Rattus norvegicus

108 known processes

Apex1

APEX nuclease (multifunctional DNA repair enzyme) 1

(Aliases: Apex,REF-1)

Apex1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of cell proliferation GO:0042127 359 0.137
programmed cell death GO:0012501 392 0.118
regulation of catalytic activity GO:0050790 304 0.107
apoptotic process GO:0006915 381 0.102
cellular response to stress GO:0033554 269 0.100
response to peptide GO:1901652 292 0.100
regulation of programmed cell death GO:0043067 341 0.094
regulation of molecular function GO:0065009 398 0.087
negative regulation of programmed cell death GO:0043069 183 0.087
regeneration GO:0031099 163 0.086
response to inorganic substance GO:0010035 377 0.085
single organism biosynthetic process GO:0044711 342 0.082
negative regulation of apoptotic process GO:0043066 181 0.081
cellular response to lipid GO:0071396 201 0.076
regulation of cellular component organization GO:0051128 368 0.075
cellular amino acid metabolic process GO:0006520 107 0.073
response to peptide hormone GO:0043434 278 0.071
response to cytokine GO:0034097 215 0.063
cell projection organization GO:0030030 302 0.062
response to ketone GO:1901654 182 0.061
neuron projection development GO:0031175 273 0.061
aging GO:0007568 241 0.060
regulation of phosphate metabolic process GO:0019220 349 0.060
catabolic process GO:0009056 351 0.059
negative regulation of metabolic process GO:0009892 331 0.058
response to metal ion GO:0010038 253 0.056
neuron differentiation GO:0030182 368 0.056
negative regulation of cell death GO:0060548 229 0.056
cellular homeostasis GO:0019725 252 0.055
positive regulation of apoptotic process GO:0043065 154 0.054
positive regulation of multicellular organismal process GO:0051240 387 0.054
regulation of cellular protein metabolic process GO:0032268 267 0.054
intracellular signal transduction GO:0035556 314 0.054
response to temperature stimulus GO:0009266 94 0.054
regulation of protein metabolic process GO:0051246 289 0.053
immune system process GO:0002376 204 0.052
pyrimidine nucleotide biosynthetic process GO:0006221 9 0.052
positive regulation of neurogenesis GO:0050769 165 0.052
response to nutrient GO:0007584 248 0.052
organophosphate metabolic process GO:0019637 370 0.052
purine containing compound metabolic process GO:0072521 253 0.051
positive regulation of developmental process GO:0051094 283 0.051
cellular response to organic cyclic compound GO:0071407 202 0.050
carboxylic acid metabolic process GO:0019752 289 0.050
positive regulation of cell development GO:0010720 176 0.049
cellular response to oxygen containing compound GO:1901701 386 0.049
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.049
central nervous system development GO:0007417 311 0.049
positive regulation of programmed cell death GO:0043068 157 0.048
homeostatic process GO:0042592 331 0.048
rhythmic process GO:0048511 156 0.048
reproductive structure development GO:0048608 128 0.047
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.047
cellular response to organonitrogen compound GO:0071417 197 0.046
macromolecular complex assembly GO:0065003 273 0.046
nucleoside phosphate metabolic process GO:0006753 283 0.046
regulation of membrane potential GO:0042391 110 0.045
carbohydrate derivative metabolic process GO:1901135 346 0.045
response to estrogen GO:0043627 232 0.045
regulation of phosphorus metabolic process GO:0051174 349 0.044
gland development GO:0048732 155 0.043
protein phosphorylation GO:0006468 345 0.043
positive regulation of molecular function GO:0044093 230 0.043
regulation of neuron death GO:1901214 115 0.042
positive regulation of phosphorus metabolic process GO:0010562 262 0.042
oxoacid metabolic process GO:0043436 290 0.042
rna biosynthetic process GO:0032774 380 0.042
cellular catabolic process GO:0044248 295 0.042
positive regulation of cell death GO:0010942 184 0.041
