Rattus norvegicus

313 known processes

Pla2g6

phospholipase A2, group VI (cytosolic, calcium-independent)

(Aliases: MGC93880,iPla2)

Pla2g6 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of multicellular organismal development GO:2000026 376 0.195
response to extracellular stimulus GO:0009991 380 0.128
programmed cell death GO:0012501 392 0.111
enzyme linked receptor protein signaling pathway GO:0007167 116 0.092
reproductive process GO:0022414 372 0.091
oxoacid metabolic process GO:0043436 290 0.085
cation transport GO:0006812 382 0.083
regulation of cell proliferation GO:0042127 359 0.079
cellular amino acid metabolic process GO:0006520 107 0.077
reproduction GO:0000003 245 0.076
synaptic growth at neuromuscular junction GO:0051124 1 0.074
tissue development GO:0009888 252 0.073
apoptotic process GO:0006915 381 0.071
response to nutrient levels GO:0031667 370 0.069
synaptic transmission GO:0007268 235 0.068
carboxylic acid metabolic process GO:0019752 289 0.067
amine metabolic process GO:0009308 38 0.067
neurological system process GO:0050877 219 0.066
ribonucleotide metabolic process GO:0009259 231 0.065
cellular response to endogenous stimulus GO:0071495 377 0.063
regulation of programmed cell death GO:0043067 341 0.061
organic acid metabolic process GO:0006082 292 0.060
single organism reproductive process GO:0044702 297 0.059
regulation of nervous system development GO:0051960 264 0.055
anatomical structure morphogenesis GO:0009653 298 0.055
transcription from rna polymerase ii promoter GO:0006366 252 0.054
organic substance catabolic process GO:1901575 316 0.054
cell cell signaling GO:0007267 335 0.054
rna metabolic process GO:0016070 406 0.054
ion transmembrane transport GO:0034220 365 0.053
regulation of cell differentiation GO:0045595 320 0.053
positive regulation of cellular biosynthetic process GO:0031328 295 0.049
nucleic acid templated transcription GO:0097659 379 0.049
positive regulation of signaling GO:0023056 270 0.049
intracellular signal transduction GO:0035556 314 0.049
regulation of apoptotic process GO:0042981 335 0.048
chemical homeostasis GO:0048878 292 0.047
regulation of signal transduction GO:0009966 318 0.046
cellular protein localization GO:0034613 122 0.045
transmembrane transport GO:0055085 412 0.045
positive regulation of response to stimulus GO:0048584 285 0.045
response to nutrient GO:0007584 248 0.045
cellular component assembly GO:0022607 360 0.044
cellular response to organonitrogen compound GO:0071417 197 0.043
single organism catabolic process GO:0044712 283 0.043
metal ion transport GO:0030001 289 0.043
behavior GO:0007610 205 0.043
neuron differentiation GO:0030182 368 0.042
secretion GO:0046903 307 0.042
cellular response to oxygen containing compound GO:1901701 386 0.041
macromolecule localization GO:0033036 252 0.040
locomotion GO:0040011 237 0.040
organophosphate metabolic process GO:0019637 370 0.040
Human
cellular component biogenesis GO:0044085 368 0.039
intracellular transport GO:0046907 185 0.039
regulation of cellular component organization GO:0051128 368 0.039
positive regulation of phosphorus metabolic process GO:0010562 262 0.039
nucleobase containing small molecule metabolic process GO:0055086 316 0.039
cell projection morphogenesis GO:0048858 123 0.039
growth GO:0040007 165 0.038
central nervous system development GO:0007417 311 0.038
cellular catabolic process GO:0044248 295 0.038
organonitrogen compound biosynthetic process GO:1901566 167 0.038
single organism intracellular transport GO:1902582 166 0.038
regulation of cellular protein metabolic process GO:0032268 267 0.037
cardiovascular system development GO:0072358 134 0.037
mapk cascade GO:0000165 140 0.037
purine ribonucleotide metabolic process GO:0009150 227 0.037
carbohydrate derivative metabolic process GO:1901135 346 0.037
cellular amine metabolic process GO:0044106 38 0.036
negative regulation of response to stimulus GO:0048585 155 0.036
