Rattus norvegicus

230 known processes

Rapgef2

Rap guanine nucleotide exchange factor (GEF) 2

Rapgef2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of intracellular signal transduction GO:1902531 218 0.131
positive regulation of multicellular organismal process GO:0051240 387 0.126
regulation of signal transduction GO:0009966 318 0.122
regulation of cellular component organization GO:0051128 368 0.094
learning or memory GO:0007611 90 0.090
neurological system process GO:0050877 219 0.080
positive regulation of developmental process GO:0051094 283 0.079
central nervous system development GO:0007417 311 0.079
regulation of locomotion GO:0040012 148 0.078
Rat
brain development GO:0007420 247 0.078
behavior GO:0007610 205 0.076
positive regulation of cell differentiation GO:0045597 217 0.073
programmed cell death GO:0012501 392 0.069
Human
regulation of programmed cell death GO:0043067 341 0.065
Human
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.064
regulation of cell development GO:0060284 263 0.062
positive regulation of response to stimulus GO:0048584 285 0.060
head development GO:0060322 247 0.060
amine metabolic process GO:0009308 38 0.058
cell projection organization GO:0030030 302 0.057
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.056
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.055
single organism behavior GO:0044708 130 0.055
intracellular signal transduction GO:0035556 314 0.051
regulation of transcription dna templated GO:0006355 374 0.050
vesicle mediated transport GO:0016192 181 0.048
secretion by cell GO:0032940 248 0.048
nucleoside phosphate metabolic process GO:0006753 283 0.048
phosphatidylinositol dephosphorylation GO:0046856 4 0.047
cellular ion homeostasis GO:0006873 184 0.047
single organism intracellular transport GO:1902582 166 0.047
protein import into nucleus GO:0006606 35 0.045
positive regulation of gene expression GO:0010628 244 0.044
response to metal ion GO:0010038 253 0.043
positive regulation of biosynthetic process GO:0009891 319 0.043
nucleic acid templated transcription GO:0097659 379 0.043
regulation of apoptotic process GO:0042981 335 0.043
Human
negative regulation of signaling GO:0023057 157 0.042
Rat
regulation of protein metabolic process GO:0051246 289 0.042
regulation of nervous system development GO:0051960 264 0.042
divalent metal ion transport GO:0070838 132 0.042
response to cytokine GO:0034097 215 0.041
forebrain development GO:0030900 98 0.040
oxoacid metabolic process GO:0043436 290 0.040
cellular response to stress GO:0033554 269 0.040
positive regulation of signaling GO:0023056 270 0.040
regulation of multicellular organismal development GO:2000026 376 0.040
cellular chemical homeostasis GO:0055082 247 0.039
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.039
adult locomotory behavior GO:0008344 4 0.039
response to carbohydrate GO:0009743 183 0.039
positive regulation of cellular biosynthetic process GO:0031328 295 0.038
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.038
cellular component morphogenesis GO:0032989 155 0.038
Human
cellular protein localization GO:0034613 122 0.038
cellular lipid metabolic process GO:0044255 208 0.037
divalent inorganic cation homeostasis GO:0072507 165 0.037
reproductive process GO:0022414 372 0.037
secretion GO:0046903 307 0.037
carboxylic acid metabolic process GO:0019752 289 0.036
cellular response to oxygen containing compound GO:1901701 386 0.036
Human
ion homeostasis GO:0050801 212 0.036
cellular divalent inorganic cation homeostasis GO:0072503 162 0.036
regulation of phosphorylation GO:0042325 248 0.035
transcription dna templated GO:0006351 377 0.035
organic acid metabolic process GO:0006082 292 0.034
positive regulation of endocytosis GO:0045807 28 0.034
catabolic process GO:0009056 351 0.034
cellular calcium ion homeostasis GO:0006874 160 0.033
regulation of molecular function GO:0065009 398 0.033
nitrogen compound transport GO:0071705 229 0.032
dephosphorylation GO:0016311 98 0.032
cation homeostasis GO:0055080 195 0.032
cellular catabolic process GO:0044248 295 0.032
single organism cellular localization GO:1902580 102 0.032
cellular component movement GO:0006928 248 0.032
Rat
response to acid chemical GO:0001101 222 0.032