positive regulation of biosynthetic process GO:0009891 319 0.041
rna metabolic process GO:0016070 406 0.040
purine nucleoside triphosphate metabolic process GO:0009144 141 0.040
nucleobase containing small molecule metabolic process GO:0055086 316 0.039
regulation of cell differentiation GO:0045595 320 0.039
cation transport GO:0006812 382 0.039
response to nutrient levels GO:0031667 370 0.039
protein complex subunit organization GO:0071822 302 0.039
protein complex biogenesis GO:0070271 263 0.038
regulation of neuron differentiation GO:0045664 208 0.037
positive regulation of phosphate metabolic process GO:0045937 262 0.037
regulation of hydrolase activity GO:0051336 143 0.037
regulation of apoptotic process GO:0042981 335 0.037
response to amino acid GO:0043200 75 0.036
single organism reproductive process GO:0044702 297 0.036
negative regulation of cell proliferation GO:0008285 119 0.036
negative regulation of macromolecule metabolic process GO:0010605 260 0.035
cellular component assembly GO:0022607 360 0.035
response to purine containing compound GO:0014074 126 0.035
response to oxidative stress GO:0006979 186 0.035
organic substance catabolic process GO:1901575 316 0.035
protein transport GO:0015031 132 0.035
neuron death GO:0070997 127 0.035
reproductive system development GO:0061458 128 0.035
cellular response to cytokine stimulus GO:0071345 127 0.035
reproduction GO:0000003 245 0.034
growth GO:0040007 165 0.034
response to wounding GO:0009611 254 0.034
response to extracellular stimulus GO:0009991 380 0.034
reproductive process GO:0022414 372 0.034
transmembrane transport GO:0055085 412 0.034
regulation of multicellular organismal development GO:2000026 376 0.034
positive regulation of cellular protein metabolic process GO:0032270 167 0.034
response to amine GO:0014075 46 0.034
response to oxygen levels GO:0070482 265 0.033
development of primary sexual characteristics GO:0045137 107 0.033
negative regulation of cellular metabolic process GO:0031324 281 0.033
negative regulation of biosynthetic process GO:0009890 168 0.033
glycosyl compound metabolic process GO:1901657 182 0.033
positive regulation of catalytic activity GO:0043085 184 0.033
nucleotide metabolic process GO:0009117 279 0.032
organic acid metabolic process GO:0006082 292 0.032
regulation of intracellular signal transduction GO:1902531 218 0.032
ion transmembrane transport GO:0034220 365 0.032
cellular response to endogenous stimulus GO:0071495 377 0.032
purine nucleotide metabolic process GO:0006163 229 0.032
cellular component biogenesis GO:0044085 368 0.031
response to monosaccharide GO:0034284 159 0.031
protein complex assembly GO:0006461 263 0.031
establishment of protein localization GO:0045184 141 0.031
aromatic compound catabolic process GO:0019439 168 0.031
positive regulation of protein metabolic process GO:0051247 178 0.030
reactive oxygen species metabolic process GO:0072593 37 0.030
regulation of myeloid cell differentiation GO:0045637 12 0.030
positive regulation of rna metabolic process GO:0051254 203 0.030
neuron apoptotic process GO:0051402 88 0.030
regulation of neurogenesis GO:0050767 247 0.029
chemical homeostasis GO:0048878 292 0.029
response to ethanol GO:0045471 162 0.029
positive regulation of nervous system development GO:0051962 178 0.029
regulation of purine nucleotide metabolic process GO:1900542 115 0.029
neuron development GO:0048666 286 0.029
positive regulation of cell differentiation GO:0045597 217 0.029
muscle system process GO:0003012 115 0.029
negative regulation of multicellular organismal process GO:0051241 203 0.029
positive regulation of cellular component organization GO:0051130 200 0.028
ribonucleoside metabolic process GO:0009119 174 0.028
response to carbohydrate GO:0009743 183 0.028
positive regulation of cell projection organization GO:0031346 111 0.028
