Rattus norvegicus

57 known processes

P2rx4

purinergic receptor P2X, ligand-gated ion channel 4

P2rx4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of cellular component organization GO:0051128 368 0.082
Rat
reproductive process GO:0022414 372 0.080
carbohydrate derivative metabolic process GO:1901135 346 0.080
response to wounding GO:0009611 254 0.078
Rat
cellular response to stress GO:0033554 269 0.073
response to cytokine GO:0034097 215 0.068
response to oxidative stress GO:0006979 186 0.059
positive regulation of response to stimulus GO:0048584 285 0.058
Human
neuron differentiation GO:0030182 368 0.057
regulation of multicellular organismal development GO:2000026 376 0.057
Rat
regulation of cellular localization GO:0060341 263 0.055
Human Rat
anatomical structure morphogenesis GO:0009653 298 0.055
intracellular signal transduction GO:0035556 314 0.054
Human
regulation of cell proliferation GO:0042127 359 0.053
cellular response to endogenous stimulus GO:0071495 377 0.053
Human
protein phosphorylation GO:0006468 345 0.052
Rat
vesicle mediated transport GO:0016192 181 0.051
response to inorganic substance GO:0010035 377 0.049
positive regulation of transport GO:0051050 245 0.049
Human Rat
secretion GO:0046903 307 0.049
Rat
positive regulation of signaling GO:0023056 270 0.047
Human
cellular component assembly GO:0022607 360 0.046
regulation of phosphorus metabolic process GO:0051174 349 0.046
Rat
macromolecular complex subunit organization GO:0043933 339 0.043
regulation of phosphate metabolic process GO:0019220 349 0.043
Rat
macromolecule localization GO:0033036 252 0.042
Rat
positive regulation of intracellular signal transduction GO:1902533 138 0.042
Human
regulation of molecular function GO:0065009 398 0.041
Rat
cellular component biogenesis GO:0044085 368 0.041
response to estrogen GO:0043627 232 0.040
response to lipopolysaccharide GO:0032496 191 0.039
programmed cell death GO:0012501 392 0.039
Human Rat
cell projection organization GO:0030030 302 0.039
Rat
response to corticosteroid GO:0031960 235 0.038
protein complex subunit organization GO:0071822 302 0.038
regulation of programmed cell death GO:0043067 341 0.038
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.038
regulation of cell differentiation GO:0045595 320 0.038
protein localization GO:0008104 191 0.037
Rat
response to peptide hormone GO:0043434 278 0.037
response to reactive oxygen species GO:0000302 120 0.037
regulation of nucleic acid templated transcription GO:1903506 380 0.037
positive regulation of phosphorus metabolic process GO:0010562 262 0.037
Rat
cellular component movement GO:0006928 248 0.037
response to extracellular stimulus GO:0009991 380 0.036
response to purine containing compound GO:0014074 126 0.036
Human Rat
positive regulation of cell communication GO:0010647 271 0.036
Human
localization of cell GO:0051674 202 0.036
regulation of rna biosynthetic process GO:2001141 381 0.035
central nervous system development GO:0007417 311 0.035
response to organophosphorus GO:0046683 102 0.035
Human Rat
organelle organization GO:0006996 266 0.034
Rat
positive regulation of phosphate metabolic process GO:0045937 262 0.034
Rat
response to metal ion GO:0010038 253 0.034
cell cell signaling GO:0007267 335 0.033
Rat
rna metabolic process GO:0016070 406 0.032
cellular response to nitrogen compound GO:1901699 210 0.032
Human
response to hydrogen peroxide GO:0042542 89 0.032
organophosphate metabolic process GO:0019637 370 0.032
cellular catabolic process GO:0044248 295 0.032
lipid metabolic process GO:0006629 283 0.031
head development GO:0060322 247 0.031
ion transmembrane transport GO:0034220 365 0.031
single organism intracellular transport GO:1902582 166 0.031
Human
intracellular transport GO:0046907 185 0.031
Human
regulation of cellular protein metabolic process GO:0032268 267 0.030
Rat
catabolic process GO:0009056 351 0.030
regulation of response to stress GO:0080134 126 0.030