organophosphate metabolic process GO:0019637 370 0.032
rna metabolic process GO:0016070 406 0.031
cellular amine metabolic process GO:0044106 38 0.031
regulation of cellular amine metabolic process GO:0033238 8 0.031
memory GO:0007613 54 0.030
ribonucleotide metabolic process GO:0009259 231 0.030
cognition GO:0050890 92 0.030
single organism biosynthetic process GO:0044711 342 0.030
negative regulation of transport GO:0051051 136 0.030
regulation of phosphorus metabolic process GO:0051174 349 0.030
enzyme linked receptor protein signaling pathway GO:0007167 116 0.030
cellular homeostasis GO:0019725 252 0.029
cellular response to growth factor stimulus GO:0071363 162 0.029
regulation of cellular ketone metabolic process GO:0010565 27 0.029
locomotion GO:0040011 237 0.029
Rat
calcium ion homeostasis GO:0055074 162 0.028
homeostatic process GO:0042592 331 0.028
response to oxygen levels GO:0070482 265 0.028
cellular cation homeostasis GO:0030003 180 0.028
response to extracellular stimulus GO:0009991 380 0.028
organophosphate catabolic process GO:0046434 148 0.028
regulation of nucleic acid templated transcription GO:1903506 380 0.028
negative regulation of cell communication GO:0010648 158 0.028
Rat
regulation of neuron death GO:1901214 115 0.028
positive regulation of neurogenesis GO:0050769 165 0.028
purine containing compound metabolic process GO:0072521 253 0.027
limbic system development GO:0021761 38 0.027
positive regulation of nervous system development GO:0051962 178 0.027
cellular response to endogenous stimulus GO:0071495 377 0.027
regulation of rna metabolic process GO:0051252 391 0.027
response to calcium ion GO:0051592 59 0.027
protein modification by small protein conjugation GO:0032446 31 0.027
cation transport GO:0006812 382 0.027
neuron development GO:0048666 286 0.027
multicellular organism growth GO:0035264 1 0.027
response to nutrient levels GO:0031667 370 0.026
positive regulation of transport GO:0051050 245 0.026
regulation of protein phosphorylation GO:0001932 183 0.026
insulin like growth factor receptor signaling pathway GO:0048009 3 0.026
positive regulation of phosphate metabolic process GO:0045937 262 0.026
glycosyl compound catabolic process GO:1901658 126 0.026
negative regulation of cell death GO:0060548 229 0.026
transmembrane transport GO:0055085 412 0.026
tissue development GO:0009888 252 0.026
Human
negative regulation of apoptotic process GO:0043066 181 0.026
inorganic cation transmembrane transport GO:0098662 202 0.025
regulation of cellular amino acid metabolic process GO:0006521 2 0.025
positive regulation of cell development GO:0010720 176 0.025
rhythmic process GO:0048511 156 0.025
apoptotic process GO:0006915 381 0.025
Human
single organism nuclear import GO:1902593 35 0.025
regulation of cellular protein metabolic process GO:0032268 267 0.025
membrane organization GO:0061024 94 0.024
response to interleukin 15 GO:0070672 4 0.024
positive regulation of cellular amine metabolic process GO:0033240 3 0.024
metal ion homeostasis GO:0055065 186 0.024
regulation of secretion by cell GO:1903530 208 0.024
lipid metabolic process GO:0006629 283 0.024
response to peptide hormone GO:0043434 278 0.024
positive regulation of rna biosynthetic process GO:1902680 197 0.024
learning GO:0007612 33 0.024
cytosolic calcium ion homeostasis GO:0051480 140 0.024
rna biosynthetic process GO:0032774 380 0.023
response to inorganic substance GO:0010035 377 0.023
cellular component assembly GO:0022607 360 0.023
Human
purine ribonucleotide metabolic process GO:0009150 227 0.023
cellular response to hormone stimulus GO:0032870 247 0.023
receptor mediated endocytosis GO:0006898 42 0.023
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.023
proteolysis GO:0006508 175 0.022
positive regulation of growth GO:0045927 55 0.022
divalent inorganic cation transport GO:0072511 134 0.022
muscle structure development GO:0061061 87 0.022
calcium ion transport GO:0006816 131 0.022
positive regulation of neuron differentiation GO:0045666 126 0.022
carbohydrate derivative metabolic process GO:1901135 346 0.022
single organism catabolic process GO:0044712 283 0.021
inorganic ion transmembrane transport GO:0098660 229 0.021
aromatic compound catabolic process GO:0019439 168 0.021