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.028
cellular amide metabolic process GO:0043603 44 0.028
translation GO:0006412 35 0.028
transcription from rna polymerase ii promoter GO:0006366 252 0.028
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.028
response to lead ion GO:0010288 33 0.027
cellular amine metabolic process GO:0044106 38 0.027
purine ribonucleotide metabolic process GO:0009150 227 0.027
secretion GO:0046903 307 0.027
regulation of cell development GO:0060284 263 0.027
response to hexose GO:0009746 144 0.027
positive regulation of gene expression GO:0010628 244 0.027
neurological system process GO:0050877 219 0.027
regulation of cell projection organization GO:0031344 175 0.027
negative regulation of cellular biosynthetic process GO:0031327 161 0.027
response to glucose GO:0009749 136 0.026
lipid metabolic process GO:0006629 283 0.026
cellular chemical homeostasis GO:0055082 247 0.026
ribose phosphate metabolic process GO:0019693 235 0.026
macromolecular complex subunit organization GO:0043933 339 0.026
cellular ketone metabolic process GO:0042180 51 0.026
regulation of system process GO:0044057 208 0.026
regulation of rna biosynthetic process GO:2001141 381 0.025
cellular response to external stimulus GO:0071496 118 0.025
cellular response to oxidative stress GO:0034599 76 0.025
regulation of nucleotide metabolic process GO:0006140 117 0.025
brain development GO:0007420 247 0.025
cellular response to growth factor stimulus GO:0071363 162 0.025
regulation of neuron projection development GO:0010975 161 0.025
nucleic acid templated transcription GO:0097659 379 0.025
organic hydroxy compound metabolic process GO:1901615 115 0.025
positive regulation of response to stimulus GO:0048584 285 0.025
developmental process involved in reproduction GO:0003006 159 0.025
amine metabolic process GO:0009308 38 0.024
organonitrogen compound biosynthetic process GO:1901566 167 0.024
female gonad development GO:0008585 53 0.024
anion transport GO:0006820 178 0.024
response to growth factor GO:0070848 189 0.024
ribonucleoside triphosphate metabolic process GO:0009199 141 0.024
regulation of phosphorylation GO:0042325 248 0.024
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.024
macromolecule localization GO:0033036 252 0.024
defense response GO:0006952 194 0.024
regulation of protein phosphorylation GO:0001932 183 0.024
regulation of nucleic acid templated transcription GO:1903506 380 0.024
transcription dna templated GO:0006351 377 0.024
regulation of immune system process GO:0002682 123 0.023
glial cell differentiation GO:0010001 65 0.023
positive regulation of neuron differentiation GO:0045666 126 0.023
negative regulation of molecular function GO:0044092 133 0.023
response to molecule of bacterial origin GO:0002237 194 0.023
negative regulation of protein metabolic process GO:0051248 114 0.023
cellular response to abiotic stimulus GO:0071214 85 0.023
protein oligomerization GO:0051259 191 0.023
pyrimidine ribonucleotide biosynthetic process GO:0009220 5 0.022
response to acid chemical GO:0001101 222 0.022
small molecule biosynthetic process GO:0044283 124 0.022
spindle organization GO:0007051 2 0.022
positive regulation of phosphorylation GO:0042327 177 0.022
response to decreased oxygen levels GO:0036293 237 0.022
positive regulation of cell communication GO:0010647 271 0.021
cellular response to peptide GO:1901653 133 0.021
regulation of cellular amino acid metabolic process GO:0006521 2 0.021
response to transition metal nanoparticle GO:1990267 122 0.021
dna metabolic process GO:0006259 96 0.021
single organism catabolic process GO:0044712 283 0.021
positive regulation of protein modification process GO:0031401 142 0.021
cellular component morphogenesis GO:0032989 155 0.021
cellular response to drug GO:0035690 30 0.021
gonad development GO:0008406 104 0.021