regulation of molecular function GO:0065009 398 0.036
regulation of cellular ketone metabolic process GO:0010565 27 0.036
purine containing compound metabolic process GO:0072521 253 0.036
positive regulation of cell communication GO:0010647 271 0.036
aromatic compound catabolic process GO:0019439 168 0.036
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.035
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.035
regulation of neurogenesis GO:0050767 247 0.035
regulation of neuron differentiation GO:0045664 208 0.035
protein localization GO:0008104 191 0.034
homeostatic process GO:0042592 331 0.034
cellular component morphogenesis GO:0032989 155 0.034
positive regulation of cell proliferation GO:0008284 249 0.034
anion transport GO:0006820 178 0.034
multicellular organism reproduction GO:0032504 233 0.033
negative regulation of multicellular organismal process GO:0051241 203 0.033
organic cyclic compound catabolic process GO:1901361 175 0.033
regulation of rna biosynthetic process GO:2001141 381 0.033
sexual reproduction GO:0019953 148 0.033
cell projection organization GO:0030030 302 0.033
protein transport GO:0015031 132 0.033
learning or memory GO:0007611 90 0.033
nitrogen compound transport GO:0071705 229 0.032
regulation of cellular amino acid metabolic process GO:0006521 2 0.032
negative regulation of developmental process GO:0051093 125 0.032
positive regulation of biosynthetic process GO:0009891 319 0.032
negative regulation of cell death GO:0060548 229 0.032
cellular homeostasis GO:0019725 252 0.031
cellular response to hormone stimulus GO:0032870 247 0.031
neuron development GO:0048666 286 0.030
protein phosphorylation GO:0006468 345 0.030
cellular component movement GO:0006928 248 0.030
cellular response to nitrogen compound GO:1901699 210 0.030
multi organism reproductive process GO:0044703 262 0.030
regulation of cellular amine metabolic process GO:0033238 8 0.030
inorganic cation transmembrane transport GO:0098662 202 0.030
negative regulation of signaling GO:0023057 157 0.030
negative regulation of nervous system development GO:0051961 79 0.029
gamete generation GO:0007276 124 0.029
developmental process involved in reproduction GO:0003006 159 0.029
ribose phosphate metabolic process GO:0019693 235 0.029
positive regulation of molecular function GO:0044093 230 0.029
monocarboxylic acid transport GO:0015718 52 0.029
cellular nitrogen compound catabolic process GO:0044270 163 0.029
nucleotide metabolic process GO:0009117 279 0.029
monovalent inorganic cation transport GO:0015672 172 0.029
organonitrogen compound catabolic process GO:1901565 179 0.028
g protein coupled receptor signaling pathway GO:0007186 242 0.028
response to oxygen levels GO:0070482 265 0.028
hormone transport GO:0009914 121 0.028
neuron projection development GO:0031175 273 0.028
negative regulation of metabolic process GO:0009892 331 0.028
regulation of neuron projection development GO:0010975 161 0.027
regulation of phosphate metabolic process GO:0019220 349 0.027
cellular ketone metabolic process GO:0042180 51 0.027
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.027
positive regulation of apoptotic process GO:0043065 154 0.027
cellular amide metabolic process GO:0043603 44 0.027
regulation of protein metabolic process GO:0051246 289 0.026
catabolic process GO:0009056 351 0.026
transmission of nerve impulse GO:0019226 42 0.026
response to decreased oxygen levels GO:0036293 237 0.026
protein complex subunit organization GO:0071822 302 0.026
macromolecular complex subunit organization GO:0043933 339 0.026
negative regulation of cell communication GO:0010648 158 0.025
response to inorganic substance GO:0010035 377 0.025
regulation of protein modification process GO:0031399 194 0.025
positive regulation of transport GO:0051050 245 0.025
regulation of response to external stimulus GO:0032101 106 0.025