positive regulation of signal transduction GO:0009967 175 0.021
positive regulation of nucleic acid templated transcription GO:1903508 197 0.021
cellular amino acid metabolic process GO:0006520 107 0.021
nucleobase containing small molecule metabolic process GO:0055086 316 0.021
regulation of membrane potential GO:0042391 110 0.020
cell part morphogenesis GO:0032990 123 0.020
Human
regulation of vesicle mediated transport GO:0060627 81 0.020
cellular response to cytokine stimulus GO:0071345 127 0.020
cell cell signaling GO:0007267 335 0.020
positive regulation of cellular component organization GO:0051130 200 0.020
positive regulation of cell projection organization GO:0031346 111 0.020
regulation of rna biosynthetic process GO:2001141 381 0.020
positive regulation of rna metabolic process GO:0051254 203 0.020
action potential GO:0001508 54 0.020
carbohydrate derivative biosynthetic process GO:1901137 124 0.020
positive regulation of molecular function GO:0044093 230 0.020
cellular response to interleukin 15 GO:0071350 3 0.020
neuron differentiation GO:0030182 368 0.020
purine nucleotide metabolic process GO:0006163 229 0.020
alcohol metabolic process GO:0006066 77 0.020
organelle organization GO:0006996 266 0.020
purine containing compound catabolic process GO:0072523 138 0.020
transmission of nerve impulse GO:0019226 42 0.020
response to reactive oxygen species GO:0000302 120 0.019
protein transport GO:0015031 132 0.019
negative regulation of programmed cell death GO:0043069 183 0.019
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.019
ras protein signal transduction GO:0007265 29 0.019
Human
glycosyl compound metabolic process GO:1901657 182 0.019
nucleobase containing compound catabolic process GO:0034655 152 0.019
positive regulation of protein metabolic process GO:0051247 178 0.019
negative regulation of response to stimulus GO:0048585 155 0.019
positive regulation of locomotion GO:0040017 102 0.019
Rat
regulation of homeostatic process GO:0032844 101 0.019
chemical homeostasis GO:0048878 292 0.019
interleukin 12 production GO:0032615 3 0.019
protein complex subunit organization GO:0071822 302 0.019
macromolecular complex subunit organization GO:0043933 339 0.019
striated muscle tissue development GO:0014706 58 0.018
positive regulation of calcium ion dependent exocytosis GO:0045956 6 0.018
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.018
synapse organization GO:0050808 46 0.018
cellular ketone metabolic process GO:0042180 51 0.018
positive regulation of hormone secretion GO:0046887 65 0.018
cellular response to extracellular stimulus GO:0031668 73 0.018
telencephalon development GO:0021537 62 0.018
regulation of cell morphogenesis GO:0022604 77 0.018
Human
neuronal action potential GO:0019228 35 0.018
response to growth factor GO:0070848 189 0.017
motor neuron axon guidance GO:0008045 1 0.017
regulation of canonical wnt signaling pathway GO:0060828 4 0.017
ion transmembrane transport GO:0034220 365 0.017
response to estrogen GO:0043627 232 0.017
cellular protein complex assembly GO:0043623 44 0.017
multicellular organismal signaling GO:0035637 44 0.017
negative regulation of signal transduction GO:0009968 83 0.017
regulation of purine nucleotide metabolic process GO:1900542 115 0.017
muscle tissue development GO:0060537 58 0.017
cellular response to external stimulus GO:0071496 118 0.017
axon guidance GO:0007411 24 0.017
cation transmembrane transport GO:0098655 263 0.017
regulation of cellular component movement GO:0051270 150 0.017
Rat
response to bacterium GO:0009617 200 0.017
growth GO:0040007 165 0.017
positive regulation of neuron projection development GO:0010976 99 0.016
developmental growth GO:0048589 100 0.016
intracellular protein transport GO:0006886 79 0.016
negative regulation of macromolecule metabolic process GO:0010605 260 0.016
cellular response to organic cyclic compound GO:0071407 202 0.016
Human
signal release GO:0023061 145 0.016
regulation of cellular extravasation GO:0002691 2 0.016
carbohydrate homeostasis GO:0033500 75 0.016
organic substance catabolic process GO:1901575 316 0.016
arp2 3 complex mediated actin nucleation GO:0034314 2 0.016
regulation of transferase activity GO:0051338 123 0.016
protein complex assembly GO:0006461 263 0.015
