016
positive regulation of transport GO:0051050 245 0.015
regulation of neurogenesis GO:0050767 247 0.015
negative regulation of gene expression GO:0010629 199 0.015
cellular response to stress GO:0033554 269 0.015
anion transport GO:0006820 178 0.015
cytoplasmic transport GO:0016482 115 0.015
cation homeostasis GO:0055080 195 0.015
response to external biotic stimulus GO:0043207 221 0.015
lipid transport GO:0006869 61 0.015
transmission of nerve impulse GO:0019226 42 0.015
negative regulation of molecular function GO:0044092 133 0.015
small gtpase mediated signal transduction GO:0007264 36 0.015
cellular response to abiotic stimulus GO:0071214 85 0.015
neuron projection morphogenesis GO:0048812 122 0.015
metal ion transport GO:0030001 289 0.015
gland development GO:0048732 155 0.015
positive regulation of ion transport GO:0043270 94 0.015
rhythmic process GO:0048511 156 0.015
organic anion transport GO:0015711 132 0.015
metal ion homeostasis GO:0055065 186 0.015
regulation of cellular component movement GO:0051270 150 0.014
purine nucleotide biosynthetic process GO:0006164 83 0.014
regulation of transferase activity GO:0051338 123 0.014
cyclic nucleotide metabolic process GO:0009187 80 0.014
cellular divalent inorganic cation homeostasis GO:0072503 162 0.014
cellular catabolic process GO:0044248 295 0.014
anterior posterior pattern specification GO:0009952 1 0.014
regulation of nucleotide metabolic process GO:0006140 117 0.014
mapk cascade GO:0000165 140 0.014
cytosolic calcium ion homeostasis GO:0051480 140 0.014
defense response GO:0006952 194 0.014
cell type specific apoptotic process GO:0097285 134 0.014
head development GO:0060322 247 0.014
cardiovascular system development GO:0072358 134 0.014
positive regulation of apoptotic process GO:0043065 154 0.014
cellular ion homeostasis GO:0006873 184 0.014
response to purine containing compound GO:0014074 126 0.014
negative regulation of signaling GO:0023057 157 0.014
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.013
purine ribonucleotide catabolic process GO:0009154 136 0.013
dephosphorylation GO:0016311 98 0.013
regulation of smooth muscle cell proliferation GO:0048660 75 0.013
regulation of neuron projection development GO:0010975 161 0.013
ribonucleoside triphosphate catabolic process GO:0009203 122 0.013
brain development GO:0007420 247 0.013
cellular response to growth factor stimulus GO:0071363 162 0.013
response to bacterium GO:0009617 200 0.013
positive regulation of cell communication GO:0010647 271 0.013
negative regulation of cell communication GO:0010648 158 0.013
positive regulation of purine nucleotide biosynthetic process GO:1900373 36 0.013
cyclic purine nucleotide metabolic process GO:0052652 62 0.013
potassium ion transport GO:0006813 97 0.013
positive regulation of multicellular organismal process GO:0051240 387 0.013
positive regulation of neuron differentiation GO:0045666 126 0.013
peptidyl amino acid modification GO:0018193 126 0.013
divalent inorganic cation homeostasis GO:0072507 165 0.013
development of primary sexual characteristics GO:0045137 107 0.013
positive regulation of neurogenesis GO:0050769 165 0.013
organic acid transport GO:0015849 116 0.013
response to other organism GO:0051707 220 0.012
aging GO:0007568 241 0.012
spindle organization GO:0007051 2 0.012
embryonic axis specification GO:0000578 1 0.012
multicellular organismal signaling GO:0035637 44 0.012
hormone metabolic process GO:0042445 69 0.012
cellular response to organonitrogen compound GO:0071417 197 0.012
response to mechanical stimulus GO:0009612 134 0.012
positive regulation of secretion by cell GO:1903532 128 0.012
camp metabolic process GO:0046058 63 0.012
cellular chemical homeostasis GO:0055082 247 0.012
response to biotic stimulus GO:0009607 226 0.012
nucleotide biosynthetic process GO:0009165 98 0.012
nucleobase containing compound catabolic process GO:0034655 152 0.012
positive regulation of intracellular signal transduction GO:1902533 138 0.012
regulation of secretion by cell GO:1903530 208 0.012
hexose transport GO:0008645 29 0.012
protein processing GO:0016485 68 0.012
hormone secretion GO:0046879 115 0.012
gonad development GO:0008406 104 0.011
intracellular protein transport GO:0006886 79 0.011
cellular response to peptide hormone stimulus GO:0071375 120 0.011
response to gamma radiation GO:0010332 24 0.011
ribonucleotide catabolic process GO:0009261 136 0.011
smooth muscle cell proliferation GO:0048659 77 0.011
neuron development GO:0048666 286 0.011
endocytosis GO:0006897 84 0.011
amide transport GO:0042886 105 0.011
regulation of cell motility GO:2000145 131 0.011
response to acid chemical GO:0001101 222 0.011
regulation of protein modification process GO:0031399 194 0.011
cell part morphogenesis GO:0032990 123 0.011
negative regulation of protein metabolic process GO:0051248 114 0.011
organonitrogen compound catabolic process GO:1901565 179 0.011
nucleoside triphosphate metabolic process GO:0009141 144 0.011
regulation of neuron apoptotic process GO:0043523 83 0.011
regulation of kinase activity GO:0043549 117 0.011
positive regulation of camp metabolic process GO:0030816 31 0.011
regulation of phosphorylation GO:0042325 248 0.011
purine ribonucleoside metabolic process GO:0046128 168 0.011
bmp signaling pathway GO:0030509 4 0.011
chromosome segregation GO:0007059 2 0.011
positive regulation of cyclic nucleotide metabolic process GO:0030801 37 0.011
response to oxidative stress GO:0006979 186 0.011
regulation of cytoskeleton organization GO:0051493 49 0.011
protein transport GO:0015031 132 0.011
regulation of cell migration GO:0030334 128 0.011
calcium ion homeostasis GO:0055074 162 0.011
ion homeostasis GO:0050801 212 0.011
regulation of immune system process GO:0002682 123 0.011
regulation of intracellular signal transduction GO:1902531 218 0.011
hormone transport GO:0009914 121 0.010
regulation of protein phosphorylation GO:0001932 183 0.010
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.010
regulation of system process GO:0044057 208 0.010
axonogenesis GO:0007409 71 0.010
positive regulation of cell motility GO:2000147 97 0.010
male mating behavior GO:0060179 3 0.010
regulation of peptidase activity GO:0052547 55 0.010
positive regulation of cellular component organization GO:0051130 200 0.010
positive regulation of programmed cell death GO:0043068 157 0.010
negative regulation of developmental process GO:0051093 125 0.010
regulation of cyclic nucleotide biosynthetic process GO:0030802 45 0.010
nucleoside phosphate biosynthetic process GO:1901293 102 0.010

Map4k5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.014
disease of cellular proliferation DOID:14566 0 0.014
disease of anatomical entity DOID:7 0 0.013
nervous system disease DOID:863 0 0.013
musculoskeletal system disease DOID:17 0 0.012
organ system cancer DOID:0050686 0 0.010