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.025
regulation of transcription dna templated GO:0006355 374 0.025
purine nucleotide metabolic process GO:0006163 229 0.025
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.024
positive regulation of cellular component organization GO:0051130 200 0.024
regulation of intracellular signal transduction GO:1902531 218 0.024
single organism biosynthetic process GO:0044711 342 0.023
regulation of cell development GO:0060284 263 0.023
action potential GO:0001508 54 0.023
positive regulation of programmed cell death GO:0043068 157 0.023
multicellular organismal reproductive process GO:0048609 233 0.023
regulation of secretion GO:0051046 224 0.023
signal release GO:0023061 145 0.023
spindle organization GO:0007051 2 0.023
anterior posterior pattern specification GO:0009952 1 0.023
circulatory system development GO:0072359 134 0.023
rna biosynthetic process GO:0032774 380 0.022
transcription dna templated GO:0006351 377 0.022
rhythmic process GO:0048511 156 0.022
cell motility GO:0048870 202 0.022
response to peptide hormone GO:0043434 278 0.022
positive regulation of cell death GO:0010942 184 0.022
organic anion transport GO:0015711 132 0.022
positive regulation of multicellular organismal process GO:0051240 387 0.022
purine nucleoside metabolic process GO:0042278 169 0.022
proteolysis GO:0006508 175 0.022
epithelium development GO:0060429 96 0.022
negative regulation of macromolecule metabolic process GO:0010605 260 0.022
regulation of membrane potential GO:0042391 110 0.022
eye morphogenesis GO:0048592 4 0.021
vesicle mediated transport GO:0016192 181 0.021
regulation of proteasomal protein catabolic process GO:0061136 4 0.021
regulation of secretion by cell GO:1903530 208 0.021
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.021
carboxylic acid transport GO:0046942 115 0.021
positive regulation of neurogenesis GO:0050769 165 0.021
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.021
heterocycle catabolic process GO:0046700 167 0.021
regulation of cell projection organization GO:0031344 175 0.021
maintenance of location GO:0051235 17 0.021
organelle organization GO:0006996 266 0.021
neuron death GO:0070997 127 0.021
neuron projection morphogenesis GO:0048812 122 0.021
negative regulation of signal transduction GO:0009968 83 0.021
regulation of phosphorylation GO:0042325 248 0.020
positive regulation of nervous system development GO:0051962 178 0.020
neuronal action potential GO:0019228 35 0.020
peptidyl amino acid modification GO:0018193 126 0.020
ribonucleoside metabolic process GO:0009119 174 0.020
anatomical structure formation involved in morphogenesis GO:0048646 83 0.020
regulation of nucleic acid templated transcription GO:1903506 380 0.020
cell cycle GO:0007049 101 0.020
negative regulation of cellular metabolic process GO:0031324 281 0.020
regulation of synaptic transmission GO:0050804 141 0.020
gastrulation GO:0007369 2 0.020
glycosyl compound metabolic process GO:1901657 182 0.019
purine ribonucleotide catabolic process GO:0009154 136 0.019
positive regulation of phosphate metabolic process GO:0045937 262 0.019
organophosphate biosynthetic process GO:0090407 143 0.019
Human
glial cell differentiation GO:0010001 65 0.019
signal transduction by phosphorylation GO:0023014 144 0.019
camp metabolic process GO:0046058 63 0.019
regulation of ion transport GO:0043269 245 0.019
positive regulation of cell projection organization GO:0031346 111 0.019
positive regulation of signal transduction GO:0009967 175 0.019
cellular macromolecule localization GO:0070727 122 0.018
negative regulation of neurogenesis GO:0050768 78 0.018
regulation of cellular localization GO:0060341 263 0.018
blood circulation GO:0008015 183 0.018
cognition GO:0050890 92 0.018
regulation of growth GO:0040008 105 0.018
response to transition metal nanoparticle GO:1990267 122 0.018
negative regulation of transport GO:0051051 136 0.018