Rat
response to glucocorticoid GO:0051384 223 0.030
establishment of protein localization GO:0045184 141 0.030
Rat
response to external biotic stimulus GO:0043207 221 0.030
apoptotic process GO:0006915 381 0.030
Human Rat
developmental process involved in reproduction GO:0003006 159 0.030
cation transport GO:0006812 382 0.029
transcription from rna polymerase ii promoter GO:0006366 252 0.029
response to nutrient GO:0007584 248 0.029
response to peptide GO:1901652 292 0.029
growth GO:0040007 165 0.028
Rat
multicellular organismal reproductive process GO:0048609 233 0.028
response to bacterium GO:0009617 200 0.028
response to biotic stimulus GO:0009607 226 0.028
regulation of secretion by cell GO:1903530 208 0.028
Rat
purine containing compound metabolic process GO:0072521 253 0.027
positive regulation of signal transduction GO:0009967 175 0.027
Human
locomotion GO:0040011 237 0.027
purine ribonucleotide metabolic process GO:0009150 227 0.027
positive regulation of secretion by cell GO:1903532 128 0.026
Rat
response to insulin GO:0032868 133 0.026
nitrogen compound transport GO:0071705 229 0.026
regulation of signal transduction GO:0009966 318 0.025
Human
cation transmembrane transport GO:0098655 263 0.025
regulation of body fluid levels GO:0050878 90 0.025
anion transport GO:0006820 178 0.025
synaptic transmission GO:0007268 235 0.025
Rat
response to ketone GO:1901654 182 0.025
cellular response to growth factor stimulus GO:0071363 162 0.025
response to acid chemical GO:0001101 222 0.024
immune system process GO:0002376 204 0.024
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.024
organic substance catabolic process GO:1901575 316 0.024
nucleobase containing small molecule metabolic process GO:0055086 316 0.024
regulation of secretion GO:0051046 224 0.024
Rat
cell part morphogenesis GO:0032990 123 0.024
response to hypoxia GO:0001666 231 0.024
homeostatic process GO:0042592 331 0.024
Human
regulation of anatomical structure size GO:0090066 135 0.024
Rat
response to nutrient levels GO:0031667 370 0.024
positive regulation of molecular function GO:0044093 230 0.024
Rat
reproduction GO:0000003 245 0.024
single organism organelle organization GO:1902589 180 0.023
tissue development GO:0009888 252 0.023
Rat
neurological system process GO:0050877 219 0.023
cellular response to hormone stimulus GO:0032870 247 0.023
regulation of cell development GO:0060284 263 0.023
transcription dna templated GO:0006351 377 0.023
ribose phosphate metabolic process GO:0019693 235 0.022
regulation of phosphorylation GO:0042325 248 0.022
Rat
regulation of transcription dna templated GO:0006355 374 0.022
cell morphogenesis GO:0000902 142 0.022
neuron development GO:0048666 286 0.022
aging GO:0007568 241 0.022
regulation of protein metabolic process GO:0051246 289 0.022
Rat
organic cyclic compound catabolic process GO:1901361 175 0.022
purine ribonucleoside metabolic process GO:0046128 168 0.022
positive regulation of secretion GO:0051047 140 0.022
Rat
positive regulation of biosynthetic process GO:0009891 319 0.022
positive regulation of cellular biosynthetic process GO:0031328 295 0.021
nucleotide metabolic process GO:0009117 279 0.021
response to growth factor GO:0070848 189 0.021
ribonucleoside triphosphate metabolic process GO:0009199 141 0.021
nucleoside phosphate metabolic process GO:0006753 283 0.021
transmembrane transport GO:0055085 412 0.021
immune response GO:0006955 104 0.021
cellular response to cytokine stimulus GO:0071345 127 0.021
positive regulation of cell proliferation GO:0008284 249 0.021
regulation of rna metabolic process GO:0051252 391 0.020
negative regulation of metabolic process GO:0009892 331 0.020
metal ion homeostasis GO:0055065 186 0.020
Human
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.020
multi organism reproductive process GO:0044703 262 0.020
cellular amine metabolic process GO:0044106 38 0.020
