Rattus norvegicus

0 known processes

Plek2

pleckstrin 2

Plek2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
programmed cell death GO:0012501 392 0.066
response to monosaccharide GO:0034284 159 0.063
oxoacid metabolic process GO:0043436 290 0.061
response to inorganic substance GO:0010035 377 0.053
apoptotic process GO:0006915 381 0.049
carbohydrate derivative metabolic process GO:1901135 346 0.046
intracellular signal transduction GO:0035556 314 0.045
chemical homeostasis GO:0048878 292 0.044
organic substance catabolic process GO:1901575 316 0.043
carboxylic acid metabolic process GO:0019752 289 0.042
neuron differentiation GO:0030182 368 0.042
transcription dna templated GO:0006351 377 0.039
neurological system process GO:0050877 219 0.039
organic acid metabolic process GO:0006082 292 0.037
cellular amine metabolic process GO:0044106 38 0.036
rna metabolic process GO:0016070 406 0.036
regulation of phosphorus metabolic process GO:0051174 349 0.035
positive regulation of protein phosphorylation GO:0001934 135 0.035
circulatory system process GO:0003013 183 0.035
single organism reproductive process GO:0044702 297 0.035
positive regulation of gene expression GO:0010628 244 0.035
rna biosynthetic process GO:0032774 380 0.034
macromolecule localization GO:0033036 252 0.034
regulation of cellular component organization GO:0051128 368 0.032
regulation of phosphate metabolic process GO:0019220 349 0.032
regulation of programmed cell death GO:0043067 341 0.032
cellular response to oxygen containing compound GO:1901701 386 0.032
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.031
aging GO:0007568 241 0.031
transmembrane transport GO:0055085 412 0.031
response to hydrogen peroxide GO:0042542 89 0.030
regulation of rna metabolic process GO:0051252 391 0.030
regulation of transcription dna templated GO:0006355 374 0.030
cellular ketone metabolic process GO:0042180 51 0.030
positive regulation of multicellular organismal process GO:0051240 387 0.030
positive regulation of biosynthetic process GO:0009891 319 0.030
regulation of system process GO:0044057 208 0.030
regulation of signal transduction GO:0009966 318 0.029
response to carbohydrate GO:0009743 183 0.029
regulation of nucleic acid templated transcription GO:1903506 380 0.029
positive regulation of cellular biosynthetic process GO:0031328 295 0.029
reproduction GO:0000003 245 0.029
reproductive process GO:0022414 372 0.029
cell projection organization GO:0030030 302 0.029
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.028
purine containing compound metabolic process GO:0072521 253 0.028
positive regulation of catalytic activity GO:0043085 184 0.028
positive regulation of phosphorus metabolic process GO:0010562 262 0.028
regulation of multicellular organismal development GO:2000026 376 0.028
regulation of hormone levels GO:0010817 187 0.027
protein phosphorylation GO:0006468 345 0.027
positive regulation of phosphate metabolic process GO:0045937 262 0.027
regulation of response to external stimulus GO:0032101 106 0.027
sensory perception GO:0007600 101 0.027
negative regulation of metabolic process GO:0009892 331 0.027
negative regulation of cell death GO:0060548 229 0.027
response to metal ion GO:0010038 253 0.026
cellular response to endogenous stimulus GO:0071495 377 0.026
multi organism reproductive process GO:0044703 262 0.026
regulation of membrane potential GO:0042391 110 0.026
response to oxidative stress GO:0006979 186 0.025
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.025
positive regulation of cellular amine metabolic process GO:0033240 3 0.025
regulation of cell proliferation GO:0042127 359 0.025
sex differentiation GO:0007548 113 0.025
response to reactive oxygen species GO:0000302 120 0.025
cellular response to organic cyclic compound GO:0071407 202 0.024
regulation of neurogenesis GO:0050767 247 0.024
regulation of cell projection organization GO:0031344 175 0.024
nucleobase containing small molecule metabolic process GO:0055086 316 0.024
response to oxygen levels GO:0070482 265 0.023
multicellular organism reproduction GO:0032504 233 0.023
regulation of secretion GO:0051046 224 0.023
cellular component assembly GO:0022607 360 0.023
response to organophosphorus GO:0046683 102 0.023
homeostatic process GO:0042592 331 0.023
lipid metabolic process GO:0006629 283 0.022
positive regulation of molecular function GO:0044093 230 0.022
positive regulation of developmental process GO:0051094 283 0.022
response to acid chemical GO:0001101 222 0.022
neuron development GO:0048666 286 0.022
response to growth factor GO:0070848 189 0.022
regulation of cellular amino acid metabolic process GO:0006521 2 0.022