response to glucose GO:0009749 136 0.015
regulation of protein modification process GO:0031399 194 0.015
multi organism reproductive process GO:0044703 262 0.015
positive regulation of hydrolase activity GO:0051345 86 0.015
response to hydrogen peroxide GO:0042542 89 0.015
synaptic transmission GO:0007268 235 0.015
regulation of peptide transport GO:0090087 87 0.015
single organism organelle organization GO:1902589 180 0.015
pallium development GO:0021543 42 0.015
response to external biotic stimulus GO:0043207 221 0.015
protein ubiquitination GO:0016567 28 0.015
response to decreased oxygen levels GO:0036293 237 0.015
cytokine mediated signaling pathway GO:0019221 43 0.015
response to oxidative stress GO:0006979 186 0.015
cellular macromolecule localization GO:0070727 122 0.015
purine ribonucleotide catabolic process GO:0009154 136 0.015
taxis GO:0042330 67 0.015
ribonucleoside triphosphate catabolic process GO:0009203 122 0.015
regulation of ion transport GO:0043269 245 0.014
heterocycle catabolic process GO:0046700 167 0.014
positive regulation of cellular protein metabolic process GO:0032270 167 0.014
regulation of protein kinase a signaling GO:0010738 6 0.014
multi multicellular organism process GO:0044706 138 0.014
response to ketone GO:1901654 182 0.014
anatomical structure formation involved in morphogenesis GO:0048646 83 0.014
organic hydroxy compound metabolic process GO:1901615 115 0.014
regulation of anatomical structure size GO:0090066 135 0.014
anterior posterior pattern specification GO:0009952 1 0.014
cellular component biogenesis GO:0044085 368 0.014
Human
macromolecular complex assembly GO:0065003 273 0.014
circulatory system development GO:0072359 134 0.014
Rat
regeneration GO:0031099 163 0.014
female pregnancy GO:0007565 122 0.014
protein localization GO:0008104 191 0.014
regulation of immune system process GO:0002682 123 0.014
response to hypoxia GO:0001666 231 0.014
glutamate receptor signaling pathway GO:0007215 43 0.014
regulation of cell cycle GO:0051726 73 0.013
glycerophospholipid metabolic process GO:0006650 47 0.013
regulation of neurogenesis GO:0050767 247 0.013
muscle organ development GO:0007517 50 0.013
protein complex biogenesis GO:0070271 263 0.013
polyol metabolic process GO:0019751 20 0.013
cell growth GO:0016049 104 0.013
establishment of vesicle localization GO:0051650 31 0.013
regulation of cell motility GO:2000145 131 0.013
Rat
regulation of cell differentiation GO:0045595 320 0.013
small molecule biosynthetic process GO:0044283 124 0.013
g protein coupled acetylcholine receptor signaling pathway GO:0007213 5 0.013
response to interleukin 1 GO:0070555 55 0.013
macromolecule localization GO:0033036 252 0.013
positive regulation of transcription dna templated GO:0045893 197 0.013
negative regulation of neuron death GO:1901215 69 0.013
ribonucleoside catabolic process GO:0042454 126 0.013
cellular response to nitrogen compound GO:1901699 210 0.013
Human
positive regulation of cellular component movement GO:0051272 102 0.013
Rat
muscle cell differentiation GO:0042692 52 0.013
response to corticosteroid GO:0031960 235 0.013
nucleoside phosphate catabolic process GO:1901292 140 0.013
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 4 0.013
detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 4 0.013
organonitrogen compound catabolic process GO:1901565 179 0.013
negative regulation of cellular metabolic process GO:0031324 281 0.013
establishment of protein localization GO:0045184 141 0.013
regulation of neuron apoptotic process GO:0043523 83 0.013
organophosphate biosynthetic process GO:0090407 143 0.012
cellular response to oxidative stress GO:0034599 76 0.012
calcineurin nfat signaling cascade GO:0033173 3 0.012
regulation of hormone secretion GO:0046883 106 0.012
response to hexose GO:0009746 144 0.012
nucleotide metabolic process GO:0009117 279 0.012
regulation of response to stress GO:0080134 126 0.012
nucleotide catabolic process GO:0009166 139 0.012
calcium ion transmembrane transport GO:0070588 70 0.012
regulation of leukocyte migration GO:0002685 24 0.012
positive regulation of epithelial cell migration GO:0010634 13 0.012
response to glucocorticoid GO:0051384 223 0.012
regulation of calcium ion transport GO:0051924 77 0.012
