Rattus norvegicus

0 known processes

Trim66

tripartite motif-containing 66

Trim66 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
response to estrogen GO:0043627 232 0.402
positive regulation of cell proliferation GO:0008284 249 0.343
regulation of epithelial cell proliferation GO:0050678 49 0.235
regulation of cell proliferation GO:0042127 359 0.220
metal ion transport GO:0030001 289 0.167
response to peptide GO:1901652 292 0.162
Rat
epithelial cell proliferation GO:0050673 54 0.150
cation transmembrane transport GO:0098655 263 0.139
intracellular signal transduction GO:0035556 314 0.116
response to oxygen levels GO:0070482 265 0.107
response to hypoxia GO:0001666 231 0.106
muscle contraction GO:0006936 88 0.104
response to estradiol GO:0032355 164 0.104
response to external biotic stimulus GO:0043207 221 0.103
inorganic ion transmembrane transport GO:0098660 229 0.098
positive regulation of epithelial cell proliferation GO:0050679 32 0.091
dna metabolic process GO:0006259 96 0.091
single organism biosynthetic process GO:0044711 342 0.089
positive regulation of phosphate metabolic process GO:0045937 262 0.088
response to peptide hormone GO:0043434 278 0.082
Rat
reproductive process GO:0022414 372 0.081
positive regulation of transport GO:0051050 245 0.076
single organism reproductive process GO:0044702 297 0.076
positive regulation of response to stimulus GO:0048584 285 0.074
calcium ion homeostasis GO:0055074 162 0.073
cellular calcium ion homeostasis GO:0006874 160 0.072
positive regulation of developmental process GO:0051094 283 0.071
muscle system process GO:0003012 115 0.071
positive regulation of biosynthetic process GO:0009891 319 0.070
negative regulation of metabolic process GO:0009892 331 0.070
Mouse
response to decreased oxygen levels GO:0036293 237 0.068
response to insulin GO:0032868 133 0.066
neuron differentiation GO:0030182 368 0.065
rhythmic process GO:0048511 156 0.065
divalent inorganic cation homeostasis GO:0072507 165 0.064
ion transmembrane transport GO:0034220 365 0.063
cellular cation homeostasis GO:0030003 180 0.062
positive regulation of cellular biosynthetic process GO:0031328 295 0.060
nucleic acid templated transcription GO:0097659 379 0.060
Mouse
brain development GO:0007420 247 0.059
cell cell signaling GO:0007267 335 0.058
response to corticosteroid GO:0031960 235 0.057
regulation of multicellular organismal development GO:2000026 376 0.054
positive regulation of multicellular organismal process GO:0051240 387 0.053
positive regulation of phosphorus metabolic process GO:0010562 262 0.050
cation transport GO:0006812 382 0.050
response to biotic stimulus GO:0009607 226 0.048
protein autophosphorylation GO:0046777 66 0.047
response to bacterium GO:0009617 200 0.047
regulation of system process GO:0044057 208 0.047
regulation of homeostatic process GO:0032844 101 0.047
regulation of rna metabolic process GO:0051252 391 0.047
Mouse
multicellular organism reproduction GO:0032504 233 0.047
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.047
metal ion homeostasis GO:0055065 186 0.044
regulation of neurological system process GO:0031644 43 0.043
cellular divalent inorganic cation homeostasis GO:0072503 162 0.043
regulation of blood circulation GO:1903522 110 0.042
negative regulation of cell death GO:0060548 229 0.042
cellular ion homeostasis GO:0006873 184 0.041
response to oxidative stress GO:0006979 186 0.041
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.041
monovalent inorganic cation transport GO:0015672 172 0.041
regulation of catalytic activity GO:0050790 304 0.040
regulation of phosphorylation GO:0042325 248 0.040
mapk cascade GO:0000165 140 0.039
cytosolic calcium ion homeostasis GO:0051480 140 0.038
response to inorganic substance GO:0010035 377 0.038
regulation of protein metabolic process GO:0051246 289 0.038
positive regulation of signaling GO:0023056 270 0.038
regulation of ion transport GO:0043269 245 0.038
cellular response to stress GO:0033554 269 0.037
regulation of phosphorus metabolic process GO:0051174 349 0.037
anterior posterior pattern specification GO:0009952 1 0.037
regulation of molecular function GO:0065009 398 0.037
regulation of transcription dna templated GO:0006355 374 0.036
Mouse
cellular homeostasis GO:0019725 252 0.036
neuron death GO:0070997 127 0.035
regulation of organ formation GO:0003156 2 0.035
neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 3 0.035