regulation of neuron apoptotic process GO:0043523 83 0.021
regulation of kinase activity GO:0043549 117 0.021
cellular component movement GO:0006928 248 0.021
purine ribonucleoside metabolic process GO:0046128 168 0.021
regulation of cellular amine metabolic process GO:0033238 8 0.021
carbohydrate derivative catabolic process GO:1901136 147 0.021
ion homeostasis GO:0050801 212 0.020
cellular nitrogen compound catabolic process GO:0044270 163 0.020
synaptic transmission GO:0007268 235 0.020
negative regulation of cell communication GO:0010648 158 0.020
sex differentiation GO:0007548 113 0.020
response to toxic substance GO:0009636 133 0.020
locomotion GO:0040011 237 0.020
action potential GO:0001508 54 0.020
single organism organelle organization GO:1902589 180 0.020
positive regulation of cell proliferation GO:0008284 249 0.020
hepaticobiliary system development GO:0061008 90 0.020
mitotic cell cycle GO:0000278 49 0.020
regulation of nervous system development GO:0051960 264 0.020
metal ion transport GO:0030001 289 0.020
multicellular organismal reproductive process GO:0048609 233 0.020
signal transduction by phosphorylation GO:0023014 144 0.020
positive regulation of hydrolase activity GO:0051345 86 0.020
protein localization GO:0008104 191 0.020
biological adhesion GO:0022610 110 0.020
cation homeostasis GO:0055080 195 0.019
response to corticosteroid GO:0031960 235 0.019
positive regulation of cellular biosynthetic process GO:0031328 295 0.019
cellular response to nitrogen compound GO:1901699 210 0.019
negative regulation of cell differentiation GO:0045596 99 0.019
inflammatory response GO:0006954 150 0.019
multi organism reproductive process GO:0044703 262 0.019
muscle contraction GO:0006936 88 0.019
organic anion transport GO:0015711 132 0.019
regulation of cellular ketone metabolic process GO:0010565 27 0.019
regulation of signal transduction GO:0009966 318 0.019
purine nucleoside monophosphate metabolic process GO:0009126 84 0.019
response to glucocorticoid GO:0051384 223 0.019
mapk cascade GO:0000165 140 0.019
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.019
activation of cysteine type endopeptidase activity GO:0097202 4 0.019
alcohol metabolic process GO:0006066 77 0.019
organelle organization GO:0006996 266 0.019
regulation of rna metabolic process GO:0051252 391 0.019
nitrogen compound transport GO:0071705 229 0.019
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.018
response to starvation GO:0042594 59 0.018
nucleoside triphosphate metabolic process GO:0009141 144 0.018
purine nucleoside metabolic process GO:0042278 169 0.018
heart morphogenesis GO:0003007 3 0.018
nucleotide biosynthetic process GO:0009165 98 0.018
regulation of protein modification process GO:0031399 194 0.018
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.018
regulation of anatomical structure size GO:0090066 135 0.018
g protein coupled receptor signaling pathway GO:0007186 242 0.018
organ regeneration GO:0031100 101 0.018
cellular modified amino acid metabolic process GO:0006575 61 0.018
nucleoside metabolic process GO:0009116 179 0.018
ras protein signal transduction GO:0007265 29 0.018
cellular response to steroid hormone stimulus GO:0071383 93 0.018
axis specification GO:0009798 4 0.018
multicellular organism reproduction GO:0032504 233 0.017
guanosine containing compound metabolic process GO:1901068 74 0.017
regulation of protein kinase activity GO:0045859 105 0.017
head development GO:0060322 247 0.017
ribonucleotide metabolic process GO:0009259 231 0.017
negative regulation of neuron death GO:1901215 69 0.017
regulation of translation GO:0006417 27 0.017
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.017
posttranscriptional regulation of gene expression GO:0010608 37 0.017
multicellular organismal signaling GO:0035637 44 0.017
cellular response to extracellular stimulus GO:0031668 73 0.017