response to mechanical stimulus GO:0009612 134 0.020
blood circulation GO:0008015 183 0.020
Human Rat
organic hydroxy compound metabolic process GO:1901615 115 0.020
response to alkaloid GO:0043279 132 0.020
proteolysis GO:0006508 175 0.020
response to decreased oxygen levels GO:0036293 237 0.019
single organism biosynthetic process GO:0044711 342 0.019
cellular response to organonitrogen compound GO:0071417 197 0.019
Human
multicellular organism reproduction GO:0032504 233 0.019
response to estradiol GO:0032355 164 0.019
behavior GO:0007610 205 0.019
response to other organism GO:0051707 220 0.019
cellular component morphogenesis GO:0032989 155 0.019
single organism reproductive process GO:0044702 297 0.019
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.019
response to oxygen levels GO:0070482 265 0.018
regulation of nucleotide metabolic process GO:0006140 117 0.018
organic acid metabolic process GO:0006082 292 0.018
chromosome segregation GO:0007059 2 0.018
protein transport GO:0015031 132 0.018
Rat
regulation of response to external stimulus GO:0032101 106 0.018
Rat
cellular ion homeostasis GO:0006873 184 0.018
Human
cellular response to peptide GO:1901653 133 0.018
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.018
organonitrogen compound biosynthetic process GO:1901566 167 0.018
axis specification GO:0009798 4 0.018
negative regulation of cellular metabolic process GO:0031324 281 0.018
macromolecular complex assembly GO:0065003 273 0.018
regulation of protein modification process GO:0031399 194 0.018
Rat
protein complex biogenesis GO:0070271 263 0.017
regulation of hormone levels GO:0010817 187 0.017
cellular response to insulin stimulus GO:0032869 81 0.017
cellular response to oxygen containing compound GO:1901701 386 0.017
Human
exocytosis GO:0006887 60 0.017
defense response GO:0006952 194 0.017
cell morphogenesis involved in differentiation GO:0000904 119 0.017
cellular response to lipid GO:0071396 201 0.017
amine metabolic process GO:0009308 38 0.017
negative regulation of developmental process GO:0051093 125 0.017
anterior posterior pattern specification GO:0009952 1 0.017
signal release GO:0023061 145 0.017
rna biosynthetic process GO:0032774 380 0.017
secretion by cell GO:0032940 248 0.017
Rat
circulatory system process GO:0003013 183 0.016
Human Rat
regulation of intracellular signal transduction GO:1902531 218 0.016
Human
nucleotide catabolic process GO:0009166 139 0.016
membrane organization GO:0061024 94 0.016
ribonucleotide metabolic process GO:0009259 231 0.016
carboxylic acid metabolic process GO:0019752 289 0.016
nucleoside metabolic process GO:0009116 179 0.016
negative regulation of macromolecule metabolic process GO:0010605 260 0.016
positive regulation of apoptotic process GO:0043065 154 0.016
regulation of immune system process GO:0002682 123 0.016
reproductive system development GO:0061458 128 0.016
cellular ketone metabolic process GO:0042180 51 0.016
regulation of catalytic activity GO:0050790 304 0.016
Rat
regulation of locomotion GO:0040012 148 0.016
cellular response to external stimulus GO:0071496 118 0.016
metal ion transport GO:0030001 289 0.016
regulation of system process GO:0044057 208 0.016
Human
regulation of cytokine production GO:0001817 56 0.016
Rat
positive regulation of multicellular organismal process GO:0051240 387 0.016
Rat
negative regulation of signaling GO:0023057 157 0.016
positive regulation of neurogenesis GO:0050769 165 0.016
cell adhesion GO:0007155 110 0.016
sensory organ development GO:0007423 74 0.016
nucleic acid templated transcription GO:0097659 379 0.016
glycosyl compound metabolic process GO:1901657 182 0.015
purine ribonucleotide catabolic process GO:0009154 136 0.015
gliogenesis GO:0042063 93 0.015
ras protein signal transduction GO:0007265 29 0.015
positive regulation of cellular protein metabolic process GO:0032270 167 0.015
Rat
protein complex assembly GO:0006461 263 0.015