circulatory system process GO:0003013 183 0.035
organophosphate metabolic process GO:0019637 370 0.035
regulation of phosphate metabolic process GO:0019220 349 0.034
cardiovascular system development GO:0072358 134 0.034
cellular response to acid chemical GO:0071229 75 0.034
regulation of membrane potential GO:0042391 110 0.034
cellular response to endogenous stimulus GO:0071495 377 0.033
ion homeostasis GO:0050801 212 0.033
regulation of sodium ion transmembrane transporter activity GO:2000649 4 0.033
action potential GO:0001508 54 0.032
regulation of transmembrane transport GO:0034762 122 0.032
developmental induction GO:0031128 2 0.031
behavior GO:0007610 205 0.031
anatomical structure morphogenesis GO:0009653 298 0.031
chemical homeostasis GO:0048878 292 0.031
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.031
respiratory system development GO:0060541 45 0.030
response to ketone GO:1901654 182 0.030
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.030
regulation of dna metabolic process GO:0051052 60 0.030
alcohol metabolic process GO:0006066 77 0.030
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.029
cellular component biogenesis GO:0044085 368 0.029
blood circulation GO:0008015 183 0.029
salivary gland development GO:0007431 3 0.029
nucleotide metabolic process GO:0009117 279 0.029
negative regulation of cytosolic calcium ion concentration GO:0051481 10 0.029
positive regulation of intracellular signal transduction GO:1902533 138 0.029
coronary vasculature morphogenesis GO:0060977 3 0.028
regulation of cellular component organization GO:0051128 368 0.028
response to reactive oxygen species GO:0000302 120 0.028
regulation of blood vessel size GO:0050880 89 0.028
cellular response to peptide hormone stimulus GO:0071375 120 0.028
regulation of growth GO:0040008 105 0.027
cell growth GO:0016049 104 0.027
multi organism reproductive process GO:0044703 262 0.026
response to cytokine GO:0034097 215 0.026
central nervous system development GO:0007417 311 0.026
smooth muscle cell proliferation GO:0048659 77 0.026
circulatory system development GO:0072359 134 0.026
reproduction GO:0000003 245 0.025
negative regulation of molecular function GO:0044092 133 0.025
multicellular organismal reproductive process GO:0048609 233 0.025
protein complex assembly GO:0006461 263 0.025
signal transduction by phosphorylation GO:0023014 144 0.024
transmembrane transport GO:0055085 412 0.024
response to nutrient levels GO:0031667 370 0.024
angiotensin mediated drinking behavior GO:0003051 2 0.023
ribonucleotide metabolic process GO:0009259 231 0.023
lipid metabolic process GO:0006629 283 0.023
response to toxic substance GO:0009636 133 0.023
secretion GO:0046903 307 0.023
gamma aminobutyric acid transport GO:0015812 8 0.023
wound healing GO:0042060 122 0.023
single organism behavior GO:0044708 130 0.023
regulation of muscle system process GO:0090257 79 0.022
response to molecule of bacterial origin GO:0002237 194 0.022
negative regulation of developmental process GO:0051093 125 0.022
positive regulation of rna biosynthetic process GO:1902680 197 0.022
gamma aminobutyric acid secretion GO:0014051 6 0.022
regulation of anatomical structure size GO:0090066 135 0.022
calcium ion transport GO:0006816 131 0.021
response to acid chemical GO:0001101 222 0.021
rna metabolic process GO:0016070 406 0.021
Mouse
cellular response to reactive oxygen species GO:0034614 55 0.021
regulation of muscle contraction GO:0006937 53 0.021
sodium ion transmembrane transport GO:0035725 67 0.021
immune system process GO:0002376 204 0.020
cellular response to oxygen containing compound GO:1901701 386 0.020
response to hydrogen peroxide GO:0042542 89 0.020
positive regulation of neurogenesis GO:0050769 165 0.020
regulation of rna biosynthetic process GO:2001141 381 0.020
Mouse
sex differentiation GO:0007548 113 0.020
regulation of calcium ion transport GO:0051924 77 0.020
positive regulation of molecular function GO:0044093 230 0.020
positive regulation of protein metabolic process GO:0051247 178 0.020
regulation of ion homeostasis GO:2000021 63 0.020
regulation of cellular protein metabolic process GO:0032268 267 0.019
positive regulation of cell differentiation GO:0045597 217 0.019
cellular metal ion homeostasis GO:0006875 172 0.019
rna biosynthetic process GO:0032774 380 0.019
Mouse
locomotion GO:0040011 237 0.019
cellular response to nitrogen compound GO:1901699 210 0.019