regulation of transferase activity GO:0051338 123 0.017
organonitrogen compound catabolic process GO:1901565 179 0.017
protein processing GO:0016485 68 0.017
response to organophosphorus GO:0046683 102 0.017
response to reactive oxygen species GO:0000302 120 0.017
cell cycle checkpoint GO:0000075 2 0.017
urogenital system development GO:0001655 78 0.017
response to lipopolysaccharide GO:0032496 191 0.016
positive regulation of intracellular signal transduction GO:1902533 138 0.016
response to biotic stimulus GO:0009607 226 0.016
stress activated protein kinase signaling cascade GO:0031098 37 0.016
cellular response to molecule of bacterial origin GO:0071219 56 0.016
organophosphate catabolic process GO:0046434 148 0.016
regulation of dna metabolic process GO:0051052 60 0.016
cation transmembrane transport GO:0098655 263 0.016
response to alkaloid GO:0043279 132 0.016
regulation of response to stress GO:0080134 126 0.016
positive regulation of cyclic nucleotide metabolic process GO:0030801 37 0.016
proteolysis GO:0006508 175 0.016
intracellular transport GO:0046907 185 0.016
protein homooligomerization GO:0051260 91 0.016
cellular response to glucocorticoid stimulus GO:0071385 68 0.016
ovulation cycle process GO:0022602 50 0.016
positive regulation of cellular amine metabolic process GO:0033240 3 0.016
regulation of cellular localization GO:0060341 263 0.015
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.015
regulation of transcription dna templated GO:0006355 374 0.015
camp metabolic process GO:0046058 63 0.015
cellular protein complex assembly GO:0043623 44 0.015
positive regulation of protein phosphorylation GO:0001934 135 0.015
developmental growth GO:0048589 100 0.015
organic cyclic compound catabolic process GO:1901361 175 0.015
negative regulation of myeloid cell differentiation GO:0045638 3 0.015
protein maturation GO:0051604 68 0.015
cellular lipid metabolic process GO:0044255 208 0.015
carboxylic acid transport GO:0046942 115 0.015
negative regulation of cell cycle phase transition GO:1901988 4 0.015
gastrulation GO:0007369 2 0.015
chromosome organization GO:0051276 36 0.015
response to vitamin GO:0033273 131 0.015
organic acid transport GO:0015849 116 0.015
regulation of mapk cascade GO:0043408 116 0.015
negative regulation of catalytic activity GO:0043086 103 0.015
positive regulation of nucleic acid templated transcription GO:1903508 197 0.014
development of primary female sexual characteristics GO:0046545 56 0.014
transmission of nerve impulse GO:0019226 42 0.014
regulation of anatomical structure morphogenesis GO:0022603 141 0.014
neuronal action potential GO:0019228 35 0.014
negative regulation of phosphorus metabolic process GO:0010563 80 0.014
negative regulation of phosphate metabolic process GO:0045936 80 0.014
regulation of tube size GO:0035150 89 0.014
ribonucleoside monophosphate metabolic process GO:0009161 88 0.014
positive regulation of neuron projection development GO:0010976 99 0.014
muscle cell proliferation GO:0033002 84 0.014
regulation of response to external stimulus GO:0032101 106 0.014
response to estradiol GO:0032355 164 0.014
cellular ion homeostasis GO:0006873 184 0.014
ovulation cycle GO:0042698 67 0.014
reactive nitrogen species metabolic process GO:2001057 1 0.014
positive regulation of transcription dna templated GO:0045893 197 0.014
regulation of cytokine production GO:0001817 56 0.014
cell growth GO:0016049 104 0.014
positive regulation of nucleotide metabolic process GO:0045981 91 0.014
response to mechanical stimulus GO:0009612 134 0.014
regulation of defense response GO:0031347 68 0.014
cell cell signaling GO:0007267 335 0.014
cellular divalent inorganic cation homeostasis GO:0072503 162 0.014
circulatory system process GO:0003013 183 0.014
response to tumor cell GO:0002347 4 0.014
sexual reproduction GO:0019953 148 0.014