divalent inorganic cation homeostasis GO:0072507 165 0.018
dna metabolic process GO:0006259 96 0.018
inflammatory response GO:0006954 150 0.018
positive regulation of secretion GO:0051047 140 0.017
negative regulation of cellular component organization GO:0051129 83 0.017
chromosome organization GO:0051276 36 0.017
regulation of mapk cascade GO:0043408 116 0.017
carbohydrate derivative catabolic process GO:1901136 147 0.017
regulation of protein phosphorylation GO:0001932 183 0.017
small gtpase mediated signal transduction GO:0007264 36 0.017
brain development GO:0007420 247 0.017
cellular response to stress GO:0033554 269 0.017
neuron neuron synaptic transmission GO:0007270 60 0.017
taxis GO:0042330 67 0.017
head development GO:0060322 247 0.017
gland development GO:0048732 155 0.017
ribonucleotide biosynthetic process GO:0009260 85 0.017
negative regulation of programmed cell death GO:0043069 183 0.017
developmental growth GO:0048589 100 0.017
purine ribonucleoside metabolic process GO:0046128 168 0.016
response to carbohydrate GO:0009743 183 0.016
negative regulation of cell differentiation GO:0045596 99 0.016
axis specification GO:0009798 4 0.016
defense response GO:0006952 194 0.016
regulation of phosphorus metabolic process GO:0051174 349 0.016
axon ensheathment GO:0008366 40 0.016
organic acid transport GO:0015849 116 0.016
cell type specific apoptotic process GO:0097285 134 0.016
single organism organelle organization GO:1902589 180 0.016
positive regulation of cellular amine metabolic process GO:0033240 3 0.016
ras protein signal transduction GO:0007265 29 0.016
macromolecular complex assembly GO:0065003 273 0.016
response to estradiol GO:0032355 164 0.016
cellular cation homeostasis GO:0030003 180 0.016
synapse organization GO:0050808 46 0.016
positive regulation of cell differentiation GO:0045597 217 0.016
regulation of anatomical structure morphogenesis GO:0022603 141 0.016
regulation of camp metabolic process GO:0030814 43 0.015
positive regulation of phosphorylation GO:0042327 177 0.015
purine containing compound catabolic process GO:0072523 138 0.015
inorganic ion transmembrane transport GO:0098660 229 0.015
lipid metabolic process GO:0006629 283 0.015
regulation of tube size GO:0035150 89 0.015
heart development GO:0007507 72 0.015
positive regulation of nucleotide metabolic process GO:0045981 91 0.015
negative regulation of apoptotic process GO:0043066 181 0.015
cytoplasmic transport GO:0016482 115 0.015
positive regulation of cell development GO:0010720 176 0.015
nucleoside phosphate metabolic process GO:0006753 283 0.015
sensory perception GO:0007600 101 0.015
regulation of cell cycle GO:0051726 73 0.015
nucleoside monophosphate metabolic process GO:0009123 93 0.015
nucleoside metabolic process GO:0009116 179 0.015
negative regulation of gene expression GO:0010629 199 0.015
cation homeostasis GO:0055080 195 0.015
purine containing compound biosynthetic process GO:0072522 85 0.015
regulation of protein transport GO:0051223 68 0.015
aging GO:0007568 241 0.015
secretion by cell GO:0032940 248 0.015
response to acid chemical GO:0001101 222 0.015
positive regulation of developmental process GO:0051094 283 0.015
metal ion homeostasis GO:0055065 186 0.015
negative regulation of biosynthetic process GO:0009890 168 0.015
blood vessel development GO:0001568 69 0.015
response to hypoxia GO:0001666 231 0.014
nucleoside catabolic process GO:0009164 126 0.014
positive regulation of protein metabolic process GO:0051247 178 0.014
cellular chemical homeostasis GO:0055082 247 0.014
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.014
purine ribonucleotide biosynthetic process GO:0009152 81 0.014
positive regulation of gene expression GO:0010628 244 0.014
centrosome organization GO:0051297 1 0.014
regulation of nucleotide metabolic process GO:0006140 117 0.014
cellular response to peptide GO:1901653 133 0.014