response to transition metal nanoparticle GO:1990267 122 0.019
cellular response to hormone stimulus GO:0032870 247 0.019
positive regulation of gene expression GO:0010628 244 0.019
regulation of sensory perception GO:0051931 29 0.019
heart development GO:0007507 72 0.019
regulation of neurogenesis GO:0050767 247 0.019
regulation of metal ion transport GO:0010959 118 0.019
smooth muscle contraction GO:0006939 37 0.019
organ morphogenesis GO:0009887 75 0.019
regulation of signal transduction GO:0009966 318 0.018
ovulation cycle process GO:0022602 50 0.018
response to lipopolysaccharide GO:0032496 191 0.018
regulation of nucleic acid templated transcription GO:1903506 380 0.018
Mouse
cation homeostasis GO:0055080 195 0.018
cellular component assembly GO:0022607 360 0.018
acid secretion GO:0046717 48 0.018
calcium mediated signaling GO:0019722 23 0.018
cognition GO:0050890 92 0.018
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.018
Mouse
positive regulation of smooth muscle cell proliferation GO:0048661 51 0.017
cellular amine metabolic process GO:0044106 38 0.017
cellular chemical homeostasis GO:0055082 247 0.017
phospholipid metabolic process GO:0006644 61 0.017
erk1 and erk2 cascade GO:0070371 48 0.017
brain renin angiotensin system GO:0002035 3 0.017
transcription from rna polymerase ii promoter GO:0006366 252 0.017
negative regulation of multicellular organismal process GO:0051241 203 0.017
positive regulation of homeostatic process GO:0032846 49 0.017
heart morphogenesis GO:0003007 3 0.017
regeneration GO:0031099 163 0.017
organ regeneration GO:0031100 101 0.017
regulation of organic acid transport GO:0032890 35 0.017
positive regulation of muscle contraction GO:0045933 22 0.017
negative regulation of cellular metabolic process GO:0031324 281 0.017
Mouse
divalent metal ion transport GO:0070838 132 0.016
sodium ion transport GO:0006814 82 0.016
apoptotic process GO:0006915 381 0.016
regulation of anatomical structure morphogenesis GO:0022603 141 0.016
positive regulation of mapk cascade GO:0043410 92 0.016
muscle cell proliferation GO:0033002 84 0.016
potassium ion transport GO:0006813 97 0.016
protein phosphorylation GO:0006468 345 0.016
positive regulation of cellular component organization GO:0051130 200 0.016
monocarboxylic acid transport GO:0015718 52 0.016
organic hydroxy compound metabolic process GO:1901615 115 0.016
regulation of cell differentiation GO:0045595 320 0.016
response to glucocorticoid GO:0051384 223 0.016
response to hyperoxia GO:0055093 45 0.015
regulation of protein modification process GO:0031399 194 0.015
angiogenesis involved in coronary vascular morphogenesis GO:0060978 3 0.015
tissue development GO:0009888 252 0.015
adult locomotory behavior GO:0008344 4 0.015
regulation of amine transport GO:0051952 54 0.015
response to other organism GO:0051707 220 0.015
cellular response to growth factor stimulus GO:0071363 162 0.015
nucleoside phosphate metabolic process GO:0006753 283 0.015
vascular process in circulatory system GO:0003018 96 0.015
secretion by cell GO:0032940 248 0.015
actin filament based process GO:0030029 86 0.015
cellular component movement GO:0006928 248 0.015
negative regulation of transcription dna templated GO:0045892 116 0.015
Mouse
regulation of apoptotic process GO:0042981 335 0.015
positive regulation of nervous system development GO:0051962 178 0.015
positive regulation of cardiac muscle cell proliferation GO:0060045 4 0.015
organophosphate biosynthetic process GO:0090407 143 0.015
organ induction GO:0001759 1 0.015
g protein coupled receptor signaling pathway GO:0007186 242 0.014
purine ribonucleotide metabolic process GO:0009150 227 0.014
learning or memory GO:0007611 90 0.014
steroid metabolic process GO:0008202 73 0.014
regulation of intracellular signal transduction GO:1902531 218 0.014
glycerophospholipid metabolic process GO:0006650 47 0.014
muscle organ development GO:0007517 50 0.014
positive regulation of signal transduction GO:0009967 175 0.014
developmental process involved in reproduction GO:0003006 159 0.014
positive regulation of immune system process GO:0002684 90 0.014
cell cell signaling involved in cell fate commitment GO:0045168 2 0.014
muscle tissue development GO:0060537 58 0.014
transcription dna templated GO:0006351 377 0.013
Mouse
ribose phosphate metabolic process GO:0019693 235 0.013
glycerolipid metabolic process GO:0046486 67 0.013
regulation of tube size GO:0035150 89 0.013