organophosphate metabolic process GO:0019637 370 0.022
amine metabolic process GO:0009308 38 0.022
nucleic acid templated transcription GO:0097659 379 0.022
nucleotide metabolic process GO:0009117 279 0.022
purine ribonucleotide metabolic process GO:0009150 227 0.022
regulation of molecular function GO:0065009 398 0.022
regulation of cellular amine metabolic process GO:0033238 8 0.022
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.022
regulation of response to stress GO:0080134 126 0.022
cellular component biogenesis GO:0044085 368 0.022
regulation of protein metabolic process GO:0051246 289 0.021
negative regulation of macromolecule metabolic process GO:0010605 260 0.021
response to ethanol GO:0045471 162 0.021
regulation of cellular ketone metabolic process GO:0010565 27 0.021
transcription from rna polymerase ii promoter GO:0006366 252 0.021
locomotion GO:0040011 237 0.021
response to extracellular stimulus GO:0009991 380 0.021
cellular chemical homeostasis GO:0055082 247 0.021
catabolic process GO:0009056 351 0.021
response to nutrient levels GO:0031667 370 0.021
epithelium development GO:0060429 96 0.021
cellular homeostasis GO:0019725 252 0.021
cellular cation homeostasis GO:0030003 180 0.021
regulation of synaptic transmission GO:0050804 141 0.020
ras protein signal transduction GO:0007265 29 0.020
brain development GO:0007420 247 0.020
regulation of catalytic activity GO:0050790 304 0.020
central nervous system development GO:0007417 311 0.020
response to estradiol GO:0032355 164 0.020
positive regulation of transcription dna templated GO:0045893 197 0.020
macromolecular complex subunit organization GO:0043933 339 0.020
protein oligomerization GO:0051259 191 0.020
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.020
response to glucose GO:0009749 136 0.020
regulation of cell development GO:0060284 263 0.020
negative regulation of cellular metabolic process GO:0031324 281 0.020
response to hypoxia GO:0001666 231 0.020
epithelial cell differentiation GO:0030855 71 0.020
negative regulation of immune response to tumor cell GO:0002838 2 0.019
sexual reproduction GO:0019953 148 0.019
regulation of rna biosynthetic process GO:2001141 381 0.019
regulation of cell differentiation GO:0045595 320 0.019
intracellular transport GO:0046907 185 0.019
nucleoside metabolic process GO:0009116 179 0.019
positive regulation of cell projection organization GO:0031346 111 0.019
response to biotic stimulus GO:0009607 226 0.019
secretion by cell GO:0032940 248 0.019
response to purine containing compound GO:0014074 126 0.019
negative regulation of apoptotic process GO:0043066 181 0.019
positive regulation of rna biosynthetic process GO:1902680 197 0.019
response to hexose GO:0009746 144 0.018
positive regulation of locomotion GO:0040017 102 0.018
regulation of apoptotic process GO:0042981 335 0.018
response to ketone GO:1901654 182 0.018
response to decreased oxygen levels GO:0036293 237 0.018
signal release GO:0023061 145 0.018
development of primary sexual characteristics GO:0045137 107 0.018
ribose phosphate metabolic process GO:0019693 235 0.018
multicellular organismal reproductive process GO:0048609 233 0.017
cellular ion homeostasis GO:0006873 184 0.017
negative regulation of programmed cell death GO:0043069 183 0.017
g protein coupled receptor signaling pathway GO:0007186 242 0.017
positive regulation of signaling GO:0023056 270 0.017
positive regulation of rna metabolic process GO:0051254 203 0.017
small gtpase mediated signal transduction GO:0007264 36 0.017
neuron projection development GO:0031175 273 0.017
positive regulation of cell differentiation GO:0045597 217 0.017
cellular response to lipid GO:0071396 201 0.017
single organism intracellular transport GO:1902582 166 0.017
head development GO:0060322 247 0.017
response to lipopolysaccharide GO:0032496 191 0.017
anatomical structure morphogenesis GO:0009653 298 0.017
ribonucleotide metabolic process GO:0009259 231 0.017
regulation of cellular localization GO:0060341 263 0.017
regulation of nervous system development GO:0051960 264 0.017
gonad development GO:0008406 104 0.017
gastrulation GO:0007369 2 0.016
cellular response to hormone stimulus GO:0032870 247 0.016
cellular hormone metabolic process GO:0034754 49 0.016
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.016
cellular amino acid metabolic process GO:0006520 107 0.016
regulation of protein phosphorylation GO:0001932 183 0.016
positive regulation of cell proliferation GO:0008284 249 0.016
response to camp GO:0051591 91 0.016
negative regulation of response to stimulus GO:0048585 155 0.016
regulation of neuron projection development GO:0010975 161 0.016