nucleoside triphosphate metabolic process GO:0009141 144 0.014
gliogenesis GO:0042063 93 0.014
negative regulation of protein metabolic process GO:0051248 114 0.014
nucleotide biosynthetic process GO:0009165 98 0.014
myelination GO:0042552 39 0.014
protein heterooligomerization GO:0051291 89 0.014
cell morphogenesis GO:0000902 142 0.014
carbohydrate derivative biosynthetic process GO:1901137 124 0.014
nucleobase containing compound catabolic process GO:0034655 152 0.014
positive regulation of mapk cascade GO:0043410 92 0.014
cellular response to growth factor stimulus GO:0071363 162 0.014
macromolecule catabolic process GO:0009057 58 0.014
positive regulation of transcription dna templated GO:0045893 197 0.014
positive regulation of protein phosphorylation GO:0001934 135 0.014
response to growth factor GO:0070848 189 0.014
cell cycle process GO:0022402 57 0.014
hormone secretion GO:0046879 115 0.014
regulation of transferase activity GO:0051338 123 0.014
purine nucleotide catabolic process GO:0006195 136 0.014
positive regulation of protein modification process GO:0031401 142 0.014
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.014
immune response GO:0006955 104 0.014
response to cytokine GO:0034097 215 0.013
tube development GO:0035295 89 0.013
embryonic pattern specification GO:0009880 1 0.013
protein oligomerization GO:0051259 191 0.013
cation transmembrane transport GO:0098655 263 0.013
chromosome segregation GO:0007059 2 0.013
cellular metal ion homeostasis GO:0006875 172 0.013
positive regulation of neuron projection development GO:0010976 99 0.013
response to peptide GO:1901652 292 0.013
establishment of protein localization GO:0045184 141 0.013
regulation of cellular component biogenesis GO:0044087 86 0.013
regulation of protein kinase activity GO:0045859 105 0.013
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.013
positive regulation of neuron differentiation GO:0045666 126 0.013
response to estrogen GO:0043627 232 0.013
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 3 0.013
negative regulation of cell proliferation GO:0008285 119 0.013
vascular process in circulatory system GO:0003018 96 0.013
regulation of peptide hormone secretion GO:0090276 80 0.013
response to ethanol GO:0045471 162 0.013
microtubule organizing center organization GO:0031023 1 0.013
negative regulation of cell development GO:0010721 82 0.013
synaptic transmission glutamatergic GO:0035249 33 0.013
multicellular organismal signaling GO:0035637 44 0.013
regulation of transmembrane transport GO:0034762 122 0.013
protein complex assembly GO:0006461 263 0.012
cyclic nucleotide metabolic process GO:0009187 80 0.012
mitotic spindle organization GO:0007052 2 0.012
peptide biosynthetic process GO:0043043 3 0.012
positive regulation of rna metabolic process GO:0051254 203 0.012
regulation of synaptic plasticity GO:0048167 70 0.012
heart morphogenesis GO:0003007 3 0.012
cellular response to insulin stimulus GO:0032869 81 0.012
purine ribonucleoside catabolic process GO:0046130 124 0.012
cell cell signaling involved in cell fate commitment GO:0045168 2 0.012
negative regulation of cellular biosynthetic process GO:0031327 161 0.012
regulation of neuron apoptotic process GO:0043523 83 0.012
protein complex biogenesis GO:0070271 263 0.012
regulation of erk1 and erk2 cascade GO:0070372 41 0.012
cell migration GO:0016477 197 0.012
regulation of catalytic activity GO:0050790 304 0.012
positive regulation of cellular protein metabolic process GO:0032270 167 0.012
cell part morphogenesis GO:0032990 123 0.012
regulation of vesicle mediated transport GO:0060627 81 0.012
negative regulation of nucleic acid templated transcription GO:1903507 117 0.012
localization of cell GO:0051674 202 0.012
response to metal ion GO:0010038 253 0.012
chromatin modification GO:0016568 33 0.012
regulation of anatomical structure size GO:0090066 135 0.012