regulation of cellular ketone metabolic process GO:0010565 27 0.015
regulation of cell morphogenesis GO:0022604 77 0.015
positive regulation of phosphorylation GO:0042327 177 0.015
Rat
response to camp GO:0051591 91 0.015
calcium ion homeostasis GO:0055074 162 0.015
Human
cytoplasmic transport GO:0016482 115 0.015
Human
cellular amino acid metabolic process GO:0006520 107 0.015
response to ethanol GO:0045471 162 0.015
positive regulation of developmental process GO:0051094 283 0.015
inflammatory response GO:0006954 150 0.015
dephosphorylation GO:0016311 98 0.015
regulation of cellular component movement GO:0051270 150 0.015
dna metabolic process GO:0006259 96 0.015
cell cycle GO:0007049 101 0.014
regulation of organelle organization GO:0033043 80 0.014
Rat
small gtpase mediated signal transduction GO:0007264 36 0.014
cellular response to abiotic stimulus GO:0071214 85 0.014
innate immune response GO:0045087 35 0.014
neuron death GO:0070997 127 0.014
positive regulation of interleukin 1 secretion GO:0050716 3 0.014
Rat
divalent inorganic cation transport GO:0072511 134 0.014
Human
cell migration GO:0016477 197 0.014
regulation of cellular component biogenesis GO:0044087 86 0.014
muscle cell proliferation GO:0033002 84 0.014
organic anion transport GO:0015711 132 0.014
positive regulation of cellular component organization GO:0051130 200 0.014
Rat
heterocycle catabolic process GO:0046700 167 0.014
cellular response to organic cyclic compound GO:0071407 202 0.014
Human
cell motility GO:0048870 202 0.014
brain development GO:0007420 247 0.014
ribonucleoside metabolic process GO:0009119 174 0.014
response to amino acid GO:0043200 75 0.014
neuron projection development GO:0031175 273 0.014
negative regulation of cellular component organization GO:0051129 83 0.014
monovalent inorganic cation transport GO:0015672 172 0.014
alcohol metabolic process GO:0006066 77 0.014
gonad development GO:0008406 104 0.014
cellular lipid metabolic process GO:0044255 208 0.014
ion homeostasis GO:0050801 212 0.013
Human
aromatic compound catabolic process GO:0019439 168 0.013
cell type specific apoptotic process GO:0097285 134 0.013
embryonic pattern specification GO:0009880 1 0.013
inorganic ion transmembrane transport GO:0098660 229 0.013
regulation of anatomical structure morphogenesis GO:0022603 141 0.013
circulatory system development GO:0072359 134 0.013
smooth muscle cell proliferation GO:0048659 77 0.013
sex differentiation GO:0007548 113 0.013
cation homeostasis GO:0055080 195 0.013
Human
cardiovascular system development GO:0072358 134 0.013
cytokine production GO:0001816 61 0.013
Rat
regulation of cellular amino acid metabolic process GO:0006521 2 0.013
gland development GO:0048732 155 0.013
regulation of cell projection organization GO:0031344 175 0.013
regulation of cellular amine metabolic process GO:0033238 8 0.013
regulation of purine nucleotide metabolic process GO:1900542 115 0.013
mapk cascade GO:0000165 140 0.013
positive regulation of gene expression GO:0010628 244 0.013
organophosphate catabolic process GO:0046434 148 0.013
hormone transport GO:0009914 121 0.012
epithelial cell differentiation GO:0030855 71 0.012
leukocyte activation GO:0045321 76 0.012
learning or memory GO:0007611 90 0.012
positive regulation of cell death GO:0010942 184 0.012
Rat
purine nucleoside metabolic process GO:0042278 169 0.012
action potential GO:0001508 54 0.012
positive regulation of cellular amine metabolic process GO:0033240 3 0.012
regulation of cell migration GO:0030334 128 0.012
organophosphate biosynthetic process GO:0090407 143 0.012
cellular cation homeostasis GO:0030003 180 0.012
Human
cellular homeostasis GO:0019725 252 0.012
Human
negative regulation of gene expression GO:0010629 199 0.012
development of primary sexual characteristics GO:0045137 107 0.012
positive regulation of programmed cell death GO:0043068 157 0.012
glycerolipid metabolic process GO:0046486 67 0.012