positive regulation of neurogenesis GO:0050769 165 0.016
nucleoside phosphate metabolic process GO:0006753 283 0.016
regulation of neuron differentiation GO:0045664 208 0.016
positive regulation of cellular component organization GO:0051130 200 0.016
synaptic transmission GO:0007268 235 0.016
regulation of phosphorylation GO:0042325 248 0.016
positive regulation of cell development GO:0010720 176 0.016
blood circulation GO:0008015 183 0.016
response to nutrient GO:0007584 248 0.016
gamete generation GO:0007276 124 0.015
cellular response to organonitrogen compound GO:0071417 197 0.015
metal ion transport GO:0030001 289 0.015
localization of cell GO:0051674 202 0.015
positive regulation of programmed cell death GO:0043068 157 0.015
cellular response to alcohol GO:0097306 87 0.015
positive regulation of phosphorylation GO:0042327 177 0.015
ion homeostasis GO:0050801 212 0.015
regulation of intracellular signal transduction GO:1902531 218 0.015
nitrogen compound transport GO:0071705 229 0.015
purine nucleotide metabolic process GO:0006163 229 0.015
protein complex assembly GO:0006461 263 0.015
purine ribonucleoside metabolic process GO:0046128 168 0.015
positive regulation of neuron projection development GO:0010976 99 0.015
response to molecule of bacterial origin GO:0002237 194 0.015
ribonucleoside metabolic process GO:0009119 174 0.015
negative regulation of gene expression GO:0010629 199 0.015
ion transmembrane transport GO:0034220 365 0.015
behavior GO:0007610 205 0.014
cell cell signaling GO:0007267 335 0.014
cation homeostasis GO:0055080 195 0.014
glycosyl compound metabolic process GO:1901657 182 0.014
cation transport GO:0006812 382 0.014
proteolysis GO:0006508 175 0.014
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.014
organic cyclic compound catabolic process GO:1901361 175 0.014
protein complex biogenesis GO:0070271 263 0.014
negative regulation of innate immune response GO:0045824 4 0.014
cellular nitrogen compound catabolic process GO:0044270 163 0.014
regulation of locomotion GO:0040012 148 0.014
cell motility GO:0048870 202 0.014
response to toxic substance GO:0009636 133 0.014
response to alkaloid GO:0043279 132 0.014
defense response GO:0006952 194 0.014
oxidation reduction process GO:0055114 304 0.014
protein complex subunit organization GO:0071822 302 0.014
multicellular organism growth GO:0035264 1 0.014
action potential GO:0001508 54 0.014
developmental process involved in reproduction GO:0003006 159 0.014
membrane organization GO:0061024 94 0.014
cellular response to cytokine stimulus GO:0071345 127 0.014
single organism biosynthetic process GO:0044711 342 0.014
organelle organization GO:0006996 266 0.013
cell morphogenesis involved in differentiation GO:0000904 119 0.013
cellular component movement GO:0006928 248 0.013
positive regulation of nucleic acid templated transcription GO:1903508 197 0.013
protein localization GO:0008104 191 0.013
cellular response to nitrogen compound GO:1901699 210 0.013
negative regulation of rna metabolic process GO:0051253 123 0.013
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.013
reactive oxygen species metabolic process GO:0072593 37 0.013
positive regulation of nervous system development GO:0051962 178 0.013
positive regulation of cytokine production GO:0001819 42 0.013
negative regulation of cell proliferation GO:0008285 119 0.013
reproductive system development GO:0061458 128 0.013
secretion GO:0046903 307 0.013
hormone transport GO:0009914 121 0.013
cellular response to growth factor stimulus GO:0071363 162 0.013
cellular catabolic process GO:0044248 295 0.013
positive regulation of transport GO:0051050 245 0.013
regulation of anatomical structure morphogenesis GO:0022603 141 0.013
positive regulation of response to stimulus GO:0048584 285 0.012
positive regulation of apoptotic process GO:0043065 154 0.012
positive regulation of hydrolase activity GO:0051345 86 0.012
negative regulation of cell communication GO:0010648 158 0.012
divalent metal ion transport GO:0070838 132 0.012
metal ion homeostasis GO:0055065 186 0.012
calcium ion homeostasis GO:0055074 162 0.012
negative regulation of biosynthetic process GO:0009890 168 0.012
organonitrogen compound biosynthetic process GO:1901566 167 0.012
aromatic compound catabolic process GO:0019439 168 0.012
regulation of peptide transport GO:0090087 87 0.012
reactive nitrogen species metabolic process GO:2001057 1 0.012
response to radiation GO:0009314 137 0.012
vesicle mediated transport GO:0016192 181 0.012
regulation of dendrite development GO:0050773 59 0.012
response to transforming growth factor beta GO:0071559 46 0.012
inflammatory response GO:0006954 150 0.012