negative regulation of cellular protein metabolic process GO:0032269 106 0.014
regulation of nucleotide catabolic process GO:0030811 65 0.013
negative regulation of developmental process GO:0051093 125 0.013
cyclic purine nucleotide metabolic process GO:0052652 62 0.013
smooth muscle cell proliferation GO:0048659 77 0.013
organic acid biosynthetic process GO:0016053 83 0.013
cellular response to lipopolysaccharide GO:0071222 55 0.013
cellular response to biotic stimulus GO:0071216 59 0.013
mesoderm development GO:0007498 2 0.013
heterocycle catabolic process GO:0046700 167 0.013
negative regulation of transport GO:0051051 136 0.013
positive regulation of signal transduction GO:0009967 175 0.013
immune response GO:0006955 104 0.013
female pregnancy GO:0007565 122 0.013
alpha amino acid metabolic process GO:1901605 71 0.013
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.013
neuron fate commitment GO:0048663 4 0.013
negative regulation of response to stimulus GO:0048585 155 0.013
regulation of muscle system process GO:0090257 79 0.013
neuron projection morphogenesis GO:0048812 122 0.013
multi multicellular organism process GO:0044706 138 0.013
embryo development GO:0009790 49 0.013
bmp signaling pathway GO:0030509 4 0.013
cellular cation homeostasis GO:0030003 180 0.013
response to hypoxia GO:0001666 231 0.013
small molecule catabolic process GO:0044282 59 0.013
carbohydrate homeostasis GO:0033500 75 0.013
regulation of immune response GO:0050776 55 0.013
regulation of cell growth GO:0001558 85 0.013
regulation of muscle contraction GO:0006937 53 0.013
positive regulation of signaling GO:0023056 270 0.013
liver development GO:0001889 90 0.013
single organism cellular localization GO:1902580 102 0.013
positive regulation of camp biosynthetic process GO:0030819 28 0.012
response to external biotic stimulus GO:0043207 221 0.012
anterior posterior pattern specification GO:0009952 1 0.012
positive regulation of protein import into nucleus GO:0042307 14 0.012
chromosome segregation GO:0007059 2 0.012
response to hyperoxia GO:0055093 45 0.012
metal ion homeostasis GO:0055065 186 0.012
regulation of catabolic process GO:0009894 113 0.012
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.012
peptide biosynthetic process GO:0043043 3 0.012
regulation of synaptic transmission GO:0050804 141 0.012
mitochondrion organization GO:0007005 35 0.012
regulation of cellular component biogenesis GO:0044087 86 0.012
response to antibiotic GO:0046677 39 0.012
eye morphogenesis GO:0048592 4 0.012
regulation of canonical wnt signaling pathway GO:0060828 4 0.012
cellular response to ketone GO:1901655 51 0.012
response to bacterium GO:0009617 200 0.012
protein modification by small protein conjugation GO:0032446 31 0.012
fatty acid metabolic process GO:0006631 99 0.012
positive regulation of blood circulation GO:1903524 65 0.012
positive regulation of biomineral tissue development GO:0070169 4 0.012
telencephalon development GO:0021537 62 0.012
alditol metabolic process GO:0019400 4 0.012
dna integrity checkpoint GO:0031570 2 0.012
regulation of blood circulation GO:1903522 110 0.012
blood circulation GO:0008015 183 0.012
tissue development GO:0009888 252 0.012
embryonic pattern specification GO:0009880 1 0.012
regulation of epithelial cell proliferation GO:0050678 49 0.012
organophosphate biosynthetic process GO:0090407 143 0.012
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.012
protein autophosphorylation GO:0046777 66 0.012
gamete generation GO:0007276 124 0.012
purine nucleotide biosynthetic process GO:0006164 83 0.012
pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 3 0.012
response to dexamethasone GO:0071548 49 0.012
female sex differentiation GO:0046660 59 0.012
pyrimidine nucleoside triphosphate metabolic process GO:0009147 4 0.012
positive regulation of kinase activity GO:0033674 77 0.012