regulation of protein phosphorylation GO:0001932 183 0.012
Rat
nucleoside triphosphate metabolic process GO:0009141 144 0.012
negative regulation of catalytic activity GO:0043086 103 0.012
epithelium development GO:0060429 96 0.012
cellular chemical homeostasis GO:0055082 247 0.012
Human
regulation of apoptotic process GO:0042981 335 0.012
regulation of protein kinase activity GO:0045859 105 0.012
Rat
neuronal action potential GO:0019228 35 0.012
positive regulation of transferase activity GO:0051347 81 0.012
Rat
kidney mesenchyme development GO:0072074 2 0.012
regulation of metanephros development GO:0072215 4 0.012
negative regulation of multicellular organismal process GO:0051241 203 0.012
Human
protein heterooligomerization GO:0051291 89 0.012
Rat
organonitrogen compound catabolic process GO:1901565 179 0.012
carbohydrate derivative biosynthetic process GO:1901137 124 0.012
positive regulation of protein transport GO:0051222 41 0.012
Rat
regulation of mapk cascade GO:0043408 116 0.011
monocarboxylic acid metabolic process GO:0032787 152 0.011
cellular response to mechanical stimulus GO:0071260 48 0.011
purine nucleotide metabolic process GO:0006163 229 0.011
eye development GO:0001654 50 0.011
purine nucleoside catabolic process GO:0006152 124 0.011
multicellular organismal signaling GO:0035637 44 0.011
cellular calcium ion homeostasis GO:0006874 160 0.011
Human
sensory perception GO:0007600 101 0.011
cell activation GO:0001775 97 0.011
cellular nitrogen compound catabolic process GO:0044270 163 0.011
hormone secretion GO:0046879 115 0.011
sequestering of calcium ion GO:0051208 8 0.011
regulation of interleukin 1 beta secretion GO:0050706 3 0.011
Rat
cellular metal ion homeostasis GO:0006875 172 0.011
Human
defense response to gram positive bacterium GO:0050830 2 0.011
response to ammonium ion GO:0060359 71 0.011
protein maturation GO:0051604 68 0.011
regulation of blood vessel size GO:0050880 89 0.011
Rat
sexual reproduction GO:0019953 148 0.011
regulation of tube size GO:0035150 89 0.011
Rat
response to transition metal nanoparticle GO:1990267 122 0.011
eye morphogenesis GO:0048592 4 0.011
protein oligomerization GO:0051259 191 0.011
lipid localization GO:0010876 62 0.011
negative regulation of cell death GO:0060548 229 0.011
nucleobase containing compound catabolic process GO:0034655 152 0.011
b cell differentiation GO:0030183 2 0.011
regulation of synaptic transmission GO:0050804 141 0.010
negative regulation of rna metabolic process GO:0051253 123 0.010
negative regulation of cellular protein metabolic process GO:0032269 106 0.010
cellular divalent inorganic cation homeostasis GO:0072503 162 0.010
Human
cellular amide metabolic process GO:0043603 44 0.010
ribonucleotide biosynthetic process GO:0009260 85 0.010
regulation of neurogenesis GO:0050767 247 0.010
regeneration GO:0031099 163 0.010
Rat
negative regulation of protein metabolic process GO:0051248 114 0.010
lipid transport GO:0006869 61 0.010
rhythmic process GO:0048511 156 0.010
regulation of smooth muscle cell proliferation GO:0048660 75 0.010
negative regulation of innate immune response GO:0045824 4 0.010
cytoskeleton organization GO:0007010 111 0.010
Rat
axon development GO:0061564 96 0.010
negative regulation of nucleic acid templated transcription GO:1903507 117 0.010
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.010
rho protein signal transduction GO:0007266 11 0.010
cognition GO:0050890 92 0.010
positive regulation of catalytic activity GO:0043085 184 0.010
Rat
positive regulation of nucleic acid templated transcription GO:1903508 197 0.010
guanosine containing compound catabolic process GO:1901069 71 0.010

P2rx4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.022
inherited metabolic disorder DOID:655 0 0.022
disease of anatomical entity DOID:7 0 0.018
nervous system disease DOID:863 0 0.018
central nervous system disease DOID:331 0 0.011