positive regulation of neuron differentiation GO:0045666 126 0.012
purine containing compound catabolic process GO:0072523 138 0.012
single organism behavior GO:0044708 130 0.012
muscle system process GO:0003012 115 0.012
regulation of immune system process GO:0002682 123 0.012
peptide transport GO:0015833 97 0.012
positive regulation of nucleotide metabolic process GO:0045981 91 0.012
response to peptide hormone GO:0043434 278 0.012
response to interleukin 1 GO:0070555 55 0.012
signal transduction by phosphorylation GO:0023014 144 0.012
purine nucleoside metabolic process GO:0042278 169 0.012
glycosyl compound catabolic process GO:1901658 126 0.012
cellular divalent inorganic cation homeostasis GO:0072503 162 0.012
positive regulation of protein modification process GO:0031401 142 0.012
immune system process GO:0002376 204 0.012
positive regulation of cell death GO:0010942 184 0.012
cation transmembrane transport GO:0098655 263 0.012
small molecule biosynthetic process GO:0044283 124 0.012
ribonucleoside triphosphate metabolic process GO:0009199 141 0.012
response to transition metal nanoparticle GO:1990267 122 0.012
negative regulation of cellular biosynthetic process GO:0031327 161 0.012
response to wounding GO:0009611 254 0.012
negative regulation of signaling GO:0023057 157 0.012
positive regulation of signal transduction GO:0009967 175 0.012
anion transport GO:0006820 178 0.012
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.012
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.011
carbohydrate derivative biosynthetic process GO:1901137 124 0.011
cognition GO:0050890 92 0.011
mapk cascade GO:0000165 140 0.011
positive regulation of secretion GO:0051047 140 0.011
negative regulation of catalytic activity GO:0043086 103 0.011
spermatogenesis GO:0007283 99 0.011
defense response to gram negative bacterium GO:0050829 3 0.011
hormone metabolic process GO:0042445 69 0.011
regulation of cellular protein metabolic process GO:0032268 267 0.011
cellular macromolecule localization GO:0070727 122 0.011
regulation of blood circulation GO:1903522 110 0.011
response to estrogen GO:0043627 232 0.011
positive regulation of cell motility GO:2000147 97 0.011
protein processing GO:0016485 68 0.011
establishment of protein localization GO:0045184 141 0.011
positive regulation of cellular protein metabolic process GO:0032270 167 0.011
response to insulin GO:0032868 133 0.011
regulation of cell migration GO:0030334 128 0.011
regulation of secretion by cell GO:1903530 208 0.011
cellular response to stress GO:0033554 269 0.011
female pregnancy GO:0007565 122 0.011
organic hydroxy compound metabolic process GO:1901615 115 0.011
organonitrogen compound catabolic process GO:1901565 179 0.011
response to cytokine GO:0034097 215 0.011
cell adhesion GO:0007155 110 0.011
nucleotide catabolic process GO:0009166 139 0.011
organic anion transport GO:0015711 132 0.011
negative regulation of transport GO:0051051 136 0.011
formation of primary germ layer GO:0001704 1 0.011
protein heterooligomerization GO:0051291 89 0.011
regulation of embryonic development GO:0045995 2 0.011
regulation of hormone secretion GO:0046883 106 0.011
tissue development GO:0009888 252 0.011
male gamete generation GO:0048232 99 0.011
response to bacterium GO:0009617 200 0.011
positive regulation of cell communication GO:0010647 271 0.010
cellular calcium ion homeostasis GO:0006874 160 0.010
cellular response to tumor necrosis factor GO:0071356 46 0.010
negative regulation of natural killer cell mediated cytotoxicity GO:0045953 4 0.010
negative regulation of molecular function GO:0044092 133 0.010
calcium ion transport GO:0006816 131 0.010
rhythmic process GO:0048511 156 0.010
embryonic pattern specification GO:0009880 1 0.010
positive regulation of cell migration GO:0030335 96 0.010
carbohydrate derivative catabolic process GO:1901136 147 0.010
cellular amide metabolic process GO:0043603 44 0.010
regulation of canonical wnt signaling pathway GO:0060828 4 0.010
heterocycle catabolic process GO:0046700 167 0.010
regulation of nucleotide metabolic process GO:0006140 117 0.010
macromolecular complex assembly GO:0065003 273 0.010
regulation of defense response GO:0031347 68 0.010
negative regulation of nucleic acid templated transcription GO:1903507 117 0.010
cytoplasmic transport GO:0016482 115 0.010
cellular metal ion homeostasis GO:0006875 172 0.010
axis specification GO:0009798 4 0.010
regulation of peptide secretion GO:0002791 82 0.010

Plek2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.024
nervous system disease DOID:863 0 0.024
sensory system disease DOID:0050155 0 0.017
disease of metabolism DOID:0014667 0 0.012
central nervous system disease DOID:331 0 0.010