synaptic vesicle priming GO:0016082 4 0.012
regulation of hormone levels GO:0010817 187 0.012
intracellular transport GO:0046907 185 0.012
reproduction GO:0000003 245 0.012
negative regulation of secretion GO:0051048 82 0.012
fertilization GO:0009566 3 0.012
neuron projection development GO:0031175 273 0.012
negative regulation of secretion by cell GO:1903531 72 0.012
cellular nitrogen compound catabolic process GO:0044270 163 0.012
actin cytoskeleton organization GO:0030036 73 0.012
glycerolipid metabolic process GO:0046486 67 0.012
sequestering of calcium ion GO:0051208 8 0.011
regulation of glycoprotein biosynthetic process GO:0010559 6 0.011
neurotrophin trk receptor signaling pathway GO:0048011 10 0.011
purine nucleoside triphosphate metabolic process GO:0009144 141 0.011
skeletal muscle tissue development GO:0007519 31 0.011
regulation of phosphate metabolic process GO:0019220 349 0.011
regulation of growth GO:0040008 105 0.011
positive regulation of cell migration GO:0030335 96 0.011
Rat
glucose homeostasis GO:0042593 75 0.011
muscle system process GO:0003012 115 0.011
anion transport GO:0006820 178 0.011
regulation of endocytosis GO:0030100 42 0.011
regulation of cell proliferation GO:0042127 359 0.011
Human
response to ethanol GO:0045471 162 0.011
purine ribonucleoside metabolic process GO:0046128 168 0.011
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.011
negative regulation of gene expression GO:0010629 199 0.011
endocytosis GO:0006897 84 0.011
cell projection morphogenesis GO:0048858 123 0.011
Human
regulation of protein targeting GO:1903533 28 0.011
nucleoside triphosphate catabolic process GO:0009143 123 0.011
positive regulation of cell communication GO:0010647 271 0.011
protein phosphorylation GO:0006468 345 0.011
metal ion transport GO:0030001 289 0.011
positive regulation of catalytic activity GO:0043085 184 0.011
response to nutrient GO:0007584 248 0.011
neuron projection morphogenesis GO:0048812 122 0.011
Human
regulation of cellular component biogenesis GO:0044087 86 0.011
Human
neuron apoptotic process GO:0051402 88 0.011
axonogenesis GO:0007409 71 0.011
regulation of cell growth GO:0001558 85 0.011
cellular response to monosaccharide stimulus GO:0071326 67 0.011
ribonucleoside metabolic process GO:0009119 174 0.011
positive regulation of cell death GO:0010942 184 0.011
Human
regulation of kinase activity GO:0043549 117 0.011
regulation of catalytic activity GO:0050790 304 0.011
negative regulation of cellular component organization GO:0051129 83 0.010
Human
interleukin 1 mediated signaling pathway GO:0070498 2 0.010
cell morphogenesis involved in differentiation GO:0000904 119 0.010
Human
positive regulation of apoptotic process GO:0043065 154 0.010
Human
single fertilization GO:0007338 3 0.010
innate immune response GO:0045087 35 0.010
response to other organism GO:0051707 220 0.010
ribose phosphate metabolic process GO:0019693 235 0.010
organic cyclic compound catabolic process GO:1901361 175 0.010
phospholipid metabolic process GO:0006644 61 0.010
aging GO:0007568 241 0.010
cell type specific apoptotic process GO:0097285 134 0.010
Human
peptide secretion GO:0002790 86 0.010
protein oligomerization GO:0051259 191 0.010
organic hydroxy compound biosynthetic process GO:1901617 51 0.010
monovalent inorganic cation transport GO:0015672 172 0.010
regulation of cellular localization GO:0060341 263 0.010
positive regulation of amine transport GO:0051954 26 0.010
cell morphogenesis GO:0000902 142 0.010
Human
gland development GO:0048732 155 0.010
regulation of peptide hormone secretion GO:0090276 80 0.010
regulation of mitotic sister chromatid separation GO:0010965 1 0.010
peptide transport GO:0015833 97 0.010
negative regulation of viral process GO:0048525 4 0.010

Rapgef2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.145
nervous system disease DOID:863 0 0.145
central nervous system disease DOID:331 0 0.120
brain disease DOID:936 0 0.120
epilepsy syndrome DOID:1826 0 0.046
electroclinical syndrome DOID:0050701 0 0.030
parkinson s disease DOID:14330 0 0.014
synucleinopathy DOID:0050890 0 0.014
neurodegenerative disease DOID:1289 0 0.014
neonatal period electroclinical syndrome DOID:0050702 0 0.010
ohtahara syndrome DOID:0050709 0 0.010