positive regulation of ion transport GO:0043270 94 0.012
sensory perception of pain GO:0019233 73 0.012
purine nucleoside triphosphate metabolic process GO:0009144 141 0.012
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.012
reactive oxygen species metabolic process GO:0072593 37 0.012
toxin transport GO:1901998 3 0.011
ensheathment of neurons GO:0007272 40 0.011
regulation of neuron death GO:1901214 115 0.011
negative regulation of neuron differentiation GO:0045665 62 0.011
cellular divalent inorganic cation homeostasis GO:0072503 162 0.011
positive regulation of catalytic activity GO:0043085 184 0.011
positive regulation of nucleic acid templated transcription GO:1903508 197 0.011
peptide transport GO:0015833 97 0.011
regulation of purine nucleotide metabolic process GO:1900542 115 0.011
positive regulation of transferase activity GO:0051347 81 0.011
cyclic purine nucleotide metabolic process GO:0052652 62 0.011
camp biosynthetic process GO:0006171 47 0.011
regulation of developmental growth GO:0048638 45 0.011
purine nucleotide biosynthetic process GO:0006164 83 0.011
response to glucose GO:0009749 136 0.011
cyclic nucleotide biosynthetic process GO:0009190 63 0.011
purine nucleoside monophosphate metabolic process GO:0009126 84 0.011
ribonucleoside triphosphate catabolic process GO:0009203 122 0.011
ribonucleoside catabolic process GO:0042454 126 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.011
olfactory behavior GO:0042048 2 0.011
embryonic axis specification GO:0000578 1 0.011
anion transmembrane transport GO:0098656 77 0.011
male gamete generation GO:0048232 99 0.011
response to insulin GO:0032868 133 0.011
cellular response to peptide hormone stimulus GO:0071375 120 0.011
cellular response to acid chemical GO:0071229 75 0.011
calcium ion transport GO:0006816 131 0.011
regulation of peptide transport GO:0090087 87 0.011
regulation of system process GO:0044057 208 0.011
cellular lipid metabolic process GO:0044255 208 0.011
intracellular protein transport GO:0006886 79 0.011
ion homeostasis GO:0050801 212 0.011
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.011
tube formation GO:0035148 3 0.011
single organism behavior GO:0044708 130 0.011
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.011
regulation of rna metabolic process GO:0051252 391 0.011
ribonucleotide catabolic process GO:0009261 136 0.011
sensory organ development GO:0007423 74 0.010
cell morphogenesis involved in differentiation GO:0000904 119 0.010
regulation of blood vessel size GO:0050880 89 0.010
regulation of dna metabolic process GO:0051052 60 0.010
regulation of chromosome segregation GO:0051983 1 0.010
nucleoside triphosphate catabolic process GO:0009143 123 0.010
spermatogenesis GO:0007283 99 0.010
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.010
synapse assembly GO:0007416 29 0.010
negative regulation of phosphate metabolic process GO:0045936 80 0.010
single organism cellular localization GO:1902580 102 0.010
glycosyl compound catabolic process GO:1901658 126 0.010
gtp metabolic process GO:0046039 72 0.010
negative regulation of cellular protein metabolic process GO:0032269 106 0.010
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.010
microtubule based process GO:0007017 36 0.010
rna localization GO:0006403 4 0.010
regulation of reactive oxygen species metabolic process GO:2000377 26 0.010
response to corticosteroid GO:0031960 235 0.010

Pla2g6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.049
Human
nervous system disease DOID:863 0 0.049
Human
neuromuscular disease DOID:440 0 0.034
charcot marie tooth disease type 2 DOID:0050539 0 0.034
charcot marie tooth disease DOID:10595 0 0.034
neuropathy DOID:870 0 0.034
musculoskeletal system disease DOID:17 0 0.021
muscular disease DOID:0080000 0 0.021
muscle tissue disease DOID:66 0 0.016
disease of metabolism DOID:0014667 0 0.013
inherited metabolic disorder DOID:655 0 0.013