response to electrical stimulus GO:0051602 56 0.013
development of primary sexual characteristics GO:0045137 107 0.013
organ formation GO:0048645 3 0.013
nucleoside phosphate biosynthetic process GO:1901293 102 0.013
response to metal ion GO:0010038 253 0.013
cellular response to corticosteroid stimulus GO:0071384 69 0.013
negative regulation of macromolecule metabolic process GO:0010605 260 0.013
Mouse
amine metabolic process GO:0009308 38 0.013
macromolecule localization GO:0033036 252 0.013
regulation of nervous system development GO:0051960 264 0.013
female pregnancy GO:0007565 122 0.013
cell migration GO:0016477 197 0.013
detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 4 0.013
circadian rhythm GO:0007623 88 0.013
regulation of secretion by cell GO:1903530 208 0.012
tissue remodeling GO:0048771 40 0.012
telencephalon development GO:0021537 62 0.012
anion transport GO:0006820 178 0.012
lung development GO:0030324 43 0.012
head development GO:0060322 247 0.012
positive regulation of cellular component movement GO:0051272 102 0.012
growth GO:0040007 165 0.012
ovulation cycle GO:0042698 67 0.012
positive regulation of intracellular transport GO:0032388 39 0.012
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.012
regulation of nucleotide biosynthetic process GO:0030808 47 0.012
immune system development GO:0002520 41 0.012
negative regulation of gene expression GO:0010629 199 0.012
Mouse
positive regulation of ion transport GO:0043270 94 0.012
cellular response to peptide GO:1901653 133 0.012
gonad development GO:0008406 104 0.012
positive regulation of blood circulation GO:1903524 65 0.012
positive regulation of cell communication GO:0010647 271 0.012
cellular response to glucocorticoid stimulus GO:0071385 68 0.012
programmed cell death GO:0012501 392 0.012
embryonic pattern specification GO:0009880 1 0.012
homeostatic process GO:0042592 331 0.012
positive regulation of smooth muscle contraction GO:0045987 18 0.012
response to wounding GO:0009611 254 0.012
reproductive structure development GO:0048608 128 0.011
regulation of vascular smooth muscle contraction GO:0003056 3 0.011
protein processing GO:0016485 68 0.011
sensory perception GO:0007600 101 0.011
cell cycle GO:0007049 101 0.011
protein oligomerization GO:0051259 191 0.011
multi multicellular organism process GO:0044706 138 0.011
cellular response to cytokine stimulus GO:0071345 127 0.011
peristalsis GO:0030432 2 0.011
macromolecular complex subunit organization GO:0043933 339 0.011
multicellular organismal signaling GO:0035637 44 0.011
regulation of cellular localization GO:0060341 263 0.011
regulation of protein phosphorylation GO:0001932 183 0.011
heart contraction GO:0060047 57 0.011
response to increased oxygen levels GO:0036296 45 0.011
organic anion transport GO:0015711 132 0.011
negative regulation of nucleic acid templated transcription GO:1903507 117 0.011
Mouse
sensory perception of bitter taste GO:0050913 4 0.011
carbohydrate derivative biosynthetic process GO:1901137 124 0.011
regulation of cell development GO:0060284 263 0.011
positive regulation of catalytic activity GO:0043085 184 0.011
response to testosterone GO:0033574 55 0.011
response to osmotic stress GO:0006970 42 0.011
protein maturation GO:0051604 68 0.011
nucleobase containing small molecule metabolic process GO:0055086 316 0.011
cellular response to drug GO:0035690 30 0.011
small molecule biosynthetic process GO:0044283 124 0.011
positive regulation of protein modification process GO:0031401 142 0.011
hormone metabolic process GO:0042445 69 0.011
cellular response to insulin stimulus GO:0032869 81 0.010
purine nucleotide metabolic process GO:0006163 229 0.010
regulation of smooth muscle contraction GO:0006940 29 0.010
protein complex subunit organization GO:0071822 302 0.010
positive regulation of erk1 and erk2 cascade GO:0070374 29 0.010
positive regulation of cellular protein metabolic process GO:0032270 167 0.010
cell projection organization GO:0030030 302 0.010
proteolysis GO:0006508 175 0.010
positive regulation of phosphorylation GO:0042327 177 0.010
regulation of smoothened signaling pathway GO:0008589 2 0.010
respiratory tube development GO:0030323 43 0.010
dephosphorylation GO:0016311 98 0.010
neurological system process GO:0050877 219 0.010
regulation of programmed cell death GO:0043067 341 0.010

Trim66 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.022
musculoskeletal system disease DOID:17 0 0.022