positive regulation of camp metabolic process GO:0030816 31 0.012
regulation of intracellular transport GO:0032386 65 0.011
single organism intracellular transport GO:1902582 166 0.011
cell type specific apoptotic process GO:0097285 134 0.011
response to corticosterone GO:0051412 40 0.011
regulation of cell migration GO:0030334 128 0.011
limbic system development GO:0021761 38 0.011
negative regulation of cellular component organization GO:0051129 83 0.011
regulation of protein serine threonine kinase activity GO:0071900 64 0.011
negative regulation of gene expression GO:0010629 199 0.011
positive regulation of mitochondrion organization GO:0010822 4 0.011
negative regulation of nucleic acid templated transcription GO:1903507 117 0.011
antigen receptor mediated signaling pathway GO:0050851 1 0.011
cell morphogenesis involved in differentiation GO:0000904 119 0.011
carbohydrate derivative biosynthetic process GO:1901137 124 0.011
pyrimidine containing compound metabolic process GO:0072527 20 0.011
regulation of cell cycle GO:0051726 73 0.011
cell adhesion GO:0007155 110 0.011
mitotic cell cycle checkpoint GO:0007093 1 0.011
multicellular organism growth GO:0035264 1 0.011
mitotic spindle organization GO:0007052 2 0.011
defense response to gram negative bacterium GO:0050829 3 0.011
cellular response to dna damage stimulus GO:0006974 19 0.011
anatomical structure homeostasis GO:0060249 29 0.011
cellular metal ion homeostasis GO:0006875 172 0.011
positive regulation of organelle organization GO:0010638 48 0.011
cellular response to nutrient levels GO:0031669 60 0.011
nucleoside phosphate catabolic process GO:1901292 140 0.011
glycosyl compound catabolic process GO:1901658 126 0.011
calcium ion homeostasis GO:0055074 162 0.011
positive regulation of immune system process GO:0002684 90 0.011
positive regulation of reactive oxygen species metabolic process GO:2000379 16 0.011
cellular response to corticosteroid stimulus GO:0071384 69 0.011
regulation of homeostatic process GO:0032844 101 0.011
regulation of ion transport GO:0043269 245 0.011
cellular protein localization GO:0034613 122 0.011
positive regulation of cellular component biogenesis GO:0044089 55 0.011
response to radiation GO:0009314 137 0.011
gliogenesis GO:0042063 93 0.011
nucleocytoplasmic transport GO:0006913 48 0.011
localization of cell GO:0051674 202 0.011
mitochondrial transport GO:0006839 19 0.011
cellular calcium ion homeostasis GO:0006874 160 0.011
nucleoside triphosphate catabolic process GO:0009143 123 0.011
regulation of smooth muscle cell proliferation GO:0048660 75 0.010
positive regulation of cellular component movement GO:0051272 102 0.010
response to heat GO:0009408 60 0.010
regulation of nucleotide biosynthetic process GO:0030808 47 0.010
cellular response to alcohol GO:0097306 87 0.010
cell migration GO:0016477 197 0.010
single organism nuclear import GO:1902593 35 0.010
leukocyte activation GO:0045321 76 0.010
sequestering of calcium ion GO:0051208 8 0.010
negative regulation of immune system process GO:0002683 39 0.010
negative regulation of neuron apoptotic process GO:0043524 45 0.010
positive regulation of nucleocytoplasmic transport GO:0046824 17 0.010
cytoplasmic transport GO:0016482 115 0.010
regulation of growth GO:0040008 105 0.010
divalent inorganic cation transport GO:0072511 134 0.010

Apex1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.028
nervous system disease DOID:863 0 0.028
central nervous system disease DOID:331 0 0.017
musculoskeletal system disease DOID:17 0 0.015
gastrointestinal system cancer DOID:3119 0 0.015
intestinal cancer DOID:10155 0 0.015
cancer DOID:162 0 0.015
disease of cellular proliferation DOID:14566 0 0.015
organ system cancer DOID:0050686 0 0.015
colon carcinoma DOID:1520 0 0.013
large intestine cancer DOID:5672 0 0.013
colon cancer DOID:219 0 0.013
colorectal cancer DOID:9256 0 0.013